Novel imaging modalities for immune cell monitoring in the intestine.

Abstract:

PURPOSE OF REVIEW:The introduction of novel molecular imaging modalities that can not only define disease states on the basis of structural changes and morphology, but also allow in-vivo visualization and characterization of molecular and biochemical alterations on a cellular level add a new dimension to our current diagnostic possibilities. The advents of innovative endoscopic devices coupled with the introduction of novel targeting ligands contribute to the recent advances made in the field of molecular imaging. The purpose of this review is to present and discuss the concepts and the potential of novel endoscopic imaging modalities for immune cell monitoring in the intestine. RECENT FINDINGS:Recent progress concerning molecular imaging studies in animals and human patients implicates that this approach can be used to improve detection of mucosal lesions in wide-field imaging and for in-vivo characterization of the mucosa with the ultimate goal of assessing the likelihood of response to targeted therapy with biological agents. In particular, molecular endomicroscopy for assessment of mucosal immune responses ('immunoendoscopy') emerges as a novel approach for optimized endoscopic diagnosis and individualized therapy. SUMMARY:Molecular imaging modalities in the intestine have the immediate potential to have an impact on current clinical practice and could therefore open new frontiers for clinical endoscopy and give hope for improved diagnosis and targeted therapies.

authors

Atreya R,Neurath MF

doi

10.1097/MOG.0000000000000120

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

553-8

issue

6

eissn

0267-1379

issn

1531-7056

journal_volume

30

pub_type

杂志文章,评审
  • Eosinophilic esophagitis: diagnostic tests and criteria.

    abstract:PURPOSE OF REVIEW:To present the clinical, endoscopic, and histologic features of eosinophilic esophagitis (EoE), review the current diagnostic guidelines for EoE, and present an approach for diagnosis of EoE. It will also highlight selected techniques that are under development that may be useful in the future for dia...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328352b5ef

    authors: Dellon ES

    更新日期:2012-07-01 00:00:00

  • JC virus and colorectal cancer: a possible trigger in the chromosomal instability pathways.

    abstract:PURPOSE OF REVIEW:Most colorectal cancers (CRCs) have deletions, duplications, and rearrangements of their chromosomes that reflect a destabilizing process called chromosomal instability (CIN). The cause of CIN is controversial, but no intrinsic mutation in cancer cells has been reported that can reasonably account for...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Niv Y,Goel A,Boland CR

    更新日期:2005-01-01 00:00:00

  • Biliary tract cancer.

    abstract::Advances in cellular and molecular biology of extrahepatic cholangiocarcinoma and gallbladder adenocarcinoma are providing innovative means for the diagnosis and treatment of biliary tract cancer. Similarly, refinements in noninvasive studies--including helical computed tomography, magnetic resonance cholangiopancreat...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200109000-00009

    authors: Abdalla EK,Vauthey JN

    更新日期:2001-09-01 00:00:00

  • Diagnosis: gastric intestinal metaplasia - what to do next?

    abstract:PURPOSE OF REVIEW:One of the most vexing problems for gastroenterologists is what actions to take after receiving a histological diagnosis of gastric intestinal metaplasia. We approach the problem by starting with suggesting a biopsy protocol that ensures obtaining the biopsies required for diagnosis, assessing the sta...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000576

    authors: Graham DY,Rugge M,Genta RM

    更新日期:2019-11-01 00:00:00

  • Psychological factors and weight loss in bariatric surgery.

    abstract:PURPOSE OF REVIEW:Morbid obesity is associated with a high prevalence of psychopathological conditions that might have an impact on postsurgery outcomes. This review summarizes recent data about psychological disorders in obese patients before and after bariatric surgery as well as the assessment and impact of these fa...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3283422482

    authors: Pataky Z,Carrard I,Golay A

    更新日期:2011-03-01 00:00:00

  • Animal models of cholangiocarcinoma.

    abstract:PURPOSE OF REVIEW:Even though recent accumulated data can help to understand fundamental molecular mechanisms of progression of cholangiocarcinoma (CCA), its incidence and mortality still keep increasing worldwide with poor prognosis. As appropriate animal disease models are critical to fill the gap between the finding...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32835d6a3e

    authors: Ko KS,Peng J,Yang H

    更新日期:2013-05-01 00:00:00

  • Eosinophilic colitis and colonic eosinophilia.

    abstract:PURPOSE OF REVIEW:Eosinophilic colitis is a rare condition, with a prevalence rate in the USA of 2-3/100 000 persons (0.003%), but diagnosed in 0.1% of biopsies in those colonoscoped for diarrhoea. Secondary colonic eosinophilia is more common and associated with systemic, colonic and infectious diseases. In this revie...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000492

    authors: Walker MM,Potter MD,Talley NJ

    更新日期:2019-01-01 00:00:00

  • The impact of gut microbes in allergic diseases.

    abstract:PURPOSE OF REVIEW:The prevalence of allergic diseases continues to rise globally in developed countries. Since the initial proposal of the hygiene hypothesis, there has been increasing evidence to suggest that the intestinal microbiota, particularly during early infancy, plays a critical role in regulating immune respo...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3283573017

    authors: Russell SL,Finlay BB

    更新日期:2012-11-01 00:00:00

  • Detection and endoscopic therapy of early esophageal adenocarcinoma.

