Abstract:
:The cardiac NK-2 transcription factors are the vertebrate relatives of the Drosophila tinman gene. Without the Drosophila tinman gene, fruit flies fail to form their heart ("dorsal vessel"), and mutations or altered expression of cardiac NK-2 genes may lead to abnormal heart formation in vertebrates. Although the cardiac NK-2 gene NKX2-5 is recognized as an important factor in cases of human congenital heart disease and heart development in vertebrates, the roles of the other cardiac NK-2 genes are less clear. This report reviews what is known about the cardiac NK-2 genes in cardiac development, comparing studies in several different model systems.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Bartlett H,Veenstra GJ,Weeks DLdoi
10.1007/s00246-009-9605-0subject
Has Abstractpub_date
2010-04-01 00:00:00pages
335-41issue
3eissn
0172-0643issn
1432-1971journal_volume
31pub_type
杂志文章,评审abstract::We report a case of a 12-year-old boy with severe congenital aortic stenosis in whom magnetic resonance imaging (MRI) with delayed contrast enhancement demonstrated extensive subendocardial hyperenhancement within the left ventricle. The hyperenhancement was confirmed to be subendocardial infarct and fibrosis by histo...
journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
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更新日期:2016-12-01 00:00:00
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journal_title:Pediatric cardiology
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更新日期:1982-01-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02310569
更新日期:1991-10-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2014-03-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:Pediatric cardiology
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更新日期:2007-05-01 00:00:00
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doi:10.1007/s00246-012-0486-2
更新日期:2013-03-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/BF02505207
更新日期:1996-05-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0444-z
更新日期:2013-01-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
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journal_title:Pediatric cardiology
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更新日期:1989-01-01 00:00:00
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