Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis.

Abstract:

Background:Tumor regression grade (TRG) is widely used in gastrointestinal carcinoma to evaluate pathological responses to neoadjuvant chemotherapy (NCT), but whether it is an independent prognostic factor is still controversial. The aim of this study is to investigate the value of TRG in locally advanced gastric adenocarcinoma patients who underwent NCT and curative resection. Methods:Pathological regression was reevaluated according to the Mandard TRG. Survival curves were obtained by the Kaplan-Meier method, and differences in overall survival (OS) and disease-free survival (DFS) were compared using the log-rank test. Univariate and multivariate analyses for survival were based on the Cox proportional hazards method. Results:In total, 290 patients were identified in our electronic database. In univariable analysis, TRG was associated with OS (HR = 3.822, P ≤ 0.001) and DFS (HR = 3.374, P ≤ 0.001). However, in multivariable analysis, TRG was not an independent factor for OS (P = 0.231) or DFS (P = 0.191). In the stratified analysis, TRG retrieved prognostic significance in patients with the metastasis of lymph node (HR = 2.034, P = 0.035 for OS; HR = 2.220, P = 0.016 for DFS), while not in patients with negative lymph node (P = 0.296 for OS; P = 0.172 for DFS). Conclusions:TRG was not an independent predictor for survival, but the system regained its predicting significance in patients with lymph node metastasis.

authors

Tong Y,Zhu Y,Zhao Y,Shan Z,Zhang J,Liu D

doi

10.1155/2020/3435673

subject

Has Abstract

pub_date

2020-07-18 00:00:00

pages

3435673

eissn

1687-6121

issn

1687-630X

journal_volume

2020

pub_type

杂志文章
  • Perioperative Therapy of Oesophagogastric Adenocarcinoma: Mainstay and Future Directions.

    abstract::Perioperative chemotherapy improves overall survival in patients with oesophagogastric adenocarcinoma (OAC) and locoregional disease. The mainstay of perioperative chemotherapy in these patients is a platinum/fluoropyrimidine combination. The phase III FLOT4 trial has shown that the FLOT triplet regimen (oxaliplatin, ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5651903

    authors: Bose K,Franck C,Müller MN,Canbay A,Link A,Venerito M

    更新日期:2017-01-01 00:00:00

  • Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms.

    abstract::Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5491465

    authors: Li F,Duan K,Wang C,McClain C,Feng W

    更新日期:2016-01-01 00:00:00

  • Serum Liver Fibrosis Markers for Predicting the Presence of Gastroesophageal Varices in Liver Cirrhosis: A Retrospective Cross-Sectional Study.

    abstract::Background and Aims. A retrospective cross-sectional study was conducted to evaluate the role of hyaluronic acid (HA), laminin (LN), amino-terminal propeptide of type III procollagen (PIIINP), and collagen IV (CIV) in predicting the presence of gastroesophageal varices (GEVs) in patients with liver cirrhosis. Methods....

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/274534

    authors: Qi X,Li H,Chen J,Xia C,Peng Y,Dai J,Hou Y,Deng H,Li J,Guo X

    更新日期:2015-01-01 00:00:00

  • Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study.

    abstract::Background. There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods. A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/2952635

    authors: Sobhonslidsuk A,Wanichanuwat J,Numthavaj P,Sophonsritsuk A,Petraksa S,Pugasub A,Jittorntam P,Kongsomgan A,Roytrakul S,Phakdeekitcharoen B

    更新日期:2016-01-01 00:00:00

  • Safety of Simultaneous Hepatectomy and Splenectomy in the Treatment of Hepatocellular Carcinoma Complicated with Hypersplenism: A Meta-analysis.

    abstract:Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9065845

    authors: Liu X,Chen Z,Yu M,Zhou W,Zhi X,Li T

    更新日期:2019-08-14 00:00:00

  • Hepatorenal syndrome: aetiology, diagnosis, and treatment.

