Rifaximin Improves Visceral Hyperalgesia via TRPV1 by Modulating Intestinal Flora in the Water Avoidance Stressed Rat.

Abstract:

Background:Rifaximin is effective in relieving pain symptoms with IBS patients, although the mechanisms were not clear. The aims of the research were to investigate whether the visceral hyperalgesia was alleviated by rifaximin via TRPV1 channel in rats. Methods:Rats were subjected to water avoidance stress (WAS) and were pretreated with rifaximin by oral gavage. The visceromotor response to colorectal distension was measured. The changes of TRPV1 in peripheral and central neurons of rats were detected by immunofluorescence, western blot method, and RT-PCR. Bacterial 16S ribosomal DNA in ileal contents was assessed using the Illumina MiSeq platform. The effect of intestinal flora on TRPV1 channel was observed by fecal microbiota transplantation (FMT) methods. Results:Rifaximin could relieve the visceral hyperalgesia and reduce the TRPV1 expression of neurons and ileum mucosa in rats induced by WAS. The reduced relative abundance of intestinal flora induced by WAS could be partly prevented by rifaximin. The electromyographical activities and immunoreactivity of TRPV1 in rats could be changed after FMT. Conclusions:Rifaximin could improve visceral hyperalgesia via TRPV1 channels of peripheral and central neurons by modulating intestinal flora in rats.

authors

Yang CQ,Guo XS,Ji-Li,Wei ZB,Zhao L,Zhao GT,Sheng ST

doi

10.1155/2020/4078681

subject

Has Abstract

pub_date

2020-07-20 00:00:00

pages

4078681

eissn

1687-6121

issn

1687-630X

journal_volume

2020

pub_type

杂志文章
  • Beneficial Effects of Probiotic Treatment on Gut Microbiota in Very Low Birth Weight Infants.

    abstract::The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiota. In the present study, a total of 36 VLBW infants were randomly divided into two groups, who were treated with combined probiotics and placebo, and 72 fecal specimens on days 14 and 28 of life were collected from them. ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/3682836

    authors: Li YF,Zhu CR,Gong XL,Li HL,Xiong LK,Wang KJ,Liu GS

    更新日期:2019-10-17 00:00:00

  • Pentraxin 3 Is a Predictor for Fibrosis and Arterial Stiffness in Patients with Nonalcoholic Fatty Liver Disease.

    abstract::Objective. The aim of the present study was to investigate whether pentraxin 3 (PTX3) can be a new noninvasive marker for prediction of liver fibrosis in patients with NAFLD. We also aimed to evaluate the relationship between PTX3 and atherosclerosis in patients with NAFLD. Method. Fifty-four male patients with biopsy...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/1417962

    authors: Ozturk K,Kurt O,Dogan T,Ozen A,Demirci H,Yesildal F,Kantarcioglu M,Turker T,Guler AK,Karslioglu Y,Altun B,Uygun A,Bagci S

    更新日期:2016-01-01 00:00:00

  • Laparoscopic Appendectomy versus Mini-Incision Appendectomy in Patients with Lower Body Mass Index and Noncomplicated Appendicitis.

    abstract::Laparoscopic appendectomy has become favored over open surgical methods for its association with decreased postoperative pain, more rapid return to daily activities, and improved cosmetic results. Mini-incision appendectomy was being performed in our clinic for a long time especially in patients with noncomplicated ap...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/138648

    authors: Özsan İ,Karabuğa T,Yoldaş Ö,Alpdoğan Ö,Aydın Ü

    更新日期:2014-01-01 00:00:00

  • Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats.

    abstract::Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus b...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/8180323

    authors: Matah Marte VM,Ateufack G,Mbiantcha M,Atsamo AD,Adjouzem CF,Djuichou Nguemnang SF,Tsafack EG,Yousseu Nana W,Madjo Kouam YK,Ngoufack Azanze E

    更新日期:2020-11-28 00:00:00

  • Paraoxonase and arylesterase activities, lipid profile, and oxidative damage in experimental ischemic colitis model.

    abstract::Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis m...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/979506

    authors: Unal E,Eris C,Kaya B,Uzun H,Cavdar F,Yildar M,Kiziler AR,Aydemir B,Gunes P,Kutanis R,Titiz I

    更新日期:2012-01-01 00:00:00

  • Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland.

