Abstract:
:Pancreatic islet transplantation is a promising alternative to whole-pancreas transplantation as a treatment of type 1 diabetes mellitus. This technique has been extensively developed during the past few years, with the main purpose of minimizing the complications arising from the standard protocols used in organ transplantation. By using a variety of strategies used in tissue engineering and regenerative medicine, pancreatic islets have been successfully introduced in host patients with different outcomes in terms of islet survival and functionality, as well as the desired normoglycemic control. Here, we describe and discuss those strategies to transplant islets together with different scaffolds, in combination with various cell types and diffusible factors, and always with the aim of reducing host immune response and achieving islet survival, regardless of the site of transplantation.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Perez-Basterrechea M,Esteban MM,Vega JA,Obaya AJdoi
10.1002/bit.26821subject
Has Abstractpub_date
2018-12-01 00:00:00pages
3009-3029issue
12eissn
0006-3592issn
1097-0290journal_volume
115pub_type
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