Abstract：
:There has been substantial controversy regarding treatment of congenital heart defects in infants with trisomies 13 and 18. Most reports have focused on surgical outcomes versus expectant treatment, and rarely there has been an effort to consolidate existing evidence into a more coherent way to help clinicians with decision-making and counseling families. An extensive review of the existing literature on cardiac surgery in patients with these trisomies was conducted from 2004 to 2020. The effects of preoperative and perioperative factors on in-hospital and long-term mortality were analyzed, as well as possible predictors for postoperative chronic care needs such as tracheostomy and gastrostomy. Patients with minimal or no preoperative pulmonary hypertension and mechanical ventilation undergoing corrective surgery at a weight greater than 2.5 kg suffer from lower postoperative mortality. Infants with lower-complexity cardiac defects are likely to benefit the most from surgery, although their expected mortality is higher than that of infants without trisomy. Omphalocele confers an increased mortality risk regardless of cardiac surgery. Gastrointestinal comorbidities increased the risk of gastrostomy tube placement, while those with prolonged mechanical ventilation and respiratory comorbidities are more likely to require tracheostomy. Cardiac surgery is feasible in children with trisomies 13 and 18 and can provide improved long-term results. However, this is a clinically complex population, and both physicians and caretakers should be aware of the long-term challenges these patients face following surgery when discussing treatment options.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Carvajal HG,Callahan CP,Miller JR,Rensink BL,Eghtesady Pdoi
10.1007/s00246-020-02444-6subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1319-1333issue
7eissn
0172-0643issn
1432-1971pii
10.1007/s00246-020-02444-6journal_volume
41pub_type
杂志文章,评审abstract：:We report a unique case of tricuspid and pulmonary atresia with idiopathic progressive ductus arteriosus restriction in utero. Diligent predelivery planning and a controlled delivery environment led to a favorable outcome. ...
journal_title：Pediatric cardiology
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更新日期：2013-08-01 00:00:00
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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doi：
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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更新日期：1984-07-01 00:00:00
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journal_title：Pediatric cardiology
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doi：10.1007/s00246-011-0077-7
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010247
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journal_title：Pediatric cardiology
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更新日期：2005-09-01 00:00:00
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02265613
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journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00798068
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00788220
更新日期：1992-01-01 00:00:00
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900366
更新日期：1998-11-01 00:00:00
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journal_title：Pediatric cardiology
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doi：10.1007/s00246-005-0683-3
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02281003
更新日期：1983-01-01 00:00:00
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journal_title：Pediatric cardiology
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更新日期：1984-04-01 00:00:00
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
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更新日期：2013-06-01 00:00:00
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journal_title：Pediatric cardiology
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更新日期：2010-04-01 00:00:00
