Abstract：
:Various agents have been suggested as causal or associated factors in the pathogenesis of Kawasaki disease (KD); however, the underlying factors of KD remain unknown. Plasma exchange is one of the most effective treatments for the acute phase of KD. This indicates that plasma may contain factors associated with the pathogenesis of KD. To search for proteins that may be involved in KD pathogenesis, we analyzed serum proteins with surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF MS). Serum samples were obtained from 17 KD patients. Serum from six of the patients was collected during acute phase before acetylsalicylic acid (ASA) and intravenous immunoglobulin administration (phase A1), during remission with ASA (phase A2), and during remission without any medication (phase A3). Serum from the remaining 11 patients was collected for phases A1 and A2 only. There were two age- and sex-matched control groups comprising 8 afebrile healthy children (group B) and 8 febrile children with several infectious diseases (group C). There were no statistical differences in laboratory examination between phase A1 and group C except for albumin level, alanine aminotransferase, or sodium level. Serum samples were analyzed by SELDI-TOF MS after purification. We detected five peaks, i.e., those were specifically increased or decreased during phase A1, and identified 1 of these as α1-antitrypsin (α1-AT). α1-AT can inhibit neutrophil elastase activity. This elastase is thought to play a role in coronary artery damage. Our findings present an interesting starting point for further investigations into the pathophysiology of KD.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Kanai T,Shiraishi H,Uehara R,Ito T,Momoi MYdoi
10.1007/s00246-012-0329-1subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1343-7issue
8eissn
0172-0643issn
1432-1971journal_volume
33pub_type
杂志文章abstract：:Cardiopulmonary bypass (CPB) reduces coagulation factor levels through hemodilution and consumption. Differences in CPB-induced alterations of factor XIII (FXIII) levels in children with cyanotic and acyanotic congenital heart defects (CHDs) are not well characterized. FXIII activity (determined by Berichrom assay), p...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-0903-9
更新日期：2014-10-01 00:00:00
abstract：:The timing of pulmonary valve replacement (PVR) in asymptomatic patients with repaired tetralogy of Fallot (TOF) is typically based on cardiac magnetic resonance imaging-derived ventricular volume measurements. Current criteria do not account for sex-based differences in chamber size. The purpose of this study was to ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02181-5
更新日期：2019-10-01 00:00:00
abstract：:A 4-year-old girl had the insidious onset of congestive heart failure without apparent cause. Evaluation by echocardiography, thallous chloride TI 201 scintigraphy, and angiography suggested the presence of either a neoplasm or restrictive cardiomyopathy with a localized mass effect on the left ventricle. Pathological...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02312963
更新日期：1982-01-01 00:00:00
abstract：:This case discusses a Shone's variant with small left ventricle and mitral valve, bicuspid aortic valve, coarctation of the aorta, an unusual arrangement of atrial appendages, and partially anomalous pulmonary venous drainage due to a deviated atrial septum. The left atrial appendage could be directly entered from the...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-006-1364-6
更新日期：2006-09-01 00:00:00
abstract：:Heart failure (HF) has high morbidity and mortality in children. This study aimed to investigate the value of cardiac myosin binding protein-C (cMyBP-C) as a diagnostic and prognostic biomarker in children with heart failure. This study was a prospective case-control study that involved 50 children with acute HF and 2...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1532-2
更新日期：2017-02-01 00:00:00
abstract：:To examine factors associated with low high-density lipoprotein cholesterol (HDL-C) levels among middle school children. HDL-C levels were the primary outcome of interest. A total of 1,104 middle-school children (mean age 11.6 years, 51.2% female) were included in this analysis, of whom 177 (16%) had an HDL-C level ≤4...