    abstract::Background. An increasing resistance of Helicobacter pylori strains to antimicrobial agents is the serious therapeutic problem. The aim of this study was to compare the primary and secondary resistance of H. pylori strains isolated between 2006-2008 (data published) and 2009-2011 to clarithromycin and levofloxacin. Ma...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/418010

    authors: Karczewska E,Klesiewicz K,Skiba I,Wojtas-Bonior I,Sito E,Czajecki K,Zwolińska-Wcisło M,Budak A

    更新日期:2012-01-01 00:00:00

  • The efficacy of endoscopic submucosal dissection of type I gastric carcinoid tumors compared with conventional endoscopic mucosal resection.

    abstract::Background and Aims. Conventional endoscopic submucosal resection (EMR) of carcinoid tumors often involves the resection margin, which necessitates further intervention. Endoscopic submucosal dissection (ESD) is widely accepted for removing carcinoid tumors. We aimed to evaluate the clinical usefulness of ESD with tha...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/253860

    authors: Kim HH,Kim GH,Kim JH,Choi MG,Song GA,Kim SE

    更新日期:2014-01-01 00:00:00

  • Lack of Association Found between Helicobacter pylori Infection and Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Retrospective Study.

    abstract::Aims. The association between Helicobacter pylori (H. pylori) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue. Methods. A total of 502 inpatients with Rome III confirmed IBS-D and known H. pylori status from 8 hos...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/3059201

    authors: Xiong F,Xiong M,Ma Z,Huang S,Li A,Liu S

    更新日期:2016-01-01 00:00:00

  • Dynamic Detection of Monocyte Subsets in Peripheral Blood of Patients with Acute Hypertriglyceridemic Pancreatitis.

    abstract:Aim:Monocytes play an important role in acute pancreatitis (AP). Hypertriglyceridemic pancreatitis (HTGP) is always more severe than normal lipid-AP, whether the mechanism of aggravation involves monocyte subsets remains unknown though. The present study was aimed to analyze changes of peripheral blood M1 and M2 monocy...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/5705782

    authors: Zheng J,Fan J,Huang C,Lu Y,Huang Z,Wang X,Zeng Y

    更新日期:2019-06-10 00:00:00

  • Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis.

    abstract::Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was inject...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/8438172

    authors: Vigna SR

    更新日期:2017-01-01 00:00:00

  • Subthreshold Psychiatric Psychopathology in Functional Gastrointestinal Disorders: Can It Be the Bridge between Gastroenterology and Psychiatry?

    abstract:Background and Aims:Functional gastrointestinal disorders (FGDs) are multifactorial disorders of the gut-brain interaction. This study investigated the prevalence of Axis I and spectrum disorders in patients with FGD and established the link between FGDs and psychopathological dimensions. Methods:A total of 135 consec...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/1953435

    authors: Stasi C,Nisita C,Cortopassi S,Corretti G,Gambaccini D,De Bortoli N,Fani B,Simonetti N,Ricchiuti A,Dell'Osso L,Marchi S,Bellini M

    更新日期:2017-01-01 00:00:00

  • Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer.

    abstract::Introduction. The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC). Material and Methods. The serum levels of study factors were measured in 73 patients with CRC and in 35 ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/146819

    authors: Diakowska D,Grabowski K,Nienartowicz M,Zarębski P,Fudalej K,Markocka-Mączka K

    更新日期:2015-01-01 00:00:00

  • Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2014/386561

    authors: Sun T,Kong X,Du Y,Li Z

    更新日期:2014-01-01 00:00:00

  • Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis.

    abstract::Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology. Recently, mucosal healing has emerged as an important therapeutic endpoint in UC. Linked color imaging (LCI) is a novel endoscopic system that enhances the color differences of the gastrointestinal mucosa. Our previous study emphasi...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/3108690

    authors: Kanmura S,Tanaka A,Yutsudou K,Kuwazuru K,Komaki F,Komaki Y,Iwaya H,Arima S,Sasaki F,Tanoue S,Hashimoto S,Ido A

    更新日期:2020-03-06 00:00:00

  • Results of Medium Seventeen Years' Follow-Up after Laparoscopic Choledochotomy for Ductal Stones.

    abstract::Introduction. In a previously published article the authors reported the long-term follow-up results in 138 consecutive patients with gallstones and common bile duct (CBD) stones who underwent laparoscopic transverse choledochotomy (TC) with T-tube biliary drainage and laparoscopic cholecystectomy (LC). Aim of this st...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/9506406

    authors: Quaresima S,Balla A,Guerrieri M,Lezoche G,Campagnacci R,D'Ambrosio G,Lezoche E,Paganini AM

