当前位置： SCI文献检索 > SAUDI JOURNAL OF BIOLOGICAL SCIENCES期刊下所有文献 > Potential pharmacodynamic and pharmacokinetic interactions of Nigella Sativa and Trigonella Foenum-graecum with losartan in L-NAME induced hypertensive rats.

Potential pharmacodynamic and pharmacokinetic interactions of Nigella Sativa and Trigonella Foenum-graecum with losartan in L-NAME induced hypertensive rats.

Abstract：

:The objective of this investigation was to study whether Nigella Sativa and Trigonella Foenum-graecum, could modulate the losartan pharmacodynamic (PD) and pharmacokinetic (PK) in experimental L-NAME induced hypertensive rats. For in vivo study, the systolic blood pressure (SBP) of rats was measured by the "tail-cuff system" after the treatment of rats with herb alone and herb + losartan in hypertensive rats. The SBP of rats treated with L-NAME + losartan also recorded. For the PK study, blood samples were obtained for up to 12 h to determine the concentrations of the drug, and various PK parameters were calculated. The data displayed that the SBP was significantly (p < 0.05) decreased in the rats when administered with L-NAME + N. Sativa or L-NAME + T. Foenum-graecum in contrast to the rats administered with L-NAME alone. A more prominent decline (p < 0.05) in SBP was detected in rats administered with L-NAME + N. Sativa + losartan and L-NAME + T. Foenum-graecum + losartan. In a PK study, higher losartan Cmax and AUC0-t were noted in rats treated with N. Sativa + losartan and T. Foenum-graecum + losartan, although the difference was not significant in contrast to the control group. This study proposed that the interaction between N. Sativa & losartan and T. Foenum-graecum & losartan could take place on concurrent administration; consequently, the dose of losartan may need to be accustomed when they are utilized simultaneously.

journal_name

Saudi J Biol Sci

journal_title

Saudi journal of biological sciences

authors

Ahad A,Raish M,Bin Jardan YA,Alam MA,Al-Mohizea AM,Al-Jenoobi FI

doi

10.1016/j.sjbs.2020.05.009

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

2544-2550

issue

10

eissn

1319-562X

issn

2213-7106

pii

S1319-562X(20)30181-9

journal_volume

27

pub_type

杂志文章

相关文献

SAUDI JOURNAL OF BIOLOGICAL SCIENCES文献大全
  • Effects of hyperoxia periodic training on free radicals production, biological antioxidants potential and lactate dehydrogenase activity in the lungs of rats, Rattus norvigicus.

    abstract：:Oxygen therapy has been widely used in lung injury (Li), adult respiraotory syndrome (ARDS) and inflammatory lung diseases as well as in mechanical ventilation in intensive care units. Exposure to hyperoxia is known to induct the production of reactive oxygen species (ROS) by mitochondria. Despite decades of research,...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2009.12.010

    authors： Alttas O,Haffor AS

    更新日期：2010-01-01 00:00:00

  • In vitro biological properties of Streptomyces cangkringensis isolated from the floral rhizosphere regions.

    abstract：:This context was investigated to determine in vitro antimicrobial, antioxidative, and anticancer traits of crude ethyl acetate extract of Streptomyces cangkringensis strain TSAS 04 isolated from soil sample of rhizosphere regions. The antimicrobial activity of ethyl acetate extract of strain TSAS 04 was determined aga...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2020.09.035

    authors： Saraswathi K,Mahalakshmi S,Khusro A,Arumugam P,Khaloud Mohammed A,Alkufeidy RM

    更新日期：2020-12-01 00:00:00

  • Chemical signals and their regulations on the plant growth and water use efficiency of cotton seedlings under partial root-zone drying and different nitrogen applications.

    abstract：:Partial root-zone drying during irrigation (PRD) has been shown effective in enhancing plant water use efficiency (WUE), however, the roles of chemical signals from root and shoot that are involved and the possible interactions affected by nitrogen nutrition are not clear. Pot-grown cotton (Gossypium spp.) seedlings w...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2017.01.015

    authors： Li W,Jia L,Wang L

    更新日期：2017-03-01 00:00:00

  • Performance of three pilot-scale immobilized-cell biotrickling filters for removal of hydrogen sulfide from a contaminated air steam.

