Abstract:
:Soybean oligosaccharides (SBOSs) are potential prebiotics that may be used to improve immune function. Here, we investigated the effects of intragastric administration of SBOSs in mice to determine the effects on autochthonous intestinal microbial communities and immunological parameters. Results E: After 22-day administration, 4.0 g kg body weight (BW)-1 SBOSs significantly enhanced the proliferation of bifidobacteria and lactic acid bacteria (LAB) as compared to the control. This dose of SBOSs also significantly increased numbers of enterococci and decreased numbers of Clostridium perfringens. Treatment with 4.0 g kg BW-1 SBOSs also significantly increased the percentage of T-lymphocytes and lymphocyte proliferation as compared to the control, suggesting that SBOSs promoted cellular immunity in mice. Additionally, 4.0 g kg BW-1 SBOSs induced significant differences in hemolysin production, natural killer (NK) cell activity, phagocytic activity, cytokine production, and immunoglobulin levels compared to the control. CONCLUSION:Our data demonstrated that intragastric administration of SBOSs at a dose of 4.0 g kg BW-1 improved the numbers of beneficial intestinal microbes and enhanced immunological function of mice. Therefore, these data supported that SBOSs may have applications as a prebiotic to improve immune responses in humans. Further studies are warranted.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Ma Y,Wu X,Giovanni V,Meng Xdoi
10.1016/j.sjbs.2016.09.004subject
Has Abstractpub_date
2017-01-01 00:00:00pages
114-121issue
1eissn
1319-562Xissn
2213-7106pii
S1319-562X(16)30102-4journal_volume
24pub_type
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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