Endoscopic management of biliary disease.

abstract：PURPOSE OF REVIEW:Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. Clinical trials should help guide and improve the management of cIAIs. However, inappropriate selection or measurement of outcomes in cIAIs clinical trials can lead to misleading results on the effe...

journal_title：Current opinion in gastroenterology

authors： Ahmed S,Wilcox MH,Kirby A

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study is to provide an overview of the role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in inflammatory bowel disease (IBD). RECENT FINDINGS:Human genetic studies have identified several UPR-related genes and autophagy-related genes as IBD risk loc...

journal_title：Current opinion in gastroenterology

authors： Hosomi S,Kaser A,Blumberg RS

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Exome sequencing studies have recently expanded the genetic characterization of intrahepatic cholangiocarcinomas. Among a number of novel genes, isocitrate dehydrogenase (IDH) is recurrently mutated in intrahepatic cholangiocarcinomas. We review the effects of these mutations on several biochemical pa...

journal_title：Current opinion in gastroenterology

authors： Grassian AR,Pagliarini R,Chiang DY

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To consider observations suggesting that the bacterial protein flagellin, the primary structural component of flagella, plays a major role in mediating gut inflammation associated with infection by enteric pathogens and in inflammatory bowel disease. RECENT FINDINGS:Biochemical dissection of an in-vi...

journal_title：Current opinion in gastroenterology

authors： Gewirtz AT

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:There is a need for novel therapies for inflammatory bowel diseases (IBDs) that are well tolerated and effective. Currently, mesenchymal stem/stromal cells (MSCs) are being investigated in clinical trials for treatment of IBD. In this review, we update the recently published studies with an emphasis o...

journal_title：Current opinion in gastroenterology

authors： Dave M,Jaiswal P,Cominelli F

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recently, a new class of intracellular pattern recognition receptors belonging to the family of nucleotide binding and oligomerization domain (NOD)-like receptors that includes NOD1, NOD2 and IPAF has been described. These proteins are involved in recognizing bacterial components or their degradation ...

journal_title：Current opinion in gastroenterology

authors： Rescigno M,Nieuwenhuis EE

更新日期：2007-01-01 00:00:00

abstract：:Viral hepatitis is still one of the most common causes of acute and chronic liver disease worldwide. Major advances have been made in our knowledge of these diseases, many during the past year. Molecular biology and clinical studies have improved our understanding of the mechanisms of antiviral drugs, as well as viral...

journal_title：Current opinion in gastroenterology

authors： Regev A,Schiff ER

更新日期：1999-05-01 00:00:00

abstract：:Complementary and alternative medicine (CAM) is becoming increasingly utilized as a form of health care, with recent studies suggesting that over 40% of Americans use some form of CAM. This has major financial implications for the health care industry. Traditional physicians frequently are unaware of CAM use by their ...

journal_title：Current opinion in gastroenterology

authors： Haas L,McClain C,Varilek G

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing use of small bowel endoscopy unravels ulcers in a relevant number of patients. Although often attributed to inflammatory bowel disease (IBD), these ulcers may be unspecific or caused by a variety of other diseases. This review summarizes the recent literature related to differential diagnos...

journal_title：Current opinion in gastroenterology

authors： Keuchel M,Kurniawan N,Baltes P

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Intestinal fibrosis is a potentially serious complication of inflammatory bowel disease and its pathophysiology is still unclear. This review will discuss recent developments relating to sources of fibroblasts in intestinal inflammation, mediators that modulate fibroblast activation and function, as w...

journal_title：Current opinion in gastroenterology

authors： Rieder F,Fiocchi C

更新日期：2008-07-01 00:00:00

abstract：:Gastric adenocarcinoma is the most common malignancy of the upper gastrointestinal tract. During the past two decades it has migrated toward the gastroesophageal junction. Gastroesophageal reflux and obesity may play a role. Recent research suggests that a number of biologic and molecular differences exist in patients...

journal_title：Current opinion in gastroenterology

authors： Yao JC,Ajani JA

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This article highlights recent advances in viral hepatitis published from December 2003 to November 2004. Studies reporting novel and clinically relevant findings were selected after a PubMed search. The aim is to provide an up-to-date summary of important developments in viral hepatitis. RECENT FIND...

journal_title：Current opinion in gastroenterology

authors： Fung SK,Lok AS

更新日期：2005-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The introduction of novel molecular imaging modalities that can not only define disease states on the basis of structural changes and morphology, but also allow in-vivo visualization and characterization of molecular and biochemical alterations on a cellular level add a new dimension to our current di...

journal_title：Current opinion in gastroenterology

authors： Atreya R,Neurath MF

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Taking advantage of their rapid growth and capacity for continuous genetic adaptation, prokaryotes have colonized all possible ecological environments on earth, including the body surfaces of eukaryotes and their gastrointestinal tract. The mammalian gut contains a complex community of 10 bacteria wit...

journal_title：Current opinion in gastroenterology

authors： Gaboriau-Routhiau V,Lécuyer E,Cerf-Bensussan N

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary biliary cholangitis (PBC) is a rare autoimmune liver disease that increasingly is diagnosed at early stages of disease. Although survival has improved, a majority suffers from one or more symptom complexes associated with PBC. Much remains unknown about the mechanisms, significance, or effecti...