    abstract::Acute renal impairment is common in patients with chronic liver disease, occurring in approximately 19% of hospitalised patients with cirrhosis. A variety of types of renal impairment are recognised. The most important of these is the hepatorenal syndrome, a functional renal impairment due to circulatory and neurohorm...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/207012

    authors: Low G,Alexander GJ,Lomas DJ

    更新日期:2015-01-01 00:00:00

  • Novel Visual Nasogastric Tube Insertion System: A Feasibility and Efficiency Study in a Manikin.

    abstract::Background. Conventional nasogastric tube placement is an essential clinical procedure; however, complications may arise from blind manipulation. We tested the feasibility and efficiency of a visual nasogastric tube insertion system (VNGS) using a manikin. Methods. A microimaging fiber (0.8 mm) was integrated into the...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/7532172

    authors: Li Q,Xie J,Wu J,Guo R,Ma W,Xu G,Yang M,Deng H

    更新日期:2016-01-01 00:00:00

  • Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma.

    abstract:Objective:The aim of our study was to investigate the expression of EGFR and PTEN in tissues and measure the serum platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) to evaluate the prognostic factors of patients with epithelioid malignant peritoneal mesothelioma (MPeM). Methods:33 patients of...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/7103915

    authors: Liang Y,Zheng G,Yin W,Song H,Li C,Tian L,Yang D

    更新日期:2019-02-04 00:00:00

  • Correlation between Endosonographic and Doppler Ultrasound Features of Portal Hypertension in Patients with Cirrhosis.

    abstract::Purpose. Endoscopic ultrasound (EUS) permits the detailed visualization of clinically significant features of portal hypertension; however, it is an invasive procedure that is not widely available. The aim of this cross-sectional study was to determine whether a correlation exists between the features of portal hypert...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/395345

    authors: Wiechowska-Kozłowska A,Zasada K,Milkiewicz M,Milkiewicz P

    更新日期:2012-01-01 00:00:00

  • Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study.

    abstract:Background and Aims:Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients. Methods:All UC pati...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/4195968

    authors: Pugliese D,Aratari A,Festa S,Ferraro PM,Monterubbianesi R,Guidi L,Scribano ML,Papi C,Armuzzi A

    更新日期:2018-10-03 00:00:00

  • Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics.

    abstract::Aim. Chronic gastritis was assessed serologically, endoscopically and histologically to identify correlations between these methods. Methods. Subjects comprised 319 patients who had provided informed consent. Serological assessment of chronic gastritis was based on the pepsinogen test method. Endoscopic gastritis and ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2011/631461

    authors: Takao T,Ishikawa T,Ando T,Takao M,Matsumoto T,Isozaki Y,Okita M,Nagao Y,Oyamada H,Yokoyama K,Tatebe A,Uchiyama K,Handa O,Takagi T,Yagi N,Kokura S,Naito Y,Yoshikawa T

    更新日期:2011-01-01 00:00:00

  • Establishment of a standardized liver fibrosis model with different pathological stages in rats.

    abstract::Objective. To establish a standardized animal model for liver fibrosis with the same assessment criteria for liver fibrosis studies that have been established on a unified platform. Methods. The standardized liver fibrosis model was established using Sprague-Dawley (SD) rats that either received an intraperitoneal inj...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/560345

    authors: Li L,Hu Z,Li W,Hu M,Ran J,Chen P,Sun Q

    更新日期:2012-01-01 00:00:00

  • Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer.

    abstract::Introduction. The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC). Material and Methods. The serum levels of study factors were measured in 73 patients with CRC and in 35 ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/146819

    authors: Diakowska D,Grabowski K,Nienartowicz M,Zarębski P,Fudalej K,Markocka-Mączka K

    更新日期:2015-01-01 00:00:00

  • Balloon-Assisted Enteroscopy for Retrieval of Small Intestinal Foreign Bodies: A KASID Multicenter Study.

