Abstract:
:Foodborne pathogens are one of the major cause of food-related diseases and food poisoning. Bacterial biofilms and quorum sensing (QS) mechanism of cell-cell communication have also been found to be associated with several outbreaks of foodborne diseases and are great threat to food safety. Therefore, In the present study, we investigated the activity of three tetrahedrally coordinated copper(I) complexes against quorum sensing and biofilms of foodborne bacteria. All the three complexes demonstrated similar antimicrobial properties against the selected pathogens. Concentration below the MIC i.e. at sub-MICs all the three complexes interfered significantly with the quorum sensing regulated functions in C. violaceum (violacein), P. aeruginosa (elastase, pyocyanin and alginate production) and S. marcescens (prodigiosin). The complexes demonstrated potent broad-spectrum biofilm inhibition in Pseudomonas aeruginosa, E. coli, Chromobacterium violaceum, Serratia marcescens, Klebsiella pneumoniae and Listeria monocytogenes. Biofilm inhibition was visualized using SEM and CLSM images. Action of the copper(I) complexes on two key QS regulated functions contributing to biofilm formation i.e. EPS production and swarming motility was also studied and statistically significant reduction was recorded. These results could form the basis for development of safe anti-QS and anti-biofilm agents that can be utilized in the food industry as well as healthcare sector to prevent food-associated diseases.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Al-Shabib NA,Husain FM,Khan RA,Khan MS,Alam MZ,Ansari FA,Laeeq S,Zubair M,Shahzad SA,Khan JM,Alsalme A,Ahmad Idoi
10.1016/j.sjbs.2018.04.013subject
Has Abstractpub_date
2019-02-01 00:00:00pages
308-316issue
2eissn
1319-562Xissn
2213-7106pii
S1319-562X(18)30096-2journal_volume
26pub_type
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