当前位置： SCI文献检索 > SAUDI JOURNAL OF BIOLOGICAL SCIENCES期刊下所有文献 > Screening and identification of novel isolate Streptomyces sp., NLKPB45 from Nellore costal region for its biomedical applications.

Screening and identification of novel isolate Streptomyces sp., NLKPB45 from Nellore costal region for its biomedical applications.

Abstract：

:Actinobacteria, which are the prolific producers of antibiotics and significant suppliers to the pharmaceutical industry, can produce a wide variety of bioactive metabolites. An actinomycete strain designated NLKPB45 was isolated from mangrove soils samples of Nellore coastal regions Andhra Pradesh and assessed for antibiotic production and activity against pathogenic bacteria. From a total of 9 mangrove soil samples, 143 acinomycetes were isolated. Among the isolated them 6 actinomycetes strains showed potential antibacterial activity against at two tested pathogens gram positive and gram negative bacteria E. coli and S. aureus. The potent strain NLKPB45 was identified by 16S gene isolation and sequencing to the Streptomyces genus. The ethyl acetate extracts also as shown excellent antimicrobial activity against Salmonella sp., staphylococcus aureus, E. coli, and B. subtilus were detected in both the supernatant extract samples from fermentations of culture NLKPB45. The anticancer activity of extracts in the HeLa with IC50 value of 37.1924 μg/ml, MCF-7 IC50 value of 40.9177 μg/ml and HT 29 IC50 value of 43.3758 μg/ml.

journal_name

Saudi J Biol Sci

journal_title

Saudi journal of biological sciences

authors

Kalyani BS,Krishna PS,Sreenivasulu K

doi

10.1016/j.sjbs.2018.08.027

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1655-1660

issue

7

eissn

1319-562X

issn

2213-7106

pii

S1319-562X(18)30213-4

journal_volume

26

pub_type

杂志文章

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