New molecular approaches in the diagnosis of acute diarrhea: advantages for clinicians and researchers.

abstract：PURPOSE OF REVIEW:Complex physiological mechanisms have evolved to control food intake in mammals, which in health ensure the relative stability of body weight in adults. Central brain centres, gut-derived peptides and adipose-derived signals result in an integrative response to defend against starvation. Enteroendocri...

journal_title：Current opinion in gastroenterology

authors： Baynes KC,Dhillo WS,Bloom SR

更新日期：2006-11-01 00:00:00

abstract：:Over the last year, several interesting studies have been published on the treatment of esophageal carcinoma. Surprisingly, none of them was a randomized phase III trial. The debate on the necessary extent of a potentially curative surgical resection is ongoing. After initially disappointing results, the innovative te...

journal_title：Current opinion in gastroenterology

authors： van Lanschot JJ,González González D,Richel DJ

更新日期：2001-07-01 00:00:00

abstract：:Recently, much progress has been made in the field of tumor immunology. Much of this work has focused on understanding and exploiting the innate immune response to tumor cells. A novel human receptor-ligand system that mediates natural killer (NK) and gammadelta T-cell killing of carcinoma cells has been identified, a...

journal_title：Current opinion in gastroenterology

authors： Golby SJ,Spencer J

更新日期：2001-11-01 00:00:00

abstract：:The treatment of patients with unexplained chest pain is difficult and challenging. After a cardiac etiology has been ruled out, a diligent search for an esophageal etiology-gastroesophageal reflux disease, motility abnormalities, or esophageal hypersensitivity-should be undertaken with judicious use of a diagnostic (...

journal_title：Current opinion in gastroenterology

authors： Katz PO

更新日期：1999-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Alcohol consumption is increasing globally, as are complications of alcohol-related liver disease, including the most severe manifestation, alcoholic hepatitis. Despite the increased prevalence, many patients hospitalized with alcoholic hepatitis are either not diagnosed or inadequately treated leadin...

journal_title：Current opinion in gastroenterology

authors： Aday AW,Mitchell MC,Casey LC

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Knowledge on and understanding of the pathophysiology of inflammatory bowel disease (IBD) is continuously growing. Important insights from the last years are summarized in this review. RECENT FINDINGS:Further genetic risk factors for IBD have been identified and confirmed. Novel studies analyzing the...

journal_title：Current opinion in gastroenterology

authors： Scharl M,Rogler G

更新日期：2012-07-01 00:00:00

abstract：:Endoscopic management of biliary disease remains at the forefront of minimally invasive means of providing therapy, as well as contributing important diagnostic information in complex clinical scenarios. The authors review recent advances and reported trials of therapy and revisit important controversial issues. The m...

journal_title：Current opinion in gastroenterology

authors： Lew RJ,Kochman ML

更新日期：2000-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Exciting new developments and applications of imaging techniques in pancreatic diseases have emerged. This review discusses these new advances and how they are improving our ability to diagnose malignancies and inflammatory lesions, to grade severity of pancreatitis, and to stage pancreatic cancer acc...

journal_title：Current opinion in gastroenterology

authors： Kwon RS,Brugge WR

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:One of the most vexing problems for gastroenterologists is what actions to take after receiving a histological diagnosis of gastric intestinal metaplasia. We approach the problem by starting with suggesting a biopsy protocol that ensures obtaining the biopsies required for diagnosis, assessing the sta...

journal_title：Current opinion in gastroenterology

authors： Graham DY,Rugge M,Genta RM

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Research in celiac disease is unraveling new findings at a high rate, and major advances seem to occur in all areas such as genetics, environmental factor, pathophysiology, and even prospective therapeutic implications. RECENT FINDINGS:New insight is being gained into the interplay between genetic an...

journal_title：Current opinion in gastroenterology

authors： Guandalini S,Setty M

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The dynamic interplay of the intestinal microbiota and host has been the focus of many studies because of its impact on the health status in human life. Recent reports on the time-resolved immune and metabolic interactions between the host and microbiota, as well as the molecular signatures that mark ...

journal_title：Current opinion in gastroenterology

authors： El Aidy S,Kleerebezem M

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The gastroduodenum has multiple means by which it resists injury from intrinsic and extrinsic factors, including gastric acid, nonsteroidal anti-inflammatory drugs, and Helicobacter pylori. We review recent insights into the mechanisms by which the gastroduodenum resists injury and discuss factors con...

journal_title：Current opinion in gastroenterology

authors： Nayeb-Hashemi H,Kaunitz JD

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recently, a new class of intracellular pattern recognition receptors belonging to the family of nucleotide binding and oligomerization domain (NOD)-like receptors that includes NOD1, NOD2 and IPAF has been described. These proteins are involved in recognizing bacterial components or their degradation ...

journal_title：Current opinion in gastroenterology

authors： Rescigno M,Nieuwenhuis EE

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review studies that improve the diagnosis and treatment of autoimmune hepatitis and suggest new drug and molecular interventions. RECENT FINDINGS:Elderly patients have an indolent but aggressive disease that responds well to corticosteroid therapy. Variant syndromes are ...

journal_title：Current opinion in gastroenterology

authors： Czaja AJ

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the advances in diagnostic modalities and management options for defecatory dysfunction and highlight the areas in need of further research. RECENT FINDINGS:The diagnostic utility of high-resolution anorectal manometry (ARM), which has emerged as a promising tool for the diagnosis of def...

