The effects of Rituximab on Graves'orbitopathy: A retrospective study of 14 patients.

Abstract:

PURPOSE:Management of Graves' ophthalmopathy remains challenging. Over the last decade, previous studies have shown promising results for Rituximab in the treatment of Graves' ophthalmopathy. We present the response of 14 individuals with active moderate-to-severe Graves' ophthalmopathy to Rituximab, representing one of the largest retrospective case series reported to date. METHODS:Rituximab was administered intravenously, 1000 mg twice at a 2-week interval. The primary end point was a clinical activity score reduction (improvement by ⩾ 2 points or disease inactivation: clinical activity score < 3) at 24 weeks. Secondary end points included clinical activity score improved by ⩾ 2 points or inactivation of Graves' ophthalmopathy at 12 weeks, improvement in each item of the clinical activity score, in proptosis, in severity disease by the total eye score and in diplopia according to the Gorman score. RESULTS:A limited improvement in clinical activity score was observed (median improvement at 24 weeks by 1 point, p = 0.002, (5/14 patients, 35.7%). Disease inactivation occurred in 50% of patients (7/14 patients). At 12 weeks, clinical activity score improved by ⩾ 2 points in 2/14 patients (14.3%) and inactivation of Graves' ophthalmopathy occurred in four patients (28.6%). Improvement in proptosis and total eye score was observed in 3/9 patients (33%) and in 4/14 patients (28.6%) at 24 weeks, respectively. Only one patient experienced moderate adverse event. CONCLUSION:Rituximab is a well-tolerated treatment with a good safety profile, but offered limited and partial improvement for active moderate-to-severe Graves' ophthalmopathy with a long duration of disease.

journal_name

Eur J Ophthalmol

authors

Eid L,Coste-Verdier V,Longueville E,Ribeiro E,Nicolescu-Catargi B,Korobelnik JF

doi

10.1177/1120672119845224

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1008-1013

issue

5

eissn

1120-6721

issn

1724-6016

journal_volume

30

pub_type

杂志文章
  • Diabetic retinopathy: are we really doing all we can for our patients?

    abstract::Although it is now possible to significantly reduce the incidence of blindness secondary to diabetes mellitus, large numbers of diabetic patients still experience visual loss due to retinal complications of the disease. This implies that protocols for the diagnosis and treatment of diabetic retinopathy used in the var...

    journal_title:European journal of ophthalmology

    pub_type: 社论

    doi:10.1177/112067219900900302

    authors: Bandello F,Porta M,Brancato R

    更新日期:1999-07-01 00:00:00

  • Femtosecond laser assisted in situ keratomileusis (FS-LASIK) yields better results than transepithelial photorefractive keratectomy (Trans-PRK) for correction of low to moderate grade myopia.

    abstract:INTRODUCTION:The purpose of this study was to compare the outcomes of transepithelial photorefractive keratectomy (Trans-PRK) with femtosecond laser assisted in situ keratomileusis (FS-LASIK) for the correction of low to moderate myopia. METHODS:A retrospective cohort study design was used. The study group included pa...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672120980346

    authors: Gershoni A,Reitblat O,Mimouni M,Livny E,Nahum Y,Bahar I

    更新日期:2020-12-14 00:00:00

  • Redeployment of ophthalmologists in the United Kingdom during the Coronavirus Disease Pandemic.

    abstract:BACKGROUND:During the current coronavirus (COVID-19) pandemic, some ophthalmologists across the United Kingdom (UK) have been redeployed to areas of need across the National Health Service (NHS). This survey was performed to assess aspects of this process including training & education, tasks expected, availability of ...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672120953339

    authors: Lim C,De Silva I,Moussa G,Islam T,Osman L,Malick H,Deol S,Youssef M,Farrag A,Ashraf R,Burgula S,Thompson J

    更新日期:2020-08-27 00:00:00

  • Optical coherence tomography angiography findings in laser maculopathy.

    abstract:PURPOSE:Handheld laser pointer thermal injury affects primarily the retinal pigment epithelium (RPE). However, so far no study has reported on the possible effects of laser pointers in the deeper layers, beneath the RPE. Here, we describe the spectral-domain optical coherence tomography angiography findings in the chor...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/ejo.5000844

    authors: Tomasso L,Benatti L,La Spina C,Lattanzio R,Baldin G,Carnevali A,De Vitis LA,Querques L,Bandello F,Querques G

    更新日期:2017-01-19 00:00:00

  • Orbital metastasis from squamous cell carcinoma of the esophagus.

