Association of eNOS Gene Polymorphisms G894T and T-786C with Risk of Hepatorenal Syndrome.

Abstract:

:Background. There are no studies investigating the relationship between endothelial nitric oxide synthase (eNOS) gene polymorphisms and hepatorenal syndrome (HRS). Aim. The purpose of this study is to elucidate whether eNOS gene polymorphisms (G894T and T-786C) play a role in the development of type-2 HRS. Methods. This study was carried out in a group of 92 patients with cirrhosis (44 patients with type-2 HRS and 48 without HRS) and 50 healthy controls. Polymorphisms were determined by polymerase chain reaction (PCR) and melting curve analysis. Results. We did not find any significant difference in allele and genotype distributions of the eNOS -T-786C polymorphism among the groups (p = 0.440). However, the frequency of GT (40.9%) and TT (13.6%) genotypes and mutant allele T (34.1%) for the eNOS G894T polymorphism were significantly higher (p < 0.001 and p < 0.001, resp.) in the HRS group than in both the stable cirrhosis (14.6%, 4.2%, and 11.5%, resp.) and the control (22.0%, 2.0%, and 13.0%, resp.) groups. Conclusion. The occurrence of mutant genotypes (GT/TT) and mutant allele T in eNOS -G894T polymorphisms should be considered as a potential risk factor in cirrhotic patients with HRS.

authors

Seckin Y,Yigit A,Yesilada E,Gulbay G,Cagin YF,Gozukara H,Bılgıc Y,Yildirim O,Turkoz Y,Aksungur Z

doi

10.1155/2016/2579626

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

2579626

eissn

1687-6121

issn

1687-630X

journal_volume

2016

pub_type

杂志文章
  • Efficacy of 7-Day and 14-Day Triple Therapy Regimens for the Eradication of Helicobacter pylori: A Comparative Study in a Cohort of Romanian Patients.

    abstract::Objective. This study compared the eradication rates of of Helicobacter pylori (HP) infection by a 7-day and 14-day anti-HP regimen. Materials and Methods. An open, randomized, prospective study was performed to evaluate the response to anti-HP treatment in adult HP-positive patients following a 7-day course (Regimen ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/5061640

    authors: Arama SS,Tiliscan C,Negoita C,Croitoru A,Arama V,Mihai CM,Pop F,Garg A

    更新日期:2016-01-01 00:00:00

  • 24-Hour Measurement of Gastric pH in Rural South Africa.

    abstract::Background. Previous studies have established norms of 24-hour gastric pH profiles for western countries. This study was designed to establish the pattern for a rural African population with a high incidence of oesophageal cancer. Methods. After lower oesophageal manometry a probe was placed 10 cm distal to the lower ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/658106

    authors: Sammon AM,Ndebia EJ,Umapathy E,Iputo JE

    更新日期:2015-01-01 00:00:00

  • Therapeutic endoscopic ultrasonography: intratumoral injection for pancreatic adenocarcinoma.

    abstract::Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultraso...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/207129

    authors: Shirley LA,Aguilar LK,Aguilar-Cordova E,Bloomston M,Walker JP

    更新日期:2013-01-01 00:00:00

  • Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study.

    abstract:Background and Aims:Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients. Methods:All UC pati...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/4195968

    authors: Pugliese D,Aratari A,Festa S,Ferraro PM,Monterubbianesi R,Guidi L,Scribano ML,Papi C,Armuzzi A

    更新日期:2018-10-03 00:00:00

  • Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis.

    abstract::Autophagy is a catabolic process by which a cell degrades its intracellular materials to replenish itself. Induction of autophagy under various cellular stress stimuli can lead to either cell survival or cell death via apoptotic and/or autophagic (nonapoptotic) pathways. The NSAID sulindac sulfide induces apoptosis in...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/897678

    authors: Chiou SK,Hoa N,Ge L,Jadus MR

    更新日期:2012-01-01 00:00:00

  • Indirect comparison showed survival benefit from adjuvant chemoradiotherapy in completely resected gastric cancer with d2 lymphadenectomy.

    abstract::Background. Little data on directly comparing chemoradiotherapy with observation has yet been published in the setting of adjuvant therapy for resected gastric cancer who underwent D2 lymphadenectomy. The present indirect comparison aims to provide more evidence on comparing the two approaches. Methods. We conducted a...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2013/634929

    authors: Yang Q,Wei Y,Chen YX,Zhou SW,Jiang ZM,Xie DR

    更新日期:2013-01-01 00:00:00

  • Prognostic Roles of Inflammatory Markers in Pancreatic Cancer: Comparison between the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio.

