Multiple risk factors before pediatric cardiac transplantation are associated with increased graft loss.

Abstract:

:Identification of heart transplant recipients at highest risk for a poor outcome could lead to improved posttransplantation survival. A chart review of primary heart transplantations from 1993 to 2006 was performed. Analysis was performed to evaluate the risk of graft loss for those with a transplantation age less than 1 year, congenital heart disease (CHD), elevated pulmonary vascular resistance (index > 6), positive panel reactive antibody or crossmatch, liver or renal dysfunction, mechanical ventilation, or mechanical circulatory support (MCS). Primary transplantation was performed for 189 patients. Among these patients, 37% had CHD, 23% had mechanical ventilation, and 6% had renal dysfunction. Overall graft survival was 82% at 1 year and 68% at 5 years. The univariate risk factors for graft loss included mechanical ventilation (hazard ratio [HR], 1.9; 95% confidence interval [CI], 1.15-3.18), CHD (HR, 1.68; 95% CI, 1.04-2.70), and renal dysfunction (HR, 3.05; 95% CI, 1.34-6.70). The multivariate predictors of graft loss were CHD (HR, 1.8; 95% CI, 1.02-2.64), mechanical ventilation (HR, 1.9; 95% CI, 1.13-3.10), and the presence of two or more statistically significant univariate risk factors (SRF) (HR, 3.8; 95% CI, 2.00-7.32). Mechanical ventilation, CHD, and the presence of two or more SRFs identify pediatric patients at higher risk for graft loss and should be considered in the management of children with end-stage heart failure.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Auerbach SR,Richmond ME,Chen JM,Mosca RS,Quaegebeur JM,Addonizio LJ,Hsu DT,Lamour JM

doi

10.1007/s00246-011-0077-7

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

49-54

issue

1

eissn

0172-0643

issn

1432-1971

journal_volume

33

pub_type

杂志文章
  • Myocardial blood flow and coronary flow reserve in children with "normal" epicardial coronary arteries after the onset of Kawasaki disease assessed by positron emission tomography.

    abstract::Myocardial blood flow (MBF) was investigated in children (14.2 +/- 5.01 years) with "resolved" coronary involvement after the onset of Kawasaki disease and angiographically normal epicardial coronary arteries. Ten asymptomatic children with a history of Kawasaki disease had electrocardiography, echocardiography, and p...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-003-0472-9

    authors: Hauser M,Bengel F,Kuehn A,Nekolla S,Kaemmerer H,Schwaiger M,Hess J

    更新日期:2004-03-01 00:00:00

  • Malignant fibrosarcoma with features of myxoma.

    abstract::Left atrial tumor, diagnosed as myxoma at first investigation, was later demonstrated to be a malignant fibrosarcoma with myxoid change. Myxoma should be diagnosed and managed carefully because of its wide range of histopathologic features. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s002460010218

    authors: Hishitani T,Ogawa K,Hoshino K,Kido S,Nakamura Y,Ogawa Y

    更新日期:2001-05-01 00:00:00

  • Ventricular repolarization lability in children with Kawasaki disease.

    abstract::Kawasaki disease (KD) is an acute febrile disease of unknown etiology that develops in children and is sometimes accompanied by myocardial dysfunction and systemic vasculitis. However, myocardial repolarization lability has not yet been fully investigated. Thus, the objective of this study was to evaluate myocardial r...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00246-011-9908-9

    authors: Kuriki M,Fujino M,Tanaka K,Horio K,Kusuki H,Hosoi M,Eryu Y,Kato T,Yamazaki T,Hata T

    更新日期:2011-04-01 00:00:00

  • Fetal Echocardiographic Dimension Indices: Important Predictors of Postnatal Coarctation.

    abstract::The aim of the study is to identify reliable quantitative fetal echocardiographic predictors for postnatal development of coarctation (CoA). In this retrospective study, we included 65 fetuses with a prenatally suspected, isolated CoA, born 2010-2018. Dimensions of the cardiac structures, aortic, and ductal arches exp...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-020-02509-6

    authors: Fricke K,Liuba P,Weismann CG

    更新日期:2020-12-23 00:00:00

  • Cardiac function in congenital hypothyroidism: impairment and response to L-T4 therapy.

