Abstract:
:The mol LD50 values were correlated with Hammett sigma constants in terms of the Hansen empiric equation 6 for para substituted derivatives of 1-phenyl-3-methyltriazene. Good agreement was achieved and the line slope of the correlation, 0.3, is the same as that found during an identical experiment with derivatives of 1-phenyl-3,3-dimethyltriazene [1]. This is an indirect evidence that the considered mechanism of the interaction with biological substrate goes through the "activated carcinogen" - derivatives of 1-phenyl-3-methyltriazene, formed through the oxidative N-demethylation of the initial 1-phenyl-3,3-dimethyltriazenes.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Matrka M,Rambousek V,Zvĕrina Vsubject
Has Abstractpub_date
1978-01-01 00:00:00pages
153-6issue
2eissn
0028-2685issn
1338-4317journal_volume
25pub_type
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