Neurohormonal control of pancreatic exocrine secretion.

Abstract:

:The neurohormonal control of pancreatic exocrine secretion is a complex interaction of multiple pathways involving a large number of gut hormones, neurotransmitters, and neuropeptides. Recent studies have elucidated a role for cholecystokinin in the regulation of bicarbonate and fluid secretion from pancreatic duct cells and suggested that cholecystokinin stimulation of human pancreatic acinar cells is likely regulated by an indirect mechanism of stimulation of afferent neurons. Evidence supports the regulation of potassium channels in rat pancreatic acinar cells by the cyclic AMP-mediated agonist secretin. Mechanisms for the regulation of cholecystokinin and secretin release by releasing factors have also been elucidated. The area postrema has been implicated in the mediation of inhibition of pancreatic secretion by the gut hormones peptide YY and pancreatic polypeptide. The neurotransmitter serotonin has been demonstrated to play a role in acid-induced secretin release and in pancreatic secretion stimulated by luminal factors. The regulation of pancreatic exocrine secretion by purines, nitric oxide, and gamma-aminobutyric acid as well as by the neuropeptides pituitary adenylate cyclase-activating peptide, gastrin-releasing peptide, and substance P is reviewed. The role of the central nervous system in modulating pancreatic secretion is also described. This review highlights the recent advances in knowledge of the neurohormonal regulation of pancreatic exocrine secretion.

authors

Nathan JD,Liddle RA

doi

10.1097/00001574-200209000-00003

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

536-44

issue

5

eissn

0267-1379

issn

1531-7056

pii

00001574-200209000-00003

journal_volume

18

pub_type

杂志文章
  • Chronic pancreatitis.

    abstract::In the past year, numerous important papers were published on chronic pancreatitis, its causes, and its diagnosis; the cause of fibrosis; and pain in pancreatic cancer. More than 750 mutations have been described in the cystic fibrosis transmembrane regulator (CFTR) gene. Some mutations cause relatively mild reduction...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199909000-00005

    authors: Chari ST,Dimagno EP

    更新日期:1999-09-01 00:00:00

  • Endoscopic resection of early gastric cancer: the Japanese perspective.

    abstract:PURPOSE OF REVIEW:To examine recent advances in the techniques and technologies of endoscopic resection of early gastric cancer. RECENT FINDINGS:Endoscopic mucosal resection of early gastric cancer with no risk of lymph node metastasis has been a standard technique in Japan and is increasingly becoming accepted and re...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000239873.06243.00

    authors: Gotoda T

    更新日期:2006-09-01 00:00:00

  • Inherited metabolic disease.

    abstract::The elucidation of metabolic pathways and the genetic basis for diseases of the liver continues to increase our understanding of disease pathogenesis and advance treatment options. This selective review covers a wide range of subjects, from the identification of novel proteins and the importance of specific transport ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200205000-00003

    authors: Schilsky ML

    更新日期:2002-05-01 00:00:00

  • Functional dyspepsia.

    abstract:PURPOSE OF REVIEW:Functional dyspepsia is a common disorder, most of the time of unknown etiology and with variable pathophysiology. Therapy has been and still is largely empirical. Data from recent studies provide new clues for targeted therapy based on knowledge of etiology and pathophysiologic mechanisms. RECENT FI...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200411000-00007

    authors: Kleibeuker JH,Thijs JC

    更新日期:2004-11-01 00:00:00

  • Enteral feeding.

    abstract:PURPOSE OF REVIEW:Enteral nutrition is now the preferred route of nutritional support in malnourished and ICU patients. Studies providing evidence of its efficacy, techniques of administration, and outcome are appearing daily in the literature. This review presents the most important publications in this area and criti...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,收录出版

    doi:10.1097/00001574-200403000-00010

    authors: Jeejeebhoy KN

    更新日期:2004-03-01 00:00:00

  • Renal dysfunction in cirrhosis.

    abstract:PURPOSE OF REVIEW:Renal dysfunction causes significant morbidity in cirrhotic patients. Diagnosis is challenging because it is based on serum creatinine, which is used to calculate estimated glomerular filtration rate, which itself is not an ideal measure of renal function in patients with cirrhosis. Finding the exact ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000168

    authors: Urrunaga NH,Mindikoglu AL,Rockey DC

    更新日期:2015-05-01 00:00:00

  • Nonsteroidal anti-inflammatory drug gastrointestinal toxicity.

    abstract::Toxic effects in the upper gastrointestinal tract, primarily complicated gastric and intestinal ulcers, are the most common undesirable effects of the nonsteroidal anti-inflammatory drugs. During the last several years, there have been several advances, both in the laboratory and clinically, toward reducing nonsteroid...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200111000-00005

    authors: Cryer B

    更新日期:2001-11-01 00:00:00

  • Diagnosis and therapy of esophageal vascular disorders.

    abstract:PURPOSE OF REVIEW:The most relevant studies concerning the diagnosis of esophageal varices, primary and secondary prophylaxis and treatment of variceal bleeding published in the last year are reported. RECENT FINDINGS:The specific areas reviewed are those that refer to studies on the noninvasive or minimally invasive ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e3281299011

    authors: de Franchis R,Dell'Era A

    更新日期:2007-07-01 00:00:00

  • Parasitic infections of the gastrointestinal tract.

