Abstract:
PURPOSE OF REVIEW:Hereditary liver diseases resulting in copper and iron overload may cause significant morbidity and mortality if not diagnosed and treated early. The goal of this review is to highlight the key publications on genetics, diagnosis and management of hemochromatosis and Wilson disease over the past 18 months. RECENT FINDINGS:Several recent advancements have been made in the genetic diagnosis of hemochromatosis and Wilson disease. Uncommon HFE mutations resulting in phenotypic hemochromatosis among C282Y heterozygotes have been identified from HFE gene sequencing. A serum ferritin less than 1000 μg/l in C282Y homozygotes was found to be associated with milder symptoms of hemochromatosis. Deferasirox was shown to reduce iron overload in patients with hemochromatosis and may be an option for patients who cannot tolerate phlebotomy. There was found to be evidence of genotype and phenotype correlation in Wilson disease, which can be diagnosed by genetic sequencing. A modified diagnostic guideline has been developed for children with Wilson disease with mild liver disease that increases the sensitivity and specificity of diagnosis. Also treatment with copper chelating agents has less hepatic treatment failures when compared with zinc monotherapy. SUMMARY:Advancements in diagnosis of hemochromatosis and Wilson disease may lead to earlier diagnosis and treatment with resulting decrease in morbidity and mortality.
journal_name
Curr Opin Gastroenteroljournal_title
Current opinion in gastroenterologyauthors
Maxwell KL,Kowdley KVdoi
10.1097/MOG.0b013e3283521d82subject
Has Abstractpub_date
2012-05-01 00:00:00pages
217-22issue
3eissn
0267-1379issn
1531-7056journal_volume
28pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Endoscopic approaches to obesity may help fulfill the unmet need of over half the US adult population who would benefit from therapy for obesity but are not receiving it. Endoluminal approaches have the potential to be more efficacious than antiobesity medications and have a lower risk-cost profile co...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000203
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To present the clinical, endoscopic, and histologic features of eosinophilic esophagitis (EoE), review the current diagnostic guidelines for EoE, and present an approach for diagnosis of EoE. It will also highlight selected techniques that are under development that may be useful in the future for dia...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328352b5ef
更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Most colorectal cancers (CRCs) have deletions, duplications, and rearrangements of their chromosomes that reflect a destabilizing process called chromosomal instability (CIN). The cause of CIN is controversial, but no intrinsic mutation in cancer cells has been reported that can reasonably account for...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::Water-soluble vitamins are required as enzyme cofactors in a wide variety of metabolic reactions. Riboflavin, niacin, and vitamin C are essential in redox reactions; thiamine and biotin are involved in macronutrient metabolism; and folate, vitamin B12, pyridoxine, and riboflavin play important roles in the regulation ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200303000-00003
更新日期:2003-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will summarize the most significant work that contributed to the understanding of liver fibrosis progression and resolution, which in turn has yielded new areas of therapeutic targeting. RECENT FINDINGS:Liver fibrosis is the result of an imbalance between production and dissolution of ext...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/mog.0b013e3283279668
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To outline the recommended course of action when a subepithelial lesion is encountered during upper endoscopy. It will focus on the endoscopic and endosonographic features common to gastrointestinal stromal tumors, and the optimal tests performed to confirm the diagnosis of a gastrointestinal stromal ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32829fb39f
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Our objective was to review advances in bile acids in health and disease published in the last 2 years. Bile acid diarrhea (BAD) is recognized as a common cause of chronic diarrhea, and its recognition has been facilitated by development of new screening tests. RECENT FINDINGS:Primary BAD can account...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000344
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The dynamic interplay of the intestinal microbiota and host has been the focus of many studies because of its impact on the health status in human life. Recent reports on the time-resolved immune and metabolic interactions between the host and microbiota, as well as the molecular signatures that mark ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328365d365
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Ampullary tumors, usually adenomas, are often encountered during endoscopic evaluation, especially in patients with familial adenomatous polyposis (FAP). Because of the risk of progression to adenocarcinoma, ampullary adenomas should be treated. Endoscopic therapy is an appropriate option and recent e...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200409000-00008
更新日期:2004-09-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes the last year's literature regarding the regulation and measurement of gastric exocrine and endocrine secretion. RECENT FINDINGS:Parietal cells, distributed along much of the length of the oxyntic glands, with highest density in the neck and base, secrete HCl as well as transfo...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328331b62a
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Knowledge on and understanding of the pathophysiology of inflammatory bowel disease (IBD) is continuously growing. Important insights from the last years are summarized in this review. RECENT FINDINGS:Further genetic risk factors for IBD have been identified and confirmed. Novel studies analyzing the...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328353e61e
更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The introduction of novel molecular imaging modalities that can not only define disease states on the basis of structural changes and morphology, but also allow in-vivo visualization and characterization of molecular and biochemical alterations on a cellular level add a new dimension to our current di...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000120
更新日期:2014-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To consider observations suggesting that the bacterial protein flagellin, the primary structural component of flagella, plays a major role in mediating gut inflammation associated with infection by enteric pathogens and in inflammatory bowel disease. RECENT FINDINGS:Biochemical dissection of an in-vi...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000194791.59337.28