    abstract:Background and Aims:Balloon-assisted enteroscopy (BAE) can be used to retrieve small intestinal foreign bodies (FBs). Here, we aimed at exploring the clinical usefulness of BAE for the retrieval of small intestinal FBs. Methods:We retrospectively reviewed the medical records of 34 patients who underwent BAE to retriev...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/3814267

    authors: Kim J,Lee BJ,Ham NS,Oh EH,Choi KD,Ye BD,Byeon JS,Eun CS,Kim JS,Yang DH

    更新日期:2020-05-19 00:00:00

  • Safety of laparoscopic colorectal surgery in a low-volume setting: review of early and late outcome.

    abstract::Background. There is increasing evidence suggesting that the laparoscopic technique is the treatment of choice for large bowel resection, including for malignancy. The purpose of the study was to assess whether general surgeons, with particular skills in advanced laparoscopy, can adequately provide safe laparoscopic c...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/581523

    authors: Gandy RC,Berney CR

    更新日期:2014-01-01 00:00:00

  • Capsule Endoscopy in Patients with Cardiac Pacemakers and Implantable Cardioverter Defibrillators: (Re)evaluation of the Current State in Germany, Austria, and Switzerland 2010.

    abstract::Background and Aims. The study was a repeated evaluation of the experience of capsule endoscopy (CE) in patients with cardiac pacemaker or implantable cardioverter defibrillator (ICD). Patients and Methods. A standardized questionnaire was sent by the manufactors Given Imaging and Olympus to all centers in Germany, Au...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/717408

    authors: Bandorski D,Jakobs R,Brück M,Hoeltgen R,Wieczorek M,Keuchel M

    更新日期:2012-01-01 00:00:00

  • Current advances in the diagnosis and treatment of nonerosive reflux disease.

    abstract::Nonerosive reflux disease (NERD) is a distinct pattern of gastroesophageal reflux disease (GERD). It is defined as a subcategory of GERD characterized by troublesome reflux-related symptoms in the absence of esophageal mucosal erosions/breaks at conventional endoscopy. In clinical practice, patients with reflux sympto...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/653989

    authors: Chen CL,Hsu PI

    更新日期:2013-01-01 00:00:00

  • Corrigendum to "Incidence and Paris Classification of Pediatric Inflammatory Bowel Disease".

    abstract::[This corrects the article DOI: 10.1155/2014/904307.]. ...

    journal_title:Gastroenterology research and practice

    pub_type: 已发布勘误

    doi:10.1155/2015/804318

    authors: Müller KE,Lakatos PL,Papp M,Veres G

    更新日期:2015-01-01 00:00:00

  • Alterations of blood-brain barrier and associated factors in acute liver failure.

    abstract::Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function. Re...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/841707

    authors: Cui W,Sun CM,Liu P

    更新日期:2013-01-01 00:00:00

  • Desmoplasia in pancreatic cancer. Can we fight it?

    abstract::The hallmark of pancreatic tumours, the desmoplastic reaction, provides a unique microenvironment that affects pancreatic tumour behaviour, its ability to grow and metastasize as well as resist the effects of chemotherapy. Complex molecular interactions and pathways give rise to the desmoplastic reaction. Breakdown or...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/781765

    authors: Merika EE,Syrigos KN,Saif MW

    更新日期:2012-01-01 00:00:00

  • Does Colonic Diverticulosis Raise the Risk of Colorectal Adenoma in Patients with Colorectal Cancer?

    abstract:Background:The aim of this study was to evaluate the risk of development of colorectal adenomas in patients with colorectal cancer (CRC) with and without colonic diverticulosis. Methods:We performed a retrospective cohort study that included patients with CRC between 2008 and 2011. All patients underwent preoperative ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/8901026

    authors: Kim YJ,Kim DB,Chung WC,Lee JM

    更新日期:2019-05-20 00:00:00

  • Nutrition care for patients with weight regain after bariatric surgery.

    abstract::Achieving optimal weight outcomes for patients with obesity is important to the management of their chronic disease. All interventions present risks for weight regain. Bariatric surgery is the most efficacious treatment, producing greater weight losses that are sustained over more time compared to lifestyle interventi...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2013/256145

    authors: Johnson Stoklossa C,Atwal S

    更新日期:2013-01-01 00:00:00

  • Retracted: Influence of Gastrectomy on Cortical and Cancellous Bones in Rats.

