Role of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease.

abstract：PURPOSE OF REVIEW:Hyperplastic polyps, once considered to have no malignant potential, are now recognized to be part of a larger group of polyps known as serrated polyps. Serrated polyps can progress to CRC through an epigenetic pathway known as CpG Island Methylator Phenotype (CIMP), characterized by hypermethylation ...

journal_title：Current opinion in gastroenterology

authors： Lindholm CR,Anderson JC,Srivastava A

更新日期：2019-01-01 00:00:00

abstract：:Molecular-phylogenetic methods have revolutionized the analysis of complex microbial communities. Polymerase chain reaction amplification and phylogenetic analysis of small-subunit ribosomal RNA gene sequences allow microbes to be identified objectively, even in the absence of cultivation. Furthermore, the sequence in...

journal_title：Current opinion in gastroenterology

authors： Frank DN,Pace NR

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:It is now over 8 years since small bowel capsule endoscopy (SBCE) was first introduced to the gastrointestinal community. The original capsule (Given Imaging, YoKneam, Israel) - a disposable 26 x 11 mm video capsule containing its own optical dome, light source, batteries, transmitter and antenna - is...

journal_title：Current opinion in gastroenterology

authors： Eliakim R

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent investigations into the regulation of pancreatic acinar cell function have led to a more detailed understanding of the mechanisms regulating digestive enzyme synthesis and secretion. This review identifies and puts into context those articles which further our understanding in this area. RECEN...

journal_title：Current opinion in gastroenterology

authors： Williams JA

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Intestinal fibrosis is a potentially serious complication of inflammatory bowel disease and its pathophysiology is still unclear. This review will discuss recent developments relating to sources of fibroblasts in intestinal inflammation, mediators that modulate fibroblast activation and function, as w...

journal_title：Current opinion in gastroenterology

authors： Rieder F,Fiocchi C

更新日期：2008-07-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) affects many patients and has a negative effect on quality of life. Along with the increasing prevalence of GERD is an increase in GERD-related complications, including Barrett esophagus and esophageal adenocarcinoma. The past year has yielded new insights into the pathophysiolog...

journal_title：Current opinion in gastroenterology

authors： Sifrim D,Zerbib F

更新日期：2002-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Small bowel capsule endoscopy (SBCE) was introduced 13 years ago by Given Imaging (Yokneam, Israel). It has become one of the most important investigational tools of the small bowel. The capsule is swallowed with water after a 12 h fast, propelled via peristalsis through the gastrointestinal tract and...

journal_title：Current opinion in gastroenterology

authors： Eliakim R

更新日期：2013-03-01 00:00:00

abstract：:Gastric adenocarcinoma is the most common malignancy of the upper gastrointestinal tract. During the past two decades it has migrated toward the gastroesophageal junction. Gastroesophageal reflux and obesity may play a role. Recent research suggests that a number of biologic and molecular differences exist in patients...

journal_title：Current opinion in gastroenterology

authors： Yao JC,Ajani JA

更新日期：2000-11-01 00:00:00

abstract：:The elucidation of metabolic pathways and the genetic basis for diseases of the liver continues to increase our understanding of disease pathogenesis and advance treatment options. This selective review covers a wide range of subjects, from the identification of novel proteins and the importance of specific transport ...

journal_title：Current opinion in gastroenterology

authors： Schilsky ML

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To present the clinical, endoscopic, and histologic features of eosinophilic esophagitis (EoE), review the current diagnostic guidelines for EoE, and present an approach for diagnosis of EoE. It will also highlight selected techniques that are under development that may be useful in the future for dia...

journal_title：Current opinion in gastroenterology

authors： Dellon ES

更新日期：2012-07-01 00:00:00

abstract：:Advances in cellular and molecular biology of extrahepatic cholangiocarcinoma and gallbladder adenocarcinoma are providing innovative means for the diagnosis and treatment of biliary tract cancer. Similarly, refinements in noninvasive studies--including helical computed tomography, magnetic resonance cholangiopancreat...

journal_title：Current opinion in gastroenterology

authors： Abdalla EK,Vauthey JN

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Exciting new developments and applications of imaging techniques in pancreatic diseases have emerged. This review discusses these new advances and how they are improving our ability to diagnose malignancies and inflammatory lesions, to grade severity of pancreatitis, and to stage pancreatic cancer acc...

journal_title：Current opinion in gastroenterology

authors： Kwon RS,Brugge WR

更新日期：2005-09-01 00:00:00

abstract：:Endoscopic management of biliary disease remains at the forefront of minimally invasive means of providing therapy, as well as contributing important diagnostic information in complex clinical scenarios. The authors review recent advances and reported trials of therapy and revisit important controversial issues. The m...

journal_title：Current opinion in gastroenterology

authors： Lew RJ,Kochman ML

更新日期：2000-09-01 00:00:00

abstract：:Complementary and alternative medicine (CAM) is becoming increasingly utilized as a form of health care, with recent studies suggesting that over 40% of Americans use some form of CAM. This has major financial implications for the health care industry. Traditional physicians frequently are unaware of CAM use by their ...

journal_title：Current opinion in gastroenterology

authors： Haas L,McClain C,Varilek G

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Nutrition in the critically ill patient remains a controversial topic. Most clinicians have viewed nutrition as part of patient care but not as a therapeutic intervention. Recent studies have looked at type and timing of nutrition to determine whether they affect important clinical outcomes. RECENT F...