更新日期:2006-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Therapy for inflammatory bowel diseases (IBD) has changed dramatically in recent years with a wider use of immunomodulators and the introduction of antitumor necrosis factor (anti-TNF) agents. This article reviews the existing data on the long-term efficacy of biologics, that is, anti-TNF agents, for ...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000078
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Conflicting reports in the literature have been misinterpreted by clinicians, who conclude that nutritional therapy for the hospitalized patient is of marginal value. The true benefit of such therapy is derived from the provision of early enteral nutrition. This article describes the physiologic respo...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000618
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Increasing antimicrobial resistance in Salmonella Typhi is a serious public health concern, especially in industrializing countries. Here we review recent clinical and laboratory data concerning the evolution of antimicrobial resistance, with particular reference to the emergence resistance against fl...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000406
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The gastroduodenum has multiple means by which it resists injury from intrinsic and extrinsic factors, including gastric acid, nonsteroidal anti-inflammatory drugs, and Helicobacter pylori. We review recent insights into the mechanisms by which the gastroduodenum resists injury and discuss factors con...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e328330da7b
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Intestinal fibrosis is a potentially serious complication of inflammatory bowel disease and its pathophysiology is still unclear. This review will discuss recent developments relating to sources of fibroblasts in intestinal inflammation, mediators that modulate fibroblast activation and function, as w...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3282ff8b36
更新日期:2008-07-01 00:00:00
abstract::Molecular-phylogenetic methods have revolutionized the analysis of complex microbial communities. Polymerase chain reaction amplification and phylogenetic analysis of small-subunit ribosomal RNA gene sequences allow microbes to be identified objectively, even in the absence of cultivation. Furthermore, the sequence in...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200101000-00010
更新日期:2001-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses the advances in the pathophysiology, diagnosis, and management of the complications of portal hypertension that have occurred in the past year. RECENT FINDINGS:The specific topics reviewed are the pathophysiology of portal hypertension (including recent findings regarding intrah...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200405000-00010
更新日期:2004-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize publications on juvenile primary sclerosing cholangitis (PSC) published over the past 5 years. These studies contribute to the understanding of the clinical features, diagnostic pathways, genetic aspects, treatment and outcome of this condition. RECENT FINDINGS:Sclerosing cholangitis wit...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e3283388f5b
更新日期:2010-05-01 00:00:00
abstract::The development of small bowel transplantation has long been hindered by the immunological and infectious barriers peculiar to the small bowel. Gradual progress has been achieved during the past decade with the use of tacrolimus and the availability of better anti-infection prophylaxis. The current status of small bow...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-200003000-00006
更新日期:2000-03-01 00:00:00
abstract::The treatment of patients with unexplained chest pain is difficult and challenging. After a cardiac etiology has been ruled out, a diligent search for an esophageal etiology-gastroesophageal reflux disease, motility abnormalities, or esophageal hypersensitivity-should be undertaken with judicious use of a diagnostic (...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章
doi:10.1097/00001574-199907000-00013
更新日期:1999-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review important manuscripts published over the previous 2 years relative to sphincter of Oddi dysfunction (SOD). RECENT FINDINGS:The long-term outcomes of the Evaluating Predictors and Interventions of SOD (EPISOD) trial further substantiated results from the initial EPISOD study, reinforcing tha...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000455
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The molecular biology revolution has led to a significant improvement in our understanding of biological and physiological processes. Such expansion of knowledge has also covered the field of intestinal absorption of water-soluble vitamins and is the subject of this review. RECENT FINDINGS:Impressive...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/01.mog.0000203870.22706.52
更新日期:2006-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Nutrition in the critically ill patient remains a controversial topic. Most clinicians have viewed nutrition as part of patient care but not as a therapeutic intervention. Recent studies have looked at type and timing of nutrition to determine whether they affect important clinical outcomes. RECENT F...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000047
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Exome sequencing studies have recently expanded the genetic characterization of intrahepatic cholangiocarcinomas. Among a number of novel genes, isocitrate dehydrogenase (IDH) is recurrently mutated in intrahepatic cholangiocarcinomas. We review the effects of these mutations on several biochemical pa...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000050
更新日期:2014-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Cytokines of the intestinal microenvironment largely dictate immunological responses after mucosal insults and the dominance of homeostatic or proinflammatory pathways. This review presents important recent studies on the role of specific cytokines in the pathogenesis of intestinal inflammation. RECE...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000315
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Taking advantage of their rapid growth and capacity for continuous genetic adaptation, prokaryotes have colonized all possible ecological environments on earth, including the body surfaces of eukaryotes and their gastrointestinal tract. The mammalian gut contains a complex community of 10 bacteria wit...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0b013e32834bb82b
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Increasing use of small bowel endoscopy unravels ulcers in a relevant number of patients. Although often attributed to inflammatory bowel disease (IBD), these ulcers may be unspecific or caused by a variety of other diseases. This review summarizes the recent literature related to differential diagnos...
journal_title:Current opinion in gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MOG.0000000000000522
更新日期:2019-05-01 00:00:00