Biochemical and histological impact of Vernonia amygdalina supplemented diet in obese rats.

Abstract:

:This study was carried out to evaluate the anti-obesity effect of Vernonia amygdalina Del. (VA) supplemented diet. VA leaf powder was fed at 5% and 15% to diet-induced obese rats for 4 weeks and its effect compared with orlistat (5.14 mg/kg p.o.), an anti-obesity drug. Food intake, body and organ weights, total body fat, some lipid components and amino transaminase activities in serum, hepatocytes and brain; as well as serum glucose, were measured during or at end of the study. Result showed respective decrease of 12.78% and 38.51% in body weight gain, of VA fed rats against 17.45% of orlistat at end of study (P < 0.05); but with no effect on food intake. Total body fat was lowered by 28.04% and 30.02% vs. obese control rats (CDC) (P < 0.05). Furthermore, serum triacylglycerol (TG), serum and brain total cholesterol (TCHOL), were down regulated at 15% VA supplementation (P < 0.05). Serum glucose which increased in obese rats by 46.26% (P < 0.05) vs. NC, indicating intolerance, was restored by VA (38.75% and 34.65%) and orlistat (31.80%) vs. CDC (P < 0.05). VA diet also exerted hepato-protection, via lowering serum alanine amino transaminase (ALT) (41.35% and 27.13%) and aspartate amino transaminase (AST) (17.09% and 43.21%) activities (P < 0.05). Orlistat had no effect on these enzymes. Histology of adipose tissue corroborated the changes on total body fat. We concluded that, diet supplemented with VA can attenuate dietary obesity as well as ameliorates the potential risks of hepato-toxicity and glucose intolerance associated with obesity.

journal_name

Saudi J Biol Sci

authors

Atangwho IJ,Edet EE,Uti DE,Obi AU,Asmawi MZ,Ahmad M

doi

10.1016/j.sjbs.2012.05.003

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

385-92

issue

3

eissn

1319-562X

issn

2213-7106

pii

SJBS173

journal_volume

19

pub_type

杂志文章
  • Remote sensing of 10 years changes in the vegetation cover of the northwestern coastal land of Red Sea, Saudi Arabia.

    abstract::Accurate and up to date land use and land cover (LU/LC) changes information is the main source to understanding and assessing the environmental outcomes of such changes and is important for development plans. Thus, this study quantified the outlines of land cover variation of 10-years in the northwestern costal land o...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.07.021

    authors: Alharthi A,El-Sheikh MA,Elhag M,Alatar AA,Abbadi GA,Abdel-Salam EM,Arif IA,Baeshen AA,Eid EM

    更新日期:2020-11-01 00:00:00

  • In vitro activity of some natural honeys against Entamoeba histolytica and Giardia lamblia trophozoites.

    abstract::Considering the potentiality of honey in combating diseases, the present study was carried out aiming to assess the in vitro antiprotozoal activity of several honeys (Ziziphus spina-christi, Acacia nilotica, Acacia seyal, and Cucurbita maxima) against Entamoeba histolytica and Giardia lamblia by employing the sub-cult...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2017.06.004

    authors: Mohammed SEA,Kabbashi AS,Koko WS,Ansari MJ,Adgaba N,Al-Ghamdi A

    更新日期:2019-02-01 00:00:00

  • The extraction of different proteins in selenium enriched peanuts and their antioxidant properties.

    abstract::In this study, the selenium enriched peanuts and the different solubility proteins extracted from them were investigated. The dried defatted selenium enriched peanuts (SeP) powder (0.3147 μg/g) had a 2.5-fold higher mean total selenium concentration than general peanuts (GP) power (0.1233 μg/g). The SeP had higher con...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2015.08.007

    authors: Zhao P,Wang Y,Zhang Y,Guo T,Zhang Z,Zhang WJ,Zhang XG,Ashraf MA

    更新日期:2016-05-01 00:00:00

  • Urethrographic examinations: Patient and staff exposures and associated radiobiological risks.