journal_title：Pediatric cardiology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00246-013-0814-1
更新日期：2014-03-01 00:00:00
abstract：:There has been substantial controversy regarding treatment of congenital heart defects in infants with trisomies 13 and 18. Most reports have focused on surgical outcomes versus expectant treatment, and rarely there has been an effort to consolidate existing evidence into a more coherent way to help clinicians with de...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-020-02444-6
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Cardiac magnetic resonance imaging (MRI) is an important diagnostic tool for congenital heart disease (CHD), as reflected by class 1 recommendations for the use of cardiac MRI by various consensus panels. However, little is known about the safety and clinical utility of cardiac MRI for these critically ill i...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9295-z
更新日期：2009-02-01 00:00:00
abstract：:Aortopulmonary window is a relatively uncommon congenital heart defect. We report on a patient with a small aortopulmonary window, who presented with an asymptomatic murmur and in whom catheter closure was successfully performed with an Amplatzer Duct Occluder. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-002-0307-0
更新日期：2003-05-01 00:00:00
abstract：:Previous studies showed the reliability of cardiac magnetic resonance imaging (cMRI) in the quantification of aortic valve stenosis in adults. The aim of this retrospective study was to assess the ability of cMRI in the quantification of congenital aortic valve stenosis (CAS) in children. Nineteen patients (mean age 1...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0851-9
更新日期：2014-06-01 00:00:00
abstract：:We measured the coronary flow reserve in a 13-year-old girl with the rare anomaly of an absent left circumflex coronary artery. Although the coronary flow volume of the right coronary artery was at the same level as that of the left anterior descending coronary artery, the coronary flow reserve of the patient's right ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010188
更新日期：2001-03-01 00:00:00
abstract：:Congenital diverticulum of the ventricle is a rare disease, but most cases of congenital left ventricular diverticula are asymptomatic. We present a child with congenital left ventricular diverticulum whose routine electrocardiographic examination showed T-wave inversion in inferior and V4 to V6 leads. He was successf...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-010-9719-4
更新日期：2010-08-01 00:00:00
abstract：:Pediatric cardiothoracic surgery is often associated with low cardiac output in the postoperative period. This study sought to determine whether increasing heart rate via temporary atrial pacing is beneficial in augmenting cardiac output. Patients younger than 18 years who underwent cardiothoracic surgery and had no p...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0687-3
更新日期：2013-10-01 00:00:00
abstract：:The authors hypothesized that prospective, systematic Internet searches could identify occurrences of sudden cardiac death (SCD) in athletes and would be useful for establishing a system of active surveillance. Weekly advanced Google searches of the Internet were conducted for cases of SCD in young athletes during a 1...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0717-1
更新日期：2013-01-01 00:00:00
abstract：:Rehospitalization following pediatric heart transplantation is common. However, existing data remain somewhat limited. Using a novel linkage between administrative and clinical databases, pediatric heart transplant (HT) recipients from 29 centers who survived to discharge were retrospectively reviewed to determine the...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02326-x
更新日期：2020-03-01 00:00:00
abstract：:Prior to initiation of a formal screening program, 30 % of patients referred for device closure of an atrial septal defect (ASD) at our institution had atrial septal anatomy which precluded ASD device closure. This resulted in inefficiencies in workflow, staff utilization, and inconvenience for families. Our objective...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1135-3
更新日期：2015-08-01 00:00:00
abstract：:Pulmonary artery thrombosis in neonates occurs rarely. This report describes the case of a term infant with a pulmonary artery thrombosis presenting as persistent pulmonary hypertension of the newborn. The risk factors identified in the case included maternal diabetes and heterozygous factor V Leiden deficiency. The p...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9349-2
更新日期：2009-05-01 00:00:00
abstract：:The development of Leadless cardiac pacemakers avoids the inherent complications that may occur secondary to lead insertion. A large number of devices have been inserted in adult patients although data in pediatric patients are lacking. We aimed to assess our experience with the Leadless device in the pediatric popula...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02277-y
