Abstract：
:Autologous bone grafting and ilizarov technique are the preferred mode of treatment for bone nonunion, studies suggest that bone marrow derived mesenchymal stem cells can be effective in treatment of tibial non-union where there is length of bone defect. The current study investigates the beneficial clinical outcome of combining the ilizarov procedure with intraosseous injection of autologous mesenchymal stem cells. The open-label study enrolled 25 patients with infected tibial non-union at the Shanghai Fengxian District Central Hospital, Shanghai, China between April 2010 and July 2014. Patients were randomised to undergo the ilizarov procedure with (n = 11) or without (n = 13) intraosseous injection of bone marrow derived mesenchymal stem cells. All participants were followed prospectively until union was achieved (primary end point). The mean length of the bone defect in the Ilizarov group and Ilizarov group plus MSC group was 6.09 and 5.84 cm respectively. The mean time from the original injury to the time of the treatment for tibial non-union was 5-22 months (mean 13.5 months) for the Ilizarov group and 6-21 months (mean 13.5 months) for Ilizarov plus MSc group. All 24 patients were followed up for 12-34 months (mean 16 months). Both groups achieved the primary endpoint of stable union of the tibial fracture. No adverse events were observed in any of the group. Our study demonstrates that using autologous bone marrow derived mesenchymal stem cell as an add-on therapy to the ilizarov procedure shows significant clinical benefit in fixation of tibial non-union.
journal_name
Saudi J Biol Scijournal_title
Saudi journal of biological sciencesauthors
Zhang H,Xue F,Jun Xiao Hdoi
10.1016/j.sjbs.2016.11.001subject
Has Abstractpub_date
2018-05-01 00:00:00pages
819-825issue
4eissn
1319-562Xissn
2213-7106pii
S1319-562X(16)30156-5journal_volume
25pub_type
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章,评审
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Saudi journal of biological sciences
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更新日期：2020-07-01 00:00:00
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章,评审
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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更新日期：2018-07-01 00:00:00
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
doi：10.1016/j.sjbs.2014.04.005
更新日期：2015-01-01 00:00:00
abstract：:Feeding ecology of any species can help us to understand its natural history, ecological requirements and approaches involved in searching for food. Feeding ecology and sexual dimorphism in the horned viper, Cerastes cerastes gasperetti collected from the Al-Thumama area, central region of Saudi Arabia was described. ...
journal_title：Saudi journal of biological sciences
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
