Abstract:
:This study was carried out to evaluate the anti-obesity effect of Vernonia amygdalina Del. (VA) supplemented diet. VA leaf powder was fed at 5% and 15% to diet-induced obese rats for 4 weeks and its effect compared with orlistat (5.14 mg/kg p.o.), an anti-obesity drug. Food intake, body and organ weights, total body fat, some lipid components and amino transaminase activities in serum, hepatocytes and brain; as well as serum glucose, were measured during or at end of the study. Result showed respective decrease of 12.78% and 38.51% in body weight gain, of VA fed rats against 17.45% of orlistat at end of study (P < 0.05); but with no effect on food intake. Total body fat was lowered by 28.04% and 30.02% vs. obese control rats (CDC) (P < 0.05). Furthermore, serum triacylglycerol (TG), serum and brain total cholesterol (TCHOL), were down regulated at 15% VA supplementation (P < 0.05). Serum glucose which increased in obese rats by 46.26% (P < 0.05) vs. NC, indicating intolerance, was restored by VA (38.75% and 34.65%) and orlistat (31.80%) vs. CDC (P < 0.05). VA diet also exerted hepato-protection, via lowering serum alanine amino transaminase (ALT) (41.35% and 27.13%) and aspartate amino transaminase (AST) (17.09% and 43.21%) activities (P < 0.05). Orlistat had no effect on these enzymes. Histology of adipose tissue corroborated the changes on total body fat. We concluded that, diet supplemented with VA can attenuate dietary obesity as well as ameliorates the potential risks of hepato-toxicity and glucose intolerance associated with obesity.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Atangwho IJ,Edet EE,Uti DE,Obi AU,Asmawi MZ,Ahmad Mdoi
10.1016/j.sjbs.2012.05.003subject
Has Abstractpub_date
2012-07-01 00:00:00pages
385-92issue
3eissn
1319-562Xissn
2213-7106pii
SJBS173journal_volume
19pub_type
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.10.018
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.09.040
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2019.12.041
更新日期:2020-04-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.09.019
更新日期:2020-12-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.06.003
更新日期:2020-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2016.01.038
更新日期:2017-02-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.10.007
更新日期:2016-03-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.07.033
更新日期:2020-12-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.08.039
更新日期:2020-12-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2014.08.002
更新日期:2015-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.04.003
更新日期:2018-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2015.09.020
更新日期:2017-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.10.053
更新日期:2021-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2010.05.002
更新日期:2011-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.11.050
更新日期:2021-01-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2017.02.006
更新日期:2017-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.04.027
更新日期:2020-06-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.03.010
更新日期:2018-09-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2018.08.027
更新日期:2019-11-01 00:00:00
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journal_title:Saudi journal of biological sciences
pub_type: 杂志文章
doi:10.1016/j.sjbs.2020.11.014
更新日期:2021-01-01 00:00:00