    abstract:Background/Objectives:This meta-analysis is aimed at investigating the prognostic roles of the inflammatory markers neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with pancreatic cancer. Methods:The correlations between high inflammatory marker expression levels and prognosis i...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/9745601

    authors: Oh D,Pyo JS,Son BK

    更新日期:2018-06-07 00:00:00

  • The Relationship between C-Reactive Protein/Albumin Ratio and Disease Activity in Patients with Inflammatory Bowel Disease.

    abstract:Objectives:The aims of this study were to evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers, and parameters from the complete blood count (CBC) in patients with inflammatory bowel disease (IBD) and their associations with disease activity. Methods:A total of 876 IBD patients, composed of 27...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/3467419

    authors: Chen YH,Wang L,Feng SY,Cai WM,Chen XF,Huang ZM

    更新日期:2020-06-22 00:00:00

  • Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis.

    abstract::Background. Differentiating branch duct from mixed intraductal papillary mucinous neoplasm (BD-IPMN) is problematic, but clinically important as mixed IPMNs are managed surgically, while some BD-IPMN may be followed. Inflammatory mediator proteins (IMPs) have been implicated in acute and chronic inflammatory and malig...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/247309

    authors: Lee LS,Bellizzi AM,Banks PA,Sainani NI,Kadiyala V,Suleiman S,Conwell DL,Paulo JA

    更新日期:2012-01-01 00:00:00

  • The effects of 5-hydroxytryptophan in combination with different Fatty acids on gastrointestinal functions: a pilot experiment.

    abstract::Background. Fat affects gastric emptying (GE). 5-Hydroxythryptophan (5-HTP) is involved in central and peripheral satiety mechanisms. Influence of 5-HTP in addition to saturated or monounsaturated fatty acids (FA) on GE and hormone release was investigated. Subjects/Methods. 24 healthy individuals (12f : 12m, 22-29 ye...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/424503

    authors: Sauer H,Mack I,Kohler S,Siegle S,Rieber N,Zipfel S,Otto B,Ritze Y,Bischoff SC,Enck P

    更新日期:2014-01-01 00:00:00

  • Establish a Scoring Model for High-Risk Population of Gastric Cancer and Study on the Pattern of Opportunistic Screening.

    abstract:Objective:To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern o...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/5609623

    authors: Tao W,Wang HX,Guo YF,Yang L,Li P

    更新日期:2020-09-30 00:00:00

  • Duodenal Rare Neuroendocrine Tumor: Clinicopathological Characteristics of Patients with Gangliocytic Paraganglioma.

    abstract::Gangliocytic paraganglioma (GP) has been regarded as a rare benign tumor that commonly arises from the second part of the duodenum. As GP does not exhibit either prominent mitotic activity or Ki-67 immunoreactivity, it is often misdiagnosed as neuroendocrine tumor (NET) G1. However, the prognosis might be better in pa...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5257312

    authors: Okubo Y,Yokose T,Motohashi O,Miyagi Y,Yoshioka E,Suzuki M,Washimi K,Kawachi K,Nito M,Nemoto T,Shibuya K,Kameda Y

    更新日期:2016-01-01 00:00:00

  • Efficacy of i-Scan Imaging for the Detection and Diagnosis of Early Gastric Carcinomas.

    abstract::We determined comparative efficacy of i-Scan for detection and diagnosis of gastric cancer. Ten patients diagnosed with early gastric cancer based on histopathological findings were analyzed. White light and i-Scan moving images recorded from these patients in twin mode were separated into white light and i-Scan. Twel...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/819395

    authors: Nishimura J,Nishikawa J,Nakamura M,Goto A,Hamabe K,Hashimoto S,Okamoto T,Suenaga M,Fujita Y,Hamamoto Y,Sakaida I

    更新日期:2014-01-01 00:00:00

  • Minimal Open Access Ileocolic Resection in Complicated Crohn's Disease of the Terminal Ileum.

    abstract::The objective of this study was to evaluate the possibility to undertake an ileocolic resection in complex Crohn's disease using a minimal open abdominal access using standard laparoscopic instruments. The incision was carried out over the previous McBurney scar, with a mean length of 6 cm. Seventy-two patients with c...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/6019435

    authors: Sica GS,Di Carlo S,D'Ugo S,Arcudi C,Siragusa L,Fazzolari L,Biancone L,Monteleone G,Cardi M,Sibio S