    abstract::Electrocardiograms (heart rate, QRS voltage, QRS axis in the frontal plane. Q-Tc interval) echocardiograms [left ventricular fractional shortening (LVFS); preejection period (PEP); PEP/left ventricular ejection time (PEP/LVET) ratio; end-diastolic left ventricular free wall and interventricular septum thickness; prese...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02238495

    authors: Balducci G,Acquafredda A,Amendola F,Natuzzi M,Laforgia N,Cavallo L

    更新日期:1991-01-01 00:00:00

  • Diminished Cardiac Performance and Left Ventricular Dimensions in Neonates with Congenital Diaphragmatic Hernia.

    abstract:INTRODUCTION:Newborns with congenital diaphragmatic hernia (CDH) have varying degrees of pulmonary hypoplasia and pulmonary hypertension (PH), and there is limited evidence that cardiac dysfunction is present. We sought to study early neonatal biventricular function and performance in these patients by reviewing early ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-018-1850-7

    authors: Altit G,Bhombal S,Van Meurs K,Tacy TA

    更新日期:2018-06-01 00:00:00

  • Retrograde transfemoral catheterization of the left ventricle in children with aortic valve stenosis.

    abstract::In 19 consecutive children with aortic valve stenosis, the left ventricle was entered retrogradely with a Gensini catheter guided by a tip-deflector guidewire which could produce any desirable degree of curvature at its tip. In all patients, the aortic valve was retrogradely traversed for measurement of the pressure g...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02328955

    authors: Lau KC,Leung MP,Lo RN

    更新日期:1986-01-01 00:00:00

  • Value of the echocardiographic findings of arrhythmogenic right ventricular dysplasia with left ventricular involvement in a child.

    abstract::A 9-year-old girl was admitted because she had had palpitations for 2 years. Her electrocardiogram revealed multifocal ectopic beats with left bundle branch morphology, sinoatrial block, and first- and second-degree atrioventricular blocks. Cross-sectional echocardiography demonstrated an enlarged left ventricle and f...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02505810

    authors: Atalay S,Imamoglu A,Gümüs H,Gürdal M,Ozenci M

    更新日期:1996-01-01 00:00:00

  • Pseudohypertension in a child with Williams syndrome.

    abstract::Pseudohypertension has often been reported in elderly subjects, but is an unusual phenomenon in children. We report the case of a 5-year-old child who presented with features of Williams syndrome (characterized by elfin facies, supravalvar aortic stenosis, and peripheral pulmonary artery stenosis). Repeated blood pres...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF00796994

    authors: Narasimhan C,Alexander T,Krishnaswami S

    更新日期:1993-03-01 00:00:00

  • Catecholaminergic Ventricular Tachycardia, Pregnancy and Teenager: Are They Compatible?

    abstract::Arrhythmias in pregnancy are becoming more common given more available and effective medical, ablation and device treatment options. Several changes associated with pregnancy, increased blood volume, cardiac output, and heart rate secondary to an increased sympathetic state, facilitate more frequent occurrences of arr...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00246-015-1232-3

    authors: Friday KP,Moak JP,Fries MH,Iqbal SN

    更新日期:2015-10-01 00:00:00

  • Surgical outcome of coronary artery fistulas repair in children.

    abstract::Coronary artery fistula (CAF) is a rare congenital anomaly that can be complicated by endocarditis, myocardial infarction, or coronary aneurysms. This article reviews the clinical characteristics and surgical outcome of 10 patients with CAF in Rajae Heart Center. From 1990 to 2000, 10 patients (age, 6 months to 15 yea...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-004-0656-y

    authors: Malekahmadi M,Shahmohammadi A

    更新日期:2005-07-01 00:00:00

  • High-frequency oscillatory ventilation for cardiac surgery children with severe acute respiratory distress syndrome.

    abstract::Acute respiratory distress syndrome (ARDS) in children after open heart surgery, although uncommon, can be a significant source of morbidity. Because high-frequency oscillatory ventilation (HFOV) had been used successfully with pediatric patients who had no congenital heart defects, this therapy was used in our unit. ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-013-0655-y

    authors: Li S,Wang X,Li S,Yan J

    更新日期:2013-08-01 00:00:00

  • Anomalous origin of left pulmonary artery from aorta with atrial septal defect.

    abstract::Anomalous origin of left pulmonary artery (ALPA) from aorta with atrial septal defect (ASD) is a rare congenital cardiac malformation. We report a case of ALPA from the aorta with ASD in a 1.8-kg baby. Repair was needed at an early age due to progressive congestive heart failure. Surgical correction was performed with...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-008-9234-z

    authors: Lee JH,Jung TE,Lee YH

    更新日期:2008-07-01 00:00:00

  • Associated Factors of Liver Disease After Fontan Operation in Relation to Ultrasound Liver Elastography.