    abstract:PURPOSE:To describe a rare case of orbital metastasis from squamous cell carcinoma of the esophagus. METHODS:A 63-year-old man presented with intermittent left-sided headache. This was initially attributed to angle-closure glaucoma and bilateral peripheral laser iridotomies were performed. One month later, he develope...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210601600316

    authors: Aralikatti DA,Nylander AG

    更新日期:2006-05-01 00:00:00

  • Comparison of performance between two microcatheter systems in ab externo canaloplasty: A retrospective comparison study.

    abstract:PURPOSE:To compare the performance of two different microcatheter systems, iTrack™ 250A and Glaucolight, in ab externo canaloplasty in three major categories: intraocular pressure reduction, drug therapy reintroduction, and evaluation of viscodilation over distension of the inner wall of Schlemm's canal. METHODS:A tot...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672119833547

    authors: Vastardis I,Kontopoulou K,Fili S,Gatzioufas Z,Kohlhaas M

    更新日期:2020-05-01 00:00:00

  • Palbebral anthrax.

    abstract:PURPOSE:Anthrax is a rare infection transmitted to humans from animals or animal products. In cutaneous anthrax it may produce lesions of the eyelids which can lead to cicatricial ectropion. METHODS:We examined three women and five men with anthrax of the eyelids. Intravenous penicillin G was used alone as therapy. R...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210101100212

    authors: Celebi S,Aykan U,Alagöz G,Esmerligil S

    更新日期:2001-04-01 00:00:00

  • Anatomic and visual outcomes of 23-G vitrectomy without scleral buckling for primary rhegmatogenous retinal detachment.

    abstract:PURPOSE:To evaluate the anatomic success rate, visual acuity (VA) changes, and complications of 23-G vitrectomy without associated scleral procedures for the treatment of primary rhegmatogenous retinal detachment (PRRD). 
 METHODS:Patients diagnosed with PRRD were considered for inclusion. Patients with evidence of pr...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/ejo.5000234

    authors: Figueroa MS,Contreras I,Noval S,PACORES Study Group.

    更新日期:2013-05-01 00:00:00

  • Retinopathy of prematurity: any difference in risk factors between a high and low risk population?

    abstract:PURPOSE:To document incidence of and risk factors for development of retinopathy of prematurity (ROP) in a population of low birthweight infants (< 1500 g). METHODS:The authors registered clinical characteristics (birthweight, gestational age (GA), Clinical Risk Index for Babies (CRIB), Apgar score, respiratory charac...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672103013009-1009

    authors: Allegaert K,Casteels I,Cossey V,Devlieger H

    更新日期:2003-11-01 00:00:00

  • Quantitative corneal anatomy in emmetropic subjects.

    abstract:PURPOSE:Currently there is little information available about the corneal thickness values of healthy emmetropic subjects. Therefore, the authors decided to analyze the corneal thickness in healthy emmetropic subjects. METHODS:The authors analyzed the difference in thickness values between the thinnest corneal site an...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210601600207

    authors: Sanchis-Gimeno JA,Herrera M,Lleó-Pérez A,Alonso L,Rahhal MS

    更新日期:2006-03-01 00:00:00

  • Posterior keratoconus-clinical aspects and anterior segment optical coherence tomography findings: A case report.

    abstract:PURPOSE::To describe a case of Posterior Keratoconus (keratoconus posticus); its clinical condition, corneal, refractive response to intracorneal ring implantation (MyoRing), anterior segment optical coherence tomography findings; and micro incisional cataract surgery outcome. METHODS::Case report. RESULTS::The case ...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672118787436

    authors: Vargas V,Alió J

    更新日期:2019-01-01 00:00:00

  • Nonmydriatic fundus camera for diabetic retinopathy screening in a safety net hospital: effectiveness, prevalence, and risk factors.

    abstract:PURPOSE:To evaluate diabetic retinopathy (DR) prevalence and risk factors, and the effectiveness of nonmydriatic fundus camera as a screening tool for the detection of DR, in a safety net hospital. METHODS:This was a retrospective, population-based, cross-sectional study. Diabetic patients, referred by their primary c...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/ejo.5000515

    authors: Schwartz S,Harasawa M,Baldivieso V,Sabel AL,Mandava N,Quiroz-Mercado H

    更新日期:2015-03-01 00:00:00

  • Microperimetric evaluation of macula in retinopathy of membranoproliferative glomerulonephritis type II: a case report.

    abstract:PURPOSE:To report on the microperimetric evaluation of the central visual field in a patient with retinopathy due to membranoproliferative glomerulonephritis. METHODS:The central 20 degrees visual field was evaluated using fundus-related perimetry with (Nidek MP1) microperimeter in a patient with proven membranoprolif...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210601600425

    authors: Shenoy R,McCilvenny S

    更新日期:2006-07-01 00:00:00

  • Work-related open-globe injuries: demographics and clinical characteristics.

