Measuring outcomes in complicated intra-abdominal infections.

Abstract:

PURPOSE OF REVIEW:Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. Clinical trials should help guide and improve the management of cIAIs. However, inappropriate selection or measurement of outcomes in cIAIs clinical trials can lead to misleading results on the effectiveness of interventions. This review aims to describe how outcomes are reported in randomized controlled trials evaluating antibiotic treatment for cIAIs and discuss how outcome reporting may be improved. RECENT FINDINGS:Commonly used primary outcomes are treatment success or failure, and these outcomes are endorsed by regulatory bodies. However, a consensus objective definition of either is not available and current measures are prone to bias. Variation exists in timing of outcome evaluation and analysis populations, which can lead to further bias. Use of core outcome sets can help standardize outcome reporting. SUMMARY:Inconsistency in outcome selection and reporting can lead to misleading results and impedes meta-analysis of data. Further progress, engaging clinical trialists, regulatory authorities, clinicians and patients is required to achieve consensus on which outcomes should be reported and how and when to measure them.

authors

Ahmed S,Wilcox MH,Kirby A

doi

10.1097/MOG.0000000000000591

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

1-4

issue

1

eissn

0267-1379

issn

1531-7056

journal_volume

36

pub_type

杂志文章
  • Esophageal motor disorders: recent advances.

    abstract:PURPOSE OF REVIEW:The aim of this article is to highlight literature published during the last year in the context of previous knowledge. RECENT FINDINGS:A number of novel techniques - high-resolution manometry, esophageal electrical impedance and intra-luminal ultrasound imaging - have improved our understanding of e...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000231818.64138.8a

    authors: Dogan I,Mittal RK

    更新日期:2006-07-01 00:00:00

  • Portal hypertension.

    abstract::Portal hypertension is the main complication of cirrhosis and is responsible for its most common complications: variceal hemorrhage, ascites, and portosystemic encephalopathy. Portal hypertension is the result of increased intrahepatic resistance and increased portal venous inflow, which in turn is the result of splan...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200105000-00012

    authors: Garcia-Tsao G

    更新日期:2001-05-01 00:00:00

  • Mesenchymal stem/stromal cell therapy for inflammatory bowel disease: an updated review with maintenance of remission.

    abstract:PURPOSE OF REVIEW:There is a need for novel therapies for inflammatory bowel diseases (IBDs) that are well tolerated and effective. Currently, mesenchymal stem/stromal cells (MSCs) are being investigated in clinical trials for treatment of IBD. In this review, we update the recently published studies with an emphasis o...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000327

    authors: Dave M,Jaiswal P,Cominelli F

    更新日期:2017-01-01 00:00:00

  • Epidemiology of human noroviruses and updates on vaccine development.

    abstract:PURPOSE OF REVIEW:Noroviruses (NoVs) are the most common cause of epidemic and sporadic cases of acute gastroenteritis worldwide. This review summarizes recent NoV disease burden estimates, epidemiology findings and provides an update on virus-like particle (VLP) vaccine studies. RECENT FINDINGS:NoVs are the leading c...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000022

    authors: Ramani S,Atmar RL,Estes MK

    更新日期:2014-01-01 00:00:00

  • Diagnosis and therapy of early neoplasia in Barrett's esophagus.

    abstract:PURPOSE OF THIS REVIEW:In the last 2 years, several studies have been published that will change the management of patients with Barrett's esophagus. In this review, we will discuss the most relevant studies as well as future prospects in this field. RECENT FINDINGS:Long-term follow-up studies have shown that to be co...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Bergman JJ

    更新日期:2005-07-01 00:00:00

  • Update on viral hepatitis in 2004.

    abstract:PURPOSE OF REVIEW:This article highlights recent advances in viral hepatitis published from December 2003 to November 2004. Studies reporting novel and clinically relevant findings were selected after a PubMed search. The aim is to provide an up-to-date summary of important developments in viral hepatitis. RECENT FIND...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000158109.13722.36

    authors: Fung SK,Lok AS

    更新日期:2005-05-01 00:00:00

  • JC virus and colorectal cancer: a possible trigger in the chromosomal instability pathways.

    abstract:PURPOSE OF REVIEW:Most colorectal cancers (CRCs) have deletions, duplications, and rearrangements of their chromosomes that reflect a destabilizing process called chromosomal instability (CIN). The cause of CIN is controversial, but no intrinsic mutation in cancer cells has been reported that can reasonably account for...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Niv Y,Goel A,Boland CR

    更新日期:2005-01-01 00:00:00

  • Potential of multiomics technology in precision medicine.

    abstract:PURPOSE OF REVIEW:The 'precision medicine' refers to the generation of identification and classification criteria for advanced taxonomy of patients, exploiting advanced models to infer optimized clinical decisions for each disease phenotype. RECENT FINDINGS:The current article reviews new advances in the past 18 month...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000589

    authors: Putignani L,Gasbarrini A,Dallapiccola B

    更新日期:2019-11-01 00:00:00

  • Food addiction: true or false?