    更新日期:2016-01-01 00:00:00

  • Peripheral signals mediate the beneficial effects of gastric surgery in obesity.

    abstract::Obesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the modifications in th...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/560938

    authors: Barja-Fernández S,Folgueira C,Castelao C,Leis R,Casanueva FF,Seoane LM

    更新日期:2015-01-01 00:00:00

  • Nucleotide Analogue-Related Proximal Renal Tubular Dysfunction during Long-Term Treatment of Chronic Hepatitis B: A Cross-Sectional Study.

    abstract::Background. There have been few reports of nucleotide analogue-related renal tubular dysfunction (RTD) in CHB patients. We assessed the prevalence and presentation of nucleotide analogue-related proximal RTD. Methods. A cross-sectional study was performed in CHB patients taking nucleotide analogues. Inclusion criteria...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/2952635

    authors: Sobhonslidsuk A,Wanichanuwat J,Numthavaj P,Sophonsritsuk A,Petraksa S,Pugasub A,Jittorntam P,Kongsomgan A,Roytrakul S,Phakdeekitcharoen B

    更新日期:2016-01-01 00:00:00

  • Thread-Traction with a Sheath of Polypectomy Snare Facilitates Endoscopic Submucosal Dissection of Early Gastric Cancers.

    abstract::Although the thread-traction (TT) method has been found useful during endoscopic submucosal dissection (ESD) for early gastric cancers, the movement of the thread interferes with the movement of the endoscope, and the lesion can only be pulled to the mouth side. We have developed the novel TT method using a sheath of ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/9415497

    authors: Noda H,Ogasawara N,Koshino A,Fukuta S,Nagoya T,Hoshino H,Nagao K,Sugiyama T,Kondo Y,Ito Y,Izawa S,Ebi M,Funaki Y,Sasaki M,Kasugai K

    更新日期:2016-01-01 00:00:00

  • Optimization of Deep Sedation with Spontaneous Respiration for Therapeutic Endoscopy Combining Propofol and Bispectral Index Monitoring.

    abstract::Background/Aims. This study aimed to establish optimal propofol anesthesia for therapeutic endoscopy, which has not been established. Methodology. We retrospectively investigated data on 89 patients who underwent upper-GI endoscopic submucosal dissection or endoscopic mucosal resection under anesthesia with propofol. ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/282149

    authors: Matsumoto K,Nagahara A,Matsumoto K,Akazawa Y,Komori H,Nakagawa Y,Takeda T,Ueyama H,Shimada Y,Asaoka D,Hojo M,Watanabe S

    更新日期:2015-01-01 00:00:00

  • Corrigendum to "Incidence and Paris Classification of Pediatric Inflammatory Bowel Disease".

    abstract::[This corrects the article DOI: 10.1155/2014/904307.]. ...

    journal_title:Gastroenterology research and practice

    pub_type: 已发布勘误

    doi:10.1155/2015/804318

    authors: Müller KE,Lakatos PL,Papp M,Veres G

    更新日期:2015-01-01 00:00:00

  • Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics.

    abstract::Aim. Chronic gastritis was assessed serologically, endoscopically and histologically to identify correlations between these methods. Methods. Subjects comprised 319 patients who had provided informed consent. Serological assessment of chronic gastritis was based on the pepsinogen test method. Endoscopic gastritis and ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2011/631461

    authors: Takao T,Ishikawa T,Ando T,Takao M,Matsumoto T,Isozaki Y,Okita M,Nagao Y,Oyamada H,Yokoyama K,Tatebe A,Uchiyama K,Handa O,Takagi T,Yagi N,Kokura S,Naito Y,Yoshikawa T

    更新日期:2011-01-01 00:00:00

  • Perioperative Therapy of Oesophagogastric Adenocarcinoma: Mainstay and Future Directions.

    abstract::Perioperative chemotherapy improves overall survival in patients with oesophagogastric adenocarcinoma (OAC) and locoregional disease. The mainstay of perioperative chemotherapy in these patients is a platinum/fluoropyrimidine combination. The phase III FLOT4 trial has shown that the FLOT triplet regimen (oxaliplatin, ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5651903

    authors: Bose K,Franck C,Müller MN,Canbay A,Link A,Venerito M

    更新日期:2017-01-01 00:00:00

  • Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists.

