Genetic risk assessment towards warfarin application: Saudi Arabia study with a potential to predict and prevent side effects.

Abstract:

:Warfarin doses are greatly affected by polymorphism altering cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) gene. This study evaluated the prevalence of alleles (either single or double) and carriers of single nucleotide polymorphisms (SNPs) in both genotypes CYP2C9 and VKORC1 in alkharj area, Saudi Arabia and its association with warfarin use risk. Total 112 samples were collected and genotyped using FlexiGene DNA Kit for isolation and StepOnePlus Real-Time PCR System by TaqMan allelic discrimination methods. The results indicated the frequency of 11%, 8% and 45% for CYP2C9 *2 *3 and VKORC1-1639 G > A polymorphism. And as a combination genotype it was 15.18% For both CYP2C9 and VKORC1 polymorphism, 27.67% for CYP2C9 and 42.86% for VKORC1. Non-carriers rate came to be at 30.3%. According to previously published dosing changes in warfarin for polymorphism carriers (single-double-triple). The predicted warfarin doses reduction in order of 1-1.6, 2-2.9, 2.9-3.7 mg/day. It was found that 72.3% of the study population was carrier of a type of polymorphism, 15.18% for two types of polymorphisms. These findings predict changes in warfarin metabolism and eventually dosing alteration among patients on warfarin. Both genotypes (CYP2C9 and VKORC1) require different dosing of warfarin than non-carriers in order to minimize the risk of warfarin overdosing and avoidance of the drug-related problems (DRPs).

journal_name

Saudi J Biol Sci

authors

Al-Saikhan FI

doi

10.1016/j.sjbs.2019.11.007

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

456-459

issue

1

eissn

1319-562X

issn

2213-7106

pii

S1319-562X(19)30242-6

journal_volume

27

pub_type

杂志文章
  • Phytophagous and predaceous mites associated with vegetable crops from Riyadh, Saudi Arabia.

    abstract::This study was conducted to investigate phytophagous and predatory mites associated with vegetable plants in Riyadh, Saudi Arabia. Eight phytophagous and 10 predacious mites were collected from 14 species of vegetable crops covering five major production localities. Out of these 18 mite species, 13 species are new to ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2011.02.004

    authors: Al-Atawi FJ

    更新日期:2011-07-01 00:00:00

  • Biochemical and histological impact of Vernonia amygdalina supplemented diet in obese rats.

    abstract::This study was carried out to evaluate the anti-obesity effect of Vernonia amygdalina Del. (VA) supplemented diet. VA leaf powder was fed at 5% and 15% to diet-induced obese rats for 4 weeks and its effect compared with orlistat (5.14 mg/kg p.o.), an anti-obesity drug. Food intake, body and organ weights, total body f...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2012.05.003

    authors: Atangwho IJ,Edet EE,Uti DE,Obi AU,Asmawi MZ,Ahmad M

    更新日期:2012-07-01 00:00:00

  • Effects of hyperoxia periodic training on free radicals production, biological antioxidants potential and lactate dehydrogenase activity in the lungs of rats, Rattus norvigicus.

    abstract::Oxygen therapy has been widely used in lung injury (Li), adult respiraotory syndrome (ARDS) and inflammatory lung diseases as well as in mechanical ventilation in intensive care units. Exposure to hyperoxia is known to induct the production of reactive oxygen species (ROS) by mitochondria. Despite decades of research,...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2009.12.010

    authors: Alttas O,Haffor AS

    更新日期:2010-01-01 00:00:00

  • The intestinal cestode Hymenolepis diminuta as a lead sink for its rat host in the industrial areas of Riyadh, Saudi Arabia.

    abstract::The present study sought to assess the potential of the cestode Hymenolepis diminuta as a bioindicator for lead accumulation in two industrial areas of the city of Riyadh, Saudi Arabia. Rats (Meriones libycus) were collected from two sites (industrial area II and Salbukh) in Riyadh. In the industrial area II, the mean...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2013.09.010

    authors: Al-Quraishy S,Gewik MM,Abdel-Baki AA

    更新日期:2014-09-01 00:00:00

  • Role of calcium in AMF-mediated alleviation of the adverse impacts of cadmium stress in Bassia indica [Wight] A.J. Scott.

    abstract::The aim of this study was to evaluate cadmium stress induced changes in the growth, lipid peroxidation and antioxidant activity of Bassia indica associated with arbuscular mycorrhizal fungi (AMF) and their amelioration by calcium application. Cadmium stress can cause alterations in the physiological and biochemical pr...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2016.11.003

    authors: Hashem A,Abd Allah EF,Alqarawi AA,Malik JA,Wirth S,Egamberdieva D

    更新日期:2019-05-01 00:00:00

  • Influence of premolar extraction or non-extraction orthodontic therapy on the angular changes of mandibular third molars.

