Thiocyclam does not induce structural chromosome aberrations in human lymphocytes in vitro.

Abstract:

:Thiocyclam (trade name Evisect) is a broad-spectrum nereistoxin analogue insecticide used widely for agricultural applications. The aim of this investigation was to determine its genotoxic effects in the chromosome aberration (CA) test and determining of mitotic index (MI), using lymphocytes from peripheral blood samples of healthy human donors. A negative and a positive control (MMC) were also included. Chromosomal analyses of the metaphase plates of the samples treated with 14 different concentrations (from 0.1 to 120 μg/ml) of thiocyclam, indicating the lack effect on chromosomes. Thus thiocyclam is not genotoxic but highly toxic on cell proliferation in human lymphocytes.

journal_name

Saudi J Biol Sci

authors

Celikler S,Saleh K,Sarhan MA

doi

10.1016/j.sjbs.2010.04.004

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

215-7

issue

3

eissn

1319-562X

issn

2213-7106

pii

SJBS46

journal_volume

17

pub_type

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