Abstract:
:Optic pathway gliomas (OPG) occur in 15% of patients with neurofibromatosis type 1 (NF1; OMIM 162200). Genotype-phenotype correlations in patients with NF1 may help to determine the risk group for developing complications such as OPG in coincidence with other NF1.features. We evaluated 52 patients with NF1 (25 with OPG and 27 without OPG). All subjects underwent a clinical examination focused on neurofibromatosis type 1 and molecular diagnostics of NF1 gene using protocol based on RNA analysis confirming the diagnosis of NF1. In the group with OPG patients, there was a significantly higher incidence of freckling (P=0.017), neurofibromatosis bright objects (NBO) (P=0.0038), compared to the group without OPG. The differences between the groups with respect to Lisch nodules were on the borderline of statistical significance (P=0.088). The frequency of neurofibromas in the group with OPG was not significant (P=0.9). From all patients with the mutation localized in the first tertile of the NF1 gene majority (71%) had optic glioma compared to individuals who didn't have the OPG 29% (P=0.0049). Our results present the clustering of mutations in the 5'tertile of NF1 gene in patients with optic nerve glioma and suggest higher incidence of freckling and neurofibromatosis brain objects in these patients. Molecular analysis of NF1 gene is important part in complex management of NF1 patients and contributes to a better understanding of clinical picture of NF1 patients. .
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Bolcekova A,Nemethova M,Zatkova A,Hlinkova K,Pozgayova S,Hlavata A,Kadasi L,Durovcikova D,Gerinec A,Husakova K,Pavlovicova Z,Holobrada M,Kovacs L,Ilencikova Ddoi
10.4149/neo_2013_084subject
Has Abstractpub_date
2013-01-01 00:00:00pages
655-65issue
6eissn
0028-2685issn
1338-4317journal_volume
60pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract::Progressive ascitic growth of a spontaneous transplantable T-cell lymphoma, designated as Dalton's lymphoma (DL), in a murine host has been shown to be associated with an involution of thymus accompanied by a massive depletion of the cortical region and an alteration in the distribution of thymocytes by a decrease of ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:UNLABELLED:Expression patterns of proteins involved in serine and glycine metabolism, and correlations of these patterns with clinicopathologic factors in phyllodes tumor were investigated. Tissue microarrays were prepared from 203 phyllodes tumors (PT) and stained with antibodies specific for glycine decarboxylase (GL...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2014_069
更新日期:2014-01-01 00:00:00
abstract::Currently, mechanisms leading to both apoptosis induction and the development of hormone-independence of prostate carcinoma cells are intensively studied. Attention is also given to the possibility of restoring cell sensitivity to hormone-antagonists. The present study focuses on the effect of the combined synthetic c...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Cell surface and calf serum proteins were released in vitro from cultured virus-transformed, chemically transformed and normal rat embryo fibroblasts in 0.2 M urea containing serum-free culture medium. Fibronectin (LETS protein) was found in considerably higher amount in medium from normal rat embryo fibroblasts than ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Presented study aimed to prepare A10 aptamer-modified poly (D,L-lactic-co-glycolic acid) (PLGA) nanoparticles loaded with triplex forming oligonucleotides(TFO) for targeted prostate cancer therapy. We first synthesized a PLGA-PEG-Apt copolymer. The PLGA-PEG-Apt nanoparticles (NP-Apt) were loaded with TFO using double ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2016_410
更新日期:2016-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a particularly lethal form of cancer. Overall survival evenafter liver surgery is unsatisfactory due to high metastatic capacity and recurrence rates. Cancer stem cells (CSCs) were recently proposed to elucidate the molecular mechanism of HCC metastasis and recurrence. In our study, w...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2015_068
更新日期:2015-01-01 00:00:00
abstract::The mol LD50 values were correlated with Hammett sigma constants in terms of the Hansen empiric equation 6 for para substituted derivatives of 1-phenyl-3-methyltriazene. Good agreement was achieved and the line slope of the correlation, 0.3, is the same as that found during an identical experiment with derivatives of ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::The concentration of estradiol and progesterone receptors in tumor cytosol from human breast cancer patients represents an important factor for the selection of patients for endocrine therapy and for the prognosis of the disease. This report presents results obtained by measurement of estradiol receptor in 157 breast ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Laryngeal carcinoma is the second commonest head and neck carcinoma globally. MicroRNA-101 (miR-101) has been reported as a tumor suppressor in multiple malignancies including laryngeal squamous cell carcinoma (LSCC). However, the roles and molecular mechanisms of miR-101 in the development of LSCC have not been fully...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_180811N611
更新日期:2019-07-23 00:00:00
abstract::In this study subcellular localization of cyclin A in the human promyelocytic leukemia cell line HL-60 and the human erythroleukemic K-562 cell line was examined by immunocytochemical methods. Studies were based on light and electron microscope evaluations. Cyclin A at the level of light microscope was present in 48% ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The effect of a crude protein fraction from human urine having gonadotropin inhibitory activity (GGIM) was observed on the growth of 7,12-dimethylbenz(a)anthracene induced mammary tumors in Holtzman rat. Results show that while in 12 out 13 tumors, tumor growth was retarded/regressed following 2--4 weeks of CGIM treat...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::The cytostatic cytokine tumor necrosis factor-alpha (TNF-alpha) and proliferative hormone adrenomedullin (AM) are abundantly expressed in human tumors. However, little is known about mechanism (s) through which TNF-alpha and AM exert their regulatory effects, especially in the regulation of proliferative activity in m...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::In this study there is presented a comparative analysis of immediate results after radiotherapy and combined treatment (radio- and chemotherapy) in 174 patients with highly differentiated inoperable lung cancer. The data were provided by participants of a joint investigation in some CMEA member countries (Hungary, USS...