    abstract:AIM:To compare the angular changes of the third molars relative to the occlusal plane and to the second molar long axis in extraction group and compare these changes with a non extraction group. MATERIALS AND METHODS:The study included pre and post treatment panoramic radiograph records of 90 subjects treated by first...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2016.02.006

    authors: Durgesh BH,Gowda KH,AlShahrani OA,Almalki AD,Almalki WD,Balharith MM,Motashesh NY,Alkheraif AA,Hashem MI

    更新日期:2016-11-01 00:00:00

  • Array comparative genomic hybridization based identification of key genetic alterations at 2p21-p16.3 (MSH2, MSH6, EPCAM), 3p23-p14.2 (MLH1), 7p22.1 (PMS2) and 1p34.1-p33 (MUTYH) regions in hereditary non polyposis colorectal cancer (Lynch syndrome) in th

    abstract::Lynch syndrome is inherited in an autosomal dominant mode. Lynch syndrome is caused by impairment of one or more of the various genes (most frequently MLH1 and MSH2) involved in mismatch repair. In this study, whole genome comparative genomic hybridization array (array CGH) based genomic analysis was performed on twel...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2019.06.012

    authors: Rasool M,Pushparaj PN,Mirza Z,Imran Naseer M,Abusamra H,Alquaiti M,Shaabad M,Sibiany AMS,Gauthaman K,Al-Qahtani MH,Karim S

    更新日期:2020-01-01 00:00:00

  • The expression of macrophage migration inhibitory factor in the non-small cell lung cancer.

    abstract:Objective:The objective was to investigate the expression of macrophage migration inhibitory factor (MIF) in non-small cell lung cancer (NSCLC), as well as the effects of macrophage MIF on tumor cells. Methods:The human NSCLC cell strains H358 and H524 were selected as research objects. The Real-Time Polymerase Chain ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.04.027

    authors: Zhang H,Duan J,Wu O

    更新日期:2020-06-01 00:00:00

  • D-Pinitol treatment induced the apoptosis in human leukemia MOLT-4 cells by improved apoptotic signaling pathway.

    abstract::Cancer is still remain as a global burden with the 18.1 million and 9.6 million new cases and mortlities, respectively estimated globally. Leukemia may arise at all ages varied from the infants to elders. In this exploration, we planned to evaluate the antiproliferative effect of D-pinitol on human leukemia MOLT-4 cel...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.06.034

    authors: Yao X,Shi K,Yang Y,Gu X,Tan W,Wang Q,Gao X,Priya Veeraraghavan V,Mohan SK,Jin S

    更新日期:2020-08-01 00:00:00

  • Bacillus subtilis: A plant-growth promoting rhizobacterium that also impacts biotic stress.

    abstract::Plants encounter many biotic agents, such as viruses, bacteria, nematodes, weeds, and arachnids. These entities induce biotic stress in their hosts by disrupting normal metabolism, and as a result, limit plant growth and/or are the cause of plant mortality. Some biotic agents, however, interact symbiotically or synerg...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.sjbs.2019.05.004

    authors: Hashem A,Tabassum B,Fathi Abd Allah E

    更新日期:2019-09-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus (MRSA) screening of hospital dental clinic surfaces.

    abstract::We assessed the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strains on surfaces of hospital dental clinics. Specimens were obtained from 5 clinically symptoms-free patients of five different specialties clinics (Implantology, Pediatric Dentistry, Prosthetics, Restorative Dentistry, and Oral Medici...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2018.03.006

    authors: Faden A

    更新日期:2019-11-01 00:00:00

  • Green synthesis and characterization of Carica papaya leaf extract coated silver nanoparticles through X-ray diffraction, electron microscopy and evaluation of bactericidal properties.

    abstract::The evolution of nanotechnology and the production of nanomedicine from various sources had proven to be of intense value in the field of biomedicine. The smaller size of nanoparticles is gaining importance in research for the treatment of various diseases. Moreover the production of nanoparticles is eco-friendly and ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2015.01.007

    authors: Banala RR,Nagati VB,Karnati PR

    更新日期:2015-09-01 00:00:00

  • Biodiversity characteristics of Teucrium polium species in Saudi Arabia.

    abstract::Teucrium (Lamiaceae) is a large and polymorphic genus distributed mainly in Europe, North Africa and in the temperate parts of Asia. In this study, the anatomical features of the leaf and stem of Teucrium polium are investigated. Teucrium has 19 taxa in Iran, which mainly grow in the Irano-Turanian region between 700 ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2014.11.002

    authors: Bukhari NA,Al-Otaibi RA,Ibhrahim MM

    更新日期:2015-03-01 00:00:00

  • Remote sensing of 10 years changes in the vegetation cover of the northwestern coastal land of Red Sea, Saudi Arabia.

