Uric acid as one of the important factors in multifactorial disorders--facts and controversies.

Abstract:

:With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a significant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an "antioxidant", a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.

journal_name

Biochem Med (Zagreb)

journal_title

Biochemia medica

authors

Pasalic D,Marinkovic N,Feher-Turkovic L

doi

10.11613/bm.2012.007

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

63-75

issue

1

eissn

1330-0962

issn

1846-7482

journal_volume

22

pub_type

杂志文章,评审
  • Optimizing laboratory defined macroprolactin algorithm.

    abstract:Introduction:Macroprolactinaemia is a well-known analytical problem in diagnostics of hyperprolactinaemia usually detected with polyethylene glycol (PEG) precipitation method. Since there is no harmonization in macroprolactin detection and reporting results, this study proposes and evaluates the usefulness of in-house ...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2019.020706

    authors: Šostarić M,Bokulić A,Marijančević D,Zec I

    更新日期:2019-06-15 00:00:00

  • Effectiveness of citrate buffer-fluoride mixture in Terumo tubes as an inhibitor of in vitro glycolysis.

    abstract:INTRODUCTION:Glycolysis affects glucose determination in vitro. The placement of sample tubes in ice-water slurry with plasma separation within 30 minutes is recommended, or alternatively the use of a glycolysis inhibitor. The aim of our two-steps study was to evaluate which Terumo tube is best for glucose determinatio...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2016.006

    authors: Bonetti G,Carta M,Montagnana M,Lo Cascio C,Bonfigli AR,Mosca A,Testa R,Italian joint SIBioC-SIPMeL Study Group on Diabetes Mellitus.

    更新日期:2016-01-01 00:00:00

  • Determining biological variation of serum parathyroid hormone in healthy adults.

    abstract:Introduction:Measurement of parathyroid hormone (PTH) is essential in the investigation and management of calcium metabolism disorders. To assess the significance of any assay result when clinical decision making biological variation (BV) of the measurand must be taken into consideration. The aim of the present study i...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2019.030702

    authors: Ercan M,Akbulut ED,Avcı E,Yücel Ç,Oğuz EF,Turhan T,Serdar M

    更新日期:2019-10-15 00:00:00

  • IMPACT Observatory: tracking the evolution of clinical trial data sharing and research integrity.

    abstract:INTRODUCTION:The opening of research data is emerging thanks to the increasing possibilities of digital technology. The opening of clinical trial (CT) data is a part of this process, expected to have positive scientific, ethical, health, and economic impacts thus contributing to research integrity. The January 2016 pro...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2016.035

    authors: Krleža-Jerić K,Gabelica M,Banzi R,Martinić MK,Pulido B,Mahmić-Kaknjo M,Reveiz L,Šimić J,Utrobičić A,Hrgović I

    更新日期:2016-10-15 00:00:00

  • Classical pathway activity C3c, C4 and C1-inhibitor protein reference intervals determination in EDTA plasma.

    abstract:Introduction:Reference intervals (RIs) for complement assays in EDTA plasma samples have not previously been published. The objectives of the present study were to validate and/or determine RIs for classical pathway (CP50) activity and C3c, C4 and C1 inhibitor protein (C1INH) assays and to assess the need for age-speci...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2019.030707

    authors: Lopez B,Bertier N,Ledoult E,Joudinaud R,Maanaoui M,Majerus V,Moitrot E,Deleplancque AS,Rogeau S,Launay D,Lefèvre G,Labalette M,Dubucquoi S

    更新日期:2019-10-15 00:00:00

  • Effect of winter swimming on haematological parameters.

    abstract:INTRODUCTION:Winter swimming represents an intensive short-term exposure to cold, and thus it is considered a strong physical stress. Cold-based treatments, i.e. immersions in cold water, are spreading in sport medicine for improving recovery following muscle traumas, although a universal acceptance of that method is n...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/bm.2011.014

    authors: Lombardi G,Ricci C,Banfi G

    更新日期:2011-01-01 00:00:00

  • Utility of routine laboratory preoperative tests based on previous results: Time to give up.

