Abstract:
:Introduction. The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC). Material and Methods. The serum levels of study factors were measured in 73 patients with CRC and in 35 healthy controls who were gender- and BMI-matched to the study group. Concentrations of oxLDL, o-LAB, and CEA were detected in ELISA tests. Serum lipids, lipoproteins, and glucose levels were also coestimated. Results. Age and o-LAB were significant factors of CRC presence, but results of logistic regression analysis showed that both were weak predictors of CRC risk. Concentration of o-LAB was significantly higher in colon cancer than in rectal cancer, especially when the cancer was located in the right section of colon. Serum CEA levels were significantly elevated in the advanced stage of disease, primary tumor progression, angiolymphatic invasion, and presence of distant metastasis. Conclusions. Obtained results have demonstrated that oxLDL and o-LAB were not satisfactory risk markers of CRC. Although significant relation between o-LAB level and CRC is observed, it may be rather the result of individual differences in the host immune responses against cancer.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Diakowska D,Grabowski K,Nienartowicz M,Zarębski P,Fudalej K,Markocka-Mączka Kdoi
10.1155/2015/146819subject
Has Abstractpub_date
2015-01-01 00:00:00pages
146819eissn
1687-6121issn
1687-630Xjournal_volume
2015pub_type
杂志文章abstract::Background. Endoscopic-Ultrasonography- (EUS-) guided puncture and drainage of pancreatic pseudocyst is currently one of the most widely accepted nonsurgical treatments. To date, this technique has only been used for pancreatic pseudocysts adhesive to the gastric wall. This study introduces the technique of EUS-guided...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/785483
更新日期:2013-01-01 00:00:00
abstract:Aim:To determine the risk factors of nonadherence to azathioprine (AZA) maintenance therapy for Crohn's disease (CD) and to evaluate the influence of patients' educational program on adherence to AZA maintenance therapy. Methods:Patients receiving AZA as maintenance therapy for CD were enrolled. Demographic data, clin...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6848293
更新日期:2020-04-20 00:00:00
abstract::Background and Aim. EUS-guided intervention (EGI) for biliary therapy has been increasingly used in recent years. This report aims to describe the spectrum and experience of EUS-guided interventions in biliary diseases in a single-tertiary center. Methods. All patients with EGI were analyzed retrospectively by retriev...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/680753
更新日期:2012-01-01 00:00:00
abstract:Background/Aim:Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/1262595
更新日期:2019-05-06 00:00:00
abstract::Background/Aims. This study aimed to establish optimal propofol anesthesia for therapeutic endoscopy, which has not been established. Methodology. We retrospectively investigated data on 89 patients who underwent upper-GI endoscopic submucosal dissection or endoscopic mucosal resection under anesthesia with propofol. ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/282149
更新日期:2015-01-01 00:00:00
abstract:Background and Aims:We retrospectively investigated the incidence of acute graft-versus-host disease (GVHD) in the lower gastrointestinal (GI) tract and the diagnostic accuracy of endoscopy. Methods:Of 1231 patients who underwent allogeneic hematopoietic stem cell transplantation between January 2005 and December 2014...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/2145986
更新日期:2017-01-01 00:00:00
abstract::Background. Little data on directly comparing chemoradiotherapy with observation has yet been published in the setting of adjuvant therapy for resected gastric cancer who underwent D2 lymphadenectomy. The present indirect comparison aims to provide more evidence on comparing the two approaches. Methods. We conducted a...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/634929
更新日期:2013-01-01 00:00:00
abstract::Purpose. Radical surgical resection with adjuvant chemotherapy or chemo-radiotherapy is the most effective treatment for pancreatic ductal adenocarcinoma (PDAC). However, relatively few studies investigate the prognostic significance of biological markers in PDAC. This study aims to look into the expressions of viment...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/9207616
更新日期:2017-01-01 00:00:00
abstract::Introduction. Neoadjuvant chemoradiotherapy and total mesorectal excision are considered the standard treatment for locally advanced rectal cancer. Various studies have reported pathological downstaging and a complete pathological response rate of 15%-27% following neoadjuvant chemoradiotherapy which has translated in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/867841
更新日期:2014-01-01 00:00:00
abstract::Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of pati...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6126707
更新日期:2017-01-01 00:00:00
abstract::Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis m...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/979506
更新日期:2012-01-01 00:00:00
abstract::Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was inject...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8438172
更新日期:2017-01-01 00:00:00
abstract:Objective:To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/5609623
更新日期:2020-09-30 00:00:00
abstract:Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/9065845
更新日期:2019-08-14 00:00:00
abstract::The following is a case report of a primiparous woman who developed fulminant liver failure in the setting of HELLP syndrome complicated by hepatic rupture. It is unique in that a timely ABO compatible liver donor was unavailable, necessitating the transplantation of an ABO incompatible organ. Despite aggressive thera...
