Abstract：
:Annona muricata Linnaeus, popularly known as "graviola" and also called soursop, is a species typical of countries with a tropical climate, and it is used in folk medicine as an anticancer, analgesic and antispasmodic agent. The aim of the present study was to validate the gastroprotective activity of the hydroalcoholic extract of the leaves of A. muricata (HEAM) and to investigate the underlying mechanisms of action for this effect. Gastric lesions were induced in mice by absolute ethanol, acidified ethanol or indomethacin. Before, the animals were pretreated with saline, omeprazole or HEAM orally at doses of 50-400 mg/kg. To determine the mechanism of action of the extract, we investigated, using specific inhibitors, the involvement of nitric oxide (NO), prostaglandins (PGEs), ATP-dependent K+ channels and α2-noradrenergic receptors. HEAM showed significant antiulcer activity against lesions induced by absolute ethanol, acidified ethanol or indomethacin, which was mediated by endogenous gastric prostaglandins.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Bento EB,Júnior FEB,de Oliveira DR,Fernandes CN,de Araújo Delmondes G,Cesário FRAS,Rodrigues CKS,Sales VDS,de Figueiredo FRSDN,Lemos ICS,Monteiro ÁB,de Menezes IRA,da Costa JGM,Kerntopf MRdoi
10.1016/j.sjbs.2016.01.024subject
Has Abstractpub_date
2018-05-01 00:00:00pages
609-621issue
4eissn
1319-562Xissn
2213-7106pii
S1319-562X(16)00026-7journal_volume
25pub_type
杂志文章abstract：:The present study aims to explore the crisis of antibiotic resistance and discover more about the current challenges related to self-medication. The current challenges related to antibiotic resistance are unique and differ from the challenges of the past since new bacterial pathogens are involved and continue to evolv...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.sjbs.2017.01.004
更新日期：2017-05-01 00:00:00
abstract：:A new and simple protocol has been developed and standardized for direct somatic embryogenesis and plant regeneration from aseptic seedlings derived from immature Brassica juncea seeds. Depending on the age of immature seeds and nutrient media, in vitro occurrence of embryogenesis and the number of embryos from each s...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.11.050
更新日期：2021-01-01 00:00:00
abstract：:Fishes of the family Lethrinidae form a considerable portion of the catch from both the Red Sea and the Arabian Gulf in Saudi Arabia, and the species Lethrinus lentjan (Lacepède, 1802) is one of the most important among these fishes. This study was conducted to evaluate the demographic structure coefficients, survival...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.06.003
更新日期：2020-09-01 00:00:00
abstract：:Biochar has vital importance as soil additives due to its characteristics, which are responsible for alleviating environmental problems and climate change. These additives should be evaluated to understand their physico-chemical properties and their ecotoxicological effects on plant growth. Therefore, this study aimed...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2018.05.017
更新日期：2019-05-01 00:00:00
abstract：:Artemisinin is the first-line drugs for the treatment of malaria. In recent years, a large number of reports showed that artemisinin exhibit anti-tumor activity. In this study, we used C6 glioma cells and rat C6 brain-glioma model to study anti-tumor activity of artemisinin in vivo and in vitro. We found that artemisi...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2018.04.003
更新日期：2018-11-01 00:00:00
abstract：:The present study sought to assess the potential of the cestode Hymenolepis diminuta as a bioindicator for lead accumulation in two industrial areas of the city of Riyadh, Saudi Arabia. Rats (Meriones libycus) were collected from two sites (industrial area II and Salbukh) in Riyadh. In the industrial area II, the mean...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2013.09.010
更新日期：2014-09-01 00:00:00
abstract：:Background: Propolis is a natural product of plant resins collected by honeybees from various plant sources. It is used as a remedy in folk medicine since ancient times because of its several biological and pharmacological properties. Recently, propolis has been used by dentist to treat various oral diseases. It was a...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2016.12.019
更新日期：2017-07-01 00:00:00
abstract：:Corona viruses (CoV) are known to cause extreme pandemics in the globe. The year 2020 will be a pandemic with the spread of the novel coronavirus (SARS-CoV-2) across the globe. Coronavirus 2019 (COVID-19) has been a part of our scary life for more than a quarter of a year in 2020. The Wuhan market and China have been ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.sjbs.2020.11.035