    更新日期:2020-02-28 00:00:00

  • Evaluation of the effectiveness of endoscopic retrograde cholangiopancreatography in patients with perihilar cholangiocarcinoma and its effect on development of cholangitis.

    abstract::Objective. We aimed to determine the effectiveness of endoscopic retrograde cholangiopancreatography (ERCP) in patients with inoperable perihilar cholangiocarcinoma and establish the incidence of cholangitis development following ERCP. Material and Method. This retrospective study enrolled patients diagnosed with inop...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/508286

    authors: Ipek S,Alper E,Cekic C,Cerrah S,Arabul M,Aslan F,Unsal B

    更新日期:2014-01-01 00:00:00

  • Dynamic Detection of Monocyte Subsets in Peripheral Blood of Patients with Acute Hypertriglyceridemic Pancreatitis.

    abstract:Aim:Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocy...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/5705782

    authors: Zheng J,Fan J,Huang C,Lu Y,Huang Z,Wang X,Zeng Y

    更新日期:2019-06-10 00:00:00

  • Laparoscopic Appendectomy versus Mini-Incision Appendectomy in Patients with Lower Body Mass Index and Noncomplicated Appendicitis.

    abstract::Laparoscopic appendectomy has become favored over open surgical methods for its association with decreased postoperative pain, more rapid return to daily activities, and improved cosmetic results. Mini-incision appendectomy was being performed in our clinic for a long time especially in patients with noncomplicated ap...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/138648

    authors: Özsan İ,Karabuğa T,Yoldaş Ö,Alpdoğan Ö,Aydın Ü

    更新日期:2014-01-01 00:00:00

  • Current advances in the diagnosis and treatment of nonerosive reflux disease.

    abstract::Nonerosive reflux disease (NERD) is a distinct pattern of gastroesophageal reflux disease (GERD). It is defined as a subcategory of GERD characterized by troublesome reflux-related symptoms in the absence of esophageal mucosal erosions/breaks at conventional endoscopy. In clinical practice, patients with reflux sympto...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/653989

    authors: Chen CL,Hsu PI

    更新日期:2013-01-01 00:00:00

  • Narrow-Band Imaging Magnifying Endoscopy versus Lugol Chromoendoscopy with Pink-Color Sign Assessment in the Diagnosis of Superficial Esophageal Squamous Neoplasms: A Randomised Noninferiority Trial.

    abstract::Previous studies have shown the high diagnostic accuracy of narrow-band imaging magnifying endoscopy (NBI-ME) and Lugol chromoendoscopy with pink-color sign assessment (LCE-PS) for superficial esophageal squamous cell carcinoma (SESCC). However, there has been no controlled trial comparing these two diagnostic techniq...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/639462

    authors: Goda K,Dobashi A,Yoshimura N,Kato M,Aihara H,Sumiyama K,Toyoizumi H,Kato T,Ikegami M,Tajiri H

    更新日期:2015-01-01 00:00:00

  • Optimization of Deep Sedation with Spontaneous Respiration for Therapeutic Endoscopy Combining Propofol and Bispectral Index Monitoring.

    abstract::Background/Aims. This study aimed to establish optimal propofol anesthesia for therapeutic endoscopy, which has not been established. Methodology. We retrospectively investigated data on 89 patients who underwent upper-GI endoscopic submucosal dissection or endoscopic mucosal resection under anesthesia with propofol. ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/282149

    authors: Matsumoto K,Nagahara A,Matsumoto K,Akazawa Y,Komori H,Nakagawa Y,Takeda T,Ueyama H,Shimada Y,Asaoka D,Hojo M,Watanabe S

    更新日期:2015-01-01 00:00:00

  • The interplay of the gut microbiome, bile acids, and volatile organic compounds.

    abstract::Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/398585

    authors: Sagar NM,Cree IA,Covington JA,Arasaradnam RP

    更新日期:2015-01-01 00:00:00

  • A Downmodulated MicroRNA Profiling in Patients with Gastric Cancer.

    abstract::Objective. Here, we aim to investigate the microRNA (miR) profiling in human gastric cancer (GC). Methods. Tumoral and matched peritumoral gastric specimens were collected from 12 GC patients who underwent routine surgery. A high-throughput miR sequencing method was applied to detect the aberrantly expressed miRs in a...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/1526981

    authors: Zhang T,Liu C,Huang S,Ma Y,Fang J,Chen Y

    更新日期:2017-01-01 00:00:00

  • Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity.

