Abstract:
PURPOSE OF REVIEW:One of the most vexing problems for gastroenterologists is what actions to take after receiving a histological diagnosis of gastric intestinal metaplasia. We approach the problem by starting with suggesting a biopsy protocol that ensures obtaining the biopsies required for diagnosis, assessing the status of the gastric mucosa, and effective communication with the pathologist and patient. RECENT FINDINGS:The rediscovery and integration of the long history of gastric damage and repair resulting in pseudopyloric metaplasia (called SPEM) into the thinking of investigators working with animal models of gastric cancer has resulted in improved ability to separate changes associated with benign repair from those associated with inflammation-associated gastric carcinogenesis. SUMMARY:Gastric intestinal metaplasia is a potential reversible product of injury and repair and not directly connected with carcinogenesis. Intestinal metaplasia is a biomarker for prior gastric injury and repair. The risk of gastric cancer is best assessed in relation to the severity, extent, and, most importantly, the cause of the atrophic changes.
journal_name
Curr Opin Gastroenteroljournal_title
Current opinion in gastroenterologyauthors
Graham DY,Rugge M,Genta RMdoi
10.1097/MOG.0000000000000576subject
Has Abstractpub_date
2019-11-01 00:00:00pages
535-543issue
6eissn
0267-1379issn
1531-7056journal_volume
35pub_type
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journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
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journal_title:Current opinion in gastroenterology
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更新日期:2006-11-01 00:00:00
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journal_title:Current opinion in gastroenterology
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更新日期:2010-09-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
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