    abstract:PURPOSE OF REVIEW:Food addiction has been implicated as a putative causal factor in chronic overeating, binge eating, and obesity. The concept of food addiction has been controversial historically due to definitional and conceptual difficulties and to a lack of rigorous scientific data. RECENT FINDINGS:Support for the...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328336528d

    authors: Corsica JA,Pelchat ML

    更新日期:2010-03-01 00:00:00

  • Complications and surgery in the inflammatory bowel diseases biological era.

    abstract:PURPOSE OF REVIEW:Therapy for inflammatory bowel diseases (IBD) has changed dramatically in recent years with a wider use of immunomodulators and the introduction of antitumor necrosis factor (anti-TNF) agents. This article reviews the existing data on the long-term efficacy of biologics, that is, anti-TNF agents, for ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000078

    authors: Sokol H,Seksik P,Cosnes J

    更新日期:2014-07-01 00:00:00

  • Glutamine: role in critical illness and ongoing clinical trials.

    abstract:PURPOSE OF REVIEW:This review will assess recent clinical and mechanistic data examining glutamine's ability to reduce morbidity and mortality in critical illness. RECENT FINDINGS:Updated metaanalysis data reveal a significant benefit of glutamine supplementation on mortality, length of stay, and infectious morbidity ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3282f4db94

    authors: Wischmeyer PE

    更新日期:2008-03-01 00:00:00

  • Molecular signatures for the dynamic process of establishing intestinal host-microbial homeostasis: potential for disease diagnostics?

    abstract:PURPOSE OF REVIEW:The dynamic interplay of the intestinal microbiota and host has been the focus of many studies because of its impact on the health status in human life. Recent reports on the time-resolved immune and metabolic interactions between the host and microbiota, as well as the molecular signatures that mark ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328365d365

    authors: El Aidy S,Kleerebezem M

    更新日期:2013-11-01 00:00:00

  • Recent advances in nonalcholic fatty liver disease.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize recent advances in defining the clinical features, pathophysiology, natural history, and treatment of nonalcoholic fatty liver disease. RECENT FINDINGS:Nonalcoholic fatty liver disease is present in approximately 30% of the US population. A histologic gradin...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3282fbccf2

    authors: Greenfield V,Cheung O,Sanyal AJ

    更新日期:2008-05-01 00:00:00

  • Mechanisms of autoimmune hepatitis.

    abstract:PURPOSE OF REVIEW:Autoimmune hepatitis (AIH) is a chronic disease characterized by a lymphocyte infiltrate in the liver. For decades, nonspecific immunosuppression has been used to limit chronic liver inflammation. The high risk of relapse, the treatments side effects, and the significant number of refractory patients ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MOG.0000000000000704

    authors: Cardon A,Conchon S,Renand A

    更新日期:2021-03-01 00:00:00

  • Inherited metabolic disease.

    abstract::The elucidation of metabolic pathways and the genetic basis for diseases of the liver continues to increase our understanding of disease pathogenesis and advance treatment options. This selective review covers a wide range of subjects, from the identification of novel proteins and the importance of specific transport ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200205000-00003

    authors: Schilsky ML

    更新日期:2002-05-01 00:00:00

  • Intestinal lymphoid tissues: is variety an asset or a liability?

    abstract:PURPOSE OF REVIEW:Advances in our understanding of lymphoid tissue development has led to an appreciation of the variety of these structures in the intestinal mucosa. This knowledge has translated into more critical analysis of the function of mucosal lymphoid tissues and may lead to manipulation of development of thes...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3282f4906d

    authors: Newberry RD

    更新日期:2008-03-01 00:00:00

  • Mucosal immune responses to fungi and the implications for inflammatory bowel disease.

    abstract:PURPOSE OF REVIEW:The intestinal microbiota plays a central role in inflammatory diseases of the gut. Although most investigations regarding how the mucosal immune system interacts with the microbiota have focused on bacteria, recent studies are elucidating the additional role of commensal fungi in health and disease i...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000483

    authors: Limon JJ,Kershaw KM,Underhill DM

    更新日期:2018-11-01 00:00:00

  • Intestinal absorption of water-soluble vitamins: an update.

    abstract:PURPOSE OF REVIEW:The molecular biology revolution has led to a significant improvement in our understanding of biological and physiological processes. Such expansion of knowledge has also covered the field of intestinal absorption of water-soluble vitamins and is the subject of this review. RECENT FINDINGS:Impressive...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000203870.22706.52

    authors: Said HM,Mohammed ZM

    更新日期:2006-03-01 00:00:00

  • Gastroduodenal mucosal defense.

    abstract:PURPOSE OF REVIEW:The gastroduodenum has multiple means by which it resists injury from intrinsic and extrinsic factors, including gastric acid, nonsteroidal anti-inflammatory drugs, and Helicobacter pylori. We review recent insights into the mechanisms by which the gastroduodenum resists injury and discuss factors con...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328330da7b

    authors: Nayeb-Hashemi H,Kaunitz JD

    更新日期:2009-11-01 00:00:00

  • Clinical applications of submucosal endoscopy.

