Abstract:
:Background. Differentiating branch duct from mixed intraductal papillary mucinous neoplasm (BD-IPMN) is problematic, but clinically important as mixed IPMNs are managed surgically, while some BD-IPMN may be followed. Inflammatory mediator proteins (IMPs) have been implicated in acute and chronic inflammatory and malignant pancreatic diseases. Aim. To compare IMP profile of pancreatic cyst fluid collected endoscopically from BD-IPMN and mixed IPMN. Methods. Pancreatic cyst fluid from ten patients (5 BD-IPMN and 5 mixed IPMN) was collected by endoscopic ultrasound-guided fine needle aspiration or endoscopic retrograde cholangiopancreatography. Concentrations of 89 IMPs in these samples were determined using a multiplexed bead-based microarray protein assay and compared between BD-IPMN and mixed IPMN. Results. Eighty-six of 89 IMPs were detected in at least one of the 10 samples. Fourteen IMPs were detected only in mixed IPMN, while none were only in BD-IPMN. Of these, TGF-β1 was most prevalent, present in 3 of 5 mixed IPMNs. Seventy-two IMPs were detected in both BD-IPMN and mixed IPMNs. Of these, only G-CSF (P < 0.05) was present in higher concentrations in mixed IPMNs. Conclusion. TGF-β1 and G-CSF detected in endoscopically collected pancreatic cyst fluid are potential diagnostic biomarkers capable of distinguishing mixed IPMN from BD-IPMN.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Lee LS,Bellizzi AM,Banks PA,Sainani NI,Kadiyala V,Suleiman S,Conwell DL,Paulo JAdoi
10.1155/2012/247309subject
Has Abstractpub_date
2012-01-01 00:00:00pages
247309eissn
1687-6121issn
1687-630Xjournal_volume
2012pub_type
杂志文章abstract::Myeloproliferative neoplasms (MPNs) are the leading cause of Budd-Chiari syndrome (BCS), and the C allele of JAK2 rs4495487 was reported to be an additional candidate locus that contributed to MPNs. In the present study, we examined the role of JAK2 rs4495487 in the etiology and clinical presentation of Chinese BCS pa...
journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Gastroenterology research and practice
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doi:10.1155/2016/5076542
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
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journal_title:Gastroenterology research and practice
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journal_title:Gastroenterology research and practice
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doi:10.1155/2016/1078653
更新日期:2016-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract::Autophagy is a catabolic process by which a cell degrades its intracellular materials to replenish itself. Induction of autophagy under various cellular stress stimuli can lead to either cell survival or cell death via apoptotic and/or autophagic (nonapoptotic) pathways. The NSAID sulindac sulfide induces apoptosis in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/897678
更新日期:2012-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/3059201
更新日期:2016-01-01 00:00:00