Abstract：
:Long-term oral warfarin is recommended in pediatric Kawasaki disease patients with large coronary artery aneurysms; however, heterogeneity is considerable. This study aimed to determine variables affecting warfarin dosage in Kawasaki disease. The enrolled individuals (194 children) were divided into four groups: (1) Cases with severe coronary artery lesions (CAL) of IV to V degrees or thrombogenesis treated with oral warfarin were assigned to Group A; (2) Group B, CAL of I degrees; (3) Group C, CAL of II and III degrees cases with small or medium-sized CAL not treated with warfarin; (4) Group D, normal children without Kawasaki disease. The relevant genotypes of CYP2C9, VKORC1 (1173, - 1639, and 3730), and CYP4F2 were assessed. There were no statistically significant differences in CYP2C9, VKORC1, and CYP4F2 mutation frequencies among the 4 groups. In the 44 Group A patients, demographic features, clinical characteristics, and genotypes were recorded, and their associations with warfarin dose variability were assessed. Multivariate linear regression analysis revealed that height, VKORC1 1173, and CYP2C9 accounted for 61.2%, 7.9%, and 4.3% of dosing variability, respectively. Conclusions: Patient height is the main factor determining warfarin dosage, while genotype effects on warfarin dosage vary among studies. New formula should be defined using data obtained from children in cases with demonstrated efficacy.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Yang D,Kuang H,Zhou Y,Cai C,Lu Tdoi
10.1007/s00246-018-1957-xsubject
Has Abstractpub_date
2019-01-01 00:00:00pages
29-37issue
1eissn
0172-0643issn
1432-1971pii
10.1007/s00246-018-1957-xjournal_volume
40pub_type
杂志文章abstract：:We present a neonatal case with intractable atrial flutter that did not respond to digitalization and electrical cardioversion. Intravenous flecainide administration completely resolved the atrial flutter. Proarrhythmic effects were not induced by flecainide administration. Although the efficacy of flecainide for atri...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0226-8
更新日期：2004-03-01 00:00:00
abstract：:Novel COstatus system (Transonic Systems, Inc., NY), based on ultrasound dilution (UD), works off in situ arterial and central venous catheters in pediatric patients to measure cardiac output (CO). The purpose of the present study was to validate CO measurement by UD (COUD) with pulmonary artery (PA) thermodilution (C...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-9915-x
更新日期：2011-06-01 00:00:00
abstract：:Color-coded two-dimensional (2D) echocardiography confirmed the presence of severe congenital mitral regurgitation in an 8-month-old infant. Intraoperative inspection revealed an isolated perforation in the anterior leaflet. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02239570
更新日期：1990-04-01 00:00:00
abstract：:The reported prenatal detection rates (PDRs) for significant congenital heart disease (sCHD) have been suboptimal, even in the current era. Changes in prenatal ultrasound policy and training may lead to improved prenatal detection of sCHD. This study analyzed the results of a policy to assess fetal cardiac outflow tra...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0526-y
更新日期：2013-03-01 00:00:00
abstract：:DiGeorge syndrome (DGS) is commonly associated with both congenital heart disease (CHD) and immunologic abnormalities. While CHD may prompt consideration for heart transplantation (HTx), little is known about HTx management or outcomes in this group. The aim of this study was to describe the spectrum of patients with ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02063-w
更新日期：2019-04-01 00:00:00
abstract：:Three infants, each with a clinical picture of dilated cardiomyopathy, underwent endomyocardial biopsy. Immunohistologic analysis revealed chronic myocarditis. In one infant, a postviral etiology of chronic myocarditis could be assessed on the basis of molecular techniques. Therapy with azathioprine and prednisone res...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900292
更新日期：1998-05-01 00:00:00
abstract：:This study reviewed different types of primary cardiac and mediastinal tumors in infants and children as well as their clinical presentation and management. Altogether, 34 consecutive patients followed from 1976 through December 2005 were analyzed. Of these 34 patients, 14 (41%) underwent surgery and 20 (59%) with rha...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9256-6
更新日期：2008-11-01 00:00:00
abstract：:The COVID-19 pandemic has had devastating direct consequences on the health of affected patients. It has also had a significant impact on the ability of unaffected children to be physically active. We evaluated the effect of deconditioning from social distancing and school shutdowns implemented during the COVID-19 pan...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02513-w
更新日期：2021-01-04 00:00:00
abstract：:Inhaled nitric oxide (NO) has been used in the preoperative evaluation of patients with congenital heart disease and pulmonary hypertension. The purpose of this study was to characterize responses in pulmonary vascular resistance (PVR) to oxygen and increasing doses of NO during cardiac catheterization and to determin...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0767-5
更新日期：2005-09-01 00:00:00
abstract：:A 6-year-old girl with type 3 long QT syndrome was safely and successfully implanted with an implantable cardioverter-defibrillator (ICD) system. Prior to implantation, she had experienced uncontrollable life-threatening arrhythmia in spite of high-dose administration of mexiletine. An ICD coil lead for transvenous us...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-0065-y
更新日期：2011-10-01 00:00:00
abstract：:Noninvasive measurement of cardiac output (CO) and particularly stroke volume (SV) remain difficult but potentially valuable. These variables can be particularly challenging to measure in children with congenital heart disease (CHD). Impedance cardiography (IC) is a technique shown to be accurate in measuring SV in ad...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1456-x
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:This study aimed to provide descriptive information about off-label treatment practice with clopidogrel in a pediatric population. METHODS:Patients less than 18 years of age prescribed clopidogrel between March 2002 and August 2005 were retrospectively identified at Children's Hospital, Boston. Data from th...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9289-x
更新日期：2009-02-01 00:00:00
