Abstract:
:Objective. This study compared the eradication rates of of Helicobacter pylori (HP) infection by a 7-day and 14-day anti-HP regimen. Materials and Methods. An open, randomized, prospective study was performed to evaluate the response to anti-HP treatment in adult HP-positive patients following a 7-day course (Regimen A) of a proton pump inhibitor in association with clarithromycin and amoxicillin compared to a 14-day course (Regimen B). Gastric biopsies were performed at baseline and two months after anti-HP treatment. Results. Seventy-eight patients aged 18-64 years (28 males, 50 females) diagnosed with HP infection were included. Fifty-two (66.7%) patients received Regimen B and 26 (33.3%) Regimen A. The overall eradication rate was 70.5%. Better treatment response (p < 0.01) was seen in Regimen B (44/52, 84.2% versus 11/26, 42.3%). Significant improvement in histological features was seen in regimen B. There has been significant overall reduction in endoscopic aspects of gastric and duodenal lesions in both regimens. Younger patients ≤35 years had a better response to Regimen B. Better treatment response was seen in women, urban residents, and those with tertiary level of education in both groups. Conclusion. 14-day anti-HP regimen offered a significant better overall eradication of HP in study population.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Arama SS,Tiliscan C,Negoita C,Croitoru A,Arama V,Mihai CM,Pop F,Garg Adoi
10.1155/2016/5061640subject
Has Abstractpub_date
2016-01-01 00:00:00pages
5061640eissn
1687-6121issn
1687-630Xjournal_volume
2016pub_type
杂志文章abstract::Purpose. Endoscopic ultrasound-guided biliary drainage (EUS-BD) has been increasingly reported worldwide. However, studies concerning EUS-BD from Mainland China are sporadic. This study aims to investigate the feasibility, efficacy, and safety of EUS-BD using SEMS in a single center from Mainland China. Methods. Betwe...
journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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doi:10.1155/2017/3826087
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doi:10.1155/2017/8303046
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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doi:10.1155/2014/819395
更新日期:2014-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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更新日期:2018-07-17 00:00:00
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journal_title:Gastroenterology research and practice
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doi:10.1155/2014/473846
更新日期:2014-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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更新日期:2012-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/897678
更新日期:2012-01-01 00:00:00