Abstract:
:Background. Transanal irrigation (TAI) can successfully treat neurogenic bowel dysfunction (NBD), but patient perception of its use in chronic idiopathic constipation (CIC) is unknown. Objective. To evaluate patient perceptions of the efficacy and safety of TAI for CIC and whether there are predictive factors of perceived treatment response. Methods. Prospective data collection of baseline physiology and symptom severity; retrospective evaluation of efficacy and safety perceptions using a snapshot survey. All patients fulfilling the Rome III criteria for functional constipation with chronic idiopathic aetiology were included. The main outcome measure was the duration of patients' usage of TAI. Results. 102 patients reported 21,476 irrigations over 119 patient years, with a mean duration of therapy use of 60.5 weeks [SD 73.2 : SE 7.3]. Overall symptom improvement included general well-being (65%), rectal clearance (63%), bloating (49%), abdominal pain (48%), and bowel frequency (42%). 68 patients (67%) were "moderately better" or "very much better" on a satisfaction question. Reported complications were minor. No correlation was demonstrated between duration of therapy use and baseline measures. Conclusion. A significant proportion of CIC sufferers use TAI as a long-term or bridging therapy and perceive it as safe. This therapy demands a prospective investigation of efficacy and safety.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Etherson KJ,Minty I,Bain IM,Cundall J,Yiannakou Ydoi
10.1155/2017/3826087subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3826087eissn
1687-6121issn
1687-630Xjournal_volume
2017pub_type
杂志文章abstract:Background:The objective of this study was to determine the factors associated with severity of acute pancreatitis (AP) according to two major etiologies: alcohol and gallstones. Methods:We reviewed the medical records of consecutive patients who were admitted with AP between January 2003 and January 2013. A total of ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1219464
更新日期:2017-01-01 00:00:00
abstract::Ovarian cancer peritoneal carcinomatosis requires a multimodal-treatment approach. Current treatment considerations are analyzed in this update and include the management of recurrent malignant ascites and the understanding of its pathophysiology, the role of peritoneal washing cytology in detecting peritoneal metasta...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/5284814
更新日期:2018-04-05 00:00:00
abstract::Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man with CLL and anaemia in whom the macroscopic finding of colonoscopy was normal, but the histological specimens revealed lymphocytic leukemia in ileum and in colon. If a CLL...
journal_title:Gastroenterology research and practice
pub_type:
doi:10.1155/2008/742146
更新日期:2008-01-01 00:00:00
abstract::Corrosive injury results from the intake of corrosive-acid-based chemicals. However, this phenomenon is limited to a small number of cases and cannot be extrapolated to the epidemiology of corrosive injuries in actual situations. This study focuses on the annual incidence of corrosive injury and its connection to gend...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/7905425
更新日期:2016-01-01 00:00:00
abstract::Resveratrol is a natural polyphenol studied for its possible protective properties in inflammatory bowel diseases. Moreover, it has been shown to interact with estrogen receptors. In the present study, we aimed to investigate possible diverse effects of resveratrol on female and male mice in DSS-induced colitis. Thirt...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8051870
更新日期:2017-01-01 00:00:00
abstract:Purpose:Patients with inflammatory bowel disease (IBD) frequently suffer from venous thromboembolic events, and the risk of thromboembolism increases along with disease activity. This study was conducted to discover novel thrombophilic markers using thromboelastography (TEG) and to evaluate the relation between the pre...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3245657
更新日期:2020-05-20 00:00:00
abstract::Patients involved on coeliac disease (CD) have atypical symptoms and often remain undiagnosed. Specific oral manifestations are effective risk indicators of CD and for this reason an early diagnosis with a consequent better prognosis can be performed by the dentist. There are not researches analysing the frequency of ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/934159
更新日期:2014-01-01 00:00:00
abstract::The technological progress within the range of methods of pancreas imaging and their more common accessibility selects a group of patients requiring a microscopic diagnosis. Percutaneous fine needle aspiration biopsy under the control of ultrasonography (PCFNA/USG) is the method commonly used in determining the charac...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/908963
更新日期:2012-01-01 00:00:00
abstract::Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultraso...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/207129
更新日期:2013-01-01 00:00:00
abstract::Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5491465
更新日期:2016-01-01 00:00:00
abstract:BACKGROUNDS:Magnifying endoscopy with blue laser imaging (ME-BLI) for diagnosis of early gastric cancer (EGC) is as effective as magnifying endoscopy with narrow-band imaging (ME-NBI). However, there are different EGCs in microstructure visualization between ME-BLI and ME-NBI. This study aimed to clarify the pathologic...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8303046
更新日期:2017-01-01 00:00:00
abstract::Objective. To establish a standardized animal model for liver fibrosis with the same assessment criteria for liver fibrosis studies that have been established on a unified platform. Methods. The standardized liver fibrosis model was established using Sprague-Dawley (SD) rats that either received an intraperitoneal inj...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/560345
更新日期:2012-01-01 00:00:00
abstract::Alterations in gut microbiota are postulated to be an etiologic factor in the pathogenesis of irritable bowel syndrome (IBS). To determine whether IBS patients in China exhibited differences in their gut microbial composition, fecal samples were collected from diarrhea-predominant IBS (IBS-D) and healthy controls and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/6961783
更新日期:2018-06-05 00:00:00
abstract::Aims. We here investigated whether the combination of simvastatin and irinotecan could induce the synergistic effect on colon cancer cells with or without resistance to irinotecan. Methods. We investigated cell proliferation assay and assessed cell death detection ELISA and caspase-3 activity assay of various concentr...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/7891374
更新日期:2016-01-01 00:00:00
abstract:Background and Aim:As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s. Patients and Methods:All patients from the greater Dublin area (n = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/4946068
更新日期:2017-01-01 00:00:00
abstract::Background and Aims. Although the differential expression of microRNA (miRNA) genes has been identified in many diseases, little information exists concerning the miRNA expression profile in type 2 diabetes mellitus (T2DM) with diarrhea-predominant irritable bowel syndrome (D-IBS). Therefore, the specific expression o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/9256209
更新日期:2016-01-01 00:00:00
abstract::The following is a case report of a primiparous woman who developed fulminant liver failure in the setting of HELLP syndrome complicated by hepatic rupture. It is unique in that a timely ABO compatible liver donor was unavailable, necessitating the transplantation of an ABO incompatible organ. Despite aggressive thera...