    abstract：:Hydrogen sulfide (H2S) is a major malodorous compound emitted from wastewater treatment plants. In this study, the performance of three pilot-scale immobilized-cell biotrickling filters (BTFs) spacked with combinations of bamboo charcoal and ceramsite in different ratios was investigated in terms of H2S removal. Exten...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2014.05.008

    authors： Chen Y,Fan Z,Ma L,Yin J,Luo M,Cai W

    更新日期：2014-11-01 00:00:00

  • Identification of physiological and biochemical markers for salt (NaCl) stress in the seedlings of mungbean [Vigna radiata (L.) Wilczek] genotypes.

    abstract：:Salt stress, which is dominant among environmental stresses, poses challenges to global agriculture. We studied the role of exogenous application of sodium chloride (NaCl) in three arid and three semi-arid genotypes of mungbean [Vigna radiata (L.) Wilczek] by examining some physiological and biochemical stress indicat...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2018.08.006

    authors： Alharby HF,Al-Zahrani HS,Hakeem KR,Iqbal M

    更新日期：2019-07-01 00:00:00

  • Covid-19 pandemic outburst in Saudi Arabia: A glimpse.

    abstract：:Severe Acute Respiratory Syndrome Coronavirus2 (SARS-CoV2) provoked alertness globally. Existing pandemic eruption of infections with SARS-CoV2 has been phrased as coronavirus disease 2019 (covid-19). Worldwide pneumonia outburst attributable to new SARS-CoV2 alleged to be originated in Wuhan city of China and has aff...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.sjbs.2020.07.026

    authors： Ameen F,Amna T,Alghamdi AAA,AlKahtani MDF,AlYahya SA

    更新日期：2020-12-01 00:00:00

  • In vitro activity of some natural honeys against Entamoeba histolytica and Giardia lamblia trophozoites.

    abstract：:Considering the potentiality of honey in combating diseases, the present study was carried out aiming to assess the in vitro antiprotozoal activity of several honeys (Ziziphus spina-christi, Acacia nilotica, Acacia seyal, and Cucurbita maxima) against Entamoeba histolytica and Giardia lamblia by employing the sub-cult...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2017.06.004

    authors： Mohammed SEA,Kabbashi AS,Koko WS,Ansari MJ,Adgaba N,Al-Ghamdi A

    更新日期：2019-02-01 00:00:00

  • Free radical scavenging activity, total phenolic content, total antioxidant status, and total oxidant status of endemic Thermopsis turcica.

    abstract：:Thermopsis turcica, endemic to Turkey, is in danger of extinction. Studies on this species are very few due to the fact that it was only discovered in 1983 and grows in a small circumscribed area in Turkey. In this study, free radical scavenging activity, total phenolic content, total oxidant status (TOS), and total a...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2013.02.003

    authors： Aksoy L,Kolay E,Ağılönü Y,Aslan Z,Kargıoğlu M

    更新日期：2013-07-01 00:00:00

  • Vitamin D deficiency as a risk factor for urinary tract infection in women at reproductive age.

    abstract：:Vitamin D deficiency is a pandemic problem and an ever-increasing issue in human nutrition and health. Vitamin D (serum 25-hydroxyvitamin D) deficiency causes many health problems such as autoimmune diseases, Crohn's disease, diabetes, inflammation, asthma, hypertension, and cancer. Vitamin D3 (cholecalciferol) defici...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2020.08.008

    authors： Ali SB,Perdawood D,Abdulrahman R,Al Farraj DA,Alkubaisi NA

    更新日期：2020-11-01 00:00:00

  • Relationship between expression of CXCR7 and NF-κB in breast cancer tissue and occurrence of breast cancer and lymphatic metastasis.

