Abstract:
PURPOSE OF REVIEW:This focused, narrative review summarizes human clinical trial data for direct-acting antimicrobials in development for the treatment of gastrointestinal infections that were published in the past 18 months (1 January 2019 to 30 June 2020). RECENT FINDINGS:Antimicrobial agents for Clostridioides difficile infection (n = 6), cryptosporidiosis (n = 1), cytomegalovirus infection (n = 3) and Helicobacter pylori infection (n = 1) have completed and/or are undergoing human clinical trials. SUMMARY:Although this review highlights significant advances in four disease states, many common gastrointestinal pathogens have no antimicrobials in human clinical trials, emphasizing the need for continued prioritization in this field of study.
journal_name
Curr Opin Gastroenteroljournal_title
Current opinion in gastroenterologyauthors
Carlson TJ,Gonzales-Luna AJ,Garey KWdoi
10.1097/MOG.0000000000000696subject
Has Abstractpub_date
2021-01-01 00:00:00pages
30-36issue
1eissn
0267-1379issn
1531-7056journal_volume
37pub_type
杂志文章abstract::This article provides an overview of advances in understanding the cellular and molecular mechanisms and regulation of intestinal absorption processes of vitamins. The vitamins covered are the water-soluble vitamins folic acid, cobalamin (vitamin B12), biotin, pantothenic acid, and thiamine (vitamin B1) and the lipid-...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-199903000-00015
更新日期:1999-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent progress on endoscopic diagnosis and treatment of esophageal high-grade intraepithelial neoplasia and early adenocarcinoma and critically analyzes the literature in the context of preexisting scientific data. RECENT FINDINGS:Narrow band imaging and computed virtual chrom...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3282ff8b1f
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review article, we address emerging evidence for the medical and surgical treatment of the hospitalized patient with ulcerative colitis. RECENT FINDINGS:Ulcerative colitis is a chronic inflammatory disease involving the colon and rectum. About one-fifth of patients will be hospitalized from u...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/MOG.0000000000000637
更新日期:2020-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Virulence factors are related to the ability of a microbe to induce disease. True virulence factors must therefore have a disease association, an in-vivo correlate with disease such as increased mucosal inflammation, or both. RECENT FINDINGS:The cytotoxin-associated gene pathogenicity island; the out...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000181711.04529.d5
更新日期:2005-11-01 00:00:00
abstract::Globally, gastroesophageal reflux disease (GERD) remains a common and important clinical disorder. This review summarizes the major advances in the understanding and treatment of GERD that have been made in the past 12 months. Epidemiologic studies have yielded additional data on the clinical presentation and natural ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200307000-00009
更新日期:2003-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The workup of chronic unexplained diarrhea can be equally frustrating for care providers and patients. It carries a physical, financial, and social toll. In this review we provide a sensible approach to evaluating and managing chronic diarrhea. RECENT FINDINGS:Bile acid diarrhea is becoming increasin...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000232
更新日期:2016-01-01 00:00:00
abstract::Diarrhea is a common sequela of deregulated immune pathways underlying the wide range of intestinal acute and chronic diseases. The ongoing investigation of novel immune components and susceptibility factors allows better understanding of these pathologic mechanisms and continues to advance therapeutic options. ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200211000-00010
更新日期:2002-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Food addiction has been implicated as a putative causal factor in chronic overeating, binge eating, and obesity. The concept of food addiction has been controversial historically due to definitional and conceptual difficulties and to a lack of rigorous scientific data. RECENT FINDINGS:Support for the...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328336528d
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Colorectal cancer (CRC) is one of the most common cancers and the fourth leading cause of cancer-related deaths worldwide. Diet has a significant impact on the risk of developing CRC, but though processed meat is a known positive contributor, the effects of other dietary components are largely mixed. ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000501
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:In both Crohn's disease and ulcerative colitis, the tissue damage results from an inappropriate or exaggerated immune response to antigens of the gut microflora. This review summarizes current knowledge regarding the role of immune-inflammatory mediators in the pathogenesis of inflammatory bowel disea...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000231808.10773.8e
更新日期:2006-07-01 00:00:00
abstract::Toxic effects in the upper gastrointestinal tract, primarily complicated gastric and intestinal ulcers, are the most common undesirable effects of the nonsteroidal anti-inflammatory drugs. During the last several years, there have been several advances, both in the laboratory and clinically, toward reducing nonsteroid...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200111000-00005
更新日期:2001-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses the advances in the pathophysiology, diagnosis, and management of the complications of portal hypertension that have occurred in the past year. RECENT FINDINGS:The specific topics reviewed are the pathophysiology of portal hypertension (including recent findings regarding intrah...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200405000-00010
更新日期:2004-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Rotavirus infection is the leading cause of severe dehydrating gastroenteritis, responsible for an estimated 440,000 deaths per year in children less than 5 years of age worldwide. There was great optimism when the first rotavirus vaccine was licensed in the United States in July 1998 (rhesus rotaviru...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::Colon carcinogenesis is a multistep process that involves deletions, mutations, and changes in expression of genes that regulate growth, differentiation, and apoptosis. Hyperproliferation can initiate dysplastic growth, resulting in accumulation of genetic defects and progression of colon cancer. Although genetic inst...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200001000-00013
