The dark side of the colon: current issues surrounding the significance, prevalence, detection, diagnosis and management of serrated polyps.

abstract：:The development of small bowel transplantation has long been hindered by the immunological and infectious barriers peculiar to the small bowel. Gradual progress has been achieved during the past decade with the use of tacrolimus and the availability of better anti-infection prophylaxis. The current status of small bow...

journal_title：Current opinion in gastroenterology

authors： Prasad KR,Pollard SG

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent literature (2009-2010) on acute nonvariceal upper gastrointestinal hemorrhage. RECENT FINDINGS:There is a decreasing trend in the incidence and hospitalization for acute nonvariceal upper gastrointestinal hemorrhage worldwide, with significant improvement in rebleeding and mortality....

journal_title：Current opinion in gastroenterology

authors： Chiu PW,Sung JJ

更新日期：2010-09-01 00:00:00

abstract：:The elucidation of metabolic pathways and the genetic basis for diseases of the liver continues to increase our understanding of disease pathogenesis and advance treatment options. This selective review covers a wide range of subjects, from the identification of novel proteins and the importance of specific transport ...

journal_title：Current opinion in gastroenterology

authors： Schilsky ML

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review new advances in gastric interventional endoscopy. RECENT FINDINGS:Implementation of gastric endoscopy as a therapeutic option in obesity, gastric cancer, and gastroparesis. SUMMARY:Less invasive new gastric endoscopic procedures can potentially replace currently offered laparoscopic approa...

journal_title：Current opinion in gastroenterology

authors： Mahmoud M,Holzwanger E,Wassef W

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:According to the current paradigm, ulcerative colitis and Crohn's disease occur in genetically predisposed individuals because of dysregulated immune responses against intraluminal bacterial antigens. Data have recently accumulated supporting alternative hypotheses for the pathogenesis of inflammatory...

journal_title：Current opinion in gastroenterology

authors： Bamias G,Cominelli F

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Radiologic imaging of the large intestine continues to evolve and expand the potential for noninvasive diagnosis. The aim of this review is to provide an update on current and emerging clinical capabilities for a variety of radiologic diagnostic imaging tools for evaluating the colon and rectum. RECE...

journal_title：Current opinion in gastroenterology

authors： Pickhardt PJ

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Functional dyspepsia is a common disorder, most of the time of unknown etiology and with variable pathophysiology. Therapy has been and still is largely empirical. Data from recent studies provide new clues for targeted therapy based on knowledge of etiology and pathophysiologic mechanisms. RECENT FI...

journal_title：Current opinion in gastroenterology

authors： Kleibeuker JH,Thijs JC

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to highlight literature published during the last year in the context of previous knowledge. RECENT FINDINGS:A number of novel techniques - high-resolution manometry, esophageal electrical impedance and intra-luminal ultrasound imaging - have improved our understanding of e...

journal_title：Current opinion in gastroenterology

authors： Dogan I,Mittal RK

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Most colorectal cancers (CRCs) have deletions, duplications, and rearrangements of their chromosomes that reflect a destabilizing process called chromosomal instability (CIN). The cause of CIN is controversial, but no intrinsic mutation in cancer cells has been reported that can reasonably account for...

journal_title：Current opinion in gastroenterology

authors： Niv Y,Goel A,Boland CR

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The human gut is the natural habitat for a large and dynamic bacterial community. There is a substantial body of evidence implicating the resident flora in the pathogenesis of chronic intestinal inflammation. This review discusses the possible role of a microbial imbalance in the pathophysiology of in...

journal_title：Current opinion in gastroenterology

authors： Guarner F

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been significant interest in gluten over the last decade, with an increase in interest of gluten-related disorders outside coeliac disease. Particularly, there has been a focus on the role of gluten in noncoeliac gluten sensitivity (NCGS) and irritable bowel syndrome (IBS). There is signific...

journal_title：Current opinion in gastroenterology

authors： Rej A,Sanders DS

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Cytokines of the intestinal microenvironment largely dictate immunological responses after mucosal insults and the dominance of homeostatic or proinflammatory pathways. This review presents important recent studies on the role of specific cytokines in the pathogenesis of intestinal inflammation. RECE...

journal_title：Current opinion in gastroenterology

authors： Bamias G,Cominelli F

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hereditary liver diseases resulting in copper and iron overload may cause significant morbidity and mortality if not diagnosed and treated early. The goal of this review is to highlight the key publications on genetics, diagnosis and management of hemochromatosis and Wilson disease over the past 18 mo...

journal_title：Current opinion in gastroenterology

authors： Maxwell KL,Kowdley KV

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This article describes the evolution of combination therapy in inflammatory bowel disease and how to determine when combination may not be necessary. RECENT FINDINGS:The combination of an immunosuppressive agent with an antibody to tumor necrosis factor has proven to be more effective than monotherap...

journal_title：Current opinion in gastroenterology

authors： Bernstein CN

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The dynamic interplay of the intestinal microbiota and host has been the focus of many studies because of its impact on the health status in human life. Recent reports on the time-resolved immune and metabolic interactions between the host and microbiota, as well as the molecular signatures that mark ...