    abstract:Background:The aim of this study was to evaluate the interobserver variability in diagnosing inflammatory bowel disease (IBD)-associated neoplasia among practicing pathologists from China using telepathology, a practice of remote diagnostic consultation increasingly used nationally and internationally, and its comparis...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/8715263

    authors: Wu XR,Liu HS,Shi XY,Zhou WX,Jiang ZN,Huang Y,Karamchandani DM,Goldblum JR,Xiao SY,Zhu HF,Feely MM,Collinsworth AL,Esnakula A,Xie H,Shen B,Lan P,Liu XL

    更新日期:2018-04-23 00:00:00

  • Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity.

    abstract:Objective:Fucosterol is derived from the brown alga Eisenia bicyclis and has various biological activities, including antioxidant, anticancer, and antidiabetic properties. The aim of this study was to investigate the protective effects of fucosterol pretreatment on Concanavalin A- (ConA-) induced acute liver injury in ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/2824139

    authors: Mo W,Wang C,Li J,Chen K,Xia Y,Li S,Xu L,Lu X,Wang W,Guo C

    更新日期:2018-07-17 00:00:00

  • Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice.

    abstract::This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder. The lithogenic diet caused elevation of triglycerides, cholesterol, and low-density...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/1343969

    authors: Chen G,Wu S

    更新日期:2020-04-21 00:00:00

  • Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility.

    abstract::Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconcl...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/764163

    authors: Ni Q,Ji A,Yin J,Wang X,Liu X

    更新日期:2015-01-01 00:00:00

  • Magnifying Endoscopy with Blue Laser Imaging Improves the Microstructure Visualization in Early Gastric Cancer: Comparison of Magnifying Endoscopy with Narrow-Band Imaging.

    abstract:BACKGROUNDS:Magnifying endoscopy with blue laser imaging (ME-BLI) for diagnosis of early gastric cancer (EGC) is as effective as magnifying endoscopy with narrow-band imaging (ME-NBI). However, there are different EGCs in microstructure visualization between ME-BLI and ME-NBI. This study aimed to clarify the pathologic...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/8303046

    authors: Kimura-Tsuchiya R,Dohi O,Fujita Y,Yagi N,Majima A,Horii Y,Kitaichi T,Onozawa Y,Suzuki K,Tomie A,Okayama T,Yoshida N,Kamada K,Katada K,Uchiyama K,Ishikawa T,Takagi T,Handa O,Konishi H,Kishimoto M,Naito Y,Yanagisa

    更新日期:2017-01-01 00:00:00

  • Efficacy of i-Scan Imaging for the Detection and Diagnosis of Early Gastric Carcinomas.

    abstract::We determined comparative efficacy of i-Scan for detection and diagnosis of gastric cancer. Ten patients diagnosed with early gastric cancer based on histopathological findings were analyzed. White light and i-Scan moving images recorded from these patients in twin mode were separated into white light and i-Scan. Twel...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/819395

    authors: Nishimura J,Nishikawa J,Nakamura M,Goto A,Hamabe K,Hashimoto S,Okamoto T,Suenaga M,Fujita Y,Hamamoto Y,Sakaida I

    更新日期:2014-01-01 00:00:00

  • Association between JAK2 rs4495487 Polymorphism and Risk of Budd-Chiari Syndrome in China.

    abstract::Myeloproliferative neoplasms (MPNs) are the leading cause of Budd-Chiari syndrome (BCS), and the C allele of JAK2 rs4495487 was reported to be an additional candidate locus that contributed to MPNs. In the present study, we examined the role of JAK2 rs4495487 in the etiology and clinical presentation of Chinese BCS pa...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/807865

    authors: Zhang P,Zhang Y,Zhang J,Wang H,Ma H,Wang W,Gao X,Xu H,Lu Z

    更新日期:2015-01-01 00:00:00

  • Transitioning the Adolescent with IBD from Pediatric to Adult Care: A Review of the Literature.

    abstract::The incidence of inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), has increased in pediatric populations over the last decade. Patients diagnosed during childhood often survive well into adulthood, and therefore their healthcare requires transfer to an adult gastroenterolo...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/853530

    authors: Bollegala N,Nguyen GC

    更新日期:2015-01-01 00:00:00