Abstract:
OBJECTIVES:Complete epithelial wound healing is a milestone in early postoperative care after penetrating keratoplasty. The re-epithelialization rate after penetrating keratoplasty was measured in patients receiving a new matrix therapy agent (regenerating agent, Cacicol®) that mimics heparan sulphates. METHODS:This was a prospective, open-label, uncontrolled, single-centre observational study. A total of 33 consecutive patients (33 eyes) who underwent an 8.25-mm diameter penetrating keratoplasty were treated with regenerating agent eye drops: one drop in the operating theatre immediately after graft, then on alternate days. Patients were divided into those at low risk (13 patients) and high risk (20 patients) of delayed wound healing, and follow-up was performed by digital slit lamp with fluorescein-dye testing repeated daily at a fixed time. Dye area was measured using ImageJ freeware. The main endpoint was epithelial healing after regenerating agent therapy. RESULTS:The mean ± standard deviation time to complete healing for all patients was 2.7 ± 1.1 (median: 3, range: 1-6) days. This was obtained on Day 1 for 15% of patients, Day 2 for 33%, Day 3 for 88%, Day 4 for 94% and Day 6 for 100%. There was no significant difference between low- and high-risk patients. The area of epithelial defect decreased by a mean ± standard deviation of 75% ± 22% between Day 1 and Day 2, corresponding to a mean ± standard deviation wound-healing rate of 11.5 ± 6.5 mm2/D. There were no systemic or local side effects related to regenerating agent. CONCLUSION:These preliminary data suggest that regenerating agent could be a useful, non-invasive therapeutic approach in postoperative management of penetrating keratoplasty with the potential to accelerate re-epithelialization.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Jullienne R,Garcin T,Crouzet E,He Z,Renault D,Thuret G,Gain Pdoi
10.1177/1120672118808971subject
Has Abstractpub_date
2020-01-01 00:00:00pages
119-124issue
1eissn
1120-6721issn
1724-6016journal_volume
30pub_type
杂志文章abstract:PURPOSE:To determine the long-term visual outcomes and risk factors for visual loss in children with primary congenital glaucoma (PCG) who underwent angle surgery over a 21-year period. METHODS:This was a retrospective study of patients who underwent trabeculotomy, trabeculectomy, or combined trabeculotomy-trabeculect...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000976
更新日期:2017-11-08 00:00:00
abstract:PURPOSE:To evaluate the safety of a foldable acrylic single-piece intraocular lens (IOL) in cases of complicated cataract surgery and sulcus implantation. The setting was University and private anterior segment surgery practices. METHODS:In this observational case series study, 13 eyes of 13 patients were included aft...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000160
更新日期:2012-11-01 00:00:00
abstract::We sent questionnaires to 424 retina specialists in order to compile information on the use of fluorescein angiography in pregnant women. Four-hundred and three specialists responded. Of these, 313 (78%) had never performed fluorescein angiography on a pregnant woman. Ninety specialists (22%) had performed at least on...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:PURPOSE:To report a case of presumed bilateral acute retinal necrosis with delayed onset caused by herpes simplex virus type 2, medical treatment, and surgical approach. METHODS:Retrospective, interventional case described in a 51-year-old patient who complained of unilateral blurred vision with history of nonoperated...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000596
更新日期:2015-07-30 00:00:00
abstract:PURPOSE:To investigate the clinical effects and outcomes of intravitreal injection of 4 mg of triamcinolone acetonide (IVTA) after or concomitant with macular laser photocoagulation (MP) for clinically significant macular edema (CSME). METHODS:Forty-nine eyes of 49 patients with nonproliferative diabetic retinopathy a...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/112067210901900418
更新日期:2009-07-01 00:00:00
abstract::The objectives of this study were two-fold: to identify tear histamine content and its relationship to changes in tear histaminase activity during the early (EPR) and late phases (LPR) of the allergic reaction induced by a conjunctival provocation test (CPT) and to evaluate the effects of lodoxamide on histamine relea...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:To describe a technique for suturing a luxated intraocular lens (IOL) in the vitreous cavity directly to the ciliary sulcus using intraocular slipknot without IOL extraction. DESIGN:Noncomparative interventional case series. MATERIALS AND METHODS:A three-port vitrectomy was performed in all cases. According t...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210301300604
更新日期:2003-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/112067210301300202
更新日期:2003-03-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2019-11-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
abstract:PURPOSE:A novel application of pulsed electronic speckle pattern interferometry (PulseESPI) techniques in important corneal elasticity measurements is presented in this pilot study. For laser-ablative procedures like laser-assisted in situ keratomileusis, it has been found that elastic properties of the cornea have a r...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000208
更新日期:2010-03-01 00:00:00
abstract:INTRODUCTION:Preretinal hemorrhages can be located in subhyaloid or sub-internal limiting membrane (ILM) space. Though optical coherence tomography (OCT) may help to distinguish the exact location of hemorrhage in selected cases, it is often difficult to discern clinically. The purpose is to describe a novel clinical s...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120934958
更新日期:2020-06-22 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800415
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:To describe the visual phenotype of multiple sclerosis (MS) in the Afro-Caribbean population living in Martinique (French West Indies) and to specify the influence of the migration to metropolitan France on ocular impairment. DESIGN:Prospective consecutive observational case series. METHODS:A complete ophthal...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210501500313
更新日期:2005-05-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000118
更新日期:2012-09-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::Purpose. To compare long-term variability of retinal nerve fiber layer thickness (RNFLT) measurements made with the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) and enhanced (GDx-ECC) corneal compensation. Methods. One eye each of 110 Caucasian...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000178
更新日期:2013-01-21 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2021-01-01 00:00:00
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journal_title:European journal of ophthalmology
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doi:10.1177/112067210301300214
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journal_title:European journal of ophthalmology
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更新日期:2020-09-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2020-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000397
更新日期:2014-05-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2014-07-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2008-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:1996-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672119832432
更新日期:2019-07-01 00:00:00