    abstract：:It is designed to discuss the relationship between the expression of chemokine receptor 7 (chemokine receptor 7, CXCR7) and nuclear transcription factor-κB (nuclear factor kappa B, NF-κB) and the occurrence of the breast cancer and lymphatic metastasis. METHOD:80 samples were excised and confirmed as breast cancer th...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2017.11.009

    authors： Yuan CL,Liu ZH,Zou N,Wang YL,Chen ZY

    更新日期：2017-12-01 00:00:00

  • Impact of polycystic ovary syndrome on eating behavior, depression and health related quality of life: A cross-sectional study in Riyadh.

    abstract：Background & objectives:Polycystic ovary syndrome (PCOS) is the most common endocrinal disorder, and the greatest cause of infertility in women. Despite availability of individual data on impact of multiple endocrinal, reproductive and even metabolic factors in PCOS individuals, the data on the co-existence of BED and ...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2020.08.039

    authors： Asdaq SMB,Jomah S,Hasan R,Al-Baroudi D,Alharbi M,Alsubaie S,Buhamad MH,Alyahya B,Al-Yamani MJ

    更新日期：2020-12-01 00:00:00

  • Effects of verbenalin on prostatitis mouse model.

    abstract：:The aim of this study was to observe the treatment characteristics of verbenalin on a prostatitis mouse model. Give Xiaozhiling injection in the prostate locally to make a prostatitis mouse model. High, medium and low doses of verbenalin were each given to different mouse groups. The amount of water was determined in ...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2015.10.006

    authors： Miao M,Guo L,Yan X,Wang T,Li Z

    更新日期：2016-01-01 00:00:00

  • Molecular cloning and characterization of rosmarinic acid biosynthetic genes and rosmarinic acid accumulation in Ocimum basilicum L.

    abstract：:We have aimed to investigate the expression of genes related to rosmarinic acid (RA) synthesis and rosmarinic acid content in 2 Ocimum basilicum cultivars, green (cinnamon) and purple (red rubin) basil. Specifically, genes related to rosmarinic acid biosynthesis were cloned and characterized for O. basilicum. We obtai...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2017.03.010

    authors： Kwon DY,Li X,Kim JK,Park SU

    更新日期：2019-03-01 00:00:00

  • Ilizarov method in combination with autologous mesenchymal stem cells from iliac crest shows improved outcome in tibial non-union.

    abstract：:Autologous bone grafting and ilizarov technique are the preferred mode of treatment for bone nonunion, studies suggest that bone marrow derived mesenchymal stem cells can be effective in treatment of tibial non-union where there is length of bone defect. The current study investigates the beneficial clinical outcome o...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2016.11.001

    authors： Zhang H,Xue F,Jun Xiao H

    更新日期：2018-05-01 00:00:00

  • Traffic and industrial activities around Riyadh cause the accumulation of heavy metals in legumes: A case study.

    abstract：:The objective of this study was to analyse the effect of the continuously increasing anthropogenic activities around Riyadh, Saudi Arabia on the accumulation of heavy metals in leguminous crops. This study determined whether four legume crops, Pisum sativum L., Vicia faba L., Glycine max and Vigna sinensis, could accu...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2013.09.007

    authors： Alyemeni MN,Almohisen IA

    更新日期：2014-04-01 00:00:00

  • Phytophagous and predaceous mites associated with vegetable crops from Riyadh, Saudi Arabia.

    abstract：:This study was conducted to investigate phytophagous and predatory mites associated with vegetable plants in Riyadh, Saudi Arabia. Eight phytophagous and 10 predacious mites were collected from 14 species of vegetable crops covering five major production localities. Out of these 18 mite species, 13 species are new to ...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2011.02.004

    authors： Al-Atawi FJ

    更新日期：2011-07-01 00:00:00

  • BRAF gene: From human cancers to developmental syndromes.

    abstract：:The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.sjbs.2014.10.002

    authors： Hussain MR,Baig M,Mohamoud HS,Ulhaq Z,Hoessli DC,Khogeer GS,Al-Sayed RR,Al-Aama JY