    abstract::Intestinal parasites continue to be a significant health problem in both developed and developing countries. In developed countries, protozoans are more commonly the cause of gastrointestinal infections than are helminths. Some protozoan parasites have stages in which, in addition to being resistant to chemicals used ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200301000-00005

    authors: Harp JA

    更新日期:2003-01-01 00:00:00

  • Small bowel ulcers: when is it not inflammatory bowel disease ?

    abstract:PURPOSE OF REVIEW:Increasing use of small bowel endoscopy unravels ulcers in a relevant number of patients. Although often attributed to inflammatory bowel disease (IBD), these ulcers may be unspecific or caused by a variety of other diseases. This review summarizes the recent literature related to differential diagnos...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000522

    authors: Keuchel M,Kurniawan N,Baltes P

    更新日期:2019-05-01 00:00:00

  • Obesity pharmacology: past, present, and future.

    abstract::Over the past several years, the pharmacologic treatment of obesity has undergone changes in safety, efficacy, and therapeutic targeting. The prevalence of cardiac valvulopathy associated with treatment with phentermine, fenfluramine, and dexfenfluramine is now becoming clarified with the publication of longer-term st...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200203000-00011

    authors: Kushner RF,Manzano H

    更新日期:2002-03-01 00:00:00

  • New paradigms for organ allocation and distribution in liver transplantation.

    abstract:PURPOSE OF REVIEW:The 'Final Rule,' issued by the Health Resources and Service Administration in 2000, mandated that liver allocation policy should be based on disease severity and probability of death, and - among other factors - should be independent of a candidate's residence or listing. As a result, the Organ Procu...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000434

    authors: Kalra A,Biggins SW

    更新日期:2018-05-01 00:00:00

  • Gastroesophageal reflux disease.

    abstract::Globally, gastroesophageal reflux disease (GERD) remains a common and important clinical disorder. This review summarizes the major advances in the understanding and treatment of GERD that have been made in the past 12 months. Epidemiologic studies have yielded additional data on the clinical presentation and natural ...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200307000-00009

    authors: Nguyen NQ,Holloway RH

    更新日期:2003-07-01 00:00:00

  • Intestinal absorption of vitamins.

    abstract::This article provides an overview of advances in understanding the cellular and molecular mechanisms and regulation of intestinal absorption processes of vitamins. The vitamins covered are the water-soluble vitamins folic acid, cobalamin (vitamin B12), biotin, pantothenic acid, and thiamine (vitamin B1) and the lipid-...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199903000-00015

    authors: Said HM,Kumar C

    更新日期:1999-03-01 00:00:00

  • Update on viral hepatitis in 2004.

    abstract:PURPOSE OF REVIEW:This article highlights recent advances in viral hepatitis published from December 2003 to November 2004. Studies reporting novel and clinically relevant findings were selected after a PubMed search. The aim is to provide an up-to-date summary of important developments in viral hepatitis. RECENT FIND...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000158109.13722.36

    authors: Fung SK,Lok AS

    更新日期:2005-05-01 00:00:00

  • Endoscopic treatment of colonic obstruction.

    abstract:PURPOSE OF REVIEW:Over the past 15 years, great strides have been made in the nonsurgical management of malignant large bowel obstruction. Progress continues, particularly in the area of self-expanding metal stents. The purpose of this review is to assess the available endoscopic techniques for colonic decompression an...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/mog.0b013e32831dde47

    authors: Dekovich AA

    更新日期:2009-01-01 00:00:00

  • Food allergy and irritable bowel syndrome.

    abstract:PURPOSE OF REVIEW:Irritable bowel syndrome is a common and likely a multifactorial gastrointestinal disorder in which a disturbed brain-gut axis has been thought to have a mandatory role. Recent clinical and experimental studies imply that dietary factors may be more important in the pathogenesis of irritable bowel syn...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mog.0000181712.81657.0a

    authors: Kalliomäki MA

    更新日期:2005-11-01 00:00:00

  • Chest pain of esophageal origin.

    abstract::The treatment of patients with unexplained chest pain is difficult and challenging. After a cardiac etiology has been ruled out, a diligent search for an esophageal etiology-gastroesophageal reflux disease, motility abnormalities, or esophageal hypersensitivity-should be undertaken with judicious use of a diagnostic (...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199907000-00013

    authors: Katz PO

    更新日期:1999-07-01 00:00:00

  • Biliary endoscopy.

    abstract::Highlighting this year was the National Institutes of Health (NIH) State-of-the-Science Conference on endoscopic retrograde cholangiopancreatography. The panel addressed controversies in biliary endoscopy and set the framework for future funding for clinical research endeavors. With respect to biliary endoscopy, the l...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200305000-00013

    authors: Beilstein MC,Kochman ML

    更新日期:2003-05-01 00:00:00

  • Gastric cancer.

