Abstract:
PURPOSE:To describe a case of multiorganism, drug-resistant keratitis that responded well to corneal crosslinking (CXL) treatment. METHODS:A 52-year-old man presented to our institute with a 2-month ocular history of infectious keratitis in his right eye, on topical antibacterial, antifungal, and antiprotozoan treatment, and complained of increase in pain, discomfort, and visual deterioration. Slit-lamp examination revealed advanced infectious keratitis (extensive deep corneal infiltrate with perineuritis). Cultural and molecular analysis of obtained corneal specimens demonstrated combined fungal and Acanthamoeba infection; confocal microscopy confirmed Acanthamoeba infection. Intense targeted topical antifungal and antiprotozoan treatment was initiated immediately and 1 month later CXL was performed due to drug resistance of the infection. RESULTS:Two weeks after CXL treatment, the corneal findings had deteriorated, while a corneal abscess was formed and extended at almost half of the cornea. This was gradually limited and the corneal infiltrate and abscess were eventually decreased. In addition, the symptoms improved. CONCLUSIONS:Corneal crosslinking could be an effective therapy in the management of advanced infectious keratitis unresponsive to conventional medical treatment.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Kymionis GD,Kouroupaki AI,Liakopoulos DA,Arandjelovic IR,Tsoulnaras KIdoi
10.5301/ejo.5000755subject
Has Abstractpub_date
2016-07-01 00:00:00pages
e67-e70issue
4eissn
1120-6721issn
1724-6016pii
81E40C52-5CDD-4D5F-AE5C-A1E10199C611journal_volume
26pub_type
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