    更新日期：2015-07-01 00:00:00

  • Effects of a medicinal plant Macrotyloma uniflorum (Lam.) Verdc.formulation (MUF) on obesity-associated oxidative stress-induced liver injury.

    abstract：:Obesity is a global health burden due to lifestyle modifications that have a strong association with a high incidence of diseases, such as dyslipidemia, glucose intolerance, nonalcoholic fatty liver diseases, diabetes, hypertension, coronary heart disease and cancer. The aim of the present study is to investigate the ...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2018.03.010

    authors： Bharathi V,Rengarajan RL,Radhakrishnan R,Hashem A,Abd Allah EF,Alqarawi AA,Anand AV

    更新日期：2018-09-01 00:00:00

  • Effect of environmental factors on the yield of selected mushroom species growing in two different agro ecological zones of Pakistan.

    abstract：:Mushrooms are a rich source of protein and vitamins as human food. In view of the growing importance of mushroom in Pakistan, a research study was initiated with the objective to examine the suitability of Oyster mushroom cultivation and to compare the growth and yield of Oyster mushroom in two different areas (Peshaw...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2010.06.004

    authors： Sher H,Al-Yemeni M,Bahkali AHA,Sher H

    更新日期：2010-10-01 00:00:00

  • Morphological characteristics of worm lizard, Diplometopon zarudnyi (Squamata: Trogonophidae), in the central region of Saudi Arabia.

    abstract：:We report morphometric data for 133 specimens of Diplometopon zarudnyi (Squamata: Trogonophidae) collected across its range within Riyadh province of Saudi Arabia. One-way analyses of variance revealed that differences exist in most characters. Snout-vent length and vent-tail length showed slight and inconsistent diff...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2016.12.003

    authors： Rudayni HA,Al-Sadoon MK,Paray BA

    更新日期：2017-05-01 00:00:00

  • The construction of the scoliosis 3D finite element model and the biomechanical analysis of PVCR orthopaedy.

    abstract：Objective:The objective is to investigate the biomechanical conditions of the Posterior Vertebral Column Resection (PVCR) of the constructed scoliosis 3D finite element model. Methods:A patient with scoliosis was selected; before the PVCR orthopaedy, the patient was submitted to the radiography of normal and lateral f...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2019.12.005

    authors： Chen X,Cai H,Zhang G,Zheng F,Wu C,Lin H

    更新日期：2020-02-01 00:00:00

  • Effect of long-term exposure to mobile phone radiation on alpha-Int1 gene sequence of Candida albicans.

    abstract：:Over the last decade, communication industries have witnessed a tremendous expansion, while, the biological effects of electromagnetic waves have not been fully elucidated. Current study aimed at evaluating the mutagenic effect of long-term exposure to 900-MHz radiation on alpha-Int1 gene sequences of Candida albicans...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2015.05.001

    authors： Shahin-Jafari A,Bayat M,Shahhosseiny MH,Tajik P,Roudbar-Mohammadi S

    更新日期：2016-05-01 00:00:00

  • Interference of phosphane copper (I) complexes of β-carboline with quorum sensing regulated virulence functions and biofilm in foodborne pathogenic bacteria: A first report.

    abstract：:Foodborne pathogens are one of the major cause of food-related diseases and food poisoning. Bacterial biofilms and quorum sensing (QS) mechanism of cell-cell communication have also been found to be associated with several outbreaks of foodborne diseases and are great threat to food safety. Therefore, In the present s...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2018.04.013

    authors： Al-Shabib NA,Husain FM,Khan RA,Khan MS,Alam MZ,Ansari FA,Laeeq S,Zubair M,Shahzad SA,Khan JM,Alsalme A,Ahmad I

    更新日期：2019-02-01 00:00:00

  • Cytogenotoxic effects of Adenium obesum seeds extracts on breast cancer cells.

