[Regeneration of airway epithelium].

Abstract:

INTRODUCTION:Epithelial regeneration is a complex process. It can lead to the remodeling of the airway epithelium as in asthma, COPD or cystic fibrosis. BACKGROUND:The development of in vivo and in vitro models has allowed the analysis of remodeling mechanisms and showed the role of components of extracellular matrix, proteases, cytokines and growth factors. Airway epithelial progenitors and stems cells have been studied in these models. However, their identification remains difficult. CONCLUSION:Identification and characterization of airway epithelial progenitor/stem-cells, and a better knowledge of the regeneration process may allow the development of new therapeutic strategies for airway epithelial reconstitution.

journal_name

Rev Mal Respir

authors

Adam D,Perotin JM,Lebargy F,Birembaut P,Deslée G,Coraux C

doi

10.1016/j.rmr.2013.11.001

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

300-11

issue

4

eissn

0761-8425

issn

1776-2588

pii

S0761-8425(13)00960-1

journal_volume

31

pub_type

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