更新日期:2000-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS:The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing tha...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000455
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Significant advances in the pathophysiology, diagnosis and management of the complications of portal hypertension that have occurred in the last year are reported. RECENT FINDINGS:The specific areas reviewed are those that refer to experimental studies aimed at modifying the factors that lead to port...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000218962.93806.9a
更新日期:2006-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will summarize the most significant work that contributed to the understanding of liver fibrosis progression and resolution, which in turn has yielded new areas of therapeutic targeting. RECENT FINDINGS:Liver fibrosis is the result of an imbalance between production and dissolution of ext...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/mog.0b013e3283279668
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this study is to provide an overview of the role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in inflammatory bowel disease (IBD). RECENT FINDINGS:Human genetic studies have identified several UPR-related genes and autophagy-related genes as IBD risk loc...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000144
更新日期:2015-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Prevention of colorectal cancer relies on the detection and removal of colorectal neoplasia. Recent advances in mucosal imaging and inspection techniques have increased the detection of small and diminutive colorectal polyps with unknown clinical impact. The ability to accurately predict whether a pol...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32834ddab9
更新日期:2012-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to review recently published studies presenting novel and relevant information on small intestinal motility. RECENT FINDINGS:The reviewed studies covered a variety of topics with several themes emerging. The presentation and causes of chronic intestinal dysmotility continue...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32801424f3
更新日期:2007-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Increasing antimicrobial resistance in Salmonella Typhi is a serious public health concern, especially in industrializing countries. Here we review recent clinical and laboratory data concerning the evolution of antimicrobial resistance, with particular reference to the emergence resistance against fl...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000406
更新日期:2018-01-01 00:00:00
abstract::Over the past several years, the pharmacologic treatment of obesity has undergone changes in safety, efficacy, and therapeutic targeting. The prevalence of cardiac valvulopathy associated with treatment with phentermine, fenfluramine, and dexfenfluramine is now becoming clarified with the publication of longer-term st...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200203000-00011
更新日期:2002-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Morbid obesity is an epidemic in the United States and parts of Europe, with severe health consequences. As the number of patients undergoing bariatric surgery has increased dramatically, it is crucial for the gastroenterologist caring for these patients to have a better understanding of the procedure...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3282f094b5
更新日期:2007-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Alcohol consumption is increasing globally, as are complications of alcohol-related liver disease, including the most severe manifestation, alcoholic hepatitis. Despite the increased prevalence, many patients hospitalized with alcoholic hepatitis are either not diagnosed or inadequately treated leadin...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000359
更新日期:2017-05-01 00:00:00
abstract::Viral gastroenteritis is a major public health problem worldwide, and the number of identified pathogens continuously increases. Investigators have made considerable progress toward understanding both the epidemiology and the mechanisms of virus-cell interactions, host responses, and pathogenesis. A vaccine for the mo...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200001000-00003
更新日期:2000-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Endoscopic retrograde cholangiopancreatography is reserved primarily for therapeutic reasons. Recent literature continues to support therapeutic uses of the technique. This review addresses the literature in the field of biliary endoscopy for the year 2006 and is intended to assist gastroenterologists...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3280925617
更新日期:2007-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To review evidence relating to the strength of associations that have appeared in largely observational studies, between high-dose or long-term use of proton pump inhibitor drugs and certain possibly attributable side-effects, which emerge from studies confounded by other variables. In retrospective s...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32833ea9d9
更新日期:2010-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Autoimmune hepatitis (AIH) is a chronic disease characterized by a lymphocyte infiltrate in the liver. For decades, nonspecific immunosuppression has been used to limit chronic liver inflammation. The high risk of relapse, the treatments side effects, and the significant number of refractory patients ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/MOG.0000000000000704
更新日期:2021-03-01 00:00:00
abstract::Therapeutic biliary endoscopy continues to evolve. Key articles this year primarily involve biliary stenting and biliary stone removal, the two important maneuvers available to the biliary endoscopist. The issues addressed in this review include follow-up after the use of multiple stents for benign strictures, unilate...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200205000-00013
更新日期:2002-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine recent advances in the techniques and technologies of endoscopic resection of early gastric cancer. RECENT FINDINGS:Endoscopic mucosal resection of early gastric cancer with no risk of lymph node metastasis has been a standard technique in Japan and is increasingly becoming accepted and re...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000239873.06243.00
更新日期:2006-09-01 00:00:00