    abstract::Medical exposure of the general population due to radiological investigations is the foremost source of all artificial ionising radiation. Here, we focus on a particular diagnostic radiological procedure, as only limited data are published with regard to radiation measurements during urethrograpic imaging. Specificall...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.08.026

    authors: Alkhorayef M,Sulieman A,Barakat H,Al-Mohammed HI,Theodorou K,Kappas C,Bradley D

    更新日期:2021-01-01 00:00:00

  • Inhibition of autophagy of Cajal mesenchymal cells by gavage of tong bian decoction based on the rat model of chronic transit constipation.

    abstract::The objective of this research was to study the effect of tong bian decoction on colon transport function of interstitial cells of Cajal (ICC) in chronic transit constipation (CTC) and the inhibition of autophagy of ICC, so as to achieve the free movement of the bowels. In this research, the experimental rats were div...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2019.11.040

    authors: Zhou X,Qian H,Zhang D,Zeng L

    更新日期:2020-02-01 00:00:00

  • Impact of lactation stage on milk composition and blood biochemical and hematological parameters of dairy Baladi goats.

    abstract::The objective of this study was to elucidate the impact of lactation stage on milk composition, hematological and biochemical parameters of dairy Baladi goats under Egyptian conditions. Forty-eight Baladi goats (32.8 ± 2.9 kg of BW) were enrolled in the current study. The lactation period has been divided into three s...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2016.08.003

    authors: El-Tarabany MS,El-Tarabany AA,Roushdy EM

    更新日期:2018-12-01 00:00:00

  • Cytogenotoxic effects of Adenium obesum seeds extracts on breast cancer cells.

    abstract::The extracts prepared from various areal parts of the Adenium obesum (Forssk.) Roem. & Schult. (Family: Apocynaceae) including leaves, fruit and seeds ethanolic extracts and seed aqueous extract were evaluated against MCF-7 cells in order to investigate its potential of cytogenotoxicity and induction of apoptosis. The...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2018.12.014

    authors: Ali AQ,Farah MA,Abou-Tarboush FM,Al-Anazi KM,Ali MA,Lee J,Hailan WAQ,Mahmoud AH

    更新日期:2019-03-01 00:00:00

  • Research of population with impulsive perturbations based on dynamics of a neutral delay equation and ecological quality system.

    abstract::This paper studies the global behaviors of a nonlinear autonomous neutral delay differential population model with impulsive perturbation. This model may be suitable for describing the dynamics of population with long larval and short adult phases. It is shown that the system may have global stability of the extinctio...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2015.10.018

    authors: Xiong W,Jiang H

    更新日期:2016-01-01 00:00:00

  • Genetic diversity in exotic oat germplasm & resistance against barley yellow dwarf virus.

    abstract::Oat (Avena sativa L.) is an important fodder crop of Pakistan, though with low productivity. The present study was conducted to evaluate the performance and genetic diversity of exotic oat germplasm, with emphasis on cereal yellow dwarf virus resistance. A total of 16 exotic line (introduced from Aarhus University Den...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.05.042

    authors: Jan SF,Khan MR,Iqbal A,Khan FU,Ali S

    更新日期:2020-10-01 00:00:00

  • A field study investigating the insecticidal efficacy against Diaphorina citri Kuwayama on Kinnow mandarin, Citrus reticulata Blanco trees.

    abstract::Asian citrus psyllid is a most damaging insect pest of citrus. In this field study, the efficacy of seven insecticides (emamectin benzoate, bifenthrin, chlorfenapyr, fipronil, imidacloprid, pyriproxyfen and thiamethoxam) was evaluated against Diaphorina citri Kuwayama in the citrus orchard of Kinnow mandarin, Citrus r...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.02.006

    authors: Iqbal J,Nazeer Hussain H,Latif M,Barjees Baig M,Owayss AA,Raweh HS,Alqarni AS