更新日期：2020-04-01 00:00:00
abstract：:Dexmedetomidine is a new sedative and analgesic agent that has a unique property of lack of respiratory depression. We describe a pediatric case in which the use of dexmedetomidine enabled us to successfully extubate a 12-year-old heart transplant patient with acute pneumonia after several failed attempts with the use...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-0683-3
更新日期：2005-09-01 00:00:00
abstract：:Three infants, each with a clinical picture of dilated cardiomyopathy, underwent endomyocardial biopsy. Immunohistologic analysis revealed chronic myocarditis. In one infant, a postviral etiology of chronic myocarditis could be assessed on the basis of molecular techniques. Therapy with azathioprine and prednisone res...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900292
更新日期：1998-05-01 00:00:00
abstract：:Vitamin D has anti-inflammatory properties, and deficiency is prevalent in children. There is a paucity of data regarding vitamin D status and its correlation with low-grade inflammation and vasculature. We prospectively enrolled 25 children, 9-11 years old (13 male); 21 obese. Eight atherosclerosis-promoting risk fac...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1162-0
更新日期：2015-10-01 00:00:00
abstract：:We retrospectively investigated the effect of warfarin therapy in improving the clinical outcome of Kawasaki disease (KD) patients with giant coronary aneurysms (GAs). We followed 2350 KD patients from 1973 to 2004. The GAs (> or =8 mm in diameter) were diagnosed by coronary angiography. Sixty-eight patients (54 males...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-007-9132-9
更新日期：2008-03-01 00:00:00
abstract：:In the classic scimitar syndrome, a pulmonary vein draining all or part of the right lung enters the inferior vena cava. A variant is described with the same roentgenographic appearance, but with drainage of the anomalous pulmonary vein into both the inferior vena cava and the left atrium; the atrial septum was intact...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02079472
更新日期：1987-01-01 00:00:00
abstract：:The slip ring and nutate/rotate configuration of the new, fourth-generation, computed tomography (CT) (TCT-900S, Toshiba Medical Company) makes it possible to scan consecutively 25 slices every 75 s. This scanner also rapidly provides hemodynamic and multiplanar reconstruction images. Studies were performed on 13 chil...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02309917
更新日期：1989-04-01 00:00:00
abstract：:Our purpose was to evaluate the impact of suspicion or confirmation of heart disease on the physical and psychosocial health of children. We utilized the Child Health Questionnaire (CHQ PF-50). Children ages 5 to 18 years attending a general cardiology clinic were eligible. Those with primary noncardiac diagnoses unre...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0348-z
更新日期：2004-01-01 00:00:00
abstract：:Echocardiography has previously been of limited use in visualizing the aorta in neonates and infants. Using a new technique--right parasternal scanning--the aortic arch and brachiocephalic vessels were studied in 50 children under 18 months of age. Complete visualization was accomplished in 47 patients including those...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02426973
更新日期：1982-01-01 00:00:00
abstract：:The original version of the article unfortunately contained an alignment error in Table 1. The correct version of Table 1 is given below. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00246-018-1978-5
更新日期：2019-01-01 00:00:00
abstract：:Circulating progenitor cells have been extensively studied in the context of heart disease in adults. In these patients, they have been demonstrated to be markers of myocardial injury and recovery as well as potential therapeutic agents. However, studies in children are much more limited. Here we review current knowle...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-015-1300-8
更新日期：2016-02-01 00:00:00
abstract：:Catheter ablation in children requires placement of multiple large femoral venous sheaths and catheters. Magnetic resonance angiography (MRA) was used to evaluate the effect of indwelling lines on femoral venous blood flow. Between October 1993 and February 1994 a total of 17 patients scheduled for catheter ablation u...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900151
更新日期：1997-05-01 00:00:00
abstract：:Restrictive cardiomyopathy (RCM) is characterized by irreversible diastolic dysfunction with preserved systolic function. The aim of this study was to investigate the presence of impaired ventricular contractility even in the presence of normal ejection fraction (EF) in children with RCM. Longitudinal Doppler tissue v...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-9948-1
更新日期：2011-06-01 00:00:00