    abstract:PURPOSE OF REVIEW:This review summarizes recent progress on endoscopic diagnosis and treatment of esophageal high-grade intraepithelial neoplasia and early adenocarcinoma and critically analyzes the literature in the context of preexisting scientific data. RECENT FINDINGS:Narrow band imaging and computed virtual chrom...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3282ff8b1f

    authors: Seewald S,Ang TL,Groth S,Zhong Y,Bertschinger P,Altorfer J,Thonke F,Soehendra N

    更新日期:2008-07-01 00:00:00

  • Viral hepatitis.

    abstract::Viral hepatitis is still one of the most common causes of acute and chronic liver disease worldwide. Major advances have been made in our knowledge of these diseases, many during the past year. Molecular biology and clinical studies have improved our understanding of the mechanisms of antiviral drugs, as well as viral...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199905000-00008

    authors: Regev A,Schiff ER

    更新日期:1999-05-01 00:00:00

  • MicroRNAs and cholestatic liver diseases.

    abstract:PURPOSE OF REVIEW:To highlight the increasing evidence supporting the concept that microRNAs (miRNAs) are involved in the cause and pathogenesis of cholestatic liver disorders. RECENT FINDINGS:miRNAs play a key role in maintaining bile acid homeostasis and modulating pathological processes associated to liver cholesta...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000051

    authors: Marin JJ,Bujanda L,Banales JM

    更新日期:2014-05-01 00:00:00

  • Mucosal immune responses to fungi and the implications for inflammatory bowel disease.

    abstract:PURPOSE OF REVIEW:The intestinal microbiota plays a central role in inflammatory diseases of the gut. Although most investigations regarding how the mucosal immune system interacts with the microbiota have focused on bacteria, recent studies are elucidating the additional role of commensal fungi in health and disease i...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000483

    authors: Limon JJ,Kershaw KM,Underhill DM

    更新日期:2018-11-01 00:00:00

  • Immunopathogenesis of inflammatory bowel disease: current concepts.

    abstract:PURPOSE OF REVIEW:According to the current paradigm, ulcerative colitis and Crohn's disease occur in genetically predisposed individuals because of dysregulated immune responses against intraluminal bacterial antigens. Data have recently accumulated supporting alternative hypotheses for the pathogenesis of inflammatory...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3281c55eb2

    authors: Bamias G,Cominelli F

    更新日期:2007-07-01 00:00:00

  • Biosimilars in inflammatory bowel disease: ready for prime time?

    abstract:PURPOSE OF REVIEW:The goal is to review the most recent literature about biosimilars in inflammatory bowel disease (IBD), with emphasis on controversial regulatory issues. RECENT FINDINGS:Although biosimilars have been in use in Europe since 2005, the recent approval of CT-P13 (Remsima, Inflectra), a biosimilar of the...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000184

    authors: Gomollón F

    更新日期:2015-07-01 00:00:00

  • Imaging for Barrett's esophagus: state of the art.

    abstract:PURPOSE OF REVIEW:Barrett's esophagus is the premalignant condition for esophageal cancer and the diagnosis of esophageal adenocarcinoma on index endoscopy is increasing. Many advanced endoscopic techniques are available and aim to identify Barrett's esophagus-associated neoplasia earlier, thereby preventing progressio...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MOG.0000000000000557

    authors: Sutton RA,Sharma P

    更新日期:2019-09-01 00:00:00

  • Best techniques for endoscopic ampullectomy.

    abstract:PURPOSE OF REVIEW:Endoscopic ampullectomy has proven its safety and efficacy in multiple studies, making it the favorable option for the management of endoscopic ampullectomy. In this review, we plan to review the basic steps every endoscopist should be familiar with before undertaking endoscopic ampullectomy. RECENT ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MOG.0000000000000657

    authors: Klair JS,Irani S,Kozarek R

    更新日期:2020-09-01 00:00:00

  • The molecular basis of colorectal carcinogenesis.

    abstract::The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199901000-00002

    authors: Shattuck-Brandt RL,DuBois RN

    更新日期:1999-01-01 00:00:00

  • Esophageal motor disorders: recent advances.

    abstract:PURPOSE OF REVIEW:The aim of this article is to highlight literature published during the last year in the context of previous knowledge. RECENT FINDINGS:A number of novel techniques - high-resolution manometry, esophageal electrical impedance and intra-luminal ultrasound imaging - have improved our understanding of e...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000231818.64138.8a

    authors: Dogan I,Mittal RK

    更新日期:2006-07-01 00:00:00

  • Complementary and alternative medicine and gastrointestinal diseases.

    abstract::Complementary and alternative medicine (CAM) is becoming increasingly utilized as a form of health care, with recent studies suggesting that over 40% of Americans use some form of CAM. This has major financial implications for the health care industry. Traditional physicians frequently are unaware of CAM use by their ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200003000-00016

    authors: Haas L,McClain C,Varilek G

    更新日期:2000-03-01 00:00:00

  • Colonic and anorectal motility testing in the high-resolution era.