journal_title:Gastroenterology research and practice
pub_type:
doi:10.1155/2009/713937
更新日期:2009-01-01 00:00:00
abstract::Background. Apoptotic rates in peripheral blood lymphocytes can predict radiation induced normal tissue toxicity. We studied whether apoptosis in lymphocytes has a prognostic value for therapy outcome. Methods. Lymphocytes of 87 rectal cancer patients were ex vivo irradiated with 2 Gy, 8 Gy, or a combination of 2 Gy i...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/5076542
更新日期:2016-01-01 00:00:00
abstract:Introduction:Abdominal and anorectal disorders may be the cause of clinical decompensation in neutropenic febrile patients, particularly those with hematologic diseases. Infection is a cause for concern for the colorectal surgeon. Some conditions have few manifestations and can lead to death within a short period of ti...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/4175960
更新日期:2019-03-24 00:00:00
abstract::Survival rates among HIV patients have significantly improved since the introduction of antiretroviral therapy (ART) in HIV management. However, persistent disease progression and clinical complications in virally suppressed individuals point to additional contributing factors other than HIV replication; microbial tra...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2014/803185
更新日期:2014-01-01 00:00:00
abstract:Background:Our aim was to assess the risk of gastrointestinal (GI) hemorrhage associated with diabetes among patients taking low-dose aspirin (≤325 mg/day). Methods:A systematic search was conducted for publication in English and Chinese using term equivalents for "GI hemorrhage", "aspirin", and "diabetes mellitus" up...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2020/9824615
更新日期:2020-08-03 00:00:00
abstract:Background:The aim of this study was to evaluate the risk of development of colorectal adenomas in patients with colorectal cancer (CRC) with and without colonic diverticulosis. Methods:We performed a retrospective cohort study that included patients with CRC between 2008 and 2011. All patients underwent preoperative ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/8901026
更新日期:2019-05-20 00:00:00
abstract:Background:Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), and hepatitis C virus (HCV) infection is a leading cause of CLD, cirrhosis, and hepatocellular carcinoma (HCC). This study is aimed at assessing HRQOL in patients with HCV infection...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/6716103
更新日期:2020-01-07 00:00:00
abstract::Epstein-Barr virus (EBV) is an important DNA virus which establishes latent infection in human malignancies. Expression of EBV-encoded genes in the associated tumors is strongly modulated by promoter CpG methylation of EBV genome. This study aimed to explore the methylation status of the promoters of EBV BamHI-A right...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/3804146
更新日期:2017-01-01 00:00:00
abstract::Ovarian cancer peritoneal carcinomatosis requires a multimodal-treatment approach. Current treatment considerations are analyzed in this update and include the management of recurrent malignant ascites and the understanding of its pathophysiology, the role of peritoneal washing cytology in detecting peritoneal metasta...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/5284814
更新日期:2018-04-05 00:00:00
abstract:Objectives:To determine the prevalence and effect of dietary habits on functional constipation in preschool and early elementary school children in Japan. Study Design:A total of 3595 children aged 3 to 8 years from 28 nursery schools and 22 elementary schools in Yokohama City, Kanagawa Prefecture, Japan, were evaluat...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/3108021
更新日期:2018-02-27 00:00:00
abstract:Aim:Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocy...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5705782
更新日期:2019-06-10 00:00:00
abstract::Gastric ectopic pancreas is an uncommon developmental anomaly and its histological diagnosis is usually difficult by using a conventional biopsy forceps. In the literature, most cases of gastric ectopic pancreas were usually diagnosed by gross pattern during endoscopic examination or features of endoscopic ultrasound....
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/160601
更新日期:2014-01-01 00:00:00
abstract::Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postcon...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/2604032
更新日期:2016-01-01 00:00:00
abstract::Background and Aims. A retrospective cross-sectional study was conducted to evaluate the role of hyaluronic acid (HA), laminin (LN), amino-terminal propeptide of type III procollagen (PIIINP), and collagen IV (CIV) in predicting the presence of gastroesophageal varices (GEVs) in patients with liver cirrhosis. Methods....
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/274534
更新日期:2015-01-01 00:00:00
abstract::Gastrointestinal (GI) adverse effects such as erosion and increased permeability are common during the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Our objective was to assess whether Bifidobacterium animalis ssp. lactis 420 protects against NSAID-induced GI side effects in a rat model. A total of 120 male Wi...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/615051
更新日期:2012-01-01 00:00:00
abstract:Background and Aim:Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods:Patients ≥ 50...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6710931
更新日期:2017-01-01 00:00:00