    abstract::Although the Fontan operation can improve outcomes, surviving patients still face Fontan-associated liver disease (FALD). The aim of this study was to determine the associated factors of FALD in relation to ultrasound liver elastography. A cross-sectional study was conducted for all patients on whom an ultrasound uppe...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-020-02422-y

    authors: Sethasathien S,Silvilairat S,Sittiwangkul R,Makonkawkeyoon K,Pongprot Y

    更新日期:2020-12-01 00:00:00

  • Warfarin anticoagulation after congenital heart surgery at a large children's hospital.

    abstract::Management of warfarin in pediatric patients remains a clinical challenge. Warfarin may be administered after congenital heart surgery, and the risks of morbidity can be high. Currently, no data exist to describe the initiation of warfarin and the risk factors for morbidity in post-congenital heart surgery patients. T...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0351-3

    authors: Lowry AW,Moffett BS,Moodie D,Knudson JD

    更新日期:2012-12-01 00:00:00

  • Use of dexmedetomidine in a pediatric heart transplant patient.

    abstract::Dexmedetomidine is a new sedative and analgesic agent that has a unique property of lack of respiratory depression. We describe a pediatric case in which the use of dexmedetomidine enabled us to successfully extubate a 12-year-old heart transplant patient with acute pneumonia after several failed attempts with the use...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-005-0683-3

    authors: Chrysostomou C,Zeballos T

    更新日期:2005-09-01 00:00:00

  • Tissue Doppler echocardiography before and after the surgical reconstruction of an insufficient mitral valve in a patient with Fontan circulation.

    abstract::We report a patient with tricuspid atresia after total cavopulmonary connection who developed significant mitral valve regurgitation. Doppler myocardial echocardiography tracings showed "pseudonormalization" of diastolic velocities. After successful surgical reconstruction of the mitral valve, the diastolic myocardial...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-006-1283-6

    authors: Petzuch K,Eicken A,Marek J,Vogel M,Schreiber C,Hess J

    更新日期:2006-07-01 00:00:00

  • Regression of Neonatal Cardiac Rhabdomyoma in Two Months Through Low-Dose Everolimus Therapy: A Report of Three Cases.

    abstract::Cardiac rhabdomyoma (CR) is the most common cardiac tumor in newborns. Approximately 75% of cases are associated with tuberous sclerosis complex. Although these tumors usually spontaneously regress after 2 years of age, they can be life-threatening when they obstruct major cardiac inflow or outflow pathways. Everolimu...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-017-1688-4

    authors: Chang JS,Chiou PY,Yao SH,Chou IC,Lin CY

    更新日期:2017-10-01 00:00:00

  • Postoperative exercise training develops normal levels of physical activity in a group of children following cardiac surgery.

    abstract::Children with congenital heart defects often demonstrate a reduced capacity for exercise, even after surgical intervention. Forty subjects, with various heart defects, completed a 5-year study to evaluate the impact of a postoperative training program on their physical exercise capacity. All of the patients were signi...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02238841

    authors: Longmuir PE,Tremblay MS,Goode RC

    更新日期:1990-07-01 00:00:00

  • Prenatal diagnosis of congenital heart disease and birth outcomes.

    abstract::This study was undertaken to examine the impact that prenatal diagnosis of congenital heart disease (CHD) has on birth and early neonatal outcomes. The prevalence of prenatally diagnosed CHD has risen over the past decade, but the effect that prenatal diagnosis of CHD has on peripartum decisions remains unclear. No co...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0504-4

    authors: Landis BJ,Levey A,Levasseur SM,Glickstein JS,Kleinman CS,Simpson LL,Williams IA

    更新日期:2013-03-01 00:00:00

  • Validation of cardiac output measurement by ultrasound dilution technique with pulmonary artery thermodilution in a pediatric animal model.

    abstract::Novel COstatus system (Transonic Systems, Inc., NY), based on ultrasound dilution (UD), works off in situ arterial and central venous catheters in pediatric patients to measure cardiac output (CO). The purpose of the present study was to validate CO measurement by UD (COUD) with pulmonary artery (PA) thermodilution (C...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-011-9915-x

    authors: Darling E,Thuramalla N,Searles B

    更新日期:2011-06-01 00:00:00

  • Increased α1-antitrypsin levels in acute-phase Kawasaki disease as shown by SELDI-TOF MS analysis.