    abstract:INTRODUCTION:The usefulness and cost-effectiveness of routine laboratory preoperative tests (POTs) have been challenged recently. In fact, the American Society of Anesthesiologists (ASA) Task Force has stated that test results obtained from the medical record within 6 months of surgery generally are mostly acceptable. ...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2017.030902

    authors: Rodríguez-Borja E,Corchon-Peyrallo A,Aguilar-Aguilar G,Carratala-Calvo A

    更新日期:2017-10-15 00:00:00

  • General position of Croatian medical biochemistry laboratories on autovalidation: survey of the Working Group for Post-analytics of the Croatian Society of Medical Biochemistry and Laboratory Medicine.

    abstract:Introduction:Autovalidation (AV) is an algorithm based on predefined rules designed, among others, to automate and standardize the postanalytical phase of laboratory work. The aim of this study was to examine the overall opinion of Croatian medical biochemistry laboratories regarding various aspects of AV. Material an...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2020.020702

    authors: Rimac V,Jokic A,Podolar S,Vlasic Tanaskovic J,Honovic L,Lenicek Krleza J

    更新日期:2020-06-15 00:00:00

  • In vitro diagnostic company recalls and medical laboratory practices: an Italian case.

    abstract:INTRODUCTION:In vitro human diagnostic (IVD) company recalls are a common practice aimed to either minimize a potential error or eliminate an existing failure. In this case report, we aim to provide a critical analysis of a recent IVD recall and to provide a practical framework about what to do when an IVD company reca...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2015.028

    authors: Lima-Oliveira G,Lippi G,Salvagno GL,Brocco G,Guidi GC

    更新日期:2015-06-05 00:00:00

  • Inflammatory and angiogenic biomarkers in diabetic retinopathy.

    abstract::Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and a leading cause of blindness in working-age adults in developed countries. Numerous investigations have recognised inflammation and angiogenesis as important factors in the development of this complication of ...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2020.030502

    authors: Kaštelan S,Orešković I,Bišćan F,Kaštelan H,Gverović Antunica A

    更新日期:2020-10-15 00:00:00

  • Laboratory testing of extravascular body fluids: National recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Part I - Serous fluids.

    abstract::Extravascular body fluids (EBF) analysis can provide useful information in the differential diagnosis of conditions that caused their accumulation. Their unique nature and particular requirements accompanying EBF analysis need to be recognized in order to minimize possible negative implications on patient safety. This...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2020.010502

    authors: Milevoj Kopcinovic L,Culej J,Jokic A,Bozovic M,Kocijan I

    更新日期:2020-02-15 00:00:00

  • Scientific author names: errors, corrections, and identity profiles.

    abstract::Authorship problems are deep-rooted in the field of science communication. Some of these relate to lack of specific journal instructions. For decades, experts in journal editing and publishing have been exploring the authorship criteria and contributions deserving either co-authorship or acknowledgment. The issue of i...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2016.017

    authors: Gasparyan AY,Yessirkepov M,Gerasimov AN,Kostyukova EI,Kitas GD

    更新日期:2016-01-01 00:00:00

  • Molecular pathways in cancer-related inflammation.

    abstract::Accumulating evidence shows that chronic inflammation is associated to increased risk of cancer. An inflammatory component is present also in the microenvironment of tumours epidemiologically unrelated to inflammation. Extensive investigations over the past decade have uncovered many of the important mechanistic pathw...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/bm.2011.036

    authors: Del Prete A,Allavena P,Santoro G,Fumarulo R,Corsi MM,Mantovani A

    更新日期:2011-01-01 00:00:00

  • External Quality Assessment in Croatia: problems, challenges, and specific circumstances.

    abstract::In Croatian medical laboratories (ML), external quality assessment (EQA) has a long tradition of almost half of a century. At national level, EQA is provided by Croatian Centre for Quality Assessment in Laboratory Medicine (CROQALM) which is a part of Croatian Society of Medical Biochemistry and Laboratory Medicine.
T...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2017.011

    authors: Krleza JL,Celap I,Tanaskovic JV

    更新日期:2017-02-15 00:00:00

  • Oxidative status parameters in children with urinary tract infection.