更新日期：2021-01-01 00:00:00
abstract：:Generally, under normal conditions plants are resistant to many of the incompatible pathogens (viral, fungal and bacterial), and this is named "non-host resistance phenomenon". To understand this phenomenon, different types of food crops (faba bean, squash, barley and wheat) were inoculated with compatible and incompa...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2019.12.041
更新日期：2020-04-01 00:00:00
abstract：:Based on the massive production of cow and poultry manures, farmers in Saudi Arabia are moving towards the application of organic fertilizers in their farms. Therefore, the present work was conducted to study the response of soil and selected vegetable crops to poultry and cow manures, using ground data and Landsat-8 ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2019.06.006
更新日期：2019-11-01 00:00:00
abstract：:This study was conducted to investigate phytophagous and predatory mites associated with vegetable plants in Riyadh, Saudi Arabia. Eight phytophagous and 10 predacious mites were collected from 14 species of vegetable crops covering five major production localities. Out of these 18 mite species, 13 species are new to ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2011.02.004
更新日期：2011-07-01 00:00:00
abstract：:Liver fibrosis is a major health concern that results in significant morbidity and mortality. Up-to-date, there is no standard treatment for fibrosis because of its complex pathogenesis. Crocin is one of the main nutraceuticals isolated from the stigma of Crocus sativus with antioxidant and anti-inflammatory activitie...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2016.10.007
更新日期：2018-05-01 00:00:00
abstract：:The aim of this study was to observe the treatment characteristics of verbenalin on a prostatitis mouse model. Give Xiaozhiling injection in the prostate locally to make a prostatitis mouse model. High, medium and low doses of verbenalin were each given to different mouse groups. The amount of water was determined in ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2015.10.006
更新日期：2016-01-01 00:00:00
abstract：:The objective of this investigation was to study whether Nigella Sativa and Trigonella Foenum-graecum, could modulate the losartan pharmacodynamic (PD) and pharmacokinetic (PK) in experimental L-NAME induced hypertensive rats. For in vivo study, the systolic blood pressure (SBP) of rats was measured by the "tail-cuff ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.05.009
更新日期：2020-10-01 00:00:00
abstract：:During the last few decades, human-driven activities have led to indiscriminate habitat destruction and exploitation of many plant species in Kashmir Himalaya. As a result, many species have become threatened and are struggling for survival. Of particular concern are the endemic and critically endangered species which...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.05.006
更新日期：2020-09-01 00:00:00
abstract：:Soybean oligosaccharides (SBOSs) are potential prebiotics that may be used to improve immune function. Here, we investigated the effects of intragastric administration of SBOSs in mice to determine the effects on autochthonous intestinal microbial communities and immunological parameters. Results E: After 22-day admin...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2016.09.004
更新日期：2017-01-01 00:00:00
abstract：:Stress has many biological effects on human daily life. In the present study, dietary protein intake was correlated with the investigated stress levels of nurses and housewives of the targeted urban population. Age group ranged from 30 to 45 years and both the groups belonged to middle socioeconomic status. After calc...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2011.02.002
更新日期：2011-07-01 00:00:00
abstract：:Dysmenorrhea is the most common gynaecological problem among young females. In Arabic countries, few studies on gynaecological problems of adolescent's girls were published. OBJECTIVE:the aim of the study was to determine the prevalence of dysmenorrhea and associated factors among adolescents in public schools at Mar...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.05.022
更新日期：2020-07-01 00:00:00
abstract：:The evolution of nanotechnology and the production of nanomedicine from various sources had proven to be of intense value in the field of biomedicine. The smaller size of nanoparticles is gaining importance in research for the treatment of various diseases. Moreover the production of nanoparticles is eco-friendly and ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2015.01.007