    abstract：:The extracts prepared from various areal parts of the Adenium obesum (Forssk.) Roem. & Schult. (Family: Apocynaceae) including leaves, fruit and seeds ethanolic extracts and seed aqueous extract were evaluated against MCF-7 cells in order to investigate its potential of cytogenotoxicity and induction of apoptosis. The...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2018.12.014

    authors： Ali AQ,Farah MA,Abou-Tarboush FM,Al-Anazi KM,Ali MA,Lee J,Hailan WAQ,Mahmoud AH

    更新日期：2019-03-01 00:00:00

  • In vitro antibacterial activities of methanol and aqueous leave extracts of selected medicinal plants against human pathogenic bacteria.

    abstract：:People use medicinal plants as diet, and for treatment of infectious and noninfectious diseases and they use brief procedures like frying and cooking to do so. Medicinal plants; Moringa oleifera, Azadirachta indica, and Lepidium sativum which is believed to have active components that help to treat and manage various ...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2020.06.047

    authors： Ibrahim N,Kebede A

    更新日期：2020-09-01 00:00:00

  • Evaluation of in-vitro antioxidant and antibacterial properties of Commelina nudiflora L. extracts prepared by different polar solvents.

    abstract：:The study explored on the commonly available weed plant Commelina nudiflora which has potential in-vitro antioxidant and antimicrobial activity. The different polar solvents such as ethanol, chloroform, dichloromethane, hexane and aqueous were used for the soxhlet extraction. The extracts were identified pharmacologic...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2014.09.016

    authors： Kuppusamy P,Yusoff MM,Parine NR,Govindan N

    更新日期：2015-05-01 00:00:00

  • Integrated control of white rot disease on beans caused by Sclerotinia sclerotiorum using Contans® and reduced fungicides application.

    abstract：:This study was conducted to determine the compatibility of Contans® (Coniothyrium minitans) with fungicides against Sclerotinia sclerotiorum. Results showed that both Contans® and Topsin® significantly reduced the disease incidence caused by S. sclerotiorum by 90% and 95% survival plants, respectively when they were i...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2016.01.038

    authors： Elsheshtawi M,Elkhaky MT,Sayed SR,Bahkali AH,Mohammed AA,Gambhir D,Mansour AS,Elgorban AM

    更新日期：2017-02-01 00:00:00

  • D-Pinitol treatment induced the apoptosis in human leukemia MOLT-4 cells by improved apoptotic signaling pathway.

    abstract：:Cancer is still remain as a global burden with the 18.1 million and 9.6 million new cases and mortlities, respectively estimated globally. Leukemia may arise at all ages varied from the infants to elders. In this exploration, we planned to evaluate the antiproliferative effect of D-pinitol on human leukemia MOLT-4 cel...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章

    doi：10.1016/j.sjbs.2020.06.034

    authors： Yao X,Shi K,Yang Y,Gu X,Tan W,Wang Q,Gao X,Priya Veeraraghavan V,Mohan SK,Jin S

    更新日期：2020-08-01 00:00:00

  • A review of medicinal plant of Middle East and North Africa (MENA) region as source in tuberculosis drug discovery.

    abstract：:Tuberculosis (TB) is a disease that affects one-third of the world's population. Although currently available TB drugs have many side effects, such as nausea, headache and gastrointestinal discomfort, no new anti-TB drugs have been produced in the past 30 years. Therefore, the discovery of a new anti-TB agent with min...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.sjbs.2020.07.007

    authors： Dehyab AS,Bakar MFA,AlOmar MK,Sabran SF

    更新日期：2020-09-01 00:00:00

  • Lifestyle interventions for non-alcoholic fatty liver disease.

    abstract：:Non-alcoholic fatty liver disease (NAFLD) is a multi-factorial disease and the most common of chronic liver diseases worldwide. The four clinical-pathological entities which are usually followed by NAFLD course include non-alcoholic steatosis, non-alcoholic steatohepatitis, advanced fibrosis/cirrhosis, and hepatocellu...

    journal_title：Saudi journal of biological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.sjbs.2018.12.016

    authors： Ahmed IA,Mikail MA,Mustafa MR,Ibrahim M,Othman R

    更新日期：2019-11-01 00:00:00