    abstract:INTRODUCTION:Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acu...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2014.029

    authors: Petrovic S,Bogavac-Stanojevic N,Kotur-Stevuljevic J,Peco-Antic A,Ivanisevic I,Ivanisevic J,Paripovic D,Jelic-Ivanovic Z

    更新日期:2014-01-01 00:00:00

  • A case of severe pseudohyperkalaemia due to muscle contraction.

    abstract:Introduction:Severe hyperkalaemia is a serious medical condition requiring immediate medical attention. Before medical treatment is started, pseudohyperkalaemia has to be ruled out. Case description:A 10-month old infant presented to the emergency department with fever and coughing since 1 week. Routine venous blood t...

    journal_title:Biochemia medica

    pub_type:

    doi:10.11613/BM.2020.021004

    authors: Van Elslande J,Dominicus T,Toelen J,Frans G,Vermeersch P

    更新日期:2020-06-15 00:00:00

  • Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis.

    abstract:INTRODUCTION:We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. MATERIAL AND METHODS:In the group of 192 patients with clinically su...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/bm.2013.012

    authors: Bogavac-Stanojević N,Dopsaj V,Jelić-Ivanović Z,Lakić D,Vasić D,Petrova G

    更新日期:2013-01-01 00:00:00

  • The chi-square test of independence.

    abstract::The Chi-square statistic is a non-parametric (distribution free) tool designed to analyze group differences when the dependent variable is measured at a nominal level. Like all non-parametric statistics, the Chi-square is robust with respect to the distribution of the data. Specifically, it does not require equality o...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/bm.2013.018

    authors: McHugh ML

    更新日期:2013-01-01 00:00:00

  • The likelihood ratio and its graphical representation.

    abstract::Diagnostic tests are important clinical tools. Bayes' theorem and Bayesian approach are important methods for interpreting test results. The Bayesian factor, the so-called likelihood ratio, has not always been well-understood. In this article, we try to discuss the likelihood ratio and its value for a specific test re...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2019.020101

    authors: Habibzadeh F,Habibzadeh P

    更新日期:2019-06-15 00:00:00

  • Diagnostic accuracy of urinary prostate protein glycosylation profiling in prostatitis diagnosis.

    abstract:INTRODUCTION:Although prostatitis is a common male urinary tract infection, clinical diagnosis of prostatitis is difficult. The developmental mechanism of prostatitis is not yet unraveled which led to the elaboration of various biomarkers. As changes in asparagine-linked-(N-)-glycosylation were observed between healthy...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2015.045

    authors: Vermassen T,Van Praet C,Poelaert F,Lumen N,Decaestecker K,Hoebeke P,Van Belle S,Rottey S,Delanghe J

    更新日期:2015-10-15 00:00:00

  • Indications for laboratory tests in primary care: assessment of the most frequent indications and requests with blank clinical information.

    abstract:INTRODUCTION:The aim of this work is twofold. Firstly, to study the temporal evolution in the number of laboratory requests from primary care without clinical indication, and to analyse the number of such requests before and after the implementation of an automated requesting procedure. Secondly, to investigate what ar...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2016.045

    authors: Salinas M,López-Garrigós M,Flores E,Leiva-Salinas M,Esteban P,Ahumada M,Leiva-Salinas C

    更新日期:2016-10-15 00:00:00

  • Redefinition of gestational diabetes mellitus: implications for laboratory practice in Croatia.

    abstract::An increasing prevalence of gestational diabetes has become a very challenging task in prenatal care worldwide. International Association of Diabetes and Pregnancy Study Groups (IADPSG) has recently issued recommendations on the diagnosis and classification of hyperglycaemia in pregnancy. These recommendations, the fi...

    journal_title:Biochemia medica

    pub_type: 社论

    doi:10.11613/bm.2013.002

    authors: Lovrencić MV,Honović L,Kralik S,Matica J,Prasek M,Pape-Medvidović E,Ivanisević M,Delmis J