    更新日期:2020-05-01 00:00:00

  • Plastome comparison and evolution within the tribes of Plantaginaceae: Insights from an Asian gypsyweed.

    abstract::In spite of availability of several plastomes representing different tribes of Plantaginaceae, sparse attempts have been made to understand the plastome structure, evolution, and phylogenomics. In the present study, we have made an effort to understand the gene content and plastome evolution in the family Plantaginace...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.09.040

    authors: Maurya S,Darshetkar AM,Yi DK,Kim J,Lee C,Ali MA,Choi S,Choudhary RK,Kim SY

    更新日期:2020-12-01 00:00:00

  • Biochemical and molecular characterization of non-host resistance keys in food crops.

    abstract::Generally, under normal conditions plants are resistant to many of the incompatible pathogens (viral, fungal and bacterial), and this is named "non-host resistance phenomenon". To understand this phenomenon, different types of food crops (faba bean, squash, barley and wheat) were inoculated with compatible and incompa...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2019.12.041

    authors: Hafez YM,Mourad RY,Nasr EB,Attia K,Abdelaal KA,Ghazy AI,Al-Ateeq TK,Ibrahim EI,Mohammed AA

    更新日期:2020-04-01 00:00:00

  • Bioanthropological analysis of human occipital condyles using geometric morphometric method.

    abstract::Sex differences are present in all parts of the body, including the skeletal system. Several methods are used to analyze the sex differences of skeleton, while more recently, a new method called geometric morphometry has been used. The aim of this study was to examine the sexual dimorphism of occipital condyles on hum...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.09.019

    authors: Aida SH,Zurifa A,Ilvana H,Senad Š,Maida RT,Izeta A,Kapo Sanita M,Rifat H

    更新日期:2020-12-01 00:00:00

  • Demographic structure and stock status of Lethrinus lentjan in Saudi coastal waters of the Red Sea.

    abstract::Fishes of the family Lethrinidae form a considerable portion of the catch from both the Red Sea and the Arabian Gulf in Saudi Arabia, and the species Lethrinus lentjan (Lacepède, 1802) is one of the most important among these fishes. This study was conducted to evaluate the demographic structure coefficients, survival...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.06.003

    authors: Younis EM,Abdel-Warith AA,Al-Asgah NA,Gabr MH,Shamlol FS

    更新日期:2020-09-01 00:00:00

  • Integrated control of white rot disease on beans caused by Sclerotinia sclerotiorum using Contans® and reduced fungicides application.

    abstract::This study was conducted to determine the compatibility of Contans® (Coniothyrium minitans) with fungicides against Sclerotinia sclerotiorum. Results showed that both Contans® and Topsin® significantly reduced the disease incidence caused by S. sclerotiorum by 90% and 95% survival plants, respectively when they were i...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2016.01.038

    authors: Elsheshtawi M,Elkhaky MT,Sayed SR,Bahkali AH,Mohammed AA,Gambhir D,Mansour AS,Elgorban AM

    更新日期:2017-02-01 00:00:00

  • Comparison of cold resistance physiological and biochemical features of four Herba Rhodiola seedlings under low temperature.

    abstract::To discuss the cold resistance performance of different Herba Rhodiolae and successfully transplant Herba Rhodiolae to the Gansu plateau area for nursing, domestication and planting, this paper systematically studies six physiological and biochemical features of Rhodiola kirilowii, Rhodiola algida, Rhodiola crenulata ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2015.10.007

    authors: He S,Zhao K,Ma L,Yang J,Chang Y,Ashraf MA

    更新日期:2016-03-01 00:00:00

  • Responses of Corpuscles of Stannius to intra-peritoneal vitamin-D3 administration in teleost Labeo rohita (Hamilton, 1822) reared in water with two different levels of calcium concentration.

