Abstract:
:Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconclusive or even controversial. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk. Methods. A comprehensive literature search was performed in multiple internet-based electronic databases. Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI). Results. C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association. Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model. Conclusion. SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer. Further well-designed studies should be considered to validate the potential effect.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Ni Q,Ji A,Yin J,Wang X,Liu Xdoi
10.1155/2015/764163subject
Has Abstractpub_date
2015-01-01 00:00:00pages
764163eissn
1687-6121issn
1687-630Xjournal_volume
2015pub_type
杂志文章,评审abstract::We determined comparative efficacy of i-Scan for detection and diagnosis of gastric cancer. Ten patients diagnosed with early gastric cancer based on histopathological findings were analyzed. White light and i-Scan moving images recorded from these patients in twin mode were separated into white light and i-Scan. Twel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/819395
更新日期:2014-01-01 00:00:00
abstract:Background:The da Vinci robotic system was considered an effectively alternative treatment option for early gastric cancer patients in recent years. The aim of our study was to evaluate the safety and feasibility of robot-assisted gastrectomy in our center. Methods:This study included 33 patients who underwent robot-a...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/9059176
更新日期:2019-10-23 00:00:00
abstract:Background:Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), and hepatitis C virus (HCV) infection is a leading cause of CLD, cirrhosis, and hepatocellular carcinoma (HCC). This study is aimed at assessing HRQOL in patients with HCV infection...
journal_title:Gastroenterology research and practice
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doi:10.1155/2020/6716103
更新日期:2020-01-07 00:00:00
abstract::Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus b...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/8180323
更新日期:2020-11-28 00:00:00
abstract::Background. The problems of fungal infections in edentulous have been discussed in literature. Findings show that oral mycosis has an influence on the mycosis of oesophageal mucosa. Based on this we started to follow from 2007 in patients who wear dentures mycological examination, to evaluate changes of yeasts numbers...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/951572
更新日期:2012-01-01 00:00:00
abstract::Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was inject...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/8438172
更新日期:2017-01-01 00:00:00
abstract::Alterations in gut microbiota are postulated to be an etiologic factor in the pathogenesis of irritable bowel syndrome (IBS). To determine whether IBS patients in China exhibited differences in their gut microbial composition, fecal samples were collected from diarrhea-predominant IBS (IBS-D) and healthy controls and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/6961783
更新日期:2018-06-05 00:00:00
abstract:Background:The aim of this study was to evaluate the interobserver variability in diagnosing inflammatory bowel disease (IBD)-associated neoplasia among practicing pathologists from China using telepathology, a practice of remote diagnostic consultation increasingly used nationally and internationally, and its comparis...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/8715263
更新日期:2018-04-23 00:00:00
abstract::Objective. Balloon enteroscopy (BE) and capsule enteroscopy (CE) are enteroscopy methods that allow examination and treatment of the small bowel. Before the CE and BE era, the small intestine was difficult to access for investigation. Small intestinal tumours are infrequent conditions, but about half of them are malig...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/702536
更新日期:2013-01-01 00:00:00
abstract:Background and Aims:Functional gastrointestinal disorders (FGDs) are multifactorial disorders of the gut-brain interaction. This study investigated the prevalence of Axis I and spectrum disorders in patients with FGD and established the link between FGDs and psychopathological dimensions. Methods:A total of 135 consec...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/1953435
更新日期:2017-01-01 00:00:00
abstract::Objective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD). Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospective clinical researc...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/672460
更新日期:2015-01-01 00:00:00
abstract:Background/Aim:Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/1262595
更新日期:2019-05-06 00:00:00
abstract::Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology. Recently, mucosal healing has emerged as an important therapeutic endpoint in UC. Linked color imaging (LCI) is a novel endoscopic system that enhances the color differences of the gastrointestinal mucosa. Our previous study emphasi...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3108690
更新日期:2020-03-06 00:00:00
abstract::The injurious effects of NSAIDs on the small intestine were not fully appreciated until the widespread use of capsule endoscopy. It is estimated that over two-thirds of regular NSAID users develop injury in the small intestinal injuries and that these injuries are more common than gastroduodenal mucosal injuries. Rece...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/761060
更新日期:2013-01-01 00:00:00