journal_title：Current opinion in gastroenterology

authors： Fremont RD,Rice TW

更新日期：2014-03-01 00:00:00

abstract：:Recently, much progress has been made in the field of tumor immunology. Much of this work has focused on understanding and exploiting the innate immune response to tumor cells. A novel human receptor-ligand system that mediates natural killer (NK) and gammadelta T-cell killing of carcinoma cells has been identified, a...

journal_title：Current opinion in gastroenterology

authors： Golby SJ,Spencer J

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Esophageal varices and Mallory Weiss syndrome are the two major esophageal bleeding disorders. Although there have been major breakthroughs in the treatment of peptic ulcer bleeding, the management of esophageal bleeding disorders remains a challenging problem. This review focuses on studies published...

journal_title：Current opinion in gastroenterology

authors： Wu JC,Chan FK

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Fermentable oligosaccharides disaccharides monosaccharides and polyols (FODMAP) dietary restriction ameliorates irritable bowel syndrome (IBS) symptoms; however, not all individuals with IBS respond. Given the gut microbiome's role in carbohydrate fermentation, investigators have evaluated whether the...

journal_title：Current opinion in gastroenterology

authors： Chumpitazi BP

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Irritable bowel syndrome is a common and likely a multifactorial gastrointestinal disorder in which a disturbed brain-gut axis has been thought to have a mandatory role. Recent clinical and experimental studies imply that dietary factors may be more important in the pathogenesis of irritable bowel syn...

journal_title：Current opinion in gastroenterology

authors： Kalliomäki MA

更新日期：2005-11-01 00:00:00

abstract：:Globally, gastroesophageal reflux disease (GERD) remains a common and important clinical disorder. This review summarizes the major advances in the understanding and treatment of GERD that have been made in the past 12 months. Epidemiologic studies have yielded additional data on the clinical presentation and natural ...

journal_title：Current opinion in gastroenterology

authors： Nguyen NQ,Holloway RH

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Food addiction has been implicated as a putative causal factor in chronic overeating, binge eating, and obesity. The concept of food addiction has been controversial historically due to definitional and conceptual difficulties and to a lack of rigorous scientific data. RECENT FINDINGS:Support for the...

journal_title：Current opinion in gastroenterology

authors： Corsica JA,Pelchat ML

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The human gut is the natural habitat for a large and dynamic bacterial community. There is a substantial body of evidence implicating the resident flora in the pathogenesis of chronic intestinal inflammation. This review discusses the possible role of a microbial imbalance in the pathophysiology of in...

journal_title：Current opinion in gastroenterology

authors： Guarner F

更新日期：2005-07-01 00:00:00

abstract：:The neurohormonal control of pancreatic exocrine secretion is a complex interaction of multiple pathways involving a large number of gut hormones, neurotransmitters, and neuropeptides. Recent studies have elucidated a role for cholecystokinin in the regulation of bicarbonate and fluid secretion from pancreatic duct ce...

journal_title：Current opinion in gastroenterology

authors： Nathan JD,Liddle RA

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Bariatric surgery is recognized as the most effective treatment against obesity as it results in significant weight reduction and a high rate of remission of obesity-related comorbidities. However, bariatric surgery is not uncommonly associated with complications and an endoscopic approach to manageme...

journal_title：Current opinion in gastroenterology

authors： Kumbhari V,Cai JX,Schweitzer MA

更新日期：2015-09-01 00:00:00

abstract：:Viral hepatitis is still one of the most common causes of acute and chronic liver disease worldwide. Major advances have been made in our knowledge of these diseases, many during the past year. Molecular biology and clinical studies have improved our understanding of the mechanisms of antiviral drugs, as well as viral...

journal_title：Current opinion in gastroenterology

authors： Regev A,Schiff ER

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant advances in the pathophysiology, diagnosis and management of the complications of portal hypertension that have occurred in the last year are reported. RECENT FINDINGS:The specific areas reviewed are those that refer to experimental studies aimed at modifying the factors that lead to port...

journal_title：Current opinion in gastroenterology

authors： Garcia-Tsao G

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize recent advances in defining the clinical features, pathophysiology, natural history, and treatment of nonalcoholic fatty liver disease. RECENT FINDINGS:Nonalcoholic fatty liver disease is present in approximately 30% of the US population. A histologic gradin...

journal_title：Current opinion in gastroenterology

authors： Greenfield V,Cheung O,Sanyal AJ

更新日期：2008-05-01 00:00:00

abstract：:Portal hypertension is the main complication of cirrhosis and is responsible for its most common complications: variceal hemorrhage, ascites, and portosystemic encephalopathy. Portal hypertension is the result of increased intrahepatic resistance and increased portal venous inflow, which in turn is the result of splan...

journal_title：Current opinion in gastroenterology

authors： Garcia-Tsao G

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To critically appraise evidence on probiotic use for prevention and treatment of diarrhea in children and adults. RECENT FINDINGS:Several randomized controlled trials and meta-analyses suggested that probiotics are effective in primary and secondary prevention of gastroenteritis and its treatment. Se...

journal_title：Current opinion in gastroenterology

authors： Guarino A,Lo Vecchio A,Canani RB

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine recent advances in the techniques and technologies of endoscopic resection of early gastric cancer. RECENT FINDINGS:Endoscopic mucosal resection of early gastric cancer with no risk of lymph node metastasis has been a standard technique in Japan and is increasingly becoming accepted and re...

journal_title：Current opinion in gastroenterology

authors： Gotoda T

更新日期：2006-09-01 00:00:00