更新日期：2015-09-01 00:00:00
abstract：:Schistosomiasis is still one of the main parasitic diseases that affect human health in tropical regions. Whilst praziquantel (PZQ) is the main classic antischistosomal drug, the need for new drugs is still a must due to the low effectiveness of the drug on the schistosome young worms, and the evolving of PZQ resistan...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2016.12.017
更新日期：2017-09-01 00:00:00
abstract：:Sex differences are present in all parts of the body, including the skeletal system. Several methods are used to analyze the sex differences of skeleton, while more recently, a new method called geometric morphometry has been used. The aim of this study was to examine the sexual dimorphism of occipital condyles on hum...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.09.019
更新日期：2020-12-01 00:00:00
abstract：:Vitamin D deficiency is a pandemic problem and an ever-increasing issue in human nutrition and health. Vitamin D (serum 25-hydroxyvitamin D) deficiency causes many health problems such as autoimmune diseases, Crohn's disease, diabetes, inflammation, asthma, hypertension, and cancer. Vitamin D3 (cholecalciferol) defici...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.08.008
更新日期：2020-11-01 00:00:00
abstract：:Faba beans are acknowledged as a good source of proteins, minerals, fibers, vitamins and antioxidants. A blending study was undertaken in order to prepare naturally bread from enriched flours with added nutritional value, mainly in terms of Iron and proteins. Enriched flours were prepared with varied levels (25, 30, 3...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.10.053
更新日期：2021-01-01 00:00:00
abstract：:Numerical simulations are used to investigate the wake structure and hydrodynamic performance of bionic flapping foils. The study is motivated by the quest to understand the fluid dynamics of fish fins and use it in the underwater propulsion. The simulations employ an immersed boundary method that makes it possible to...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2016.09.015
更新日期：2017-09-01 00:00:00
abstract：AIM:To compare the angular changes of the third molars relative to the occlusal plane and to the second molar long axis in extraction group and compare these changes with a non extraction group. MATERIALS AND METHODS:The study included pre and post treatment panoramic radiograph records of 90 subjects treated by first...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2016.02.006
更新日期：2016-11-01 00:00:00
abstract：:Stimulation of complex chaperone activity may be a viable means of therapy for neurodegenerative diseases. These chaperons execute reactivation of thermally and chemically aggregated protein substrates by cooperating with their partner co-chaperons. We optimized the expression and purification conditions of Tid1-L cha...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2020.09.006
更新日期：2020-11-01 00:00:00
abstract：:In forensic science, the human identification is the major goal in criminal cases and in paternity dispute, based on DNA profiling of individual. Analysis of short tandem repeat (STRs) markers used as a reliable technique for this purpose. In this study the main objective was to develop a human identification based on...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2018.10.001
更新日期：2018-12-01 00:00:00
abstract：:Use of honey has a very long history. Honey has been used since ancient time due to its nutritional and therapeutic values. There had been varied ways of consumption honey including its use as a sweetener and flavoring agent. Honey is produced all over the world. The most important nutriment of honey is carbohydrates ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章,评审
doi：10.1016/j.sjbs.2016.12.010
更新日期：2017-07-01 00:00:00
abstract：:Warfarin doses are greatly affected by polymorphism altering cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) gene. This study evaluated the prevalence of alleles (either single or double) and carriers of single nucleotide polymorphisms (SNPs) in both genotypes CYP2C9 and VKORC1 ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2019.11.007
更新日期：2020-01-01 00:00:00
abstract：:We report morphometric data for 133 specimens of Diplometopon zarudnyi (Squamata: Trogonophidae) collected across its range within Riyadh province of Saudi Arabia. One-way analyses of variance revealed that differences exist in most characters. Snout-vent length and vent-tail length showed slight and inconsistent diff...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2016.12.003
更新日期：2017-05-01 00:00:00