journal_title:Gastroenterology research and practice
pub_type:
doi:10.1155/2009/713937
更新日期:2009-01-01 00:00:00
abstract::Objective. Here, we aim to investigate the microRNA (miR) profiling in human gastric cancer (GC). Methods. Tumoral and matched peritumoral gastric specimens were collected from 12 GC patients who underwent routine surgery. A high-throughput miR sequencing method was applied to detect the aberrantly expressed miRs in a...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1526981
更新日期:2017-01-01 00:00:00
abstract::Although the thread-traction (TT) method has been found useful during endoscopic submucosal dissection (ESD) for early gastric cancers, the movement of the thread interferes with the movement of the endoscope, and the lesion can only be pulled to the mouth side. We have developed the novel TT method using a sheath of ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/9415497
更新日期:2016-01-01 00:00:00
abstract::Activation of innate immunity is associated with the development of liver disease, including non-alcoholic fatty liver disease (NAFLD). In the innate immune system, Toll-like receptors (TLRs) are sensors that recognize bacterial and viral components such as lipopolysaccharide, bacterial DNA, and peptidoglycan. Recent ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2010/362847
更新日期:2010-01-01 00:00:00
abstract:Purpose:Countries with nationwide quality programmes in colorectal cancer report an improved outcome. In Germany, a self-organized and self-financed observational quality assurance project exists, based on voluntary participation. The object of the present study was to ascertain whether this nationwide project also imp...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/3925062
更新日期:2018-05-08 00:00:00
abstract::The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3682836
更新日期:2019-10-17 00:00:00
abstract:Background/Aims:The damage of interstitial cells of Cajal and smooth muscle cells has far-reaching implications in the pathogenesis of gastroparesis in diabetic patients. Gastric electrical stimulation (GES) is an efficient therapy for gastric motility disorders, but the mechanisms of GES require clarification. Method...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/6309157
更新日期:2018-11-13 00:00:00
abstract::Reorganization of the actin cytoskeleton underlies cell migration in a wide variety of physiological and pathological processes, such as embryonic development, wound healing, and tumor cell invasion. It has been shown that actin assembly and disassembly are precisely regulated by intracellular signaling cascades that ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/930157
更新日期:2015-01-01 00:00:00
abstract:Objective:Aortoesophageal fistula (AEF) related to aortic aneurysm and dissection is an uncommon but life-threatening condition. We performed a systematic review of risk factors for mortality and factors associated with the prognosis of AEF. Methods:A systematic search of the PubMed, Embase, and Cochrane Library datab...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2020/4850287
更新日期:2020-09-17 00:00:00
abstract::Purpose. Endoscopic ultrasound-guided biliary drainage (EUS-BD) has been increasingly reported worldwide. However, studies concerning EUS-BD from Mainland China are sporadic. This study aims to investigate the feasibility, efficacy, and safety of EUS-BD using SEMS in a single center from Mainland China. Methods. Betwe...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6284094
更新日期:2017-01-01 00:00:00
abstract:Background/Aim:Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/1262595
更新日期:2019-05-06 00:00:00
abstract::Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/393015
更新日期:2013-01-01 00:00:00
abstract::Helicobacter pylori colonizes the stomachs of greater than 50% of the world's human population making it arguably one of the most successful bacterial pathogens. Chronic H. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with H. pylori is associated ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/3019362
更新日期:2016-01-01 00:00:00
abstract:Aim:Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocy...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/5705782
更新日期:2019-06-10 00:00:00