Abstract:
PURPOSE OF REVIEW:The introduction of novel molecular imaging modalities that can not only define disease states on the basis of structural changes and morphology, but also allow in-vivo visualization and characterization of molecular and biochemical alterations on a cellular level add a new dimension to our current diagnostic possibilities. The advents of innovative endoscopic devices coupled with the introduction of novel targeting ligands contribute to the recent advances made in the field of molecular imaging. The purpose of this review is to present and discuss the concepts and the potential of novel endoscopic imaging modalities for immune cell monitoring in the intestine. RECENT FINDINGS:Recent progress concerning molecular imaging studies in animals and human patients implicates that this approach can be used to improve detection of mucosal lesions in wide-field imaging and for in-vivo characterization of the mucosa with the ultimate goal of assessing the likelihood of response to targeted therapy with biological agents. In particular, molecular endomicroscopy for assessment of mucosal immune responses ('immunoendoscopy') emerges as a novel approach for optimized endoscopic diagnosis and individualized therapy. SUMMARY:Molecular imaging modalities in the intestine have the immediate potential to have an impact on current clinical practice and could therefore open new frontiers for clinical endoscopy and give hope for improved diagnosis and targeted therapies.
journal_name
Curr Opin Gastroenteroljournal_title
Current opinion in gastroenterologyauthors
Atreya R,Neurath MFdoi
10.1097/MOG.0000000000000120subject
Has Abstractpub_date
2014-11-01 00:00:00pages
553-8issue
6eissn
0267-1379issn
1531-7056journal_volume
30pub_type
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journal_title:Current opinion in gastroenterology
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doi:10.1097/MOG.0b013e328352b5ef
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:
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journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
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更新日期:2014-05-01 00:00:00
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journal_title:Current opinion in gastroenterology
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doi:10.1097/MOG.0000000000000483
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3281c55eb2
更新日期:2007-07-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000184
更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
abstract::The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-199901000-00002
更新日期:1999-01-01 00:00:00
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doi:10.1097/01.mog.0000231818.64138.8a
更新日期:2006-07-01 00:00:00
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journal_title:Current opinion in gastroenterology
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