abstract：:A 5-year-old child with a Fontan circulation presented with acquired left pulmonary vein occlusion related to a previous surgical repair. We managed this lesion using a hybrid technique to perforate, dilate and stent the obstructed vessel. This approach should be considered when percutaneous access to the pulmonary ve...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1376-9
更新日期：2016-06-01 00:00:00
abstract：:We herein describe, for the first time, the fetal presentation of a case of ventricular inversion, restrictive ventricular septal defect, pulmonary stenosis, hypertensive left ventricle and double outlet right ventricle at 34 weeks of gestational age. Postnatal echocardiography confirmed the prenatal diagnosis. The pa...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-018-2048-8
更新日期：2019-01-01 00:00:00
abstract：:Anomalous origin of left pulmonary artery (ALPA) from aorta with atrial septal defect (ASD) is a rare congenital cardiac malformation. We report a case of ALPA from the aorta with ASD in a 1.8-kg baby. Repair was needed at an early age due to progressive congestive heart failure. Surgical correction was performed with...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9234-z
更新日期：2008-07-01 00:00:00
abstract：:We report a 4-month-old infant with torsade de pointes secondary to procainamide treatment. The infant presented with atrial flutter and converted to normal sinus rhythm with intravenous procainamide. Oral procainamide therapy was initiated as the infusion was tapered, and the patient subsequently developed incessant ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00796823
更新日期：1995-03-01 00:00:00
abstract：:Cardiac involvement of Duchenne and Becker muscular dystrophies (DMD/BMD) is the most common cause of fatal outcomes. It is still unclear whether some DMD/BMD gene mutations might be predictive of cardiac involvement. In this study, we provide a comprehensive overview on genotypes of cardiac disease in DMD/BMD. We sys...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02470-4
更新日期：2020-10-09 00:00:00
abstract：:There has been substantial controversy regarding treatment of congenital heart defects in infants with trisomies 13 and 18. Most reports have focused on surgical outcomes versus expectant treatment, and rarely there has been an effort to consolidate existing evidence into a more coherent way to help clinicians with de...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-020-02444-6
更新日期：2020-10-01 00:00:00
abstract：:Anomalous origin of left coronary artery (LCA) from the right coronary cusp with an intramural course is usually managed with unroofing of the intramural segment. Available literature demonstrates an uneventful course following surgery in most patients. Coronary stenosis following the unroofing procedure treated with ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-2005-6
更新日期：2019-01-01 00:00:00
abstract：:Little data are published about right ventricular (RV) growth and function in infants and neonates after balloon pulmonary valvuloplasty (BPV) for critical valvular pulmonary stenosis (PS). We aimed to assess the RV growth and function during 1 year after BPV for critical valvular PS in neonates and infants. A total o...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02314-1
更新日期：2020-04-01 00:00:00
abstract：:Debilitating cardiomyocyte loss underlies the progression to heart failure. Although there have been significant advances in treatment, current therapies are intended to improve or preserve heart function rather than regenerate lost myocardium. A major hurdle in implementing a cell-based regenerative therapy is the in...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-009-9409-2
更新日期：2009-07-01 00:00:00
abstract：:Intravenous immunoglobulin (IVIG) administered in the acute stage of Kawasaki disease (KD) is the standard therapy. Few reports describe nonresponders to initial treatment with IVIG in KD, which remains the most consistent risk factor for coronary artery lesions (CALs). This study aimed to investigate whether the seru...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0724-2
更新日期：2013-01-01 00:00:00
abstract：:Use of extracorporeal membrane oxygenation (ECMO) in infants with congenital heart disease is becoming more frequent. We present the first reported use of balloon atrial septostomy during ECMO support and describe possible complications of such procedures unique to ECMO therapy. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00795647
更新日期：1993-07-01 00:00:00
abstract：:Congenital left ventricular diverticulum is a rare cardiac malformation. The incidence of left ventricular diverticulum is reported to be 0.05% of all congenital heart malformations. This case series comprised three infants with the diagnosis of congenital left ventricular diverticulum determined by echocardiography. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0153-7
更新日期：2012-04-01 00:00:00
abstract：:The development of Leadless cardiac pacemakers avoids the inherent complications that may occur secondary to lead insertion. A large number of devices have been inserted in adult patients although data in pediatric patients are lacking. We aimed to assess our experience with the Leadless device in the pediatric popula...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02277-y
更新日期：2020-04-01 00:00:00
abstract：:The transplanted heart experiences numerous hemodynamic changes during and after cardiac transplantation. This study sought to evaluate the left ventricular myocardial mechanics in the pediatric heart transplant population using Velocity Vector Imaging (VVI). This study retrospectively evaluated 28 heart transplant re...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0205-z
更新日期：2012-06-01 00:00:00
abstract：:Left atrial isomerism includes a complex spectrum of cardiac and extracardiac anomalies. The records of all patients with left isomerism born during the period of 1973-2010 and treated at the Children's Hospital, Helsinki were reviewed. The short- and long-term outcomes were studied. The review included 38 patients (5...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0184-0
更新日期：2012-04-01 00:00:00
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-0109-3
更新日期：2012-01-01 00:00:00
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1168-7
更新日期：2015-10-01 00:00:00
abstract：:We report our findings in the microscopic examination of the conduction system in four infants with glycogen storage disease, one of whom had adequate electrophysiologic studies. The electrophysiologic studies in the latter case showed P-A and A-H intervals at the lower limits of normal, but the H-V interval was just ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02265613
更新日期：1982-01-01 00:00:00
