Abstract:
:Purpose. In the present study, the prognostic significance of CpG island methylator phenotype (CIMP) in stage II/III sporadic colorectal cancer was evaluated using a five-gene panel. Methods. Fifty stage II/III colorectal cancer patients who received radical resection were included in this study. Promoter methylation of p14ARF, hMLH1, p16INK4a, MGMT, and MINT1 was determined by methylation specific polymerase chain reaction (MSP). CIMP positive was defined as hypermethylation of three or more of the five genes. Impact factors on disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier method (log-rank test) and adjusted Cox proportional hazards model. Results. Twenty-four percent (12/50) of patients were characterized as CIMP positive. Univariate analysis showed stage III (P = 0.049) and CIMP positive (P = 0.014) patients who had significantly inferior DFS. In Cox regression analysis, CIMP positive epigenotype was independently related with poor DFS with HR = 2.935 and 95% CI: 1.193-7.220 (P = 0.019). In patients with CIMP positive tumor, those receiving adjuvant chemotherapy had a poor DFS than those without adjuvant chemotherapy (P = 0.023). Conclusions. CIMP positive was significantly correlated with decreased DFS in stage II/III colorectal cancer. Patients with CIMP positive locally advanced sporadic colorectal cancers may not benefit from 5-fluorouracil based adjuvant chemotherapy.
journal_name
Gastroenterol Res Practjournal_title
Gastroenterology research and practiceauthors
Wang Y,Long Y,Xu Y,Guan Z,Lian P,Peng J,Cai S,Cai Gdoi
10.1155/2014/436985subject
Has Abstractpub_date
2014-01-01 00:00:00pages
436985eissn
1687-6121issn
1687-630Xjournal_volume
2014pub_type
杂志文章abstract::Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/393015
更新日期:2013-01-01 00:00:00
abstract:Aim:To evaluate the prevalence and risk factors of H. pylori infection in the pediatric and adult population seen at a public hospital in São José do Rio Preto, SP, Brazil. Methods:This is a retrospective study that evaluated 2406 medical records of children, adolescents, and adults with dyspeptic symptoms who underwe...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/8454125
更新日期:2018-09-04 00:00:00
abstract::Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultraso...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2013/207129
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate the differences in the results of esophageal function tests for functional heartburn (FH) and reflux hypersensitivity (RH). METHODS:Patients with FH and RH and healthy volunteers (HVs) from the Department of Gastroenterology, Beijing Anzhen Hospital and Beijing Chao-Yang hospital, who underwen...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/3596148
更新日期:2017-01-01 00:00:00
abstract::Helicobacter pylori colonizes the stomachs of greater than 50% of the world's human population making it arguably one of the most successful bacterial pathogens. Chronic H. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with H. pylori is associated ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/3019362
更新日期:2016-01-01 00:00:00
abstract::Background and Aims. Conventional endoscopic submucosal resection (EMR) of carcinoid tumors often involves the resection margin, which necessitates further intervention. Endoscopic submucosal dissection (ESD) is widely accepted for removing carcinoid tumors. We aimed to evaluate the clinical usefulness of ESD with tha...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/253860
更新日期:2014-01-01 00:00:00
abstract:Background:Tumor regression grade (TRG) is widely used in gastrointestinal carcinoma to evaluate pathological responses to neoadjuvant chemotherapy (NCT), but whether it is an independent prognostic factor is still controversial. The aim of this study is to investigate the value of TRG in locally advanced gastric adeno...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3435673
更新日期:2020-07-18 00:00:00
abstract::Ovarian cancer peritoneal carcinomatosis requires a multimodal-treatment approach. Current treatment considerations are analyzed in this update and include the management of recurrent malignant ascites and the understanding of its pathophysiology, the role of peritoneal washing cytology in detecting peritoneal metasta...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2018/5284814
更新日期:2018-04-05 00:00:00
abstract::Inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) is a chronic and disabling disease with unknown etiology. There have been some controversies regarding the role of psychological factors in the course of IBD. The purpose of this paper is to review that role. First the evidence...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/106502
更新日期:2012-01-01 00:00:00
abstract::Introduction. Neoadjuvant chemoradiotherapy and total mesorectal excision are considered the standard treatment for locally advanced rectal cancer. Various studies have reported pathological downstaging and a complete pathological response rate of 15%-27% following neoadjuvant chemoradiotherapy which has translated in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/867841
更新日期:2014-01-01 00:00:00
abstract:Background and Aims:Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients. Methods:All UC pati...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/4195968
更新日期:2018-10-03 00:00:00
abstract::We explain the state of the art of the immunohistochemical markers of response in rectal cancers treated with neoadjuvant medical therapies and its implication with prognosis. Neoadjuvant chemoradiotherapy is widely used to improve the outcome of patients with locally advanced rectal cancer, and the evaluation of the ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2017/2808235
更新日期:2017-01-01 00:00:00
abstract:Background/Objectives:This meta-analysis is aimed at investigating the prognostic roles of the inflammatory markers neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with pancreatic cancer. Methods:The correlations between high inflammatory marker expression levels and prognosis i...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/9745601
更新日期:2018-06-07 00:00:00
abstract::Colon cancer is a serious health problem, and novel preventive and therapeutical avenues are urgently called for. Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here. Interestingly, bone morphogenetic pr...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/895462
更新日期:2012-01-01 00:00:00
