Abstract:
:Survival rates among HIV patients have significantly improved since the introduction of antiretroviral therapy (ART) in HIV management. However, persistent disease progression and clinical complications in virally suppressed individuals point to additional contributing factors other than HIV replication; microbial translocation is one such factor. The role of underlying commensal microbes and microbial products that traverse the intestinal lumen into systemic circulation in the absence of overt bacteraemia is under current investigation. This review focuses on current knowledge of the complex microbial communities and microbial markers involved in the disruption of mucosal immune T-cells in the promotion of inflammatory processes in HIV infections. Unanswered questions and aims for future studies are addressed. We provide perspective for discussing potential future therapeutic strategies focused on modulating the gut microbiota to abate HIV disease progression.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Nwosu FC,Avershina E,Wilson R,Rudi Kdoi
10.1155/2014/803185subject
Has Abstractpub_date
2014-01-01 00:00:00pages
803185eissn
1687-6121issn
1687-630Xjournal_volume
2014pub_type
杂志文章,评审abstract:Aim:This study aims to analyze factors possibly related to the prognosis of duodenal gastrointestinal stromal tumors (DGISTs). Methods:We collected and retrospectively analyzed clinical and pathological data of 62 patients with primary DGISTs. All the patients were hospitalized and received complete surgical resection...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/4812703
更新日期:2018-02-20 00:00:00
abstract:Aim:This study is aimed at comparing gastric cancer T and N staging between virtual monochromatic energy images and fusion images generated by dual-source computed tomography (DSCT) dual-energy mode data acquisition prospectively while measuring the iodine concentration of gastric cancer and lymph nodes at different T ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/5015202
更新日期:2018-12-04 00:00:00
abstract::The hallmark of pancreatic tumours, the desmoplastic reaction, provides a unique microenvironment that affects pancreatic tumour behaviour, its ability to grow and metastasize as well as resist the effects of chemotherapy. Complex molecular interactions and pathways give rise to the desmoplastic reaction. Breakdown or...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/781765
更新日期:2012-01-01 00:00:00
abstract:Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/9065845
更新日期:2019-08-14 00:00:00
abstract::Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). In the innate immune system, Toll-like receptors (TLRs) are sensors that recognize bacterial and viral components such as lipopolysaccharide, bacterial DNA, and peptidoglycan. Recent ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2010/362847
更新日期:2010-01-01 00:00:00
abstract::High throughput methodologies have revealed the existence of an unexpectedly large number of long noncoding RNAs (lncRNAs). The unconventional role of lncRNAs in gene expression regulation and their broad implication in oncogenic and tumor suppressive pathways have introduced lncRNAs as novel biological tumor markers....
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/319861
更新日期:2015-01-01 00:00:00
abstract::Background. There are no studies investigating the relationship between endothelial nitric oxide synthase (eNOS) gene polymorphisms and hepatorenal syndrome (HRS). Aim. The purpose of this study is to elucidate whether eNOS gene polymorphisms (G894T and T-786C) play a role in the development of type-2 HRS. Methods. Th...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/2579626
更新日期:2016-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2013/381616.]. ...
journal_title:Gastroenterology research and practice
pub_type: 撤回出版物
doi:10.1155/2020/5109831
更新日期:2020-10-31 00:00:00
abstract:Purpose:To investigate the oncological outcome and survival of patients following a conservative approach on the portal-mesenteric axis, in an intraoperative ultrasound-selected group of pancreatoduodenectomy (PD), performed on patients with primary resectable with vascular contact (prVC) pancreatic ductal adenocarcino...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/1081494
更新日期:2018-11-25 00:00:00
abstract::Perioperative chemotherapy improves overall survival in patients with oesophagogastric adenocarcinoma (OAC) and locoregional disease. The mainstay of perioperative chemotherapy in these patients is a platinum/fluoropyrimidine combination. The phase III FLOT4 trial has shown that the FLOT triplet regimen (oxaliplatin, ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/5651903
更新日期:2017-01-01 00:00:00
abstract::The rapid rise of obesity and type 2 diabetes poses a global threat to healthcare and is a major cause of mortality and morbidity. Bariatric surgery has revolutionised the treatment of both these conditions but is invasive and associated with an increased risk of complications. The EndoBarrier is a device placed endos...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/7823182
更新日期:2018-07-26 00:00:00
abstract::Although the thread-traction (TT) method has been found useful during endoscopic submucosal dissection (ESD) for early gastric cancers, the movement of the thread interferes with the movement of the endoscope, and the lesion can only be pulled to the mouth side. We have developed the novel TT method using a sheath of ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/9415497
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to establish a retrospective evaluation and comparison of the hydrogen/methane (H2/CH4) breath test and genetic test (C/T-13910 polymorphism) results in lactose malabsorption testing. In total 263 consecutive patients with suspected lactose malabsorption were included in this study. They unde...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/464382
更新日期:2014-01-01 00:00:00
