Abstract:
:In this study, anti-convulsant effect of Sidr leaf extract was examined by using pentylenetetrazol (PTZ) model on male albino rat by evaluating the changes in norepinephrine (NE), dopamine (DA) and serotonin (5-HT) contents in different brain regions (cerebellum, brainstem, striatum, cerebral cortex, hypothalamus and hippocampus). The administration of subconvulsive dose of PTZ (40 mg/kg i.p.) every other day for 9 days caused a significant decrease in monoamine content in different brain areas, this is may be due to the increase in nitric oxide levels, although antagonized the GABAA receptors which led to neurotransmitter release so the content is decreased. Administration of PTZ after treatment with Sidr (50 mg/kg i.p.) leaf extract for 3 weeks as a protective group and administration of Sidr leaf extract for 3 weeks after treatment of PTZ as a therapeutic group caused significant increase in NE, DA, and 5-HT contents in all tested brain regions at most of the time intervals studied. This may be due to the presence of peptide and cyclopeptide alkaloids in the extract which inhibit neurotransmitter activity which led to the inhibition of neurotransmitter release. From these results, we can say that the Sidr leaf extract has neuroprotective and therapeutic roles against pentylenetetrazol convulsant effect.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Waggas AM,Al-Hasani RHdoi
10.1016/j.sjbs.2010.05.003subject
Has Abstractpub_date
2010-10-01 00:00:00pages
269-74issue
4eissn
1319-562Xissn
2213-7106pii
SJBS58journal_volume
17pub_type
杂志文章abstract::Background: Propolis is a natural product of plant resins collected by honeybees from various plant sources. It is used as a remedy in folk medicine since ancient times because of its several biological and pharmacological properties. Recently, propolis has been used by dentist to treat various oral diseases. It was a...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2016.12.019
更新日期:2017-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.01.011
更新日期:2018-07-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2019.09.009
更新日期:2019-12-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.03.001
更新日期:2020-04-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.10.016
更新日期:2021-01-01 00:00:00
abstract::The evolution of nanotechnology and the production of nanomedicine from various sources had proven to be of intense value in the field of biomedicine. The smaller size of nanoparticles is gaining importance in research for the treatment of various diseases. Moreover the production of nanoparticles is eco-friendly and ...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.01.007
更新日期:2015-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2017.01.015
更新日期:2017-03-01 00:00:00
abstract::Feed ingredients used in swine diets contain various levels and availabilities of nutrients. Nutritional precision evaluation of each ingredient is necessary for formulating diets of pigs. Especially, phosphorous (P) is one of important nutrients for metabolism. However, current data of P digestibility were most appar...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.12.003
更新日期:2019-02-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2016.09.004
更新日期:2017-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.10.007
更新日期:2016-03-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.06.034
更新日期:2020-08-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.06.009
更新日期:2015-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.sjbs.2019.05.004
更新日期:2019-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.04.027
更新日期:2020-06-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2017.01.002
更新日期:2019-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2019.12.041
更新日期:2020-04-01 00:00:00
abstract::People use medicinal plants as diet, and for treatment of infectious and noninfectious diseases and they use brief procedures like frying and cooking to do so. Medicinal plants; Moringa oleifera, Azadirachta indica, and Lepidium sativum which is believed to have active components that help to treat and manage various ...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.06.047
更新日期:2020-09-01 00:00:00
abstract::Obesity is a global health burden due to lifestyle modifications that have a strong association with a high incidence of diseases, such as dyslipidemia, glucose intolerance, nonalcoholic fatty liver diseases, diabetes, hypertension, coronary heart disease and cancer. The aim of the present study is to investigate the ...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.03.010
更新日期:2018-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2019.11.040
更新日期:2020-02-01 00:00:00
abstract::Teucrium (Lamiaceae) is a large and polymorphic genus distributed mainly in Europe, North Africa and in the temperate parts of Asia. In this study, the anatomical features of the leaf and stem of Teucrium polium are investigated. Teucrium has 19 taxa in Iran, which mainly grow in the Irano-Turanian region between 700 ...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2014.11.002
更新日期:2015-03-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.sjbs.2017.01.004
更新日期:2017-05-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.10.006
更新日期:2016-01-01 00:00:00
abstract::In order to systematically study the predatory behavior and digestion regularity of spiders, real-time fluorescence quantification PCR technique was used to detect the number of CO-I genes in Pardosa pseudoannulata after it preyed on rice planthoppers in different temperatures within different periods. At 28 °C, 0, 1,...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2017.01.046
更新日期:2017-03-01 00:00:00
abstract::A field experiment was conducted to investigate the effect of seed presoaking of shikimic acid (30, 60 and 120 ppm) on growth parameters, fruit productivity and quality, transpiration rate, photosynthetic pigments and some mineral nutrition contents of tomato plants. Shikimic acid at all concentrations significantly i...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2013.03.002
更新日期:2013-10-01 00:00:00
abstract::Arbuscular mycorrhizal fungi (AMF) inoculation and biochar amendment has been reported to improve growth of several crop plants however their role in stress amelioration individually as well as in combination has not been worked out. This experiment was conducted to evaluate the application of AMF and biochar on the p...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.11.005
更新日期:2019-03-01 00:00:00
abstract::Tuberculosis (TB) is a disease that affects one-third of the world's population. Although currently available TB drugs have many side effects, such as nausea, headache and gastrointestinal discomfort, no new anti-TB drugs have been produced in the past 30 years. Therefore, the discovery of a new anti-TB agent with min...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章,评审
doi:10.1016/j.sjbs.2020.07.007
更新日期:2020-09-01 00:00:00
abstract::Prediction of a complex super-secondary structure is a key step in the study of tertiary structures of proteins. The strand-loop-helix-loop-strand (βαβ) motif is an important complex super-secondary structure in proteins. Many functional sites and active sites often occur in polypeptides of βαβ motifs. Therefore, the ...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.10.005
更新日期:2016-01-01 00:00:00
abstract::Stimulation of complex chaperone activity may be a viable means of therapy for neurodegenerative diseases. These chaperons execute reactivation of thermally and chemically aggregated protein substrates by cooperating with their partner co-chaperons. We optimized the expression and purification conditions of Tid1-L cha...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.09.006
更新日期:2020-11-01 00:00:00
abstract::The effects of exposing meat-type breeder eggs to magnetic field (MF) before incubation on hatchability traits (percents of hatchability and hatchability failures of eggs), chick weight at hatch, and post-hatch performance (weight gain, feed intake, and feed conversion ratio (FCR)) from 1 to 39 d of age were investiga...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2011.06.004
更新日期:2011-10-01 00:00:00
abstract::Lethal and sub lethal effects of fresh and old residues of azadirachtin, spinosad, Bacillus thuringiensis var. kurstaki (Bt var. k), and deltamethrin, were evaluated at their recommended field doses against adult and immature stages of Trichogramma brassicae under in vitro conditions. The experiments were carried out ...
journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2016.04.007
更新日期:2018-05-01 00:00:00