    abstract::Various agents have been suggested as causal or associated factors in the pathogenesis of Kawasaki disease (KD); however, the underlying factors of KD remain unknown. Plasma exchange is one of the most effective treatments for the acute phase of KD. This indicates that plasma may contain factors associated with the pa...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-012-0329-1

    authors: Kanai T,Shiraishi H,Uehara R,Ito T,Momoi MY

    更新日期:2012-12-01 00:00:00

  • Trends in Infant Mortality After TAPVR Repair over 18 Years in Texas and Impact of Hospital Surgical Volume.

    abstract::For some congenital heart lesions, higher institutional surgical volume has been associated with better survival than in lower volume centers. The relationship between institutional surgical volume and mortality in infants after total anomalous pulmonary vein return (TAPVR) repair has not been well explored. The Texas...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-019-02224-x

    authors: Lahiri S,Wang Y,Caldarone CA,Morris SA

    更新日期:2020-01-01 00:00:00

  • Combined semilunar valve stenoses in neonates: management approaches and literature review.

    abstract::Combination of right and left ventricular outflow tracts obstruction is extremely rare. Neonates with combined aortic stenosis (AS) and pulmonary stenosis (PS) present in critical condition and required urgent treatment. The management approach is not well defined. We report five female neonates with combined AS and P...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-014-1000-9

    authors: Elhoury ME,El-Segaier M,Momenah T,Galal MO

    更新日期:2014-12-01 00:00:00

  • Beta-blocker therapy failures in symptomatic probands with genotyped long-QT syndrome.

    abstract::Beta-blocker therapy is one of the principal therapies for congenital long-QT syndrome (LQTS). However, breakthrough cardiac events occur while being treated with beta-blockers. We sought to determine the frequency of and clinical correlates underlying beta-blocker therapy failures in genotyped, symptomatic LQTS proba...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-003-0567-3

    authors: Chatrath R,Bell CM,Ackerman MJ

    更新日期:2004-09-01 00:00:00

  • Congenital giant aneurysm of the left innominate vein: is surgical treatment required?

    abstract::Congenital aneurysms of the thoracic venous system are rare. In particular, innominate venous aneurysms are extremely rare. We describe a 16-year-old girl whose chest x-ray suggested a mediastinal tumor. Three-dimensional contrast-enhancement magnetic resonance venography showed a giant sacciform aneurysm of the left ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-003-0499-y

    authors: Tsuji A,Katada Y,Tanimoto M,Fujita I

    更新日期:2004-07-01 00:00:00

  • Transcatheter management of subtotal cor triatriatum sinister: a rare anomaly.

    abstract::Subtotal cor triatriatum sinister (partially divided left atrium) is characterized by a membrane dividing the left atrium into two portions: a dorsal accessory proximal chamber that receives part of the pulmonary venous return and a small restrictive defect in the membrane that obstructs blood flow from the accessory ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-008-9205-4

    authors: Sivakumar K,Satish R,Tailor K,Coelho R

    更新日期:2008-07-01 00:00:00

  • Ultrasound assessment of ductal closure, pulmonary blood flow velocity, and systolic pulmonary arterial pressure in healthy neonates.

    abstract::Ultrasound Doppler was used to establish time of ductal closure, normal values for blood flow velocity in the pulmonary artery (PA), and time interval between pulmonary valve closure (Pc) and tricuspid valve opening (To) in 37 healthy neonates. Ductal closure had occurred in 23% of the children within 12 h after deliv...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:

    authors: Freund M,Wranne B

    更新日期:1986-01-01 00:00:00

  • Pulse-oximetry screening to detect critical congenital heart disease in the neonatal intensive care unit.

    abstract::The current pulse-oximetry screening (POS) protocol for detection of critical congenital heart defects (CCHDs) is recommended only for newborns in well-infant and intermediate care nurseries, and there is no evidence-based protocol for infants discharged from the neonatal intensive care unit (NICU). The objectives of ...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/s00246-013-0793-2

    authors: Iyengar H,Kumar P,Kumar P

    更新日期:2014-03-01 00:00:00

  • Isolated congenital left ventricular diverticulum.

    abstract::Congenital diverticulum of the left ventricle, a rare malformation, is usually associated with midline thoracoabdominal defect. We describe a case with congenital left ventricular diverticulum presenting as an isolated lesion. The lesion was suspected on two-dimensional echocardiography and was confirmed by cardiac ca...

    journal_title:Pediatric cardiology

    pub_type: 杂志文章

    doi:10.1007/BF02524804

    authors: Wu JM,Yu CY

    更新日期:1996-07-01 00:00:00