Abstract：
:Intravenous immunoglobulin (IVIG) administered in the acute stage of Kawasaki disease (KD) is the standard therapy. Few reports describe nonresponders to initial treatment with IVIG in KD, which remains the most consistent risk factor for coronary artery lesions (CALs). This study aimed to investigate whether the serum level of N-terminal pro-brain natriuretic peptide (NT-proBNP) can be a predictive indicator for identifying patients with KD at higher risk of IVIG treatment failure. In this study, 135 patients with a diagnosis of KD admitted for IVIG treatment were retrospectively enrolled for analysis. Of these 135 patients, 22 were nonresponders who received additional rescue therapy because they had an elevated body temperature 36 h after completion of initial IVIG treatment. The NT-proBNP concentration was significantly higher in the nonresponder group (2,465.36 ± 3,293.24 pg/mL) than in the responder group (942.38 ± 1,293.48 pg/mL) (p < 0.05). The optimal sensitivity and specificity cutoff point for predicted nonresponders was 1,093.00 pg/mL or higher. The sensitivity and specificity for prediction of IVIG response were respectively 70.0 and 76.5 %. The findings show that NT-proBNP is a helpful marker in determining patients at risk for not responding to initial IVIG treatment. The authors suggest that patients with an NT-proBNP level of 1,093.00 pg/dL or higher are likely to fail initial IVIG and may require further rescue therapy.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Kim SY,Han MY,Cha SH,Jeon YBdoi
10.1007/s00246-013-0724-2subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1837-43issue
8eissn
0172-0643issn
1432-1971journal_volume
34pub_type
杂志文章abstract：:Congenital heart disease (CHD) is the most common congenital anomaly, affecting 1 % of live births. The field of pediatric cardiology has witnessed major advances over the past 25 years triggered by research initiatives focusing on CHD. However, large disparities exist in research capabilities between Arab developing ...
journal_title：Pediatric cardiology
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pub_type： 杂志文章,评审
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Pediatric cardiology
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journal_title：Pediatric cardiology
pub_type： 杂志文章
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journal_title：Pediatric cardiology
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更新日期：2006-01-01 00:00:00
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更新日期：2000-03-01 00:00:00
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更新日期：2007-07-01 00:00:00
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journal_title：Pediatric cardiology
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更新日期：2015-02-01 00:00:00
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更新日期：2019-03-01 00:00:00
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journal_title：Pediatric cardiology
pub_type： 杂志文章
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更新日期：1992-07-01 00:00:00
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02427049
更新日期：1984-07-01 00:00:00
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更新日期：2017-10-01 00:00:00
abstract：:This study aimed to clarify the characteristics of pulmonary arterial resistance (Rp)-compliance (Cp) coupling in individuals with Down syndrome (DS), who have increased risks of pulmonary arterial hypertension (PAH). We performed cardiac catheterization before and after corrective surgery in 85 DS infants and 85 cont...
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更新日期：2019-04-01 00:00:00
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journal_title：Pediatric cardiology
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更新日期：2004-07-01 00:00:00
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02310333
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abstract：:It is unclear if neonatal tetralogy of Fallot repair offers better outcomes compared to repair later in infancy. We therefore conducted a meta-analysis comparing outcomes of neonatal and non-neonatal repair. Manuscripts were identified and reviewed for quality and bias with favorably scored manuscripts being included ...
journal_title：Pediatric cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00246-017-1579-8
更新日期：2017-06-01 00:00:00
