Abstract：
:Debilitating cardiomyocyte loss underlies the progression to heart failure. Although there have been significant advances in treatment, current therapies are intended to improve or preserve heart function rather than regenerate lost myocardium. A major hurdle in implementing a cell-based regenerative therapy is the inefficient differentiation of cardiomyocytes from either endogenous or exogenous stem cell sources. Moreover, cardiomyocytes that develop in human embryonic stem cell (hESC) or human-induced pluripotent stem cell (hIPSC) cultures are comparatively immature, even after prolonged culture, and differences in their calcium handling, ion channel, and force generation properties relative to adult cardiomyocytes raise concerns of improper integration and function after transplantation. Thus, the discovery of natural and novel small molecule synthetic regulators of differentiation and maturation would accelerate the development of stem-cell-based myocardial therapies. Here, we document recent advances in defining natural signaling pathways that direct the multistep cardiomyogenic differentiation program and the development of small molecules that might be used to enhance differentiation as well as the potential characteristics of lead candidates for pharmaceutical stimulation of endogenous myocardial replacement.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Willems E,Bushway PJ,Mercola Mdoi
10.1007/s00246-009-9409-2subject
Has Abstractpub_date
2009-07-01 00:00:00pages
635-42issue
5eissn
0172-0643issn
1432-1971journal_volume
30pub_type
杂志文章abstract：:Near-infrared spectroscopy (NIRS) can monitor changes in cerebral regional oxygen saturation (rSO2) and tissue hemoglobin content (HbT). The relation between cerebral NIRS readings and vital parameters has not been analyzed before at a fine temporal scale. This study analyzed this relation during cardiopulmonary bypas...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0754-9
更新日期：2014-01-01 00:00:00
abstract：:Common arterial trunk is relatively a straightforward diagnosis on echocardiography. We describe a neonate who was referred to our centre as a case of common arterial trunk but on evaluation was found to have pulmonary atresia with ventricular septal defect and aortopulmonary window, for which he underwent repair with...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0240-9
更新日期：2012-10-01 00:00:00
abstract：:The COVID-19 pandemic has had devastating direct consequences on the health of affected patients. It has also had a significant impact on the ability of unaffected children to be physically active. We evaluated the effect of deconditioning from social distancing and school shutdowns implemented during the COVID-19 pan...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02513-w
更新日期：2021-01-04 00:00:00
abstract：:Our purpose was to evaluate the impact of suspicion or confirmation of heart disease on the physical and psychosocial health of children. We utilized the Child Health Questionnaire (CHQ PF-50). Children ages 5 to 18 years attending a general cardiology clinic were eligible. Those with primary noncardiac diagnoses unre...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0348-z
更新日期：2004-01-01 00:00:00
abstract：:Neo-aortic arch obstruction (NAAO) is a common complication following the Norwood/Sano procedure (NP) for hypoplastic left heart syndrome (HLHS) and is associated with increased morbidity and mortality. However, there is currently no objective method for predicting which patients will develop NAAO. This study was desi...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0713-5
更新日期：2013-01-01 00:00:00
abstract：:Assessment of ventricular dysfunction and asynchrony is very important in predicting the outcome for children with a single right ventricle. However, the assessment is inaccurate and subjective because of the unusual ventricular shape. This study aimed to evaluate the feasibility and clinical value of velocity vector ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-0908-4
更新日期：2014-10-01 00:00:00
abstract：:This study is presented to identify and characterize the spectrum of the cardiovascular anomalies in children presenting with Williams-Beuren syndrome and cardiovascular anomalies at The Hospital for Sick Children, Toronto from 1966 to 1988. Forty-nine children were diagnosed and followed. The female to male ratio was...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02310569
更新日期：1991-10-01 00:00:00
abstract：:Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare condition. The majority of cases present with impaired left ventricular function. We report on a premature infant who was diagnosed at a gestational age near term with ALCAPA during routine cardiac examination. The patient showed...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0878-z
更新日期：2006-03-01 00:00:00
abstract：:Atrial flutter/fibrillation (AFL/AF) is a late complication in adults with repaired tetralogy of Fallot (TOF). Its effects on long-term prognosis are not fully understood. We evaluate the impact of AFL/AF in adults with repaired TOF on global mortality and unplanned hospitalizations during follow-up, and the predictor...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02106-2
更新日期：2019-06-01 00:00:00
abstract：:In the fetus, the cardiac neural crest gives rise to both the thymus and the conotruncus of the heart. In newborn screening for severe T-cell lymphopenia neonates with congenital heart defects may be detected. In this study, we investigated the occurrence of T-cell lymphopenia in neonates with or without 22q11.2 delet...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02317-y
更新日期：2020-04-01 00:00:00
abstract：:Recurrent congenital left atrial aneurysm presenting in a newborn as cardiac tamponade is described. Such a presentation has not been previously reported. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900269
更新日期：1998-03-01 00:00:00
abstract：:A 12-year-old male presented with a 6-week history of apparent digital vasculitis with color changes of the distal fingers and erythematous macules of the palms and soles. Physical examination revealed skin findings of Carney complex and an abnormal cardiac examination. Echocardiography demonstrated a large left atria...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-1238-3
更新日期：2006-03-01 00:00:00
abstract：:For adults with sickle cell disease (SCD), cardiac changes are well described and may account for up to one-fourth of disease-related mortality. Much less is known about heart disease in pediatric SCD patients. This retrospective study analyzed a contemporary cohort of children with SCD followed at a single tertiary c...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0587-y
更新日期：2013-04-01 00:00:00