    abstract:PURPOSE OF REVIEW:Submucosal endoscopy with mucosal flap (SEMF), a new diagnostic and therapeutic intervention of flexible endoscopy, has been examined from the perspective of developmental laboratory work, procedural details, and results of early clinical experiences. RECENT FINDINGS:Diagnostic natural orifice transl...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328349cf8e

    authors: Sumiyama K,Gostout CJ

    更新日期:2011-09-01 00:00:00

  • Pathology of the liver.

    abstract::Traditional anatomic pathology studies and molecular investigations both contributed to the breadth of current information in the field of liver pathology this year. Techniques such as reverse transcription polymerase chain reaction can identify recurrence of hepatitis C virus infection in the liver as early as 5 days...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200105000-00002

    authors: Lefkowitch JH

    更新日期:2001-05-01 00:00:00

  • Biliary endoscopy.

    abstract::Highlighting this year was the National Institutes of Health (NIH) State-of-the-Science Conference on endoscopic retrograde cholangiopancreatography. The panel addressed controversies in biliary endoscopy and set the framework for future funding for clinical research endeavors. With respect to biliary endoscopy, the l...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200305000-00013

    authors: Beilstein MC,Kochman ML

    更新日期:2003-05-01 00:00:00

  • Acute nonvariceal upper gastrointestinal bleeding.

    abstract:PURPOSE OF REVIEW:To review recent literature (2009-2010) on acute nonvariceal upper gastrointestinal hemorrhage. RECENT FINDINGS:There is a decreasing trend in the incidence and hospitalization for acute nonvariceal upper gastrointestinal hemorrhage worldwide, with significant improvement in rebleeding and mortality....

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32833d1746

    authors: Chiu PW,Sung JJ

    更新日期:2010-09-01 00:00:00

  • Drug-induced liver disease.

    abstract::This year's review has been divided into five sections: The first describes the natural history of drug-induced liver disease, the second discusses the issue of placebo-related increases in liver-associated enzymes, the third describes agents newly reported to cause hepatic injury, the fourth discusses new reports of ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200005000-00005

    authors: Mayoral W,Lewis JH

    更新日期:2000-05-01 00:00:00

  • Autoimmune liver disease.

    abstract:PURPOSE OF REVIEW:The aim of this article is to review studies that improve the diagnosis and treatment of autoimmune hepatitis and suggest new drug and molecular interventions. RECENT FINDINGS:Elderly patients have an indolent but aggressive disease that responds well to corticosteroid therapy. Variant syndromes are ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328034f234

    authors: Czaja AJ

    更新日期:2007-05-01 00:00:00

  • Pancreatic surgery for adenocarcinoma.

    abstract:PURPOSE OF REVIEW:Pancreatic resection remains among the most formidable and complex of abdominal surgical operations. Nonetheless, recent observations have continued to provide incremental improvement in both our evidence for treatment regimens and the technology, resulting in better outcomes. RECENT FINDINGS:Neoadju...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3283567f2c

    authors: Warshaw AL,Lillemoe KD,Fernandez-del Castillo C

    更新日期:2012-09-01 00:00:00

  • Celiac disease.

    abstract:PURPOSE OF REVIEW:Research in celiac disease is unraveling new findings at a high rate, and major advances seem to occur in all areas such as genetics, environmental factor, pathophysiology, and even prospective therapeutic implications. RECENT FINDINGS:New insight is being gained into the interplay between genetic an...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32830f4527

    authors: Guandalini S,Setty M

    更新日期:2008-11-01 00:00:00

  • Ion transport in the small intestine.

    abstract:PURPOSE OF REVIEW:The 2009 review on small intestinal ion transport, in this series, focused on recent advances in duodenal bicarbonate secretion, the importance of scaffolding proteins and the pathophysiology of inflammation-associated diarrhea. The current review focuses on advances in ion-coupled solute transport, t...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3283358a45

    authors: Venkatasubramanian J,Ao M,Rao MC

    更新日期:2010-03-01 00:00:00

  • Chronic pancreatitis.

    abstract::In the past year, numerous important papers were published on chronic pancreatitis, its causes, and its diagnosis; the cause of fibrosis; and pain in pancreatic cancer. More than 750 mutations have been described in the cystic fibrosis transmembrane regulator (CFTR) gene. Some mutations cause relatively mild reduction...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199909000-00005

    authors: Chari ST,Dimagno EP

    更新日期:1999-09-01 00:00:00

  • Absorption of water-soluble vitamins.

    abstract::Water-soluble vitamins are required as enzyme cofactors in a wide variety of metabolic reactions. Riboflavin, niacin, and vitamin C are essential in redox reactions; thiamine and biotin are involved in macronutrient metabolism; and folate, vitamin B12, pyridoxine, and riboflavin play important roles in the regulation ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200303000-00003

    authors: Halsted CH

    更新日期:2003-03-01 00:00:00