journal_title：Current opinion in gastroenterology

authors： El Aidy S,Kleerebezem M

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The remarkable resistance of the mucosal lining the upper gastrointestinal tract to concentrated gastric acid remains one of the biggest unsolved mysteries of upper gastrointestinal physiology. Even with the discovery of the involvement of Helicobacter pylori in gastroduodenal injury, the mechanism by...

journal_title：Current opinion in gastroenterology

authors： Bi LC,Kaunitz JD

更新日期：2003-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent data on techniques, efficacy and complications of endoscopic management of chronic pancreatitis. RECENT FINDINGS:Extracorporeal shock wave lithotripsy with or without endoscopic retrograde cholangiopancreatography is the first-line treatment for large painful obstructive pancreati...

journal_title：Current opinion in gastroenterology

authors： Talukdar R,Nageshwar Reddy D

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in our understanding of lymphoid tissue development has led to an appreciation of the variety of these structures in the intestinal mucosa. This knowledge has translated into more critical analysis of the function of mucosal lymphoid tissues and may lead to manipulation of development of thes...

journal_title：Current opinion in gastroenterology

authors： Newberry RD

更新日期：2008-03-01 00:00:00

abstract：:Gastric adenocarcinoma is the most common malignancy of the upper gastrointestinal tract. During the past two decades it has migrated toward the gastroesophageal junction. Gastroesophageal reflux and obesity may play a role. Recent research suggests that a number of biologic and molecular differences exist in patients...

journal_title：Current opinion in gastroenterology

authors： Yao JC,Ajani JA

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize recent advances in defining the clinical features, pathophysiology, natural history, and treatment of nonalcoholic fatty liver disease. RECENT FINDINGS:Nonalcoholic fatty liver disease is present in approximately 30% of the US population. A histologic gradin...

journal_title：Current opinion in gastroenterology

authors： Greenfield V,Cheung O,Sanyal AJ

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Morbid obesity is associated with a high prevalence of psychopathological conditions that might have an impact on postsurgery outcomes. This review summarizes recent data about psychological disorders in obese patients before and after bariatric surgery as well as the assessment and impact of these fa...

journal_title：Current opinion in gastroenterology

authors： Pataky Z,Carrard I,Golay A

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Jaundice, the physical finding associated with hyperbilirubinemia, results when the liver is unable to properly metabolize or excrete bilirubin. The purpose of this review is to examine some of the most common causes of jaundice in adults, provide insight into the diagnostic evaluation of jaundice, an...

journal_title：Current opinion in gastroenterology

authors： Sullivan JI,Rockey DC

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To critically appraise evidence on probiotic use for prevention and treatment of diarrhea in children and adults. RECENT FINDINGS:Several randomized controlled trials and meta-analyses suggested that probiotics are effective in primary and secondary prevention of gastroenteritis and its treatment. Se...

journal_title：Current opinion in gastroenterology

authors： Guarino A,Lo Vecchio A,Canani RB

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the advances in diagnostic modalities and management options for defecatory dysfunction and highlight the areas in need of further research. RECENT FINDINGS:The diagnostic utility of high-resolution anorectal manometry (ARM), which has emerged as a promising tool for the diagnosis of def...

journal_title：Current opinion in gastroenterology

authors： Neshatian L

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent progress on endoscopic diagnosis and treatment of esophageal high-grade intraepithelial neoplasia and early adenocarcinoma and critically analyzes the literature in the context of preexisting scientific data. RECENT FINDINGS:Narrow band imaging and computed virtual chrom...

journal_title：Current opinion in gastroenterology

authors： Seewald S,Ang TL,Groth S,Zhong Y,Bertschinger P,Altorfer J,Thonke F,Soehendra N

更新日期：2008-07-01 00:00:00

abstract：:Diarrhea is a common sequela of deregulated immune pathways underlying the wide range of intestinal acute and chronic diseases. The ongoing investigation of novel immune components and susceptibility factors allows better understanding of these pathologic mechanisms and continues to advance therapeutic options. ...

journal_title：Current opinion in gastroenterology

authors： Lahav M,Chang E

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The introduction of novel molecular imaging modalities that can not only define disease states on the basis of structural changes and morphology, but also allow in-vivo visualization and characterization of molecular and biochemical alterations on a cellular level add a new dimension to our current di...

journal_title：Current opinion in gastroenterology

authors： Atreya R,Neurath MF

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There is a need for novel therapies for inflammatory bowel diseases (IBDs) that are well tolerated and effective. Currently, mesenchymal stem/stromal cells (MSCs) are being investigated in clinical trials for treatment of IBD. In this review, we update the recently published studies with an emphasis o...

journal_title：Current opinion in gastroenterology

authors： Dave M,Jaiswal P,Cominelli F

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Intestinal fibrosis is a potentially serious complication of inflammatory bowel disease and its pathophysiology is still unclear. This review will discuss recent developments relating to sources of fibroblasts in intestinal inflammation, mediators that modulate fibroblast activation and function, as w...

journal_title：Current opinion in gastroenterology

authors： Rieder F,Fiocchi C

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) dietary restriction ameliorates irritable bowel syndrome (IBS) symptoms; however, not all individuals with IBS respond. Given the gut microbiome's role in carbohydrate fermentation, investigators have evaluated whether the...

journal_title：Current opinion in gastroenterology

authors： Chumpitazi BP

更新日期：2020-03-01 00:00:00