journal_title：Current opinion in gastroenterology

authors： Kuo A,Kuo A,Bowlus CL

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This focused, narrative review summarizes human clinical trial data for direct-acting antimicrobials in development for the treatment of gastrointestinal infections that were published in the past 18 months (1 January 2019 to 30 June 2020). RECENT FINDINGS:Antimicrobial agents for Clostridioides diff...

journal_title：Current opinion in gastroenterology

authors： Carlson TJ,Gonzales-Luna AJ,Garey KW

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The 2009 review on small intestinal ion transport, in this series, focused on recent advances in duodenal bicarbonate secretion, the importance of scaffolding proteins and the pathophysiology of inflammation-associated diarrhea. The current review focuses on advances in ion-coupled solute transport, t...

journal_title：Current opinion in gastroenterology

authors： Venkatasubramanian J,Ao M,Rao MC

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:With recent advances in radiographic testing, there have been increases in the incidental identification of pancreatic cysts. Determining management, specifically, which cysts can be watched versus intervened upon has significant impact on at the patient-physician level as well as globally on resource...

journal_title：Current opinion in gastroenterology

authors： Harrison JM,Castillo CF

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Enteral nutrition is now the preferred route of nutritional support in malnourished and ICU patients. Studies providing evidence of its efficacy, techniques of administration, and outcome are appearing daily in the literature. This review presents the most important publications in this area and criti...

journal_title：Current opinion in gastroenterology

authors： Jeejeebhoy KN

更新日期：2004-03-01 00:00:00

abstract：:Therapeutic biliary endoscopy continues to evolve. Key articles this year primarily involve biliary stenting and biliary stone removal, the two important maneuvers available to the biliary endoscopist. The issues addressed in this review include follow-up after the use of multiple stents for benign strictures, unilate...

journal_title：Current opinion in gastroenterology

authors： Barnett JL

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Rotavirus infection is the leading cause of severe dehydrating gastroenteritis, responsible for an estimated 440,000 deaths per year in children less than 5 years of age worldwide. There was great optimism when the first rotavirus vaccine was licensed in the United States in July 1998 (rhesus rotaviru...

journal_title：Current opinion in gastroenterology

authors： Bines JE

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) dietary restriction ameliorates irritable bowel syndrome (IBS) symptoms; however, not all individuals with IBS respond. Given the gut microbiome's role in carbohydrate fermentation, investigators have evaluated whether the...

journal_title：Current opinion in gastroenterology

authors： Chumpitazi BP

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Conflicting reports in the literature have been misinterpreted by clinicians, who conclude that nutritional therapy for the hospitalized patient is of marginal value. The true benefit of such therapy is derived from the provision of early enteral nutrition. This article describes the physiologic respo...

journal_title：Current opinion in gastroenterology

authors： McClave SA,Omer E

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Historically, surgical treatment of choledochal cyst consisted of cyst enterostomy. However, incomplete cyst excision can result in recurrent symptoms and malignant transformation within the cyst remnant. Accordingly, management of choledochal cyst now includes complete cyst excision whenever possible...

journal_title：Current opinion in gastroenterology

authors： Ronnekleiv-Kelly SM,Soares KC,Ejaz A,Pawlik TM

更新日期：2016-05-01 00:00:00

abstract：:Viral gastroenteritis is a major public health problem worldwide, and the number of identified pathogens continuously increases. Investigators have made considerable progress toward understanding both the epidemiology and the mechanisms of virus-cell interactions, host responses, and pathogenesis. A vaccine for the mo...

journal_title：Current opinion in gastroenterology

authors： Shaw RD

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic liver disease (CLD) causes significant morbidity and mortality, mainly due to complications [hepatic encephalopathy, ascites, hepatorenal syndrome (HRS) and esophageal variceal hemorrhage (EVH)]. Studies of the complications, management and outcomes in patients with CLD over the last 18 months...

journal_title：Current opinion in gastroenterology

authors： Rahimi RS,Rockey DC

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Cytokines of the intestinal microenvironment largely dictate immunological responses after mucosal insults and the dominance of homeostatic or proinflammatory pathways. This review presents important recent studies on the role of specific cytokines in the pathogenesis of intestinal inflammation. RECE...

journal_title：Current opinion in gastroenterology

authors： Bamias G,Cominelli F

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this brief review is to provide an up-to-date view of the role played by α-smooth muscle actin-positive cancer-associated fibroblastic cells in promoting intrahepatic cholangiocarcinoma progression. RECENT FINDINGS:An increase in α-smooth muscle actin-positive cancer-associated fibroblasti...

journal_title：Current opinion in gastroenterology

authors： Sirica AE,Campbell DJ,Dumur CI

更新日期：2011-05-01 00:00:00

abstract：:Toxic effects in the upper gastrointestinal tract, primarily complicated gastric and intestinal ulcers, are the most common undesirable effects of the nonsteroidal anti-inflammatory drugs. During the last several years, there have been several advances, both in the laboratory and clinically, toward reducing nonsteroid...

journal_title：Current opinion in gastroenterology

authors： Cryer B

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The intestinal microbiota plays a central role in inflammatory diseases of the gut. Although most investigations regarding how the mucosal immune system interacts with the microbiota have focused on bacteria, recent studies are elucidating the additional role of commensal fungi in health and disease i...

journal_title：Current opinion in gastroenterology

authors： Limon JJ,Kershaw KM,Underhill DM

更新日期：2018-11-01 00:00:00