Examining the cardiac NK-2 genes in early heart development.

Abstract:

:The cardiac NK-2 transcription factors are the vertebrate relatives of the Drosophila tinman gene. Without the Drosophila tinman gene, fruit flies fail to form their heart ("dorsal vessel"), and mutations or altered expression of cardiac NK-2 genes may lead to abnormal heart formation in vertebrates. Although the cardiac NK-2 gene NKX2-5 is recognized as an important factor in cases of human congenital heart disease and heart development in vertebrates, the roles of the other cardiac NK-2 genes are less clear. This report reviews what is known about the cardiac NK-2 genes in cardiac development, comparing studies in several different model systems.

journal_name

Pediatr Cardiol

journal_title

Pediatric cardiology

authors

Bartlett H,Veenstra GJ,Weeks DL

doi

10.1007/s00246-009-9605-0

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

335-41

issue

3

eissn

0172-0643

issn

1432-1971

journal_volume

31

pub_type

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