    abstract:Objective:Fucosterol is derived from the brown alga Eisenia bicyclis and has various biological activities, including antioxidant, anticancer, and antidiabetic properties. The aim of this study was to investigate the protective effects of fucosterol pretreatment on Concanavalin A- (ConA-) induced acute liver injury in ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/2824139

    authors: Mo W,Wang C,Li J,Chen K,Xia Y,Li S,Xu L,Lu X,Wang W,Guo C

    更新日期:2018-07-17 00:00:00

  • Prevalence of Functional Constipation and Relationship with Dietary Habits in 3- to 8-Year-Old Children in Japan.

    abstract:Objectives:To determine the prevalence and effect of dietary habits on functional constipation in preschool and early elementary school children in Japan. Study Design:A total of 3595 children aged 3 to 8 years from 28 nursery schools and 22 elementary schools in Yokohama City, Kanagawa Prefecture, Japan, were evaluat...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/3108021

    authors: Fujitani A,Sogo T,Inui A,Kawakubo K

    更新日期:2018-02-27 00:00:00

  • Small intestinal tumours.

    abstract::Objective. Balloon enteroscopy (BE) and capsule enteroscopy (CE) are enteroscopy methods that allow examination and treatment of the small bowel. Before the CE and BE era, the small intestine was difficult to access for investigation. Small intestinal tumours are infrequent conditions, but about half of them are malig...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/702536

    authors: Kopáčová M,Rejchrt S,Bureš J,Tachecí I

    更新日期:2013-01-01 00:00:00

  • Epidemiological and Clinical-Pathological Aspects of Helicobacter pylori Infection in Brazilian Children and Adults.

    abstract:Aim:To evaluate the prevalence and risk factors of H. pylori infection in the pediatric and adult population seen at a public hospital in São José do Rio Preto, SP, Brazil. Methods:This is a retrospective study that evaluated 2406 medical records of children, adolescents, and adults with dyspeptic symptoms who underwe...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/8454125

    authors: Toscano EP,Madeira FF,Dutra-Rulli MP,Gonçalves LOM,Proença MA,Borghi VS,Cadamuro ACT,Mazzale GW,Acayaba R,Silva AE

    更新日期:2018-09-04 00:00:00

  • Thromboelastography in Patients with Inflammatory Bowel Disease.

    abstract:Purpose:Patients with inflammatory bowel disease (IBD) frequently suffer from venous thromboembolic events, and the risk of thromboembolism increases along with disease activity. This study was conducted to discover novel thrombophilic markers using thromboelastography (TEG) and to evaluate the relation between the pre...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/3245657

    authors: Shen Y,Shi L,Zhang J,Zhu H,Yao Y,Liu Z,Zou X,Zhang X

    更新日期:2020-05-20 00:00:00

  • Endoscopic Ultrasound-Guided Biliary Drainage Using Self-Expandable Metal Stent for Malignant Biliary Obstruction.

    abstract::Purpose. Endoscopic ultrasound-guided biliary drainage (EUS-BD) has been increasingly reported worldwide. However, studies concerning EUS-BD from Mainland China are sporadic. This study aims to investigate the feasibility, efficacy, and safety of EUS-BD using SEMS in a single center from Mainland China. Methods. Betwe...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/6284094

    authors: Lu L,Tang X,Jin H,Yang J,Zhang X

    更新日期:2017-01-01 00:00:00

  • Proximal Sessile Serrated Adenomas Are More Prevalent in Caucasians, and Gastroenterologists Are Better Than Nongastroenterologists at Their Detection.

    abstract:Background and Aim:Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods:Patients ≥ 50...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/6710931

    authors: Parikh MP,Muthukuru S,Jobanputra Y,Naha K,Gupta NM,Wadhwa V,Lopez R,Thota PN,Sanaka MR

    更新日期:2017-01-01 00:00:00

  • Percutaneous fine needle biopsy in pancreatic tumors: a study of 42 cases.

    abstract::The technological progress within the range of methods of pancreas imaging and their more common accessibility selects a group of patients requiring a microscopic diagnosis. Percutaneous fine needle aspiration biopsy under the control of ultrasonography (PCFNA/USG) is the method commonly used in determining the charac...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/908963

    authors: Lewitowicz P,Matykiewicz J,Heciak J,Koziel D,Gluszek S

    更新日期:2012-01-01 00:00:00