journal_title：Current opinion in gastroenterology

authors： Neshatian L

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Most colorectal cancers (CRCs) have deletions, duplications, and rearrangements of their chromosomes that reflect a destabilizing process called chromosomal instability (CIN). The cause of CIN is controversial, but no intrinsic mutation in cancer cells has been reported that can reasonably account for...

journal_title：Current opinion in gastroenterology

authors： Niv Y,Goel A,Boland CR

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Availability of direct acting antivirals (DAAs) that demonstrate remarkable clinical efficacy and safety has revolutionized the ability to treat chronic infection with hepatitis C virus (HCV). An equal measure of clinical success has now been achieved in persons coinfected with HCV and the HIV, a hist...

journal_title：Current opinion in gastroenterology

authors： Meissner EG

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) dietary restriction ameliorates irritable bowel syndrome (IBS) symptoms; however, not all individuals with IBS respond. Given the gut microbiome's role in carbohydrate fermentation, investigators have evaluated whether the...

journal_title：Current opinion in gastroenterology

authors： Chumpitazi BP

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Bariatric surgery is recognized as the most effective treatment against obesity as it results in significant weight reduction and a high rate of remission of obesity-related comorbidities. However, bariatric surgery is not uncommonly associated with complications and an endoscopic approach to manageme...

journal_title：Current opinion in gastroenterology

authors： Kumbhari V,Cai JX,Schweitzer MA

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Endoscopic ampullectomy has proven its safety and efficacy in multiple studies, making it the favorable option for the management of endoscopic ampullectomy. In this review, we plan to review the basic steps every endoscopist should be familiar with before undertaking endoscopic ampullectomy. RECENT ...

journal_title：Current opinion in gastroenterology

authors： Klair JS,Irani S,Kozarek R

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic liver disease (CLD) causes significant morbidity and mortality, mainly due to complications [hepatic encephalopathy, ascites, hepatorenal syndrome (HRS) and esophageal variceal hemorrhage (EVH)]. Studies of the complications, management and outcomes in patients with CLD over the last 18 months...

journal_title：Current opinion in gastroenterology

authors： Rahimi RS,Rockey DC

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Immunoglobulin G4-associated cholangitis is a recently identified clinical entity characterized by infiltration of immunoglobulin G4 -bearing plasma cells in bile ducts and other affected tissues. This review is focused mainly on the most recent studies published during the last 2 years that have incr...

journal_title：Current opinion in gastroenterology

authors： Björnsson E

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Conflicting reports in the literature have been misinterpreted by clinicians, who conclude that nutritional therapy for the hospitalized patient is of marginal value. The true benefit of such therapy is derived from the provision of early enteral nutrition. This article describes the physiologic respo...

journal_title：Current opinion in gastroenterology

authors： McClave SA,Omer E

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the increasing evidence supporting the concept that microRNAs (miRNAs) are involved in the cause and pathogenesis of cholestatic liver disorders. RECENT FINDINGS:miRNAs play a key role in maintaining bile acid homeostasis and modulating pathological processes associated to liver cholesta...

journal_title：Current opinion in gastroenterology

authors： Marin JJ,Bujanda L,Banales JM

更新日期：2014-05-01 00:00:00

abstract：:Intensive investigation into the interactions of Helicobacter pylori with the human host during the period of this review has led to several important developments in our understanding of H. pylori pathogenesis. There is direct evidence to support a central role for bacterial adhesion to host gastric epithelial Lewis ...

journal_title：Current opinion in gastroenterology

authors： Wilson KT,Fantry GT

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent literature (2009-2010) on acute nonvariceal upper gastrointestinal hemorrhage. RECENT FINDINGS:There is a decreasing trend in the incidence and hospitalization for acute nonvariceal upper gastrointestinal hemorrhage worldwide, with significant improvement in rebleeding and mortality....

journal_title：Current opinion in gastroenterology

authors： Chiu PW,Sung JJ

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Endoscopic retrograde cholangiopancreatography is reserved primarily for therapeutic reasons. Recent literature continues to support therapeutic uses of the technique. This review addresses the literature in the field of biliary endoscopy for the year 2006 and is intended to assist gastroenterologists...

journal_title：Current opinion in gastroenterology

authors： Wamsteker EJ

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Hyperplastic polyps, once considered to have no malignant potential, are now recognized to be part of a larger group of polyps known as serrated polyps. Serrated polyps can progress to CRC through an epigenetic pathway known as CpG Island Methylator Phenotype (CIMP), characterized by hypermethylation ...

journal_title：Current opinion in gastroenterology

authors： Lindholm CR,Anderson JC,Srivastava A

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review evidence relating to the strength of associations that have appeared in largely observational studies, between high-dose or long-term use of proton pump inhibitor drugs and certain possibly attributable side-effects, which emerge from studies confounded by other variables. In retrospective s...

journal_title：Current opinion in gastroenterology

authors： McCarthy DM

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There have been considerable advances in our understanding of the molecular pathogenesis of enteropathogenic Escherichia coli and enterohemorrhagic E. coli infection. Given the difficulty of infecting laboratory mice with these diarrhea-causing pathogens, a growing number of studies have found the mur...

journal_title：Current opinion in gastroenterology

authors： Borenshtein D,McBee ME,Schauer DB

更新日期：2008-01-01 00:00:00