    abstract::[This retracts the article DOI: 10.1155/2013/381616.]. ...

    journal_title:Gastroenterology research and practice

    pub_type: 撤回出版物

    doi:10.1155/2020/5109831

    authors: Research And Practice G

    更新日期:2020-10-31 00:00:00

  • Outcomes of endoscopic-ultrasound-guided cholangiopancreatography: a literature review.

    abstract::Endoscopic retrograde cholangiopancreatography (ERCP) can fail in 3-10% of the cases even in experienced hands. Although percutaneous transhepatic cholangiography (PTC) and surgery are the traditional alternatives, there are morbidity and mortality associated with both. In this paper, we have discussed the efficacy an...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/869214

    authors: Iqbal S,Friedel DM,Grendell JH,Stavropoulos SN

    更新日期:2013-01-01 00:00:00

  • Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model.

    abstract::Background and Aim. Crohn's disease is associated with gut microbiota (GM) dysbiosis. Treatment with the anti-IL-12p40 monoclonal antibody (12p40-mAb) has therapeutic effect in Crohn's disease patients. This study addresses whether a 12p40-mAb treatment influences gut microbiota (GM) composition in mice with adoptive ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/4953120

    authors: Castro-Mejía J,Jakesevic M,Krych Ł,Nielsen DS,Hansen LH,Sondergaard BC,Kvist PH,Hansen AK,Holm TL

    更新日期:2016-01-01 00:00:00

  • Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats.

    abstract::Background. Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/3126280

    authors: Dembiński A,Warzecha Z,Ceranowicz P,Dembiński M,Cieszkowski J,Gosiewski T,Bulanda M,Kuśnierz-Cabala B,Gałązka K,Konturek PC

    更新日期:2016-01-01 00:00:00

  • Hepatitis B virus-related glomerulonephritis: not a predominant cause of proteinuria in korean patients with chronic hepatitis B.

    abstract::Background/Aims. Hepatitis B virus (HBV) can form immune complexes which may result in various types of glomerulonephritis (GN). However, proteinuria can occur because of other kidney diseases besides HBV-related GN (HBV-GN). The aim of this study is to elucidate the causes of proteinuria and report on the clinical ou...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/126532

    authors: Yoo JJ,Lee JH,Yoon JH,Lee M,Lee DH,Cho Y,Jang ES,Cho EJ,Yu SJ,Kim YJ,Lee HS

    更新日期:2015-01-01 00:00:00

  • E. coli-produced BMP-2 as a chemopreventive strategy for colon cancer: a proof-of-concept study.

    abstract::Colon cancer is a serious health problem, and novel preventive and therapeutical avenues are urgently called for. Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. Interestingly, bone morphogenetic pr...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/895462

    authors: Yuvaraj S,Al-Lahham SH,Somasundaram R,Figaroa PA,Peppelenbosch MP,Bos NA

    更新日期:2012-01-01 00:00:00

  • Colorectal Malignancy in a Prospective Irish Inflammatory Bowel Disease Population 15 Years Since Diagnosis: Comparison with the EC-IBD Cohort.

    abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/4946068

    authors: Shuhaibar M,O'Morain C

    更新日期:2017-01-01 00:00:00

  • Pancreatoduodenectomy without Vascular Resection in Patients with Primary Resectable Adenocarcinoma and Unilateral Venous Contact: A Matched Case Study.

    abstract:Purpose:To investigate the oncological outcome and survival of patients following a conservative approach on the portal-mesenteric axis, in an intraoperative ultrasound-selected group of pancreatoduodenectomy (PD), performed on patients with primary resectable with vascular contact (prVC) pancreatic ductal adenocarcino...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/1081494

    authors: Morelli L,Berchiolli R,Guadagni S,Palmeri M,Furbetta N,Gianardi D,Bianchini M,Funel N,Caprili G,Pollina LE,Di Candio G,Mosca F,Di Franco G,Cuschieri A

    更新日期:2018-11-25 00:00:00