    abstract::Gastric adenocarcinoma is the most common malignancy of the upper gastrointestinal tract. During the past two decades it has migrated toward the gastroesophageal junction. Gastroesophageal reflux and obesity may play a role. Recent research suggests that a number of biologic and molecular differences exist in patients...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200011000-00009

    authors: Yao JC,Ajani JA

    更新日期:2000-11-01 00:00:00

  • Expression profiling in pancreatic cancer research: the initial steps and the road ahead.

    abstract::A part of living in a new and exciting era for the biologic sciences and medicine, novel high throughput tools allow exploration of the human genome in an unprecedented manner. This "information revolution" is fueled by the study of genome-wide expression profiles for complex biologic and pathophysiologic conditions u...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-200309000-00005

    authors: Fernandez-Zapico ME,Callahan G,Delgado S,Urrutia R

    更新日期:2003-09-01 00:00:00

  • Microbiota and innate immunity in intestinal inflammation and neoplasia.

    abstract:PURPOSE OF REVIEW:This review focuses on recent advances and novel insights into the mechanistic events that may link commensal microbiota and host innate immunity in the pathophysiology of intestinal inflammation and neoplasia. Unanswered questions are discussed and future perspectives in the field are highlighted. R...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32835a670e

    authors: Cario E

    更新日期:2013-01-01 00:00:00

  • Nod-like receptors in intestinal host defense: controlling pathogens, the microbiota, or both?

    abstract:PURPOSE OF REVIEW:Nod-like receptors (NLRs) are intracellular innate immune sensors of microbes and danger signals that control multiple aspects of inflammatory responses. We review the evidence that highlights the critical importance of NLRs in the host response to intestinal pathogens. Moreover, we discuss the potent...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e32835a68ea

    authors: Robertson SJ,Girardin SE

    更新日期:2013-01-01 00:00:00

  • Rotavirus vaccines and intussusception risk.

    abstract:PURPOSE OF REVIEW:Rotavirus infection is the leading cause of severe dehydrating gastroenteritis, responsible for an estimated 440,000 deaths per year in children less than 5 years of age worldwide. There was great optimism when the first rotavirus vaccine was licensed in the United States in July 1998 (rhesus rotaviru...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Bines JE

    更新日期:2005-01-01 00:00:00

  • Eosinophilic esophagitis: diagnostic tests and criteria.

    abstract:PURPOSE OF REVIEW:To present the clinical, endoscopic, and histologic features of eosinophilic esophagitis (EoE), review the current diagnostic guidelines for EoE, and present an approach for diagnosis of EoE. It will also highlight selected techniques that are under development that may be useful in the future for dia...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0b013e328352b5ef

    authors: Dellon ES

    更新日期:2012-07-01 00:00:00

  • Measuring outcomes in complicated intra-abdominal infections.

    abstract:PURPOSE OF REVIEW:Complicated intra-abdominal infections (cIAIs) are associated with significant morbidity and mortality. Clinical trials should help guide and improve the management of cIAIs. However, inappropriate selection or measurement of outcomes in cIAIs clinical trials can lead to misleading results on the effe...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MOG.0000000000000591

    authors: Ahmed S,Wilcox MH,Kirby A

    更新日期:2020-01-01 00:00:00

  • Epidemiology of human noroviruses and updates on vaccine development.

    abstract:PURPOSE OF REVIEW:Noroviruses (NoVs) are the most common cause of epidemic and sporadic cases of acute gastroenteritis worldwide. This review summarizes recent NoV disease burden estimates, epidemiology findings and provides an update on virus-like particle (VLP) vaccine studies. RECENT FINDINGS:NoVs are the leading c...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MOG.0000000000000022

    authors: Ramani S,Atmar RL,Estes MK

    更新日期:2014-01-01 00:00:00

  • JC virus and colorectal cancer: a possible trigger in the chromosomal instability pathways.

    abstract:PURPOSE OF REVIEW:Most colorectal cancers (CRCs) have deletions, duplications, and rearrangements of their chromosomes that reflect a destabilizing process called chromosomal instability (CIN). The cause of CIN is controversial, but no intrinsic mutation in cancer cells has been reported that can reasonably account for...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Niv Y,Goel A,Boland CR

    更新日期:2005-01-01 00:00:00

  • Pathogenesis of inflammatory bowel disease.

    abstract::In spite of expanding knowledge of cellular and molecular mechanisms of intestinal inflammation, the etiology and pathogenesis of inflammatory bowel disease (IBD) remain obscure. The link between the environment and IBD is still circumstantial, but definite progress is occurring in defining genetic susceptibility loci...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00001574-199907000-00003

    authors: Katz JA,Itoh J,Fiocchi C

    更新日期:1999-07-01 00:00:00

  • Primary biliary cirrhosis in 2014.

    abstract:PURPOSE OF REVIEW:Primary biliary cirrhosis (PBC) was first described in the 1950s as a clinical syndrome of progressive cholestatic liver disease resulting from chronic inflammatory destruction of the intrahepatic bile ducts. In the 1980s, the autoimmune nature of the disease was appreciated with the discovery of dise...

    journal_title:Current opinion in gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MOG.0000000000000058

    authors: Flores A,Mayo MJ

    更新日期:2014-05-01 00:00:00