Abstract：
:Schistosomiasis is still one of the main parasitic diseases that affect human health in tropical regions. Whilst praziquantel (PZQ) is the main classic antischistosomal drug, the need for new drugs is still a must due to the low effectiveness of the drug on the schistosome young worms, and the evolving of PZQ resistant strains. Nanotechnology is one of the most important recent and current methods used to treat human diseases including parasitic ones. Therefore, the present study aimed to examine the curative role of gold nanoparticles (GNPs) on splenic tissue of mice infected with Schistosoma mansoni Sambon, 1907. High-resolution transmission electron microscopy was used for characterization of nanoparticles (NP). GNPs of 1 mg/kg mice body weight were inoculated into mice infected with S. mansoni. The parasite caused deteriorations in histological architecture of the spleen tissue, and splenomegaly. Additionally, the parasite induced a significant reduction in splenic tissue glutathione levels; however, the concentrations of nitric oxide and malondialdehyde were significantly increased. Treatment of mice with GNPs reduced the extent of histological impairment and oxidative stress in spleen tissue. Therefore, our results demonstrate the protective role of GNPs against splenic damage in mice infected with S. mansoni.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Dkhil MA,Khalil MF,Diab MSM,Bauomy AA,Al-Quraishy Sdoi
10.1016/j.sjbs.2016.12.017subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1418-1423issue
6eissn
1319-562Xissn
2213-7106pii
S1319-562X(16)30193-0journal_volume
24pub_type
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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