    abstract:PURPOSE:To describe the demographics and clinical characteristics of work-related open-globe injuries (OGIs) at a level I trauma center over a 10-year period. METHODS:Retrospective series. RESULTS:A total of 183 eyes with work-related OGIs were identified. The majority of injuries occurred in men (96.7%). The anatomi...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/ejo.5000209

    authors: Bauza AM,Emami P,Son JH,Langer P,Zarbin M,Bhagat N

    更新日期:2013-03-01 00:00:00

  • Comparison of higher order aberrations with spherical and aspheric IOLs compared to normal phakic eyes.

    abstract:PURPOSE:To compare higher order aberrations (HOA) in AcrySof SN60AT and Acrysof IQ SN60WF intraocular lenses (IOLs) and natural crystalline lenses in an age-matched population. METHODS:Sixty-nine eyes of 55 patients were examined. Group I included AcrySof spheric lenses, group II AcrySof aspheric lenses, and group III...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210801800511

    authors: Rekas M,Krix-Jachym K,Zelichowska B

    更新日期:2008-09-01 00:00:00

  • Fibrin reaction after uveitic cataract surgery: treatment and prevention.

    abstract:PURPOSE:To describe the management with intracameral recombinant tissue plasminogen activator (rtPA) of severe fibrin effusion after phacoemulsification, and its prevention with sustained-release dexamethasone intravitreal implant. METHODS:A 59-year-old man with chronic HLA-B27-associated uveitis underwent phacoemulsi...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/ejo.5000442

    authors: da Rocha Lima B,Pichi F,Nucci P,Srivastava SK,Lowder CY

    更新日期:2014-07-01 00:00:00

  • Eye health care in Hungary.

    abstract:PURPOSE:To describe eye health-care services provided by in patient Departments of Ophthalmology in Hungary as of 1998. METHODS:A standardised questionnaire was sent to all Hungarian in-patient ophthalmic departments. The response rate was 100%, and data from six university departments and 56 hospitals with ophthalmic...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210201200310

    authors: Németh J,Molnár F,Kocur I

    更新日期:2002-05-01 00:00:00

  • Loss of chance: a new kind of damage to ophthalmologic patients from Europe to Italy.

    abstract::This work was inspired by a recent juridical development in Italy, whose purpose is to prevent rejection of damage claims whenever it is not possible to prove a causal link between iatrogenic illicit behavior and damage to the patient, despite the fact that the patient has clearly suffered physical or mental injury. I...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/EJO.2010.6211

    authors: Molinelli A,Bonsignore A,Capecchi M,Calabria G

    更新日期:2011-05-01 00:00:00

  • Combined spatial, contrast, and temporal functions perimetry in mild glaucoma and ocular hypertension.

    abstract:PURPOSE:To evaluate the diagnostic ability of a new perimetric procedure in glaucoma. METHODS:Pulsar perimeter shows white circular sinusoidal grating patterns with decreasing amplitude, 5 in diameter, 500 msec in duration in 66 locations. The stimuli scale combines spatial resolution and contrast. The stimuli were sh...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/EJO.2008.2727

    authors: Gonzalez-Hernandez M,Garcia-Feijo J,Sanchez Mendez M,Gonzalez de la Rosa M

    更新日期:2004-01-01 00:00:00

  • Pseudophakic pseudoexfoliation of an AkreosFit intraocular lens.

    abstract:PURPOSE:To describe a case of intraocular lens opacification resembling pseudophakic pseudoexfoliation affecting an AkreosFit intraocular lens (IOL). METHODS:Single case analysis. RESULTS:A patient had IOL opacification resembling pseudophakic pseudoexfoliation. CONCLUSIONS:An 83-year-old woman with normal tension g...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Roberts MA,Hawksworth NR

    更新日期:2009-11-01 00:00:00

  • Endophthalmitis associated with fungal keratitis and penetrating injuries in North China.

    abstract:PURPOSE:To report the laboratory findings, management strategies, and visual outcomes of culture-proven exogenous fungal endophthalmitis in North China. METHODS:The microbiological and treatment records of patients with culture-positive exogenous fungal endophthalmitis who visited the Affiliated Hospital of Qingdao Un...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672119833896

    authors: Liu MY,Zhang L,Yin XL,Sun SY

    更新日期:2020-05-01 00:00:00

  • Induction of controlled wound healing with PMMA segments in the deep stroma in corneas of hens.

    abstract:PURPOSE:Polymethylmethacrylate (PMMA) segments are normally used in additive surgery to treat both corneal ectasia post laser-assisted in situ keratomileusis and keratoconus. The aim of this work was to develop an experimental animal model to induce wound healing in the deep stroma in corneas of hens. METHODS:PMMA seg...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067211002000108

    authors: Merayo-Lloves J,Blanco-Mezquita T,Ibares-Frias L,Fabiani L,Alvarez-Barcia A,Martinez-Garcia C

