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Effects of a medicinal plant Macrotyloma uniflorum (Lam.) Verdc.formulation (MUF) on obesity-associated oxidative stress-induced liver injury.

Abstract：

:Obesity is a global health burden due to lifestyle modifications that have a strong association with a high incidence of diseases, such as dyslipidemia, glucose intolerance, nonalcoholic fatty liver diseases, diabetes, hypertension, coronary heart disease and cancer. The aim of the present study is to investigate the protective effects of a Macrotyloma uniflurom formulation (MUF) against high-fat diet (HFD)-induced oxidative stress and inflammation in obese rats. Male albino Wistar rats were fed a high-fat diet for 6 weeks to facilitate fat-induced oxidative stress and were simultaneously treated with MUF (400 mg/kg b.w.) through oral gavage from the third week onwards during the treatment phase. At the end of the experimental period, hepatic and oxidative stress markers were examined. The mRNA expression levels of inflammatory marker genes [Tumor Necrosis Factor-α (TNF-α) and Interleukin-6 (IL-6)] were also determined by reverse transcriptase-polymerase chain reaction in liver tissue. Hepatic marker enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma glutamyl transferase) and lipid peroxidation markers (Thiobarbituric acid reactive substances and LOOH) were significantly increased in HFD-fed rats, and administration of MUF resulted in remarkable suppression of these markers. Administration of MUF to HFD rats enhanced the activity of enzymatic (superoxide dismutase, catalase and glutathione peroxidase and non-enzymatic (vitamin E, vitamin C and glutathione) antioxidants compared to HFD-fed rats. An anti-inflammatory effect of MUF was demonstrated by attenuating gene expression of TNF-α and IL-6. Therefore, the results of this study indicate that MUF could be a strong herbal therapeutic alternative for the protection of the liver as well as prevention and treatment of high-fat-induced oxidative stress and inflammation.

journal_name

Saudi J Biol Sci

journal_title

Saudi journal of biological sciences

authors

Bharathi V,Rengarajan RL,Radhakrishnan R,Hashem A,Abd Allah EF,Alqarawi AA,Anand AV

doi

10.1016/j.sjbs.2018.03.010

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1115-1121

issue

eissn

1319-562X

issn

2213-7106

pii

S1319-562X(18)30079-2

journal_volume

pub_type

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Effects of a medicinal plant Macrotyloma uniflorum (Lam.) Verdc.formulation (MUF) on obesity-associated oxidative stress-induced liver injury.