abstract:Objectives:To determine the prevalence and effect of dietary habits on functional constipation in preschool and early elementary school children in Japan. Study Design:A total of 3595 children aged 3 to 8 years from 28 nursery schools and 22 elementary schools in Yokohama City, Kanagawa Prefecture, Japan, were evaluat...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2018/3108021
更新日期:2018-02-27 00:00:00
abstract:Background/Aim:Endoscopic balloon dilation (EBD) has been effective for small-bowel strictures in patients with Crohn's disease (CD). However, its efficacy and indication for small-bowel strictures in non-CD patients have not been established. This study evaluated the clinical efficacy and safety of EBD for small-bowel...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2019/1262595
更新日期:2019-05-06 00:00:00
abstract::Background. Here we aimed to evaluate and compare the efficacy and safety between partial full-thickness myotomy and circular muscle myotomy during POEM procedure in achalasia patients. Methods. Clinical data of achalasia of cardia (AC) patients who underwent POEM in our center during January 2014 to January 2015 was ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/2676513
更新日期:2017-01-01 00:00:00
abstract:Background and Aims:Balloon-assisted enteroscopy (BAE) can be used to retrieve small intestinal foreign bodies (FBs). Here, we aimed at exploring the clinical usefulness of BAE for the retrieval of small intestinal FBs. Methods:We retrospectively reviewed the medical records of 34 patients who underwent BAE to retriev...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/3814267
更新日期:2020-05-19 00:00:00
abstract::Background/Aims. Hepatitis B virus (HBV) can form immune complexes which may result in various types of glomerulonephritis (GN). However, proteinuria can occur because of other kidney diseases besides HBV-related GN (HBV-GN). The aim of this study is to elucidate the causes of proteinuria and report on the clinical ou...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/126532
更新日期:2015-01-01 00:00:00
abstract::Medicinal plants and probiotics both have very high potential in terms of their antimicrobial activity against antibiotic-resistant enteric pathogens. The probiotics being enteric microorganism do not have any parasitic effect on human beings. They have been an integral part of daily food for centuries. They have been...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/457150
更新日期:2012-01-01 00:00:00
abstract::Introduction. Preoperative malnutrition is a major risk factor for increased postoperative morbidity and mortality. Definition and diagnosis of malnutrition and its treatment is still subject for controversy. Furthermore, practical implementation of nutrition-related guidelines is unknown. Methods. A review of the ava...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2011/739347
更新日期:2011-01-01 00:00:00
abstract::Background. No predictive or prognostic biomarker is available for patients with locally advanced rectal cancer (LARC) undergoing perioperative chemoradiotherapy (CRT). Members of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases EGFR (HER1, ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HE...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/3481578
更新日期:2016-01-01 00:00:00
abstract::The following is a case report of a primiparous woman who developed fulminant liver failure in the setting of HELLP syndrome complicated by hepatic rupture. It is unique in that a timely ABO compatible liver donor was unavailable, necessitating the transplantation of an ABO incompatible organ. Despite aggressive thera...
journal_title:Gastroenterology research and practice
pub_type:
doi:10.1155/2009/713937
更新日期:2009-01-01 00:00:00
abstract::Autophagy is a catabolic process by which a cell degrades its intracellular materials to replenish itself. Induction of autophagy under various cellular stress stimuli can lead to either cell survival or cell death via apoptotic and/or autophagic (nonapoptotic) pathways. The NSAID sulindac sulfide induces apoptosis in...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2012/897678
更新日期:2012-01-01 00:00:00
abstract::Myeloproliferative neoplasms (MPNs) are the leading cause of Budd-Chiari syndrome (BCS), and the C allele of JAK2 rs4495487 was reported to be an additional candidate locus that contributed to MPNs. In the present study, we examined the role of JAK2 rs4495487 in the etiology and clinical presentation of Chinese BCS pa...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2015/807865
更新日期:2015-01-01 00:00:00
abstract::Background. There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods. A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2016/2952635
更新日期:2016-01-01 00:00:00
abstract:Background and Aim:Proximal sessile serrated adenomas (PSSA) leading to colorectal cancer (CRC) represent an alternate pathway for CRC development. In this study, we aim to determine the prevalence of PSSAs and the impact of patient, colonoscopy, and endoscopist-related factors on PSSA detection. Methods:Patients ≥ 50...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2017/6710931
更新日期:2017-01-01 00:00:00
abstract::Background. Since the incidence of adenocarcinoma of the oesophagus is rising, the prognosis is poor, and surveillance programs are expensive and mostly cost ineffective, there is a need to increase the knowledge of risk factors in Barrett's oesophagus and oesophageal cancer in order to be able to give attention to me...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2014/408470
更新日期:2014-01-01 00:00:00
abstract::Evodiamine (Evo) is an indole alkaloid extracted from the traditional Chinese medicinal herb Evodia rutaecarpa. Evo may regulate gastrointestinal motility, but the evidence is insufficient, and the mechanisms remain unknown. The aim of this study was to investigate the effect of Evo on colonic motility of rats and the...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章
doi:10.1155/2020/8610653
更新日期:2020-04-03 00:00:00
abstract:Background:We conducted this meta-analysis to compare the efficacy and safety of simultaneous hepatectomy and splenectomy (HS) with hepatectomy alone (HA) in patients with hepatocellular carcinoma (HCC) and hypersplenism. Materials and Methods:A systematic search was conducted in PubMed, Embase, Cochrane Library, and ...
journal_title:Gastroenterology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2019/9065845
更新日期:2019-08-14 00:00:00