    abstract:PURPOSE OF REVIEW:The past few years have seen an increase in the number of research and clinical groups around the world using high-resolution manometry (HRM) to record contractile activity in the anorectum and colon. Yet despite the uptake and growing number of publications, the clinical utility and potential advanta...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000229

    authors: Dinning PG,Carrington EV,Scott SM

    更新日期:2016-01-01 00:00:00

  • Update on viral hepatitis in 2004.

    abstract:PURPOSE OF REVIEW:This article highlights recent advances in viral hepatitis published from December 2003 to November 2004. Studies reporting novel and clinically relevant findings were selected after a PubMed search. The aim is to provide an up-to-date summary of important developments in viral hepatitis. RECENT FIND...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000158109.13722.36

    authors: Fung SK,Lok AS

    更新日期:2005-05-01 00:00:00

  • Probiotics as prevention and treatment for diarrhea.

    abstract:PURPOSE OF REVIEW:To critically appraise evidence on probiotic use for prevention and treatment of diarrhea in children and adults. RECENT FINDINGS:Several randomized controlled trials and meta-analyses suggested that probiotics are effective in primary and secondary prevention of gastroenteritis and its treatment. Se...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32831b4455

    authors: Guarino A,Lo Vecchio A,Canani RB

    更新日期:2009-01-01 00:00:00

  • How soon should we start interventional feeding in the ICU?

    abstract:PURPOSE OF REVIEW:Nutrition in the critically ill patient remains a controversial topic. Most clinicians have viewed nutrition as part of patient care but not as a therapeutic intervention. Recent studies have looked at type and timing of nutrition to determine whether they affect important clinical outcomes. RECENT F...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000047

    authors: Fremont RD,Rice TW

    更新日期:2014-03-01 00:00:00

  • Endoscopic diagnosis of gastrointestinal stromal cell tumors.

    abstract:PURPOSE OF REVIEW:To outline the recommended course of action when a subepithelial lesion is encountered during upper endoscopy. It will focus on the endoscopic and endosonographic features common to gastrointestinal stromal tumors, and the optimal tests performed to confirm the diagnosis of a gastrointestinal stromal ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32829fb39f

    authors: Rodriguez SA,Faigel DO

    更新日期:2007-09-01 00:00:00

  • Small bowel ulcers: when is it not inflammatory bowel disease ?

    abstract:PURPOSE OF REVIEW:Increasing use of small bowel endoscopy unravels ulcers in a relevant number of patients. Although often attributed to inflammatory bowel disease (IBD), these ulcers may be unspecific or caused by a variety of other diseases. This review summarizes the recent literature related to differential diagnos...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000522

    authors: Keuchel M,Kurniawan N,Baltes P

    更新日期:2019-05-01 00:00:00

  • Intestinal absorption of water-soluble vitamins: an update.

    abstract:PURPOSE OF REVIEW:The molecular biology revolution has led to a significant improvement in our understanding of biological and physiological processes. Such expansion of knowledge has also covered the field of intestinal absorption of water-soluble vitamins and is the subject of this review. RECENT FINDINGS:Impressive...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000203870.22706.52

    authors: Said HM,Mohammed ZM

    更新日期:2006-03-01 00:00:00

  • Pathogenesis of Helicobacter pylori infection.

    abstract::Intensive investigation into the interactions of Helicobacter pylori with the human host during the period of this review has led to several important developments in our understanding of H. pylori pathogenesis. There is direct evidence to support a central role for bacterial adhesion to host gastric epithelial Lewis ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199901000-00012

    authors: Wilson KT,Fantry GT

    更新日期:1999-01-01 00:00:00

  • Video capsule endoscopy of the small bowel.

    abstract:PURPOSE OF REVIEW:Small bowel capsule endoscopy (SBCE) was introduced 13 years ago by Given Imaging (Yokneam, Israel). It has become one of the most important investigational tools of the small bowel. The capsule is swallowed with water after a 12 h fast, propelled via peristalsis through the gastrointestinal tract and...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32835bdc03

    authors: Eliakim R

    更新日期:2013-03-01 00:00:00

  • Small intestinal motility.

    abstract:PURPOSE OF REVIEW:The aim of this article is to review recently published studies presenting novel and relevant information on small intestinal motility. RECENT FINDINGS:The reviewed studies covered a variety of topics with several themes emerging. The presentation and causes of chronic intestinal dysmotility continue...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32801424f3

    authors: Bratten JR,Jones MP

    更新日期:2007-03-01 00:00:00

  • Diet and colon: what matters?

    abstract:PURPOSE OF REVIEW:Colorectal cancer (CRC) is one of the most common cancers and the fourth leading cause of cancer-related deaths worldwide. Diet has a significant impact on the risk of developing CRC, but though processed meat is a known positive contributor, the effects of other dietary components are largely mixed. ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000501

    authors: Pan P,Yu J,Wang LS

    更新日期:2019-03-01 00:00:00