    更新日期:2013-01-01 00:00:00

  • Laboratory diagnostics of chronic kidney disease in Croatia: state of the art.

    abstract:INTRODUCTION:Early identification and management of chronic kidney disease (CKD) is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease. In 2014, the Joint Croatian Working Group (JCWG) for laboratory diagnostic of CKD on the behalf of Croatian society of medical bioch...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2015.009

    authors: Biljak VR,Honović L,Matica J,Knežević B,Vojak SŠ

    更新日期:2015-01-01 00:00:00

  • Reference intervals for six salivary cortisol measures based on the Croatian Late Adolescence Stress Study (CLASS).

    abstract:Introduction:The aim of this nested study is to provide the reference intervals for already published measurements of salivary cortisol from the Croatian Adolescence Stress Study (CLASS). Material and methods:A total of 969 individuals (372 males and 597 females) were included in the reference sample (age range: 18-21...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2018.010902

    authors: Šupe-Domić D,Milas G,Stanišić L,Drmić Hofman I,Martinović Klarić I

    更新日期:2018-02-15 00:00:00

  • Analytical robustness of nine common assays: frequency of outliers and extreme differences identified by a large number of duplicate measurements.

    abstract:INTRODUCTION:Duplicate measurements can be used to describe the performance and analytical robustness of assays and to identify outliers. We performed about 235,000 duplicate measurements of nine routinely measured quantities and evaluated the observed differences between the replicates to develop new markers for analy...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2017.021

    authors: Neubig S,Grotevendt A,Kallner A,Nauck M,Petersmann A

    更新日期:2017-02-15 00:00:00

  • Urinary free cortisol assessment by liquid chromatography tandem mass spectrometry: a case study of ion suppression due to unacquainted administration of piperacillin.

    abstract:Introduction:Liquid chromatography coupled to atmospheric pressure ionization tandem mass spectrometry (LC-ESI-MS/MS) is currently considered the reference method for quantitative determination of urinary free cortisol (UFC). One of the major drawbacks of this measurement is a particular form of matrix effect, conventi...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2017.031001

    authors: Danese E,Salvagno GL,Guzzo A,Scurati S,Fava C,Lippi G

    更新日期:2017-10-15 00:00:00

  • The diagnostic accuracy of clinical and laboratory parameters in the diagnosis of acute appendicitis in the adult emergency department population - a case control pilot study.

    abstract:Introduction:The evaluation of patients with suspected appendicitis strives to identify all patients with presenting symptoms while minimizing negative appendectomy rate. The aim of the study was to identify the optimal combination of clinical and laboratory parameters that should facilitate the emergency department su...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2018.030712

    authors: Soldo I,Radisic Biljak V,Bakula B,Bakula M,Simundic AM

    更新日期:2018-10-15 00:00:00

  • Understanding logistic regression analysis.

    abstract::Logistic regression is used to obtain odds ratio in the presence of more than one explanatory variable. The procedure is quite similar to multiple linear regression, with the exception that the response variable is binomial. The result is the impact of each variable on the odds ratio of the observed event of interest....

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2014.003

    authors: Sperandei S

    更新日期:2014-02-15 00:00:00

  • Interrater reliability: the kappa statistic.

    abstract::The kappa statistic is frequently used to test interrater reliability. The importance of rater reliability lies in the fact that it represents the extent to which the data collected in the study are correct representations of the variables measured. Measurement of the extent to which data collectors (raters) assign th...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:

    authors: McHugh ML

    更新日期:2012-01-01 00:00:00

  • ICMJE authorship criteria are not met in a substantial proportion of manuscripts submitted to Biochemia Medica.

    abstract:INTRODUCTION:Our aim was to investigate if: (a) authors of Biochemia Medica meet authorship criteria given by International Committee of Medical Journal Editors (ICMJE), (b) authorship violations are more frequent in submissions containing some type of scientific misconduct. MATERIALS AND METHODS:Self-reported authors...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2015.033

    authors: Šupak-Smolčić V,Mlinarić A,Antončić D,Horvat M,Omazić J,Šimundić AM

    更新日期:2015-10-15 00:00:00