    更新日期:2010-01-01 00:00:00

  • Inferior sclerotomies without subretinal fluid drainage for exudative retinal detachment in diffuse retinal pigment epitheliopathy.

    abstract:PURPOSE:To evaluate the efficacy of inferior sutureless sclerotomies without subretinal fluid drainage for the treatment of bullous exudative retinal detachment secondary to diffuse retinal pigment epitheliopathy. METHODS:A retrospective interventional case series of eyes treated with two inferior postequatorial full-...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210801800618

    authors: Figueroa MS,Arruabarrena C,Sales-Sanz M,Mingo-Botin D

    更新日期:2008-11-01 00:00:00

  • Optical coherence tomography angiography in myopic choroidal neovascularization after intravitreal ranibizumab.

    abstract:PURPOSE::To describe the optical coherence tomography angiography characteristics of myopic patients with choroidal neovascularization secondary to pathologic myopia during ranibizumab therapy. METHODS::Nineteen patients were enrolled in this prospective study (13 females, 6 males, mean age 55.25 ± 9.63 years) for a t...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672118785495

    authors: Cennamo G,Amoroso F,Schiemer S,Velotti N,Alfieri M,de Crecchio G

    更新日期:2019-03-01 00:00:00

  • Risk factors for vitreous loss in cataract surgery.

    abstract:PURPOSE:To evaluate the risk factors for posterior capsule rupture with or without vitreous loss (PCR +/- VL) in extracapsular cataract extraction (ECCE). METHODS:The charts of 2794 consecutive patients who had ECCE with or without intraocular lens implantation between January 1992 and December 1997 were reviewed retr...

    journal_title:European journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/112067210001000306

    authors: Abbasoğlu OE,Hoşal B,Tekeli O,Gürsel E

    更新日期:2000-07-01 00:00:00

  • Lp(a) is not related to retinopathy in diabetic subjects.

    abstract:PURPOSE:To examine the association between Lp(a) concentrations and the severity of retinopathy in 22 younger-onset and 48 older-onset diabetic subjects from the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR), a population-based study of diabetic retinopathy. METHODS:We used a subset of the WESDR popula...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Haffner SM,Klein BE,Moss SE,Klein R

    更新日期:1995-04-01 00:00:00

  • A comparison of higher order aberrations in eyes implanted with AcrySof IQ SN60WF and AcrySof SN60AT intraocular lenses.

    abstract:PURPOSE:To evaluate the efficacy of AcrySof SN60WF aspheric intraocular lens (IOL) in decreasing spherical aberration and total higher order aberrations (HOAs) after cataract surgery compared to the spherical SN60AT lens. METHODS:Wavefront analysis was conducted on 28 eyes of 28 patients that underwent un-complicated ...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210701700307

    authors: Awwad ST,Lehmann JD,McCulley JP,Bowman RW

    更新日期:2007-05-01 00:00:00

  • A novel mutation of BEST1 gene in Best disease.

    abstract:PURPOSE:To describe a new genetic variation of BEST1 gene in Best vitelliform macular dystrophy. METHODS:A patient with bilateral multiple retinal yellowish lesions at the posterior pole underwent fluorescein angiography, fundus autofluorescence, optical coherence tomography, electrooculogram and blood sample for gene...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672120920536

    authors: Campa C,Parmeggiani F,Spena R,Ognibene D,Passerini I,Gualandi F

    更新日期:2020-04-22 00:00:00

  • Neuro-ophthalmic manifestations of intracranial cavernous hemangiomas.

    abstract:PURPOSE:To describe the neuro-ophthalmic manifestations of patients with intracranial cavernous hemangiomas (cavernomas). METHODS:A retrospective review of all patients with intracranial cavernomas with neuroophthalmic manifestations who were treated at the Royal Adelaide Hospital in Australia between 1994 and 2004. ...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210601600124

    authors: Leibovitch I,Pakrou D,Selva D,Crompton J

    更新日期:2006-01-01 00:00:00

  • The role of mitomycin C and porcine extracellular matrix in phacotrabeculectomy.

    abstract:PURPOSE:To compare between mitomycin C alone, porcine extracellular matrix alone, and combined low dose mitomycin C with porcine extracellular matrix in term of efficacy and safety in phaco-trabeculectomy surgery. STUDY DESIGN:Prospective comparative. METHODS:Sixty eyes of 60 patients complaining of primary open angl...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672120944339

    authors: Hamdi MM,Hamdi IM

    更新日期:2021-01-01 00:00:00