Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro.

Abstract:

:Artemisinin is the first-line drugs for the treatment of malaria. In recent years, a large number of reports showed that artemisinin exhibit anti-tumor activity. In this study, we used C6 glioma cells and rat C6 brain-glioma model to study anti-tumor activity of artemisinin in vivo and in vitro. We found that artemisinin inhibited the proliferation in C6 cells and induced cell cycle arrest and a caspase-3-dependent cell apoptosis. It also inhibited the growth of C6 brain-glioma in vivo and enhanced living state of rat brain-glioma model. These results suggested that artemisinin had significant anti-tumor activities on C6 cells both in vitro and in vivo. Artemisinin might be exploited as a promising clinical anti-cancer drug in future.

journal_name

Saudi J Biol Sci

authors

Chen J,Zhang L,Hao M

doi

10.1016/j.sjbs.2018.04.003

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

1488-1493

issue

7

eissn

1319-562X

issn

2213-7106

pii

S1319-562X(18)30086-X

journal_volume

25

pub_type

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