Acute nonvariceal upper gastrointestinal bleeding.

abstract：PURPOSE OF REVIEW:The past few years have seen an increase in the number of research and clinical groups around the world using high-resolution manometry (HRM) to record contractile activity in the anorectum and colon. Yet despite the uptake and growing number of publications, the clinical utility and potential advanta...

journal_title：Current opinion in gastroenterology

authors： Dinning PG,Carrington EV,Scott SM

更新日期：2016-01-01 00:00:00

abstract：:Traditional anatomic pathology studies and molecular investigations both contributed to the breadth of current information in the field of liver pathology this year. Techniques such as reverse transcription polymerase chain reaction can identify recurrence of hepatitis C virus infection in the liver as early as 5 days...

journal_title：Current opinion in gastroenterology

authors： Lefkowitch JH

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Human colitis-associated cancers (CAC) represent a heterogeneous group of conditions in which multiple oncogenic pathways are involved. In this article, we review the latest studies using genetic, chemical, bacterial and innate immune-mediated experimental models of CAC. RECENT FINDINGS:Using the azo...

journal_title：Current opinion in gastroenterology

authors： Sussman DA,Santaolalla R,Strobel S,Dheer R,Abreu MT

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update of the advantages of new-generation molecular diagnostics as regards acute diarrhea, and to evaluate how they can help clinicians and researchers diagnose this condition. RECENT FINDINGS:Thanks to real-time polymerase chain reaction techniques, many enteropathogens can now be ide...

journal_title：Current opinion in gastroenterology

authors： Guarino A,Giannattasio A

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Autoimmune pancreatitis (AIP) is an increasingly recognized clinical condition. Our objective is to provide a concise review of the advances in the past year in our understanding of AIP. RECENT FINDINGS:In a hospital survey from Japan, the prevalence of AIP was estimated at 0.82 per 100,000 individua...

journal_title：Current opinion in gastroenterology

authors： Pannala R,Chari ST

更新日期：2008-09-01 00:00:00

abstract：:The pancreatic acinar cell is a valuable cell model for understanding how activation of plasma membrane receptors generates signals that propagate, amplify, diversify, and integrate to control cellular function. A primary signaling system involves the activation of heterotrimeric G proteins that stimulate phospholipas...

journal_title：Current opinion in gastroenterology

authors： Logsdon CD

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The dynamic interplay of the intestinal microbiota and host has been the focus of many studies because of its impact on the health status in human life. Recent reports on the time-resolved immune and metabolic interactions between the host and microbiota, as well as the molecular signatures that mark ...

journal_title：Current opinion in gastroenterology

authors： El Aidy S,Kleerebezem M

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. Clinical trials should help guide and improve the management of cIAIs. However, inappropriate selection or measurement of outcomes in cIAIs clinical trials can lead to misleading results on the effe...

journal_title：Current opinion in gastroenterology

authors： Ahmed S,Wilcox MH,Kirby A

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will assess recent clinical and mechanistic data examining glutamine's ability to reduce morbidity and mortality in critical illness. RECENT FINDINGS:Updated metaanalysis data reveal a significant benefit of glutamine supplementation on mortality, length of stay, and infectious morbidity ...

journal_title：Current opinion in gastroenterology

authors： Wischmeyer PE

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal is to review the most recent literature about biosimilars in inflammatory bowel disease (IBD), with emphasis on controversial regulatory issues. RECENT FINDINGS:Although biosimilars have been in use in Europe since 2005, the recent approval of CT-P13 (Remsima, Inflectra), a biosimilar of the...

journal_title：Current opinion in gastroenterology

authors： Gomollón F

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Most colorectal cancers (CRCs) have deletions, duplications, and rearrangements of their chromosomes that reflect a destabilizing process called chromosomal instability (CIN). The cause of CIN is controversial, but no intrinsic mutation in cancer cells has been reported that can reasonably account for...

journal_title：Current opinion in gastroenterology

authors： Niv Y,Goel A,Boland CR

更新日期：2005-01-01 00:00:00

abstract：:Molecular-phylogenetic methods have revolutionized the analysis of complex microbial communities. Polymerase chain reaction amplification and phylogenetic analysis of small-subunit ribosomal RNA gene sequences allow microbes to be identified objectively, even in the absence of cultivation. Furthermore, the sequence in...

journal_title：Current opinion in gastroenterology

authors： Frank DN,Pace NR

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Bariatric surgery is recognized as the most effective treatment against obesity as it results in significant weight reduction and a high rate of remission of obesity-related comorbidities. However, bariatric surgery is not uncommonly associated with complications and an endoscopic approach to manageme...

journal_title：Current opinion in gastroenterology

authors： Kumbhari V,Cai JX,Schweitzer MA

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This focused, narrative review summarizes human clinical trial data for direct-acting antimicrobials in development for the treatment of gastrointestinal infections that were published in the past 18 months (1 January 2019 to 30 June 2020). RECENT FINDINGS:Antimicrobial agents for Clostridioides diff...

journal_title：Current opinion in gastroenterology

authors： Carlson TJ,Gonzales-Luna AJ,Garey KW

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary biliary cholangitis (PBC) is a rare autoimmune liver disease that increasingly is diagnosed at early stages of disease. Although survival has improved, a majority suffers from one or more symptom complexes associated with PBC. Much remains unknown about the mechanisms, significance, or effecti...