abstract：:Anomalous origin of left coronary artery (LCA) from the right coronary cusp with an intramural course is usually managed with unroofing of the intramural segment. Available literature demonstrates an uneventful course following surgery in most patients. Coronary stenosis following the unroofing procedure treated with ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-2005-6
更新日期：2019-01-01 00:00:00
abstract：:There are few data on the incidence of echocardiographic (echo) abnormalities following catheter ablation in children in the era of 3D mapping. Wide practice variation exists regarding routine post-ablation echo. We hypothesized a low incidence of clinically significant echo abnormalities following SVT ablation in oth...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-1999-0
更新日期：2019-03-01 00:00:00
abstract：:We describe the first report of an infant who was born with hypoplastic left heart syndrome and significant pulmonary stenosis. He was successfully palliated with multiple cardiac catheterization interventions while waiting for cardiac transplantation. This unusual constellation of heart defects is an entity that is r...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0856-5
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVES:The aim of this article is to examine the frequency, timing of formation of aneurysm of the ventricular membranous septum (AVMS), and prognosis in patients with a perimembranous ventricular septal defect (VSD). PATIENTS:One hundred forty-eight patients were diagnosed with a perimembranous VSD within 90 days...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0572-6
更新日期：2004-07-01 00:00:00
abstract：:Renovascular hypertension is an uncommon disease, but it causes 5-10% of all childhood hypertension. The most common cause of renal artery stenosis is fibromuscular dysplasia, resulting in at least 60% of renovascular hypertension cases. This report describes a case of a renal artery stenosis confirmed by multidetecto...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-9944-5
更新日期：2011-06-01 00:00:00
abstract：:Plastic bronchitis is a rare, potentially life-threatening condition in which protein casts form within and occlude the bronchus, resulting in pulmonary failure, and has been identified as a complication after the Fontan procedure. We present a case of a 5-year-old girl who had undergone an extracardiac fenestrated Fo...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-0913-8
更新日期：2005-09-01 00:00:00
abstract：:Crossed pulmonary arteries (CPAs) are a rare abnormality in which the ostium of the left pulmonary artery originates superior to the right pulmonary artery and to its right. Recognition of this rare pathology is important because it generally is accompanied by other congenital heart defects, extracardiac anomalies, an...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0714-4
更新日期：2013-01-01 00:00:00
abstract：:Fifty infants with interrupted aortic arch (IAA), admitted between 1979 and 1988, were reviewed. They usually presented early in severe cardiac failure or shock. In the initial 5-year period, 17 of the 21 infants underwent diagnostic or confirmatory cardiac catheterization, in contrast with the latter 5 years when onl...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00838779
更新日期：1992-10-01 00:00:00
abstract：:Although the Fontan operation can improve outcomes, surviving patients still face Fontan-associated liver disease (FALD). The aim of this study was to determine the associated factors of FALD in relation to ultrasound liver elastography. A cross-sectional study was conducted for all patients on whom an ultrasound uppe...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02422-y
更新日期：2020-12-01 00:00:00
abstract：:To evaluate the feasibility and efficacy of the right subaxillary vertical mini-incision (RAVI) used for the closure of doubly committed subarterial ventricular septal defect (SAVSD) through tricuspid approach only. From June 2015 to September 2016, 32 SAVSD patients (mean age 2.4 ± 1.9 years, range 0.7-8 years) under...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02144-w
更新日期：2019-08-01 00:00:00
abstract：:In the classic scimitar syndrome, a pulmonary vein draining all or part of the right lung enters the inferior vena cava. A variant is described with the same roentgenographic appearance, but with drainage of the anomalous pulmonary vein into both the inferior vena cava and the left atrium; the atrial septum was intact...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02079472
更新日期：1987-01-01 00:00:00
abstract：:Calculating pulmonary vascular resistance is important in many fields of medicine. Although the influence of hematocrit on calculated resistance has been known for many years, it is rare to find the appropriate corrections in published articles. This review discusses the relationship between viscosity and resistance a...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-011-9954-3
更新日期：2011-06-01 00:00:00
abstract：:Dilated cardiomyopathy (DCM) is an important cause of chronic congestive cardiac failure in children. In patients with idiopathic DCM, endothelium vasomotor function is disturbed. There are many studies on the roles of nitric oxide (NO) and adrenomedullin (AM) in adult patients with DCM. However, to our knowledge, no ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-002-0352-8
更新日期：2003-07-01 00:00:00
abstract：:Little data are published about right ventricular (RV) growth and function in infants and neonates after balloon pulmonary valvuloplasty (BPV) for critical valvular pulmonary stenosis (PS). We aimed to assess the RV growth and function during 1 year after BPV for critical valvular PS in neonates and infants. A total o...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02314-1
更新日期：2020-04-01 00:00:00
abstract：:The patient safety movement and human factors studies are becoming an increasingly important part of everyday clinical practice. Pediatric cardiac surgery is a high-risk field that is very much dependent on safe practices and continuous research into improvement of outcomes. This article reviews the main research fram...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-006-1448-3
更新日期：2007-03-01 00:00:00
abstract：:Congenital aneurysms of the thoracic venous system are rare. In particular, innominate venous aneurysms are extremely rare. We describe a 16-year-old girl whose chest x-ray suggested a mediastinal tumor. Three-dimensional contrast-enhancement magnetic resonance venography showed a giant sacciform aneurysm of the left ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0499-y
更新日期：2004-07-01 00:00:00
abstract：:Echocardiography has previously been of limited use in visualizing the aorta in neonates and infants. Using a new technique--right parasternal scanning--the aortic arch and brachiocephalic vessels were studied in 50 children under 18 months of age. Complete visualization was accomplished in 47 patients including those...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02426973
更新日期：1982-01-01 00:00:00