    abstract::Accurate and up to date land use and land cover (LU/LC) changes information is the main source to understanding and assessing the environmental outcomes of such changes and is important for development plans. Thus, this study quantified the outlines of land cover variation of 10-years in the northwestern costal land o...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.07.021

    authors: Alharthi A,El-Sheikh MA,Elhag M,Alatar AA,Abbadi GA,Abdel-Salam EM,Arif IA,Baeshen AA,Eid EM

    更新日期:2020-11-01 00:00:00

  • Biotechnological approach of greywater treatment and reuse for landscape irrigation in small communities.

    abstract::A level of water quality intended for human consumption does not seem necessary for domestic uses such as irrigation of green spaces. Alternative water supplies like the use of greywater (GW) can thus be considered. However, GW contains pathogenic microorganisms and organic compounds which can cause environmental and ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2017.01.006

    authors: Laaffat J,Aziz F,Ouazzani N,Mandi L

    更新日期:2019-01-01 00:00:00

  • The use of three-dimensional model construction of virtual technology in orthopedic treatment.

    abstract:Objective:The objective of this study is to explore the construction of a digital three-dimensional model of virtual technology that plays an auxiliary role in orthopedic treatment. Methods:Three fracture patients were selected, with no abnormality was observed in bone examination, no musculoskeletal disease in the pa...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.03.001

    authors: Li C,Xue F,Zhou F

    更新日期:2020-04-01 00:00:00

  • Alkaline phosphatase and acid phosphatase levels in saliva and serum of patients with healthy periodontium, gingivitis, and periodontitis before and after scaling with root planing: A clinico-biochemical study.

    abstract::Periodontitis is commonly diagnosed based on clinical parameters. However, the analysis of a few unique biomarkers of the disease process present in the saliva and blood can further assist the estimation of the rate of disease progression. Aim:The present study attempted to correlate the alkaline phosphatase (ALP) an...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.10.016

    authors: Koppolu P,Sirisha S,Mishra A,Deshpande K,Lingam AS,Alotaibi DH,Saleh Alwahibi M,Penela S

    更新日期:2021-01-01 00:00:00

  • Extraction and characterization of gelatin from camel skin (potential halal gelatin) and production of gelatin nanoparticles.

    abstract::Gelatin is used as an ingredient in both food and non-food industries as a gelling agent, stabilizer, thickener, emulsifier, and film former. Porcine skins, bovine hides, and cattle bones are the most common sources of gelatin. However, mammalian gelatins are rejected by some consumers due to social, cultural, religio...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.03.022

    authors: Ahmed MA,Al-Kahtani HA,Jaswir I,AbuTarboush H,Ismail EA

    更新日期:2020-06-01 00:00:00

  • Histological alterations and biochemical changes in the liver of sheep following Echis coloratus envenomation.

    abstract::Snake envenoming is a major problem in Al-Jouf Province of Saudi Arabia where most of these envenoming are caused by Echis coloratus which is the highest risk to human and animals in this Province. Little, if any, has been carried out on the histological alterations and biochemical changes in the liver of sheep follow...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2010.12.002

    authors: Jarrar BM

    更新日期:2011-04-01 00:00:00

  • Cytotoxic and apoptotic activities of Amorphophallus campanulatus (Roxb.) Bl. tuber extracts against human colon carcinoma cell line HCT-15.

    abstract::Colorectal cancer is one of the leading causes of cancer death worldwide and is the third most common form of malignancy in both men and women. Several possible colon cancer chemopreventive agents are found in edible plants. Amorphophallus campanulatus (Roxb.) Blume (family: Araceae) is a tuber crop, largely cultivate...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2014.01.004

    authors: Ansil PN,Wills PJ,Varun R,Latha MS

    更新日期:2014-12-01 00:00:00

  • Comparative phytochemical profiling of different soybean (Glycine max (L.) Merr) genotypes using GC-MS.

    abstract::This study aimed to estimate the proximate, phenolic and flavonoids contents and phytochemicals present in seeds of twenty four soybeans (Glycine max (L.) Merr) genotypes to explore their nutritional and medicinal values. Crude protein composition ranged between 35.63 and 43.13% in Argentinian and USA (Clark) genotype...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2017.10.014

    authors: Alghamdi SS,Khan MA,El-Harty EH,Ammar MH,Farooq M,Migdadi HM

    更新日期:2018-01-01 00:00:00

  • Molecular authentication of Anthemis deserti Boiss. (Asteraceae) based on ITS2 region of nrDNA gene sequence.