journal_title:Neoplasma
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1983-01-01 00:00:00
abstract::There is some evidence that prostaglandin (PGE)-secreting cells may have a role in immunosuppression in cancer patients. In this work we investigated the effects of indomethacin--a PGE synthesis inhibitor, on PHA-induced lymphoproliferative response in vitro. Twenty patients with lung cancer before therapy were includ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::The oral cavity is continually exposed to various traumas due to the effect of thermal, mechanical and chemical stimuli, which when accompanied by inflammatory states may promote the growth of neoplastic changes. Numerous studies have revealed a correlation between the expression of p53 and Bcl-2 proteins and the prog...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer has been suggested by the development of adenocarcinomas in the murine ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::To date, epidemiological studies have assessed the association between Toll-like receptor 2 (TLR2) gene polymorphisms and cancer risk. However, the results of these studies remain controversial. We aimed to examine the associations between three SNPs (Delta22, rs3804099 and rs3804100) of TLR2 gene and cancer risk by c...
journal_title:Neoplasma
pub_type: 杂志文章,meta分析
doi:10.4149/neo_2013_060
更新日期:2013-01-01 00:00:00
abstract::This study aimed to investigate the effects of RhoGDIα knockdown on apoptosis and the chemosensitivity of lung cancer cells to paclitaxel. The signaling proteins involved were also assessed. RhoGDIα expression was assessed by RT-PCR, Western blotting and immunohistochemistry. Apoptosis was determined by flow cytometri...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2012_070
更新日期:2012-01-01 00:00:00
abstract::The clastogenic effects of N-nitrosodimethylamine (N-DMA) and dinitrosoglycolurile (DNSGU) were studied in the bone marrow of mice and in peripheral blood lymphocytes of cows. None of the tested compounds showed significant enhancement of chromosome aberrations at doses 1/2 LD50 and 1/10 LD50 in murine bone marrow cel...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The influence of 13-cis-retinoic acid on the light-caused injury of hematoporphyrin-pretreated nontransformed 10 T1/2 fibroblasts and N2a neuroblastoma cells was investigated. Retinoid reduced the percentage of damaged cells as assessed by the plating efficiency assay. N2a neuroblastoma cells were found to be better p...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::It has been shown by a number of authors that the antibiotic chloramphenicol (CP), produced in the USSE under the name of levomycetin, had considerably inhibited the growth of liver tumors, induced by various carcinogenic compounds [3,7,8,21]. Moreover, it has been found by ourselves and other authors that CP greatly ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::Cysteine proteinases cathepsin (Cath) B and L and their endogenous inhibitors stefin (Stef) A and B concentrations were measured using a quantitative immunosorbent assay (ELISA; KRKA d.d., Novo mesto, Slovenia) in serum samples from 35 patients with primary and 7 patients with recurrent squamous cell carcinoma of the ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The authors have studied the influence of primary, methylcholanthrene-induced tumor on T and B lymphocytes of spleen, thymus, draining lymph nodes and peripheral blood of rats. Differences in weight of tumors were found to correlate with changes in proportionality of T and B lymphocytes of followed organs. Small tumor...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::A 10-year old Nigerian boy was admitted to hospital with a history of swelling in the neck, change of voice, dysphagia and dyspnoea of 2 weeks duration. He died on the 2nd day of admission. Autopsy revealed a thymoma infiltrating the thyroid, trachea and neck muscles and transforming the tracheal lumen into a slit lik...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Addition of trastuzumab to chemotherapy is the cornerstone of adjuvant treatment of early HER2 positive breast cancer. Clinical trials and metaanalyses of adjuvant trastuzumab have shown significant reduction in risk of recurrence and death. Nevertheless, the real magnitude of the effect of any drug must be reevaluate...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2016_513
更新日期:2016-01-01 00:00:00
abstract:UNLABELLED:BioBran, enzymatically modified arabinoxylan from rice bran was tested for its possible effects on in vitro maturation of human dendritic cells (DC). Immature DC (iDC) derived from plastic-adhered, IL-4 and GM-CSF treated peripheral monocytes (Mo) were further cultured with cytokine maturation mix 1 (CMM1; T...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2009_02_89
更新日期:2009-01-01 00:00:00
abstract::Dendritic cells are able to induce anti-tumor immune responses by presenting tumor-specific antigens to T-lymphocytes. Various tumor-associated antigens have been studied in multiple myeloma in an effort to find a strong antigen capable of generating clinically meaningful responses in vaccinated patients. The aim of o...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2010_05_455
更新日期:2010-01-01 00:00:00
abstract::In a group of 11,153 autopsied subjects a higher number of cholecystectomies was found in both sexes in individuals with large intestine tumors as compared with the rest of the autopsied persons without tumors (p less than 0.001). The results confirmed the hypothesis that cholecystectomy is a supporting factor in the ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Many reports indicate that glutathione and enzymes cooperating with it are important in neoplastic processes. Glutathione (GSH) concentrations and glutathione S-transferase (GSH STr) and glutathione peroxidase (GSH-Px) activities were determined in breast cancer tissue and adjacent healthy tissues, as well as in blood...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The aim of our study was to evaluate the efficacy of oral clodronate supplementing systemic therapy and/or palliative irradiation in 91 patients with painful bone metastases. Clodronate was administered at a daily dose of 1600-3200 mg for a median of 11 months (range 3--36 months). Partial or complete pain relief was ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00