    abstract::This study assessed the responses of vitamin-D3 intraperitoneally injected to Rohu, Labeo rohita @ of 0 IU/kg bw (only solvent), 100 IU/kg bw and 500 IU/kg bw reared in 20 and 40 ppm of calcium (Ca) enriched water. The cellular changes in Corpuscles of Stannius (CS) gland, serum Ca, and inorganic phosphate (Pi) level ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.07.033

    authors: Sivagurunathan U,Srivastava PP,Gupta S,Krishna G

    更新日期:2020-12-01 00:00:00

  • Impact of polycystic ovary syndrome on eating behavior, depression and health related quality of life: A cross-sectional study in Riyadh.

    abstract:Background & objectives:Polycystic ovary syndrome (PCOS) is the most common endocrinal disorder, and the greatest cause of infertility in women. Despite availability of individual data on impact of multiple endocrinal, reproductive and even metabolic factors in PCOS individuals, the data on the co-existence of BED and ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.08.039

    authors: Asdaq SMB,Jomah S,Hasan R,Al-Baroudi D,Alharbi M,Alsubaie S,Buhamad MH,Alyahya B,Al-Yamani MJ

    更新日期:2020-12-01 00:00:00

  • A review of medicinal plant of Middle East and North Africa (MENA) region as source in tuberculosis drug discovery.

    abstract::Tuberculosis (TB) is a disease that affects one-third of the world's population. Although currently available TB drugs have many side effects, such as nausea, headache and gastrointestinal discomfort, no new anti-TB drugs have been produced in the past 30 years. Therefore, the discovery of a new anti-TB agent with min...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.sjbs.2020.07.007

    authors: Dehyab AS,Bakar MFA,AlOmar MK,Sabran SF

    更新日期:2020-09-01 00:00:00

  • Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment.

    abstract::Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms. Production of extended-spectrum β-lactamases (ESBLs) is a significant resistance-mechanism tha...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2014.08.002

    authors: Shaikh S,Fatima J,Shakil S,Rizvi SM,Kamal MA

    更新日期:2015-01-01 00:00:00

  • Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro.

    abstract::Artemisinin is the first-line drugs for the treatment of malaria. In recent years, a large number of reports showed that artemisinin exhibit anti-tumor activity. In this study, we used C6 glioma cells and rat C6 brain-glioma model to study anti-tumor activity of artemisinin in vivo and in vitro. We found that artemisi...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2018.04.003

    authors: Chen J,Zhang L,Hao M

    更新日期:2018-11-01 00:00:00

  • BmNPV-miR-415 up-regulates the expression of TOR2 via Bmo-miR-5738.

    abstract::MicroRNAs (miRNAs) have emerged as key players in host-pathogen interaction and many virus-encoded miRNAs have been identified (computationally and/or experimentally) in a variety of organisms. A novel Bombyx mori nucleopolyhedrosis virus (BmNPV)-encoded miRNA miR-415 was previously identified through high-throughput ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2015.09.020

    authors: Cao X,Huang Y,Xia D,Qiu Z,Shen X,Guo X,Zhao Q

    更新日期:2017-11-01 00:00:00

  • Nutritional and technological assessment of durum wheat-faba bean enriched flours, and sensory quality of developed composite bread.

    abstract::Faba beans are acknowledged as a good source of proteins, minerals, fibers, vitamins and antioxidants. A blending study was undertaken in order to prepare naturally bread from enriched flours with added nutritional value, mainly in terms of Iron and proteins. Enriched flours were prepared with varied levels (25, 30, 3...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.10.053

    authors: Benayad A,Taghouti M,Benali A,Aboussaleh Y,Benbrahim N

    更新日期:2021-01-01 00:00:00

  • Effects of Melothria maderaspatana leaf extract on antioxidant status in sham-operated and uninephrectomized DOCA-salt hypertensive rats.