abstract:Aims:To evaluate the impact of body mass index (BMI) on the surgical outcome of laparoscopic total mesorectal excision (laTME) for locally advanced rectal cancer (LARC, clinically staged as UICC stage II/III) after neoadjuvant chemoradiotherapy (nCRT). Methods:312 LARC patients undergoing laTME after nCRT were divided...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1509140
更新日期:2017-01-01 00:00:00
abstract::Gastrointestinal (GI) adverse effects such as erosion and increased permeability are common during the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Our objective was to assess whether Bifidobacterium animalis ssp. lactis 420 protects against NSAID-induced GI side effects in a rat model. A total of 120 male Wi...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/615051
更新日期:2012-01-01 00:00:00
abstract::Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/2676513
更新日期:2017-01-01 00:00:00
abstract::Objectives. This study is aimed at studying the prevalence and characteristics of different types of headaches in patients with Crohn's disease. Materials and Methods. 51 patients in Crohn's disease group (F/M: 26/25) and 51 patients in control group (F/M: 27/24) were involved. Patients in Crohn's disease group were d...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/6474651
更新日期:2016-01-01 00:00:00
abstract:Background and Aims:Magnetic resonance enterography (MRE) has become an important modality of radiological imaging in the evaluation of Crohn's disease (CD). The aim of this study was to investigate the impact of MRE in the assessment of disease activity and abdominal complications and in the making of therapeutic deci...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3467316
更新日期:2019-12-17 00:00:00
abstract::Endoscopic retrograde cholangiopancreatography (ERCP) can fail in 3-10% of the cases even in experienced hands. Although percutaneous transhepatic cholangiography (PTC) and surgery are the traditional alternatives, there are morbidity and mortality associated with both. In this paper, we have discussed the efficacy an...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/869214
更新日期:2013-01-01 00:00:00
abstract::Nonerosive reflux disease (NERD) is a distinct pattern of gastroesophageal reflux disease (GERD). It is defined as a subcategory of GERD characterized by troublesome reflux-related symptoms in the absence of esophageal mucosal erosions/breaks at conventional endoscopy. In clinical practice, patients with reflux sympto...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/653989
更新日期:2013-01-01 00:00:00
abstract::Previous studies have shown the high diagnostic accuracy of narrow-band imaging magnifying endoscopy (NBI-ME) and Lugol chromoendoscopy with pink-color sign assessment (LCE-PS) for superficial esophageal squamous cell carcinoma (SESCC). However, there has been no controlled trial comparing these two diagnostic techniq...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/639462
更新日期:2015-01-01 00:00:00
abstract:BACKGROUNDS:Magnifying endoscopy with blue laser imaging (ME-BLI) for diagnosis of early gastric cancer (EGC) is as effective as magnifying endoscopy with narrow-band imaging (ME-NBI). However, there are different EGCs in microstructure visualization between ME-BLI and ME-NBI. This study aimed to clarify the pathologic...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8303046
更新日期:2017-01-01 00:00:00
abstract:Background/Aim:Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/1262595
更新日期:2019-05-06 00:00:00
abstract:Aim:To determine the risk factors of nonadherence to azathioprine (AZA) maintenance therapy for Crohn's disease (CD) and to evaluate the influence of patients' educational program on adherence to AZA maintenance therapy. Methods:Patients receiving AZA as maintenance therapy for CD were enrolled. Demographic data, clin...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6848293
更新日期:2020-04-20 00:00:00
abstract:Background:The objective of this study was to determine the factors associated with severity of acute pancreatitis (AP) according to two major etiologies: alcohol and gallstones. Methods:We reviewed the medical records of consecutive patients who were admitted with AP between January 2003 and January 2013. A total of ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1219464
更新日期:2017-01-01 00:00:00
abstract::Background. Since the incidence of adenocarcinoma of the oesophagus is rising, the prognosis is poor, and surveillance programs are expensive and mostly cost ineffective, there is a need to increase the knowledge of risk factors in Barrett's oesophagus and oesophageal cancer in order to be able to give attention to me...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/408470
更新日期:2014-01-01 00:00:00
abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/4946068
更新日期:2017-01-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a chronic cholestatic liver condition characterized by the immune-mediated damage of the intrahepatic bile ducts. Polymorphisms of vitamin D receptor (VDR) are considered to contribute to its pathogenesis however their incidence varies in different populations and their potential ass...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/408723
更新日期:2012-01-01 00:00:00
abstract::Background. Surgical treatment of hydatid liver disease (HLD) is divided into conservative and radical procedures. While conservative techniques are easier and faster to perform, there is an emerging need to reduce their morbidity and recurrence rates. Our aim was to present and evaluate the efficiency and safety of t...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/1078653
更新日期:2016-01-01 00:00:00
abstract::Introduction. The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC). Material and Methods. The serum levels of study factors were measured in 73 patients with CRC and in 35 ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/146819
更新日期:2015-01-01 00:00:00