    abstract::The dried plant material of medicinally important Anthemis deserti Boiss. (family: Asteraceae) especially when it remains in the powdered form often look similar to Anthemis melampodina Del.; and therefore, difficult to distinguish, finally lead to chances of adulteration. The adulteration in medicinal plants effects ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2018.09.003

    authors: Ajmal Ali M

    更新日期:2019-01-01 00:00:00

  • Investigating the response of soil and vegetable crops to poultry and cow manure using ground and satellite data.

    abstract::Based on the massive production of cow and poultry manures, farmers in Saudi Arabia are moving towards the application of organic fertilizers in their farms. Therefore, the present work was conducted to study the response of soil and selected vegetable crops to poultry and cow manures, using ground data and Landsat-8 ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2019.06.006

    authors: Al-Gaadi KA,Madugundu R,Tola E

    更新日期:2019-11-01 00:00:00

  • Role of brain renin angiotensin system in neurodegeneration: An update.

    abstract::Renin angiotensin system (RAS) is an endocrine system widely known for its physiological roles in electrolyte homeostasis, body fluid volume regulation and cardiovascular control in peripheral circulation. However, brain RAS is an independent form of RAS expressed locally in the brain, which is known to be involved in...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.sjbs.2020.01.026

    authors: Abiodun OA,Ola MS

    更新日期:2020-03-01 00:00:00

  • Effect of long-term exposure to mobile phone radiation on alpha-Int1 gene sequence of Candida albicans.

    abstract::Over the last decade, communication industries have witnessed a tremendous expansion, while, the biological effects of electromagnetic waves have not been fully elucidated. Current study aimed at evaluating the mutagenic effect of long-term exposure to 900-MHz radiation on alpha-Int1 gene sequences of Candida albicans...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2015.05.001

    authors: Shahin-Jafari A,Bayat M,Shahhosseiny MH,Tajik P,Roudbar-Mohammadi S

    更新日期:2016-05-01 00:00:00

  • Histological and histochemical alterations in the liver induced by lead chronic toxicity.

    abstract::Adult males of the Wistar albino rats (Rattus norvegicus) were exposed to lead acetate trihydrate in drinking water (0.0%, 0.25%, 0.5%, 1% and 2% for 1-12 months) to investigate histological and histochemical alterations induced by lead intoxication in the liver. Chronic exposure to subtoxic concentrations of lead pro...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2011.12.005

    authors: Jarrar BM,Taib NT

    更新日期:2012-04-01 00:00:00

  • Cymbopogon schoenanthus (Ethkher) ameliorates cadmium induced toxicity in swiss albino mice.

    abstract::Cadmium is among the toxic and hazardous metal widely dispersed in the environment in high levels. Current studies have provided new insights into antioxidant properties of bioflavonoid which have emerged as probable therapeutic and nutraceutical agents. The present study is geared to investigate the possible role of ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2017.01.002

    authors: Saggu S,Rehman H,Aziz AT,Alzeibr FMA,Oyouni AAA,Zidan N,Panneerselvam C,Trivedi S

    更新日期:2019-11-01 00:00:00

  • Demographic structure and stock status of Lethrinus lentjan in Saudi coastal waters of the Red Sea.

    abstract::Fishes of the family Lethrinidae form a considerable portion of the catch from both the Red Sea and the Arabian Gulf in Saudi Arabia, and the species Lethrinus lentjan (Lacepède, 1802) is one of the most important among these fishes. This study was conducted to evaluate the demographic structure coefficients, survival...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.06.003

    authors: Younis EM,Abdel-Warith AA,Al-Asgah NA,Gabr MH,Shamlol FS

    更新日期:2020-09-01 00:00:00

  • In vitro biocontrol activity of halotolerant Streptomyces aureofaciens K20: A potent antagonist against Macrophomina phaseolina (Tassi) Goid.

    abstract::A halotolerant actinobacterial strain isolated from salinity affected soil of Eastern Indo-Gangetic plains (IGP), Uttar Pradesh, India, was characterised for its antagonistic potential against Macrophomina phaseolina by dual-culture assay. It was shown to effectively inhibit the growth of M. phaseolina with an inhibit...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2015.12.004

    authors: Shrivastava P,Kumar R,Yandigeri MS

    更新日期:2017-01-01 00:00:00

  • Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice.

    abstract::Annona muricata Linnaeus, popularly known as "graviola" and also called soursop, is a species typical of countries with a tropical climate, and it is used in folk medicine as an anticancer, analgesic and antispasmodic agent. The aim of the present study was to validate the gastroprotective activity of the hydroalcohol...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2016.01.024

    authors: Bento EB,Júnior FEB,de Oliveira DR,Fernandes CN,de Araújo Delmondes G,Cesário FRAS,Rodrigues CKS,Sales VDS,de Figueiredo FRSDN,Lemos ICS,Monteiro ÁB,de Menezes IRA,da Costa JGM,Kerntopf MR

    更新日期:2018-05-01 00:00:00