journal_title：Current opinion in gastroenterology

authors： Kuo A,Kuo A,Bowlus CL

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Small bowel capsule endoscopy (SBCE) was introduced 13 years ago by Given Imaging (Yokneam, Israel). It has become one of the most important investigational tools of the small bowel. The capsule is swallowed with water after a 12 h fast, propelled via peristalsis through the gastrointestinal tract and...

journal_title：Current opinion in gastroenterology

authors： Eliakim R

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic liver disease (CLD) causes significant morbidity and mortality, mainly due to complications [hepatic encephalopathy, ascites, hepatorenal syndrome (HRS) and esophageal variceal hemorrhage (EVH)]. Studies of the complications, management and outcomes in patients with CLD over the last 18 months...

journal_title：Current opinion in gastroenterology

authors： Rahimi RS,Rockey DC

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent progress on endoscopic diagnosis and treatment of esophageal high-grade intraepithelial neoplasia and early adenocarcinoma and critically analyzes the literature in the context of preexisting scientific data. RECENT FINDINGS:Narrow band imaging and computed virtual chrom...

journal_title：Current opinion in gastroenterology

authors： Seewald S,Ang TL,Groth S,Zhong Y,Bertschinger P,Altorfer J,Thonke F,Soehendra N

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Irritable bowel syndrome is a common and likely a multifactorial gastrointestinal disorder in which a disturbed brain-gut axis has been thought to have a mandatory role. Recent clinical and experimental studies imply that dietary factors may be more important in the pathogenesis of irritable bowel syn...

journal_title：Current opinion in gastroenterology

authors： Kalliomäki MA

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in our understanding of lymphoid tissue development has led to an appreciation of the variety of these structures in the intestinal mucosa. This knowledge has translated into more critical analysis of the function of mucosal lymphoid tissues and may lead to manipulation of development of thes...

journal_title：Current opinion in gastroenterology

authors： Newberry RD

更新日期：2008-03-01 00:00:00

abstract：:In spite of expanding knowledge of cellular and molecular mechanisms of intestinal inflammation, the etiology and pathogenesis of inflammatory bowel disease (IBD) remain obscure. The link between the environment and IBD is still circumstantial, but definite progress is occurring in defining genetic susceptibility loci...

journal_title：Current opinion in gastroenterology

authors： Katz JA,Itoh J,Fiocchi C

更新日期：1999-07-01 00:00:00

abstract：:The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing ...

journal_title：Current opinion in gastroenterology

authors： Shattuck-Brandt RL,DuBois RN

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review article, we address emerging evidence for the medical and surgical treatment of the hospitalized patient with ulcerative colitis. RECENT FINDINGS:Ulcerative colitis is a chronic inflammatory disease involving the colon and rectum. About one-fifth of patients will be hospitalized from u...

journal_title：Current opinion in gastroenterology

authors： Levy LC,Coburn ES,Choi S,Holubar SD

更新日期：2020-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Jaundice, the physical finding associated with hyperbilirubinemia, results when the liver is unable to properly metabolize or excrete bilirubin. The purpose of this review is to examine some of the most common causes of jaundice in adults, provide insight into the diagnostic evaluation of jaundice, an...

journal_title：Current opinion in gastroenterology

authors： Sullivan JI,Rockey DC

更新日期：2017-05-01 00:00:00

abstract：:Gastric adenocarcinoma is the most common malignancy of the upper gastrointestinal tract. During the past two decades it has migrated toward the gastroesophageal junction. Gastroesophageal reflux and obesity may play a role. Recent research suggests that a number of biologic and molecular differences exist in patients...

journal_title：Current opinion in gastroenterology

authors： Yao JC,Ajani JA

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:According to the current paradigm, ulcerative colitis and Crohn's disease occur in genetically predisposed individuals because of dysregulated immune responses against intraluminal bacterial antigens. Data have recently accumulated supporting alternative hypotheses for the pathogenesis of inflammatory...

journal_title：Current opinion in gastroenterology

authors： Bamias G,Cominelli F

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Barrett's esophagus is the premalignant condition for esophageal cancer and the diagnosis of esophageal adenocarcinoma on index endoscopy is increasing. Many advanced endoscopic techniques are available and aim to identify Barrett's esophagus-associated neoplasia earlier, thereby preventing progressio...

journal_title：Current opinion in gastroenterology

authors： Sutton RA,Sharma P

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Cholangiocarcinoma (CCA) are heterogeneous tumors that arise from the malignant transformation of cholangiocytes along the biliary tree. CCA heterogeneity occurs at multiple levels and results in resistance to therapy and poor prognosis. Here, we review the molecular classification of CCA by focusing ...

journal_title：Current opinion in gastroenterology

authors： Louis C,Papoutsoglou P,Coulouarn C

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Endoscopic approaches to obesity may help fulfill the unmet need of over half the US adult population who would benefit from therapy for obesity but are not receiving it. Endoluminal approaches have the potential to be more efficacious than antiobesity medications and have a lower risk-cost profile co...

journal_title：Current opinion in gastroenterology

authors： Kumbhari V,Oberbach A,Nimgaonkar A

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Catheter-related bloodstream infections (CRBSIs) account for a major source of morbidity in children with intestinal failure. Many of these patients require long-term central venous access, placing them at significant risk for these infections. The purpose of this review is to highlight the most curre...

journal_title：Current opinion in gastroenterology

authors： Piper HG,Wales PW

更新日期：2013-01-01 00:00:00