Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications.

Abstract:

:Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC proliferation, invasion, chemosensitivity, and radiosensitivity, as well as prognosis. Greater understanding of the roles of miRNAs in PDAC could provide insights into this disease and identify potential diagnostic markers and therapeutic targets. The current review focuses on recent advances with respect to the roles of miRNAs in PDAC and their practical value.

authors

Sun T,Kong X,Du Y,Li Z

doi

10.1155/2014/386561

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

386561

eissn

1687-6121

issn

1687-630X

journal_volume

2014

pub_type

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