abstract::This study was to investigate the association of psychological characteristics and functional dyspepsia treatment outcome. 109 patients who met the criteria for FD were enrolled. Eysenck Personality Questionnaire (EPQ), Symptom Checklist 90 (SCL90), and the Pittsburgh Sleep Quality Index (PSQI) were used to measure pe...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/5984273
更新日期:2016-01-01 00:00:00
abstract::Due to the call for fast KRAS mutation status analysis for treatment of patients with monoclonal antibodies for metastatic colorectal cancer, sensitive, economic, and easily feasible methods are required. Under this aspect, the sensitivity and specificity of the SNaPshot analysis in comparison to the commonly used DNA...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2010/789363
更新日期:2010-01-01 00:00:00
abstract::Purpose. Endoscopic ultrasound (EUS) permits the detailed visualization of clinically significant features of portal hypertension; however, it is an invasive procedure that is not widely available. The aim of this cross-sectional study was to determine whether a correlation exists between the features of portal hypert...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/395345
更新日期:2012-01-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2014/386561
更新日期:2014-01-01 00:00:00
abstract::Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postcon...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/2604032
更新日期:2016-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) ranks second amongst all causes of cancer deaths globally. It is on a rise in Pakistan and might represent the most common cancer in adult males. Pakistan contributes significantly to global burden of hepatitis C, which is a known risk factor for HCC, and has one of the highest prevalenc...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/5942306
更新日期:2016-01-01 00:00:00
abstract::Background. No predictive or prognostic biomarker is available for patients with locally advanced rectal cancer (LARC) undergoing perioperative chemoradiotherapy (CRT). Members of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases EGFR (HER1, ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HE...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/3481578
更新日期:2016-01-01 00:00:00
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journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/7182429
更新日期:2017-01-01 00:00:00
abstract::Gastric ectopic pancreas is an uncommon developmental anomaly and its histological diagnosis is usually difficult by using a conventional biopsy forceps. In the literature, most cases of gastric ectopic pancreas were usually diagnosed by gross pattern during endoscopic examination or features of endoscopic ultrasound....
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/160601
更新日期:2014-01-01 00:00:00
abstract::Objective. This study compared the eradication rates of of Helicobacter pylori (HP) infection by a 7-day and 14-day anti-HP regimen. Materials and Methods. An open, randomized, prospective study was performed to evaluate the response to anti-HP treatment in adult HP-positive patients following a 7-day course (Regimen ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/5061640
更新日期:2016-01-01 00:00:00
abstract:Background:Both long-term proton pump inhibitor use and surgical fundoplication have potential drawbacks as treatments for chronic gastroesophageal reflux disease (GERD). Our aim was to investigate the potential efficacy of antireflux mucosectomy (ARMS) in porcine and determine the optimal circumference of resection in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/3286738
更新日期:2019-02-24 00:00:00
abstract:Objective:To investigate and study the related risk factors of gastric cancer (GC) patients, to establish a high-risk scoring model of GC by multiple logistic regression analysis, and to explore the establishment of a GC screening mode with clinical opportunistic screening as the main method, and by using the pattern o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/5609623
更新日期:2020-09-30 00:00:00
abstract:Background:Environmental factors and genetic mutations have been increasingly recognized as risk factors for chronic pancreatitis (CP). The PRSS1 p.R122H mutation was the first discovered to affect hereditary CP, with 80% penetrance. We performed here a systematic review and meta-analysis to evaluate the associations o...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/9505460
更新日期:2017-01-01 00:00:00
abstract::Background. Transanal irrigation (TAI) can successfully treat neurogenic bowel dysfunction (NBD), but patient perception of its use in chronic idiopathic constipation (CIC) is unknown. Objective. To evaluate patient perceptions of the efficacy and safety of TAI for CIC and whether there are predictive factors of perce...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/3826087
更新日期:2017-01-01 00:00:00
abstract::The incidence of inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), has increased in pediatric populations over the last decade. Patients diagnosed during childhood often survive well into adulthood, and therefore their healthcare requires transfer to an adult gastroenterolo...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/853530
更新日期:2015-01-01 00:00:00
abstract:Purpose:Countries with nationwide quality programmes in colorectal cancer report an improved outcome. In Germany, a self-organized and self-financed observational quality assurance project exists, based on voluntary participation. The object of the present study was to ascertain whether this nationwide project also imp...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/3925062
更新日期:2018-05-08 00:00:00