    abstract::The present study was designed to investigate the antihypertensive and antioxidant effect of Melothria maderaspatana leaf extract (MME) on sham-operated and DOCA-salt (deoxycorticosterone acetate) induced hypertensive rats. Administration of DOCA-salt significantly increased the systolic (from 127 to 212 mm Hg) and di...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2010.05.002

    authors: Veeramani C,Aristatile B,Pushpavalli G,Pugalendi KV

    更新日期:2011-01-01 00:00:00

  • Induction of somatic embryogenesis in Brassica juncea L. and analysis of regenerants using ISSR-PCR and flow cytometer.

    abstract::A new and simple protocol has been developed and standardized for direct somatic embryogenesis and plant regeneration from aseptic seedlings derived from immature Brassica juncea seeds. Depending on the age of immature seeds and nutrient media, in vitro occurrence of embryogenesis and the number of embryos from each s...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.11.050

    authors: Faisal M,Abdel-Salam EM,Alatar AA,Qahtan AA

    更新日期:2021-01-01 00:00:00

  • Influence of the mixtures composed of slow-release insecticide formulations against Aedes aegypti mosquito larvae reared in pond water.

    abstract::Vector borne diseases remain the major source of illness and death worldwide. Aedes aegypti is the primary carrier of dengue and dengue haemorrhagic fever in many developing countries in the tropical world. Because A. aegypti populations are becoming more and more resistant to conventional and non conventional insecti...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2017.02.006

    authors: Alkenani NA

    更新日期:2017-09-01 00:00:00

  • The expression of macrophage migration inhibitory factor in the non-small cell lung cancer.

    abstract:Objective:The objective was to investigate the expression of macrophage migration inhibitory factor (MIF) in non-small cell lung cancer (NSCLC), as well as the effects of macrophage MIF on tumor cells. Methods:The human NSCLC cell strains H358 and H524 were selected as research objects. The Real-Time Polymerase Chain ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.04.027

    authors: Zhang H,Duan J,Wu O

    更新日期:2020-06-01 00:00:00

  • Effects of a medicinal plant Macrotyloma uniflorum (Lam.) Verdc.formulation (MUF) on obesity-associated oxidative stress-induced liver injury.

    abstract::Obesity is a global health burden due to lifestyle modifications that have a strong association with a high incidence of diseases, such as dyslipidemia, glucose intolerance, nonalcoholic fatty liver diseases, diabetes, hypertension, coronary heart disease and cancer. The aim of the present study is to investigate the ...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2018.03.010

    authors: Bharathi V,Rengarajan RL,Radhakrishnan R,Hashem A,Abd Allah EF,Alqarawi AA,Anand AV

    更新日期:2018-09-01 00:00:00

  • Screening and identification of novel isolate Streptomyces sp., NLKPB45 from Nellore costal region for its biomedical applications.

    abstract::Actinobacteria, which are the prolific producers of antibiotics and significant suppliers to the pharmaceutical industry, can produce a wide variety of bioactive metabolites. An actinomycete strain designated NLKPB45 was isolated from mangrove soils samples of Nellore coastal regions Andhra Pradesh and assessed for an...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2018.08.027

    authors: Kalyani BS,Krishna PS,Sreenivasulu K

    更新日期:2019-11-01 00:00:00

  • Identification of operative dose of NPK on yield enhancement of desi and kabuli chickpea (Cicer arietinum L.) in diverse milieu.

    abstract::The effect of fertilizer on yield and yield related traits studied in two consecutive years at two different locations. Three different doses of fertilizer (NPK) applied at the rate of 9:23:0, 18:46:12 and 27:69:25 respectively on sixteen chickpea, genotypes (Desi and Kabuli advance lines and commercial varieties). Da...

    journal_title:Saudi journal of biological sciences

    pub_type: 杂志文章

    doi:10.1016/j.sjbs.2020.11.014

    authors: Rashid K,Akhtar M,Latif Cheema K,Rasool I,Zahid MA,Hussain A,Qadeer Z,Jahanzaib Khalid M

    更新日期:2021-01-01 00:00:00